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Its expression is frequently elevated across diverse cancer cells and is associated with cancer development and poor clinical outcomes. Mechanistically, LINC01116 influences cancer gene expression through pathways such as microRNA “sponging” and other non-genic modes, thereby affecting proliferation, migration, invasion, and chemoresistance. The review consolidates current evidence on its biological functions and molecular mechanisms, supporting future therapeutic and prognostic applications.",{"@graph":69,"@context":122},[70,84,105],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":40,"@type":76,"position":81},"https://docshare.wps.com/document/research-report/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/biological-functions-and-molecular-mechanisms-of-linc01116-in-cancer-review-article/329320/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/biological-functions-and-molecular-mechanisms-of-linc01116-in-cancer-review-article/329320.png","ImageObject",300,407,{"name":92,"@type":93},"Eden","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-11-10","2026-09-21",true,{"@type":102,"interactionType":103,"userInteractionCount":39},"InteractionCounter",{"@type":104},"ViewAction",{"@type":106,"mainEntity":107},"FAQPage",[108,114,118],{"name":109,"@type":110,"acceptedAnswer":111},"What biological roles does LINC01116 play in cancer progression?","Question",{"text":112,"@type":113},"LINC01116 regulates key cancer-related processes including cell growth, migration, invasion, and chemoresistance, contributing to tumor progression.","Answer",{"name":115,"@type":110,"acceptedAnswer":116},"How is LINC01116 expression related to cancer prognosis?",{"text":117,"@type":113},"Elevated LINC01116 expression is significantly associated with cancer development and poor prognosis in cancer patients.",{"name":119,"@type":110,"acceptedAnswer":120},"What molecular mechanisms are discussed for LINC01116 in cancer?",{"text":121,"@type":113},"The review describes mechanisms such as microRNA sponging (e.g., via ceRNA-like pathways) and interactions with regulatory components that influence gene expression and oncogenic processes.","https://schema.org",{"og:url":83,"og:type":124,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":126,"canonical":83},"index,follow",{"doc_id":128,"site_id":62},329320,1790980453,{"code":4,"msg":5,"data":131},{"doc_id":128,"user_id":132,"nickname":92,"user_avatar":133,"doc_module":4,"category_id":39,"category_name":40,"doc_title":65,"doc_description":67,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":39,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":39,"language":139,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":140,"faqs":141,"seo_title":142,"seo_description":67,"update_tm":143,"read_time":46,"preview_page_count":4},1374391974468,"https://ap-avatar.wpscdn.com/davatar_29158cc5080c5b710cf443261637dec0","Heliyon 10 (2024) e38490  \nContents lists available at ScienceDirect  \nHeliyon  \njournal [homepage:](homepage: www.cell.com/heliyon)[ www.cell.com/heliyon](homepage: www.cell.com/heliyon)  \n| Review article\u003Cbr>Biological functions and molecular mechanisms of LINC01116 in cancer\u003Cbr>Ke Shia, Xue-Ying Wang b,c, Li-De Huang d, Qiang Guob, Wei Yuan c,**, Yan Lve,*, Dan Li f,***\u003Cbr>a Department of Thoracic Surgery, Beilun District People’s Hospital of Ningbo, Ningbo City, China b Department of Cardiothoracic Surgery, Taihe Hospital, Hubei Medical University, Shiyan City, China c Department of Basic Medicine, Hubei University of Medicine, Shiyan City, China\u003Cbr>d Department of Pain management, People’s Hospital of Shiyan City, Hubei Medical University, Shiyan City, China e Department of Thoracic Surgery, The Second Affiliated Hospital of Zunyi Medical University, Zunyi, China f Department of Oncology, Taihe Hospital, Hubei University of Medicine, Shiyan City, China |  |\n| --- | --- |\n| A R T I C L E I N F O\u003Cbr>Keywords: LINC01116 microRNA Biofunction Prognosis | A B S T R A C T |\n|  | LINC01116, a long non-coding RNA (lncRNA), serves as an important regulator in the progression of cancer cells and has attracted increased attention in biological fields. It is overexpressed in various cancer cells and is significantly correlated with cancer development and poor prognosis in cancer patients. Moreover, LINC01116 regulates the gene expression of various cancers through intricate pathways, such as sponging the microRNAs or other non-genic manners. These signaling pathways greatly affect the cancer’s biological functions, including cell growth, migration, invasion, and chemoresistance. Hence, LINC01116 may serve as a prognostic biomarker and therapeutic target for human cancer. This paper summarizes the current evidence regarding the biological functions and molecular mechanisms of LINC01116 in the progression of cancer, providing theoretical references for LINC01116-related cancer treatment in the future. |\n\n1. Introduction  \nCancer poses a grave threat to human health and is the leading cause of mortality worldwide, with rapidly increasing annual incidence and mortality rates [1–5]. Numerous effective therapeutics have been developed to combat cancer, including chemotherapy, radiotherapy, and targeted therapy. Traditional chemotherapy and radiotherapy have achieved short-term efficacy by directly killing tumor cells, but long-term treatment is limited by immune response suppression, tumor drug resistance, and toxicity to normal cells. In contrast, targeted therapy directly acts on disease-related biomarkers and molecular targets, thereby reducing the damage and side effects to normal tissues to achieve superior therapeutic efficacy [6–13]. In recent years, long non-coding RNAs (lncRNAs) have garnered attention for their crucial roles in regulating gene expression and their influence on cancer development and progression via multiple mechanisms. LncRNAs have been found to be closely associated with the occurrence, development, and prognosis of various cancer types [14–20]. For instance, lncRNA-SNHG16 is overexpressed in bladder cancer (BCa) tissues and cells and is closely related to  \n* Corresponding author.  \n** Corresponding author.  \n*** Corresponding author.  \nE-mail addresses: [yw2017dna@163.com](yw2017dna@163.com) (W. Yuan), [568633195@qq.com](568633195@qq.com) (Y. Lv), [lq949661259@163.com](lq949661259@163.com) (D. Li).  \n[https://doi.org/10.1016/j.heliyon.2024.e38490](https://doi.org/10.1016/j.heliyon.2024.e38490)  \nReceived 6 July 2024; Received in revised form 24 September 2024; Accepted 25 September 2024 Available online 30 September 2024  \n2405-8440/© 2024 Published by Elsevier Ltd. This is an open access article under the CC BY-NC-ND license  \n([http://creativecommons.org/licenses/by-nc-nd/4.0/](http://creativecommons.org/licenses/by-nc-nd/4.0/)).  \npoor prognosis in patients. LncRNA-SNHG16 directly binds to the enhancer of Ze","cbCaiecHeyMQYDrm","https://ap.wps.com/l/cbCaiecHeyMQYDrm","pdf",1310737,"English","# Introduction\n# Mechanisms of LINC01116 in cancer\n## LINC01116-miRNAs","[{\"question\":\"What biological roles does LINC01116 play in cancer progression?\",\"answer\":\"LINC01116 regulates key cancer-related processes including cell growth, migration, invasion, and chemoresistance, contributing to tumor progression.\"},{\"question\":\"How is LINC01116 expression related to cancer prognosis?\",\"answer\":\"Elevated LINC01116 expression is significantly associated with cancer development and poor prognosis in cancer patients.\"},{\"question\":\"What molecular mechanisms are discussed for LINC01116 in cancer?\",\"answer\":\"The review describes mechanisms such as microRNA sponging (e.g., via ceRNA-like pathways) and interactions with regulatory components that influence gene expression and oncogenic processes.\"}]","Biological functions and molecular mechanisms of LINC01116 in cancer - Review article | PDF",1789983651]