[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"doc-seo-331121-105":3,"doc-detail-331121-en":81,"detail-sidebar-cat-0-en-105":99},{"code":4,"msg":5,"data":6},0,"ok",{"site_id":7,"language":8,"slug":9,"title":10,"keywords":11,"description":12,"schema_data":13,"social_meta":74,"head_meta":76,"extra_data":78,"updated_unix":80},105,"en","biological-evaluation-of-dinuclear-platinumii-complexes-with-aromatic-n-heterocycles-as-bridging-ligands","Biological Evaluation of Dinuclear Platinum(II) Complexes with Aromatic N-Heterocycles as Bridging Ligands","","The review outlines the evolution of effective anti-cancer platinum drugs, beginning with cisplatin and highlighting the improvements offered by second-generation carboplatin in efficacy and tolerability. It emphasizes renewed interest in platinum chemotherapy and focuses on dinuclear platinum(II) complexes containing aromatic N-heterocycles as bridging ligands, represented by[{Pt(L)Cl}2(µ-bridging ligand)]2+. These compounds are synthesized for targeted action against cancer-related conditions, with reported antitumor, antiproliferative, and apoptosis-inducing potential.",{"@graph":14,"@context":73},[15,34,56],{"@type":16,"itemListElement":17},"BreadcrumbList",[18,23,27,31],{"item":19,"name":20,"@type":21,"position":22},"https://docshare.wps.com","Home","ListItem",1,{"item":24,"name":25,"@type":21,"position":26},"https://docshare.wps.com/document/","Document",2,{"item":28,"name":29,"@type":21,"position":30},"https://docshare.wps.com/document/research-report/","Research & Report",3,{"item":32,"name":10,"@type":21,"position":33},"https://docshare.wps.com/document/biological-evaluation-of-dinuclear-platinumii-complexes-with-aromatic-n-heterocycles-as-bridging-ligands/331121/",4,{"url":32,"name":10,"@type":35,"image":36,"author":41,"headline":10,"publisher":44,"fileFormat":47,"inLanguage":8,"description":12,"dateModified":48,"datePublished":49,"encodingFormat":47,"isAccessibleForFree":50,"interactionStatistic":51},"DigitalDocument",{"url":37,"@type":38,"width":39,"height":40},"https://docshare.wps.com/thumbnails/biological-evaluation-of-dinuclear-platinumii-complexes-with-aromatic-n-heterocycles-as-bridging-ligands/331121.png","ImageObject",300,407,{"name":42,"@type":43},"Oliver","Person",{"url":19,"name":45,"@type":46},"DocShare","Organization","application/pdf","2026-10-23","2026-09-21",true,{"@type":52,"interactionType":53,"userInteractionCount":55},"InteractionCounter",{"@type":54},"ViewAction",10,{"@type":57,"mainEntity":58},"FAQPage",[59,65,69],{"name":60,"@type":61,"acceptedAnswer":62},"What is the central focus of the biological evaluation described in the document?","Question",{"text":63,"@type":64},"The document centers on biological evaluation of dinuclear platinum(II) complexes with aromatic N-heterocycles used as bridging ligands, assessing their potential as next-generation platinum-based therapies.","Answer",{"name":66,"@type":61,"acceptedAnswer":67},"How do cisplatin and DNA interactions contribute to apoptosis?",{"text":68,"@type":64},"Cisplatin binds covalently to DNA after ligand substitution, forming intrastrand cross-links that disrupt DNA structure; this can lead to cell death if not repaired and initiate apoptosis processes.",{"name":70,"@type":61,"acceptedAnswer":71},"What factors can affect the effectiveness or resistance of platinum drugs?",{"text":72,"@type":64},"Treatment outcomes can be influenced by DNA repair mechanisms such as nucleotide excision repair and by cellular and blood-related interactions that contribute to drug resistance.","https://schema.org",{"og:url":32,"og:type":75,"og:title":10,"og:site_name":45,"og:description":12},"article",{"robots":77,"canonical":32},"index,follow",{"doc_id":79,"site_id":7},331121,1790661487,{"code":4,"msg":82,"data":83},"success",{"doc_id":79,"user_id":84,"nickname":42,"user_avatar":85,"doc_module":4,"category_id":86,"category_name":29,"doc_title":10,"doc_description":12,"doc_content":87,"file_id":88,"file_url":89,"file_type":90,"file_size":91,"view_count":55,"is_deleted":4,"is_public":22,"is_downloadable":22,"audit_status":22,"page_count":92,"language":93,"language_code":8,"site_id":7,"html_lang":8,"table_of_contents":94,"faqs":95,"seo_title":96,"seo_description":12,"update_tm":97,"read_time":98,"preview_page_count":4},8796095461610,"https://ap-avatar.wpscdn.com/davatar_276721f389ce27ea32af1340a28f341c",8,"Review  \nBiological Evaluation of Dinuclear Platinum(II) Complexes with Aromatic N-Heterocycles as Bridging Ligands  \nDesimir Lukovi´c 1, Andjela A. Franich 2, Marija D. Živkovi´c 3, *, Snežana Rajkovi´c 2, Bojan Stojanovi´c 1,4, *, Nevena Gajovi´c 1, Milena Juriševi´c 1,5, Slaana Pavlovi´c 1, Bojana Simovi´c Markovi´c 1, Marina Jovanovi´c 1, Bojana S. Stojanovi´c 1,6, Radiša Pavlovi´c 5 and Ivan Jovanovi´c 1  \nCitation: Lukovi´c, D.; Franich, A.A.;Živkovi´c, M.D.; Rajkovi´c, S.; Stojanovi´c, B.; Gajovi´c, N.; Juriševi´c, M.; Pavlovi´c, S.; Simovi´c Markovi´c, B.; Jovanovi´c, M.; et al. Biological Evaluation of Dinuclear Platinum(II) Complexes with Aromatic  \nN-Heterocycles as Bridging Ligands. Int. J. Mol. Sci. 2024, 25, 8525 . [https://doi.org/10.3390/ijms25158525](https://doi.org/10.3390/ijms25158525)  \nAcademic Editor: Maria Carmela Bonaccorsi Di Patti  \nReceived: 13 July 2024  \nRevised: 30 July 2024  \nAccepted: 31 July 2024  \nPublished: 5 August 2024  \nCopyright: © 2024 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license ([https://](https://)[ ](https://)[creativecommons.org/licenses/by/](creativecommons.org/licenses/by/)[ ](creativecommons.org/licenses/by/)[4.0/](4.0/)) .  \n1 Center for Molecular Medicine and Stem Cell Research, Faculty of Medical Sciences, University of Kragujevac,  \nS. Markovi´ca 69, 34000 Kragujevac, Serbia; [desimir.lukovic79@gmail.com](desimir.lukovic79@gmail.com) (D.L.);  \n[gajovicnevena@yahoo.com](gajovicnevena@yahoo.com) (N.G.); [milena.jurisevic13@gmail.com](milena.jurisevic13@gmail.com) (M.J.); [sladjadile@gmail.com](sladjadile@gmail.com) (S.P.);  \n[bojana.simovic@gmail.com](bojana.simovic@gmail.com) (B.S.M.); [marina_jovanovic@rocketmail.com](marina_jovanovic@rocketmail.com) (M.J.);  \n[bojana.stojanovic04@gmail.com](bojana.stojanovic04@gmail.com) (B.S.S.); [ivanjovanovic77@gmail.com](ivanjovanovic77@gmail.com) (I.J.)  \n2 Department of Chemistry, Faculty of Science, University of Kragujevac, R. Domanovi´ca 12, 34000 Kragujevac, Serbia; [andjela.frenich@pmf.kg.ac.rs](andjela.frenich@pmf.kg.ac.rs) (A.A.F.); [snezana.rajkovic@pmf.kg.ac.rs](snezana.rajkovic@pmf.kg.ac.rs) (S.R.)  \n3 Department of Pharmacy, Faculty of Medical Sciences, University of Kragujevac, S. Markovi´ca 69,  \n34000 Kragujevac, Serbia  \n4 Department of Surgery, Faculty of Medical Sciences, University of Kragujevac, S. Markovi´ca 69,  \n34000 Kragujevac, Serbia  \n5 Department of Clinical Pharmacy, Faculty of Medical Sciences, University of Kragujevac, S. Markovi´ca 69, 34000 Kragujevac, Serbia; [r.pavlovic2407@gmail.com](r.pavlovic2407@gmail.com)  \n6 Department of Pathophysiology, Faculty of Medical Sciences, University of Kragujevac, S. Markovi´ca 69, 34000 Kragujevac, Serbia  \n* [Correspondence: mzivkovic@kg.ac.rs](Correspondence: mzivkovic@kg.ac.rs) (M.D.Ž .);  \n[bojan.stojanovic01@gmail.com or bojan.stojanovic@fmn.kg.ac.rs](bojan.stojanovic01@gmail.com or bojan.stojanovic@fmn.kg.ac.rs) (B.S.)  \nAbstract: The history of effective anti-cancer medications begins with the discovery of cisplatin’santi-cancer properties. Second-generation analogue, carboplatin, with a similar range of effectiveness, made progress in improving these drugs with fewer side effects and better solubility. Renewed interest in platinum-based drugs has been increasing in the past several years. These developments highlight a revitalized enthusiasm and ongoing exploration in platinum chemotherapy based on the series of dinuclear platinum(II) complexes,[{Pt(L)Cl} 2(µ-bridging ligand)]2+ , which have been synthesized and evaluated for their biological activities. These complexes are designed to target various cancerous conditions, exhibiting promising antitumor, antiproliferative, and apoptosis-inducing activities. The current work aims to shed light on the potential of these complexes as next-generation platinum-based therapies, ","cbCaicehLxcIVbwQ","https://ap.wps.com/l/cbCaicehLxcIVbwQ","pdf",4105831,18,"English","# Introduction\n## Cisplatin as a foundational platinum anticancer agent\n## DNA binding, cross-links, and apoptosis initiation\n## Factors influencing treatment effectiveness and resistance\n## Platinum complexes for human anticancer use","[{\"question\":\"What is the central focus of the biological evaluation described in the document?\",\"answer\":\"The document centers on biological evaluation of dinuclear platinum(II) complexes with aromatic N-heterocycles used as bridging ligands, assessing their potential as next-generation platinum-based therapies.\"},{\"question\":\"How do cisplatin and DNA interactions contribute to apoptosis?\",\"answer\":\"Cisplatin binds covalently to DNA after ligand substitution, forming intrastrand cross-links that disrupt DNA structure; this can lead to cell death if not repaired and initiate apoptosis processes.\"},{\"question\":\"What factors can affect the effectiveness or resistance of platinum drugs?\",\"answer\":\"Treatment outcomes can be influenced by DNA repair mechanisms such as nucleotide excision repair and by cellular and blood-related interactions that contribute to drug resistance.\"}]","Biological Evaluation of Dinuclear Platinum(II) Complexes with Aromatic N-Heterocycles as Bridging Ligands | PDF",1789991874,45,{"code":4,"msg":82,"data":100},[101,105,109,113,118,123,128,131,136,139,142],{"id":22,"doc_module":4,"doc_module_name":25,"category_name":102,"show_sort_weight":103,"slug":104},"Story & Novel",90,"story-novel",{"id":26,"doc_module":4,"doc_module_name":25,"category_name":106,"show_sort_weight":107,"slug":108},"Literature",80,"literature",{"id":33,"doc_module":4,"doc_module_name":25,"category_name":110,"show_sort_weight":111,"slug":112},"Exam",70,"exam",{"id":114,"doc_module":4,"doc_module_name":25,"category_name":115,"show_sort_weight":116,"slug":117},5,"Comic",60,"comic",{"id":119,"doc_module":4,"doc_module_name":25,"category_name":120,"show_sort_weight":121,"slug":122},6,"Technology",50,"technology",{"id":124,"doc_module":4,"doc_module_name":25,"category_name":125,"show_sort_weight":126,"slug":127},7,"Healthcare",40,"healthcare",{"id":86,"doc_module":4,"doc_module_name":25,"category_name":29,"show_sort_weight":129,"slug":130},30,"research-report",{"id":132,"doc_module":4,"doc_module_name":25,"category_name":133,"show_sort_weight":134,"slug":135},9,"Religion & Spirituality",20,"religion-spirituality",{"id":134,"doc_module":4,"doc_module_name":25,"category_name":137,"show_sort_weight":134,"slug":138},"World Cup","world-cup",{"id":55,"doc_module":4,"doc_module_name":25,"category_name":140,"show_sort_weight":55,"slug":141},"Lifestyle","lifestyle",{"id":143,"doc_module":4,"doc_module_name":25,"category_name":144,"show_sort_weight":114,"slug":145},19,"General","general"]