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is the main focus of this review article?","Question",{"text":63,"@type":64},"The review focuses on bioinspired semi-hemic iron(III) complexes used as catalysts for oxygen atom transfer (OAT) reactions in chemical and photochemical systems.","Answer",{"name":66,"@type":61,"acceptedAnswer":67},"How do the discussed iron complexes support oxygen atom transfer mechanisms?",{"text":68,"@type":64},"They stabilize high-valent iron-oxo intermediates that are essential for OAT, and spectroscopic studies clarify interactions between iron centers and substrates.",{"name":70,"@type":61,"acceptedAnswer":71},"Which biological regulators and inhibitor strategies are highlighted?",{"text":72,"@type":64},"Endosulfatases HSulf1 and HSulf2 are highlighted for regulating heparan sulfate sulfation, and sulfamate-containing inhibitor strategies targeting these enzymes are discussed as promising for modulating sulfation 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2642-1747  \nReview Article Copyright© Nasser Thallaj  \nBioinspired Iron (III) Complexes: Catalysts for Sustainable Oxygen Atom Transfer Reactions  \nGhassan Shannan1, Zeina S Malek2 and Nasser Thallaj3*  \n1Head of Biochemistry Department, Al Rasheed University for Science and Technology, Damascus, Syria  \n2Physiology Professor. Faculty of Dentistry, Syrian Private University, Damascus, Syria. ORCID:0009-0006-7075-7991  \n3Pharmaceutical chemistry and drug quality control Department, Faculty of Pharmacy, Al-Rachid privet University, Damascus, Syria. ORCID ID: 0000- 0002-6279-768X  \n*Corresponding author: prof. Dr. Nasser Thallaj Pharmaceutical chemistry and drug quality control Department, Faculty of Pharmacy, Al-Rachid privet University, Damascus, Syria. ORCID ID: 0000-0002-6279-768X.  \nTo Cite This Article: Ghassan Shannan, Zeina S Malek and Nasser Thallaj*. Bioinspired Iron (III) Complexes: Catalysts for Sustainable Oxygen Atom Transfer Reactions. Am J Biomed Sci & Res. 2025 27(1) AJBSR.MS.ID.003516, DOI: 10.34297/AJBSR.2025.27.003516  \nReceived:  March 06, 2025; Published:  May 05, 2025  \nAbstract  \nThis review focuses on bioinspired semi-hemic iron (III) complexes as innovative catalysts for chemical and photochemical Oxygen Atom Transfer (OAT) reactions. Endosulfatases, particularly HSulf1 and HSulf2, play critical roles in regulating Heparan Sulfate (HS) sulfation, influencing various biological processes and disease mechanisms, including cancer and inflammation. We examine the synthesis and characterization of novel dipyrrin-based iron complexes, which stabilize high-valent iron-oxo intermediates essential for OAT. Utilizing environmentally friendly oxidants such as dioxygen and water aligns with sustainable chemistry principles, promoting efficient catalytic systems.  \nThe mechanisms of OAT reactions are elucidated through spectroscopic techniques, revealing insights into the interactions between iron centers and substrates. Challenges related to the instability of high-valent iron species are addressed, highlighting innovative activation strategies that enhance their reactivity and stability. Additionally, the review discusses current inhibitor strategies targeting endosulfatases, particularly sulfamate-containing compounds, which show promise in modulating HS sulfation patterns. By advancing the understanding of iron-mediated catalysis and the development of specific inhibitors, this research underscores the potential for therapeutic applications in diseases characterized by aberrant HS interactions. Future directions aim to refine inhibitor potency and selectivity while exploring targeted drug delivery methods. This exploration not only enhances our comprehension of iron-catalyzed oxidation processes but also paves the way for innovative solutions in glyco-chemistry and biomedicine.  \nKeywords: Bioinspired, Iron (III) Complexes, Oxygen Atom Transfer (OAT), Catalysis, High-Valent Iron-Oxo Species, Sustainable Chemistry, Dipyrrin  \nAm J Biomed Sci & Res Copyright© Nasser Thallaj  \nIntroduction  \nThe exploration of transition metal complexes for catalysing oxidation reactions has garnered significant attention in recent years, particularly within the field of green chemistry. Among these, iron complexes have emerged as promising candidates due to their abundance, low toxicity, and ability to mimic the reactivity of natural metalloenzymes [1] . Oxidation reactions involving Oxygen Atom Transfer (OAT) and hydrogen atom abstraction are fundamental transformations in organic synthesis, yet they often rely on precious and toxic metals such as palladium, iridium, and rhodium, along with hazardous oxidizing agents [2] . This reliance poses both economic and environmental challenges, highlighting the urgent need for the development of sustainable catalytic systems. Natural enzymatic systems, particularly those involving iron, h","cbCaikxCe5W2oFE1","https://ap.wps.com/l/cbCaikxCe5W2oFE1","pdf",1124104,"English","# Abstract\n# Introduction","[{\"question\":\"What is the main focus of this review article?\",\"answer\":\"The review focuses on bioinspired semi-hemic iron(III) complexes used as catalysts for oxygen atom transfer (OAT) reactions in chemical and photochemical systems.\"},{\"question\":\"How do the discussed iron complexes support oxygen atom transfer mechanisms?\",\"answer\":\"They stabilize high-valent iron-oxo intermediates that are essential for OAT, and spectroscopic studies clarify interactions between iron centers and substrates.\"},{\"question\":\"Which biological regulators and inhibitor strategies are highlighted?\",\"answer\":\"Endosulfatases HSulf1 and HSulf2 are highlighted for regulating heparan sulfate sulfation, and sulfamate-containing inhibitor strategies targeting these enzymes are discussed as promising for modulating sulfation patterns.\"}]","Bioinspired Iron (III) Complexes - Catalysts for Sustainable Oxygen Atom Transfer Reactions | PDF"]