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Edited by Michael R. Barnes and Ian C. Gray Copyright ¶ 2003 John Wiley & Sons, Ltd. ISBNs: 0-470-84393-4 (HB); 0-470-84394-2 (PB)  \nBIOINFORMATICS FOR GENETICISTS  \nBIOINFORMATICS FOR GENETICISTS  \nEdited by  \nMichael R. Barnes  \nGenetic Bioinformatics GlaxoSmithKline Pharmaceuticals, UK and  \nIan C. Gray  \nDiscovery Genetics GlaxoSmithKline Pharmaceuticals, UK  \nCopyright 􀀁 2003 John Wiley & Sons Ltd, The Atrium, Southern Gate, Chichester,  \nWest Sussex PO19 8SQ, England  \nTelephone ( +44) 1243 779777  \nEmail (for orders and customer service enquiries): [cs-books@wiley.co.uk](cs-books@wiley.co.uk)  \n[Visit our Home Page on www.wileyeurope.com or www.wiley.com](Visit our Home Page on www.wileyeurope.com or www.wiley.com)  \nAll Rights Reserved. No part of this publication may be reproduced, stored in a retrieval system or transmitted in any form or by any means, electronic, mechanical, photocopying, recording, scanning or otherwise, except under the terms of the Copyright, Designs and Patents Act 1988 or under the terms of a licence issued by the Copyright Licensing Agency Ltd, 90 Tottenham Court Road, London W1T 4LP, UK, without the permission in writing of the Publisher. Requests to the Publisher should be addressed to the Permissions Department, John Wiley & Sons Ltd, The Atrium, Southern Gate, Chichester, West Sussex PO19 8SQ, England, or emailed to [permreq@wiley.co.uk](permreq@wiley.co.uk), or faxed to (+44) 1243 770620.  \nThis publication is designed to provide accurate and authoritative information in regard to the subject matter covered. It is sold on the understanding that the Publisher is not engaged in rendering professional services. If professional advice or other expert assistance is required, the services of a competent professional should be sought.  \nOther Wiley Editorial Offices  \nJohn Wiley & Sons Inc., 111 River Street, Hoboken, NJ 07030, USA Jossey-Bass, 989 Market Street, San Francisco, CA 94103-1741, USA Wiley-VCH Verlag GmbH, Boschstr. 12, D-69469 Weinheim, Germany  \nJohn Wiley & Sons Australia Ltd, 33 Park Road, Milton, Queensland 4064, Australia  \nJohn Wiley & Sons (Asia) Pte Ltd, 2 Clementi Loop \\#02-01, Jin Xing Distripark, Singapore 129809  \nJohn Wiley & Sons Canada Ltd, 22 Worcester Road, Etobicoke, Ontario, Canada M9W 1L1  \nWiley also publishes its books in a variety of electronic formats. Some content that appears in print may not be available in electronic books.  \nBritish Library Cataloguing in Publication Data  \nA catalogue record for this book is available from the British Library  \nISBN 0-470-84393-4  \nISBN 0-470-84394-2 (PB)  \nTypeset in 9/11pt Times by Laserwords Private Limited, Chennai, India Printed and bound in Great Britain by TJ International, Padstow, Cornwall  \nThis book is printed on acid-free paper responsibly manufactured from sustainable forestry in which at least two trees are planted for each one used for paper production.  \n CONTENTS  \nList of contributors xi  \nForeword xiii  \nSECTION I. AN INTRODUCTION TO BIOINFORMATICS FOR THE GENETICIST 1  \nChapter 1 Introduction: The Role of Genetic Bioinformatics 3  \nMichael R. Barnes and Ian C. Gray  \n1.1 Introduction 3  \n1.2 Genetics in the post-genome era—the role of bioinformatics 6  \n1.3 Knowledge management and expansion 6  \n1.4 Data management and mining 6  \n1.5 Genetic study designs 8  \n1.6 Physical locus analysis 12  \n1.7 Selecting candidate genes for analysis 14  \n1.8 Progressing from candidate gene to disease-susceptibility gene 14  \n1.9 Comparative genetics and genomics 15  \n1.10 Conclusions 17  \nReferences 18  \nChapter 2 Internet Resources for the Geneticist 21  \nMichael R. Barnes and Christopher Southan  \n2.1 Introduction 22  \n2.2 Sub-division of biological data on the internet 23  \n2.3 Searching the internet for genetic information 24  \n2.4 Which web search engine? 24  \n2.5 Search syntax: the mathematics of search engine use 26  \n2.6 Boolean searching 27  \n2.7 Searching scientific literatur","cbCaieqbQh4cX20a","https://ap.wps.com/l/cbCaieqbQh4cX20a","pdf",6059116,411,"English","# List of contributors\n# Foreword\n# SECTION I. AN INTRODUCTION TO BIOINFORMATICS FOR THE GENETICIST\n## Chapter 1 Introduction: The Role of Genetic Bioinformatics\n## Chapter 2 Internet Resources for the Geneticist\n## Chapter 3 Human Genetic Variation: Databases and Concepts\n## Chapter 4 Finding, Delineating and Analysing Genes\n# SECTION II. THE IMPACT OF COMPLETE GENOME SEQUENCESON GENETICS\n## Chapter 5 Assembling a View of the Human Genome\n## Chapter 6 Mouse and Rat Genome Informatics","[{\"question\":\"What is the main focus of Bioinformatics for Geneticists?\",\"answer\":\"It focuses on using computational approaches to manage, search, and analyze genetic and genomic information for genetic study and interpretation.\"},{\"question\":\"How does the book help geneticists find and use online resources?\",\"answer\":\"It includes a dedicated section on internet resources, teaching subdivision of data online and search strategies, including search syntax and Boolean searching, as well as sequence and genomic data sources.\"},{\"question\":\"Which topics are covered under human genetic variation?\",\"answer\":\"It covers databases and concepts for human genetic variation, including SNP databases, mutation databases, marker and microsatellite databases, and tools for visualizing SNPs and mutations in genomic and gene contexts.\"}]","Bioinformatics for Geneticists - Book | PDF",1789975178,1036]