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The IKK complex, formed by CHUK, IKBKB, and IKBKG, governs activation of the NF-kB signaling pathway. This study uses publicly available bioinformatics resources to define the oncogenic relevance of IKK genes in selected gastrointestinal cancers. Results show IKBKB and IKBKG are significantly upregulated across examined cancers, while CHUK upregulation appears in esophageal carcinoma and stomach adenocarcinoma.",{"@graph":69,"@context":122},[70,84,105],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":40,"@type":76,"position":81},"https://docshare.wps.com/document/research-report/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/bioinformatic-analysis-of-ikk-complex-genes-expression-in-selected-gastrointestinal-cancers/331336/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/bioinformatic-analysis-of-ikk-complex-genes-expression-in-selected-gastrointestinal-cancers/331336.png","ImageObject",300,407,{"name":92,"@type":93},"Miles","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-11-13","2026-09-21",true,{"@type":102,"interactionType":103,"userInteractionCount":34},"InteractionCounter",{"@type":104},"ViewAction",{"@type":106,"mainEntity":107},"FAQPage",[108,114,118],{"name":109,"@type":110,"acceptedAnswer":111},"What genes make up the IKK complex analyzed in this study?","Question",{"text":112,"@type":113},"The study focuses on the IKK complex consisting of CHUK, IKBKB, and IKBKG, described as the canonical I kappa B kinase.","Answer",{"name":115,"@type":110,"acceptedAnswer":116},"Which IKK genes show upregulation across the examined gastrointestinal cancers?",{"text":117,"@type":113},"IKBKB and IKBKG are significantly upregulated in all examined cancers.",{"name":119,"@type":110,"acceptedAnswer":120},"How are IKK gene expression patterns linked to prognosis in these cancers?",{"text":121,"@type":113},"The study reports that IKK gene expression varies by histological grade and nodal metastases and that lower or higher expression of specific IKK genes correlates with overall survival in different cancer types.","https://schema.org",{"og:url":83,"og:type":124,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":126,"canonical":83},"index,follow",{"doc_id":128,"site_id":62},331336,1792207311,{"code":4,"msg":5,"data":131},{"doc_id":128,"user_id":132,"nickname":92,"user_avatar":133,"doc_module":4,"category_id":39,"category_name":40,"doc_title":65,"doc_description":67,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":34,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":139,"language":140,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":141,"faqs":142,"seo_title":143,"seo_description":67,"update_tm":144,"read_time":26,"preview_page_count":4},13056703019404,"https://ap-avatar.wpscdn.com/davatar_29158cc5080c5b710cf443261637dec0","Article  \nBioinformatic Analysis of IKK Complex Genes Expression in Selected Gastrointestinal Cancers  \nMarta Z˙ebrowska-Nawrocka 1,2, *, Dagmara Szmajda-Krygier 1,2, Adrian Krygier 1, Agnieszka Jele ´n 1,2 and Ewa Balcerczak 1,2  \nCitation: Z˙ ebrowska-Nawrocka, M.; Szmajda-Krygier, D.; Krygier, A.; Jele ´n, A.; Balcerczak, E. Bioinformatic Analysis of IKK Complex Genes Expression in Selected Gastrointestinal Cancers. Int. J. Mol. Sci. 2024, 25, 9868. [https://](https://)[ ](https://)[doi.org/10.3390/ijms25189868](doi.org/10.3390/ijms25189868)  \nAcademic Editor: Hirokazu Fukui  \nReceived: 12 July 2024  \nRevised: 28 August 2024  \nAccepted: 10 September 2024  \nPublished: 12 September 2024  \nCopyright: © 2024 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license ([https://](https://)[ ](https://)[creativecommons.org/licenses/by/](creativecommons.org/licenses/by/)[ ](creativecommons.org/licenses/by/)[4.0/](4.0/)) .  \n1 Department of Pharmaceutical Biochemistry and Molecular Diagnostics, Medical University of Lodz, Muszynskiego 1, 90-151 Lodz, Poland; [dagmara.szmajda@umed.lodz.pl](dagmara.szmajda@umed.lodz.pl) (D.S.-K.);  \n[adrian.krygier@umed.lodz.pl](adrian.krygier@umed.lodz.pl) (A.K.); [agnieszka.jelen@umed.lodz.pl](agnieszka.jelen@umed.lodz.pl) (A.J.); [ewa.balcerczak@umed.lodz.pl](ewa.balcerczak@umed.lodz.pl) (E.B.)  \n2 Laboratory of Molecular Diagnostics, Brain Laboratories, Medical University of Lodz, Czechoslowacka 4, 92-216 Lodz, Poland  \n* [Correspondence: marta.zebrowska@umed.lodz.pl](Correspondence: marta.zebrowska@umed.lodz.pl)  \nAbstract: Gastrointestinal cancers account for over a quarter of all cancer cases and are associated with poor prognosis and high mortality rates. The IKK complex (the canonical I kappa B kinase), comprising the CHUK, IKBKB, and IKBKG genes, plays a crucial role in activating the NF-kB signaling pathway. This study aimed to analyze publicly available bioinformatics data to elucidate the oncogenic role of IKK genes in selected gastrointestinal cancers. Our findings reveal that IKBKB and IKBKGare significantly upregulated in all examined cancers, while CHUK is upregulated in esophageal carcinoma and stomach adenocarcinoma. Additionally, the expression of IKK genes varies with histological grade and nodal metastases. For instance, in stomach adenocarcinoma, CHUK and IKBKBare upregulated in higher histological grades and greater lymph node infiltration. Lower expression levels of CHUK, IKBKB, and IKBKG in stomach adenocarcinoma and IKBKB in esophageal squamous cell carcinoma correlate with shorter overall survival. Conversely, in esophageal adenocarcinoma, reduced IKBKG expression is linked to longer overall survival, while higher IKBKB expression in colon adenocarcinoma is associated with longer overall survival. Given the significant role of IKK genes in the development and progression of selected gastrointestinal cancers, they hold potential as prognostic markers and therapeutic targets, offering valuable insights for clinical practice.  \nKeywords: CHUK; IKBKB; IKBKG; gastrointestinal cancer; expression; prognostic marker  \n1. Introduction  \nGastrointestinal cancers (GI) are a heterogeneous group of diseases that represent more than one-quarter of cancers globally and more than one-third of all malignancies. It is estimated that 4.8 million new cases were reported in 2018, with a mortality rate of 3.4 million people, worldwide. According to the current dynamics of change, it is projected that morbidity and mortality due to GI will double over the next 20 years. Gastrointestinal (GI) cancers share common risk factors but differ significantly in etiology and epidemiology. Over half of GI cancers are attributed to modifiable factors, such as alcohol consumption, smoking, infections, diet, and obesity [1,2] . Among GI cancers, esophageal carcinoma (ESCA), stomach aden","cbCain4YgwWtz8Qp","https://ap.wps.com/l/cbCain4YgwWtz8Qp","pdf",7399842,24,"English","# Introduction\n## Gastrointestinal cancer burden and risk factors\n## Major gastrointestinal cancer types and clinical features\n# Abstract\n## IKK complex and NF-kB pathway background\n## Study aim and findings\n# Keywords\n## Gene targets and relevance","[{\"question\":\"What genes make up the IKK complex analyzed in this study?\",\"answer\":\"The study focuses on the IKK complex consisting of CHUK, IKBKB, and IKBKG, described as the canonical I kappa B kinase.\"},{\"question\":\"Which IKK genes show upregulation across the examined gastrointestinal cancers?\",\"answer\":\"IKBKB and IKBKG are significantly upregulated in all examined cancers.\"},{\"question\":\"How are IKK gene expression patterns linked to prognosis in these cancers?\",\"answer\":\"The study reports that IKK gene expression varies by histological grade and nodal metastases and that lower or higher expression of specific IKK genes correlates with overall survival in different cancer types.\"}]","Bioinformatic Analysis of IKK Complex Genes Expression in Selected Gastrointestinal Cancers | PDF",1789992697]