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This systematic review evaluates the evidence for clinical use of bioimpedance spectroscopy (BIS) in detecting oral squamous cell carcinoma and oral potentially malignant disorders. Methods: The review followed PRISMA guidelines and searched PubMed, MEDLINE, Embase, EBSCOhost, and Google Scholar through March 2022. Results: 6754 records were identified and 481 were eligible, but only five studies met inclusion criteria. All studies showed significant divergence in BIS metrics between cancerous and normal tissue at 20 Hz and 50 kHz. Conclusion: BIS is promising for noninvasive, portable community screening of malignancies.",{"@graph":69,"@context":122},[70,84,105],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":40,"@type":76,"position":81},"https://docshare.wps.com/document/research-report/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/bioimpedance-a-tool-for-screening-oral-cancer-a-systematic-review/377069/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/bioimpedance-a-tool-for-screening-oral-cancer-a-systematic-review/377069.png","ImageObject",300,407,{"name":92,"@type":93},"Sarah ","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-09-27","2026-09-24",true,{"@type":102,"interactionType":103,"userInteractionCount":14},"InteractionCounter",{"@type":104},"ViewAction",{"@type":106,"mainEntity":107},"FAQPage",[108,114,118],{"name":109,"@type":110,"acceptedAnswer":111},"What was the objective of this systematic review?","Question",{"text":112,"@type":113},"To investigate the current evidence for the clinical application of bioimpedance in detecting oral squamous cell carcinoma and oral potentially malignant disorders.","Answer",{"name":115,"@type":110,"acceptedAnswer":116},"Which databases and timeframe were used in the search?",{"text":117,"@type":113},"PubMed, MEDLINE, Embase, EBSCOhost, and Google Scholar were searched through March 2022.",{"name":119,"@type":110,"acceptedAnswer":120},"What were the main findings regarding BIS measurements?",{"text":121,"@type":113},"Across included studies, BIS metrics significantly differed between cancerous and normal tissue at 20 Hz and 50 kHz.","https://schema.org",{"og:url":83,"og:type":124,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":126,"canonical":83},"index,follow",{"doc_id":128,"site_id":62},377069,1790468773,{"code":4,"msg":5,"data":131},{"doc_id":128,"user_id":132,"nickname":92,"user_avatar":133,"doc_module":4,"category_id":39,"category_name":40,"doc_title":65,"doc_description":67,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":14,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":34,"language":139,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":140,"faqs":141,"seo_title":142,"seo_description":67,"update_tm":143,"read_time":144},962085320529,"https://ap-avatar.wpscdn.com/davatar_9964176cb1d06d4a9deccf72a44ae3dc","Systematic Review  \nBioimpedance: A Tool for Screening Oral Cancer – A Systematic Review  \nAbstract  \nObjective: The successful management of cancer depends on proper screening and treatment methods. Bioimpedance spectroscopy (BIS) is an established technique in detecting breast cancer, cervical cancer, and prostate cancer. This systematic review sought to investigate the current evidence regarding the clinical application of bioimpedance in the detection of oral squamous cell carcinoma and oral potentially malignant disorders. Study Design: The Preferred Reporting Items for Systematic Reviews and Meta‑Analyses guidelines were followed to perform this review. Electronic databases such as PubMed, MEDLINE, Embase, EBSCOhost, and Google Scholar were searched till March 2022. Articles published in the English medical literature on human participants report on the application of BIS in the screening of precancerous and cancerous lesions. The primary endpoint was defined as the ability to differentiate between normal and cancerous tissue. Results: A total of 6754 articles were identified; of which 481 were eligible for inclusion. Only five articles met the eligibility criteria and were included in the study. Qualitative analysis for each study was done to assess the data provided. All the studies demonstrated a significant divergence in BIS metrics between cancerous and normal tissue at 20 Hz and 50 KHz. Conclusion: Bioimpedance appears to be a promising novel tool for the detection of various malignancies which can be used in community screening due to its noninvasiveness and portability.  \nKeywords: Bioimpedance, bioimpedance spectroscopy, cancer screening, electrical impedance spectroscopy, malignancy, oral cancer, oral squamous cell carcinoma   \nVaibhav Gupta, Usha Agrawal, Poonam Goel  \nCRIB Lab, National Institute of Pathology ‑ ICMR, Delhi, India  \nIntroduction  \nImpedance is an effective resistance of an electric circuit or constituent to alternating current (AC), occurring from the joint result of ohmic resistance and reactance, and it is measured as a ratio of voltage‑to‑current in an AC circuit. The impedance sourced by inductance and capacitance jointly represents reactance and presents the imaginary part of impedance, whereas the resistance presents the real part.[1]  \nImpedance spectroscopy (IS) is a common phrase that considers the small‑signal assessment of the linear electrical reaction of a material of concern (including electrode effects) and the consequent examination of the response to give valuable data about the physicochemical characteristics of the method.[2]  \nBioelectrical impedance or bioimpedance can be described as organic tissue’s response to block an external electric current or how a living organism responds  \nThis is an open access journal, and articles are distributed under the terms of the Creative Commons Attribution‑NonCommercial‑ShareAlike 4.0 License, which allows others to remix, tweak, and build upon the work non‑commercially, as long as appropriate credit is given and the new creations are licensed under the identical terms.  \nFor reprints [contact:](contact: WKHLRPMedknow_reprints@wolterskluwer.com)[ WKHLRPMedknow_reprints@wolterskluwer.com](contact: WKHLRPMedknow_reprints@wolterskluwer.com)  \nto the current. It is the measurement of the impedance signal, done by inserting electrical currents and assessing the voltage produced by the tissue impedance through the electrodes. The physiological and chemical status of the biological cells and/ or tissues greatly influences the frequency response of bioimpedance and differs for each individual.[3,4]  \nBioimpedance includes both resistance and capacitance and may be described as Z = R + jX, where X is reactance, R is resistance, and Z is impedance. Resistance measured is the opposite of the conductor of electricity, and reactance is created by the excess antagonism to the current from capacitance result of cell membranes. Capacitance can be defi","cbCaijFvuuFYrlU0","https://ap.wps.com/l/cbCaijFvuuFYrlU0","pdf",1167638,"English","# Abstract\n## Objective\n## Methods\n## Results\n## Conclusion\n# Introduction\n## Impedance and impedance spectroscopy\n## Bioelectrical impedance and BIS measurement\n# Citation and Publication Details","[{\"question\":\"What was the objective of this systematic review?\",\"answer\":\"To investigate the current evidence for the clinical application of bioimpedance in detecting oral squamous cell carcinoma and oral potentially malignant disorders.\"},{\"question\":\"Which databases and timeframe were used in the search?\",\"answer\":\"PubMed, MEDLINE, Embase, EBSCOhost, and Google Scholar were searched through March 2022.\"},{\"question\":\"What were the main findings regarding BIS measurements?\",\"answer\":\"Across included studies, BIS metrics significantly differed between cancerous and normal tissue at 20 Hz and 50 kHz.\"}]","Bioimpedance: A Tool for Screening Oral Cancer - A Systematic Review | PDF",1790222974,18]