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Recent bone defect repair strategies increasingly explore biodegradable implants that decompose gradually during tissue regeneration. Magnesium alloy–based materials offer tunable degradation, strong biocompatibility, suitable mechanical strength, and osteogenic potential, making Mg-containing implants central to bone regenerative medicine. Remaining barriers include rapid degradation and limited osteogenic performance, motivating further refinement of magnesium alloy application approaches.",{"@graph":69,"@context":122},[70,84,105],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":35,"@type":76,"position":81},"https://docshare.wps.com/document/healthcare/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/biodegradable-materials-applications-and-advances-of-magnesium-alloys-in-bone-defects/406786/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/biodegradable-materials-applications-and-advances-of-magnesium-alloys-in-bone-defects/406786.png","ImageObject",300,407,{"name":92,"@type":93},"Fans","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-10-30","2026-09-28",true,{"@type":102,"interactionType":103,"userInteractionCount":44},"InteractionCounter",{"@type":104},"ViewAction",{"@type":106,"mainEntity":107},"FAQPage",[108,114,118],{"name":109,"@type":110,"acceptedAnswer":111},"What makes bone defects a significant clinical problem?","Question",{"text":112,"@type":113},"Bone defects arise from diverse etiologies such as tumors, trauma, necrosis, and congenital deformities. 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In recent years, novel approaches for bone defect repair have been continuously explored. Biodegradable synthetic materials, particularly those capable of gradual decomposition during tissue regeneration processes, are recognized as ideal candidates for bone repair implants. Natural or synthetic polymer-based materials have been extensively employed in osteochondral repair due to their favorable biocompatibility. Furthermore, biodegradable magnesium (Mg)-based metals constitute another crucial category of bone substitutes. Mg alloys demonstrate unique advantages, including tunable degradation rates, excellent biocompatibility, appropriate mechanical strength, and remarkable osteogenic potential, positioning Mgcontaining implants as a pivotal direction in bone regenerative medicine. However, clinical applications of Mg alloys still face challenges such as rapid degradation kinetics and insufficient osteogenic performance. Further investigation into advanced application strategies for Mg alloys holds significant clinical implications for bone defect therapeutics.  \nKey Words: Bone defects; Biodegradable synthetic materials; Magnesium alloys; Multiple  \n WJO  [https://www.wjgnet.com](https://www.wjgnet.com) 1 December 18, 2025  Volume 16  Issue 12   \nLu JS et al. Applications and advances of Mg alloys for bone defects  \nmechanisms; Biocompatibility  \n©The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved.  \nCore Tip: Degradable magnesium (Mg) alloys have been extensively utilized in the treatment of bone defects owing to their superior mechanical properties, excellent biocompatibility, and potent osteogenic capabilities. Mg alloys enhance bone tissue regeneration via multiple mechanisms, including t","cbCaiqt1QBw2C4Nc","https://ap.wps.com/l/cbCaiqt1QBw2C4Nc","pdf",844915,"English","# Abstract\n# Core Tip\n# Citation\n# Bone Defects and Current Treatments","[{\"question\":\"What makes bone defects a significant clinical problem?\",\"answer\":\"Bone defects arise from diverse etiologies such as tumors, trauma, necrosis, and congenital deformities. Limited natural repair capacity can severely affect patients’ quality of life and increase socioeconomic burdens.\"},{\"question\":\"Why are biodegradable materials considered promising for bone defect repair?\",\"answer\":\"Biodegradable synthetic materials can gradually decompose during tissue regeneration, supporting implant-to-tissue transition. The text highlights their role as ideal candidates for bone repair implants.\"},{\"question\":\"What advantages do magnesium alloys provide, and what challenges remain?\",\"answer\":\"Mg alloys offer tunable degradation rates, excellent biocompatibility, appropriate mechanical strength, and strong osteogenic potential. Clinical use is still constrained by rapid degradation kinetics and insufficient osteogenic performance.\"}]","Biodegradable materials - Applications and advances of magnesium alloys in bone defects | PDF",1790567834,15]