[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"detail-sidebar-cat-0-en-105":3,"doc-seo-455838-105":59,"doc-detail-455838-en":130},{"code":4,"msg":5,"data":6},0,"success",[7,13,18,23,28,33,38,43,48,51,55],{"id":8,"doc_module":4,"doc_module_name":9,"category_name":10,"show_sort_weight":11,"slug":12},1,"Document","Story & Novel",90,"story-novel",{"id":14,"doc_module":4,"doc_module_name":9,"category_name":15,"show_sort_weight":16,"slug":17},2,"Literature",80,"literature",{"id":19,"doc_module":4,"doc_module_name":9,"category_name":20,"show_sort_weight":21,"slug":22},4,"Exam",70,"exam",{"id":24,"doc_module":4,"doc_module_name":9,"category_name":25,"show_sort_weight":26,"slug":27},5,"Comic",60,"comic",{"id":29,"doc_module":4,"doc_module_name":9,"category_name":30,"show_sort_weight":31,"slug":32},6,"Technology",50,"technology",{"id":34,"doc_module":4,"doc_module_name":9,"category_name":35,"show_sort_weight":36,"slug":37},7,"Healthcare",40,"healthcare",{"id":39,"doc_module":4,"doc_module_name":9,"category_name":40,"show_sort_weight":41,"slug":42},8,"Research & Report",30,"research-report",{"id":44,"doc_module":4,"doc_module_name":9,"category_name":45,"show_sort_weight":46,"slug":47},9,"Religion & Spirituality",20,"religion-spirituality",{"id":46,"doc_module":4,"doc_module_name":9,"category_name":49,"show_sort_weight":46,"slug":50},"World Cup","world-cup",{"id":52,"doc_module":4,"doc_module_name":9,"category_name":53,"show_sort_weight":52,"slug":54},10,"Lifestyle","lifestyle",{"id":56,"doc_module":4,"doc_module_name":9,"category_name":57,"show_sort_weight":24,"slug":58},19,"General","general",{"code":4,"msg":60,"data":61},"ok",{"site_id":62,"language":63,"slug":64,"title":65,"keywords":66,"description":67,"schema_data":68,"social_meta":123,"head_meta":125,"extra_data":127,"updated_unix":129},105,"en","biochemistry-sample-items","Biochemistry Sample Items","","Biochemistry sample questions covering core molecular and clinical biochemistry concepts through multiple-choice scenarios. Topics include DNA synthesis specificity using labeled precursors, translation and tRNA anticodons for codon changes, protein degradation via post-translational modifications, lactose intolerance mechanisms from disaccharidase deficiency, and autosomal recessive carrier risk calculation. Additional questions address endocrine chromaffin cell secretion pathways, phenylketonuria cofactor requirements, purine metabolism disorders causing hyperuricemia and uric acid stones, connective tissue and Marfan-related protein synthesis, collagen structure, and drug-induced hemolysis with Heinz bodies.",{"@graph":69,"@context":122},[70,84,105],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":20,"@type":76,"position":81},"https://docshare.wps.com/document/exam/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/biochemistry-sample-items/455838/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/biochemistry-sample-items/455838.png","ImageObject",300,407,{"name":92,"@type":93},"MrHarris58","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-10-21","2026-09-30",true,{"@type":102,"interactionType":103,"userInteractionCount":34},"InteractionCounter",{"@type":104},"ViewAction",{"@type":106,"mainEntity":107},"FAQPage",[108,114,118],{"name":109,"@type":110,"acceptedAnswer":111},"How do you determine which labeled substance most specifically labels DNA synthesis in tissues?","Question",{"text":112,"@type":113},"Choose the labeled nucleotide that is directly incorporated into DNA during synthesis; DNA uses deoxyribose nucleotides rather than RNA-specific precursors.","Answer",{"name":115,"@type":110,"acceptedAnswer":116},"Which post-translational modification typically marks proteins like cyclin B for degradation?",{"text":117,"@type":113},"Cyclin B targeted for degradation is most likely ubiquitinated, enabling recognition by the proteasome.",{"name":119,"@type":110,"acceptedAnswer":120},"In drug-induced jaundice with Heinz bodies after sulfamethoxazole, what defect is most likely involved?",{"text":121,"@type":113},"Glucose-6-phosphate dehydrogenase deficiency is the classic cause leading to oxidative hemolysis and Heinz body formation after certain drugs.","https://schema.org",{"og:url":83,"og:type":124,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":126,"canonical":83},"index,follow",{"doc_id":128,"site_id":62},455838,1790820224,{"code":4,"msg":5,"data":131},{"doc_id":128,"user_id":132,"nickname":92,"user_avatar":133,"doc_module":4,"category_id":19,"category_name":20,"doc_title":65,"doc_description":67,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":34,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":29,"language":139,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":140,"faqs":141,"seo_title":142,"seo_description":67,"update_tm":143,"read_time":144},687212988360,"https://ap-avatar.wpscdn.com/davatar_276721f389ce27ea32af1340a28f341c","Biochemistry Sample Items  \n1. In order to determine the rate of DNA synthesis in various mammalian tissues, the administration of which of the following labeled substances would be most specific in labeling DNA?  \n(A) Adenosine  \n(B) Cytosine  \n(C) Guanosine  \n(D) Thymidine  \n(E) Uridine  \n2. A 2-year-old boy who recently emigrated from Somalia is brought to the physician because of a 1-day history of pain of his arms and legs. Physical examination shows pale mucous membranes and hepatosplenomegaly. Laboratory studies show a hemoglobin concentration of 8 g/dL. A peripheral blood smear shows sickle cells. Genetic analyses show a point mutation in the β-globin gene leading to a change of a GAG codon (glutamate) to a GUG codon (valine) . Which of the following anticodons is most likely in the tRNA for valine?  \n(A) CAC  \n(B) CTU  \n(C) CUC  \n(D) GAC  \n(E) GCC  \n3. Which of the following post-translational modifications is most likely to be found on a cyclin B protein that is targeted for degradation?  \n(A) Acetylated lysine residues  \n(B) Phosphorylated serine residues  \n(C) Phosphorylated threonine residues  \n(D) Phosphorylated tyrosine residues  \n(E) Ubiquitinated lysine residues  \n4. A previously healthy 16-year-old girl is brought to the physician because of abdominal cramps, bloating, and loose stools for 6 months. These symptoms began after she ingested skim milk in an attempt to lose weight. She is atthe 50th percentile for height and 75th percentile for weight. Physical examination shows no abnormalities. Stool studies show a 3+ Clinitest reagent response and pH of 5. After the patient ingests milk, there is an increased hydrogen concentration in expired air. A deficiency of which of the following enzyme activities is the most likely cause of the gastrointestinal symptoms in this patient?  \n(A) Amylase  \n(B) Carboxypeptidase  \n(C) Fructose-1,6-bisphosphate aldolase  \n(D) Galactokinase  \n(E) Lactase  \n(F) Sucrase  \n5. A married couple is screened to assess the risk for Gaucher disease in their children. The activities of glucocerebrosidasein the sera of the mother and father are 45% and 55%, respectively, of the reference value. The couple has one child. Which of the following is the probability of the child possessing one or more alleles of the Gaucher mutation?  \n(A) 0  \n(B) 0.25  \n(C) 0.5  \n(D) 0.75  \n(E) 1.0  \n6. The release of epinephrine from the chromaffin granules of the adrenal medulla into the bloodstream in response to neural stimulation is mediated by which of the following?  \n(A) Acetylcholine  \n(B) γ-Aminobutyric acid (GABA)  \n(C) Cortisol  \n(D) Dopamine  \n(E) Serotonin  \n7. During normal screening for phenylketonuria, a male newborn has a serum phenylalanine concentration of 35 mg/dL (greater than 20 mg/dL is considered a positive test) . Signs of tyrosine deficiency also are apparent. Enzymatic analysis using cultured fibroblasts, obtained after circumcision, shows normal activity of phenylalanine hydroxylase. A possible explanation for these findings is a deficiency in function of which of the following coenzymes?  \n(A) Adenosylcobalamin  \n(B) Biopterin  \n(C) Dihydroquinone  \n(D) Pyridoxal phosphate  \n(E) Tetrahydrofolic acid  \n8. A 2-year-old boy with intellectual developmental disorder has chewed the tips of his fingers on both hands and a portion of his lower lip. His serum uric acid concentration is increased, and he has a history of uric acid renal calculi. His 5-year-old brother has similar findings. Which of the following abnormal enzyme activities is the most likely cause of these findings?  \n(A) Decreased adenine phosphoribosyltransferase  \n(B) Decreased adenosine deaminase  \n(C) Decreased hypoxanthine-guanine phosphoribosyltransferase  \n(D) Increased phosphoribosylpyrophosphate synthetase  \n(E) Increased xanthine oxidase  \n9. A 14-year-old girl is brought to the physician because of a recent growth spurt of 15 cm (6 in) during the past year. She also has had increasing fatigue and palpitations du","cbCaio53MNbCSHfm","https://ap.wps.com/l/cbCaio53MNbCSHfm","pdf",950434,"English","# Sample Items\n## Question 1-12","[{\"question\":\"How do you determine which labeled substance most specifically labels DNA synthesis in tissues?\",\"answer\":\"Choose the labeled nucleotide that is directly incorporated into DNA during synthesis; DNA uses deoxyribose nucleotides rather than RNA-specific precursors.\"},{\"question\":\"Which post-translational modification typically marks proteins like cyclin B for degradation?\",\"answer\":\"Cyclin B targeted for degradation is most likely ubiquitinated, enabling recognition by the proteasome.\"},{\"question\":\"In drug-induced jaundice with Heinz bodies after sulfamethoxazole, what defect is most likely involved?\",\"answer\":\"Glucose-6-phosphate dehydrogenase deficiency is the classic cause leading to oxidative hemolysis and Heinz body formation after certain drugs.\"}]","Biochemistry Sample Items | PDF",1790744451,15]