[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"detail-sidebar-cat-0-en-105":3,"doc-seo-461258-105":59,"doc-detail-461258-en":131},{"code":4,"msg":5,"data":6},0,"success",[7,13,18,23,28,33,38,43,48,51,55],{"id":8,"doc_module":4,"doc_module_name":9,"category_name":10,"show_sort_weight":11,"slug":12},1,"Document","Story & Novel",90,"story-novel",{"id":14,"doc_module":4,"doc_module_name":9,"category_name":15,"show_sort_weight":16,"slug":17},2,"Literature",80,"literature",{"id":19,"doc_module":4,"doc_module_name":9,"category_name":20,"show_sort_weight":21,"slug":22},4,"Exam",70,"exam",{"id":24,"doc_module":4,"doc_module_name":9,"category_name":25,"show_sort_weight":26,"slug":27},5,"Comic",60,"comic",{"id":29,"doc_module":4,"doc_module_name":9,"category_name":30,"show_sort_weight":31,"slug":32},6,"Technology",50,"technology",{"id":34,"doc_module":4,"doc_module_name":9,"category_name":35,"show_sort_weight":36,"slug":37},7,"Healthcare",40,"healthcare",{"id":39,"doc_module":4,"doc_module_name":9,"category_name":40,"show_sort_weight":41,"slug":42},8,"Research & Report",30,"research-report",{"id":44,"doc_module":4,"doc_module_name":9,"category_name":45,"show_sort_weight":46,"slug":47},9,"Religion & Spirituality",20,"religion-spirituality",{"id":46,"doc_module":4,"doc_module_name":9,"category_name":49,"show_sort_weight":46,"slug":50},"World Cup","world-cup",{"id":52,"doc_module":4,"doc_module_name":9,"category_name":53,"show_sort_weight":52,"slug":54},10,"Lifestyle","lifestyle",{"id":56,"doc_module":4,"doc_module_name":9,"category_name":57,"show_sort_weight":24,"slug":58},19,"General","general",{"code":4,"msg":60,"data":61},"ok",{"site_id":62,"language":63,"slug":64,"title":65,"keywords":66,"description":67,"schema_data":68,"social_meta":124,"head_meta":126,"extra_data":128,"updated_unix":130},105,"en","bioactive-peptides-and-probiotic-bacteria-modulators-of-human-health","Bioactive Peptides and Probiotic Bacteria: Modulators of Human Health","","Global functional foods expand as consumers seek clean-label dietary solutions with scientifically substantiated health benefits beyond basic nutrition. Fermentation technology, driven by tailored microbial consortia such as lactic acid bacteria, bifidobacteria, and yeast, enables production of bioactive metabolites while improving safety, sensory quality, and shelf life. Bioactive peptides and probiotics synergize through the gut microbiome to modulate systemic health, including antihypertensive, antioxidant, and immunomodulatory effects, while multi-omics and AI accelerate rational design. A focused Special Issue highlights translational research bridging fermentation engineering and peptide science.",{"@graph":69,"@context":123},[70,84,106],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":35,"@type":76,"position":81},"https://docshare.wps.com/document/healthcare/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/bioactive-peptides-and-probiotic-bacteria-modulators-of-human-health/461258/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/bioactive-peptides-and-probiotic-bacteria-modulators-of-human-health/461258.png","ImageObject",300,407,{"name":92,"@type":93},"Grenda","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-10-30","2026-09-30",true,{"@type":102,"interactionType":103,"userInteractionCount":105},"InteractionCounter",{"@type":104},"ViewAction",11,{"@type":107,"mainEntity":108},"FAQPage",[109,115,119],{"name":110,"@type":111,"acceptedAnswer":112},"Why are functional foods expanding worldwide according to the editorial?","Question",{"text":113,"@type":114},"They expand due to rising consumer demand for dietary solutions that provide health benefits beyond basic nutrition, reflecting a shift toward proactive wellness management.","Answer",{"name":116,"@type":111,"acceptedAnswer":117},"How does fermentation technology support functional food development in the article?",{"text":118,"@type":114},"Fermentation enables sustainable biotransformation, enhances nutritional value and safety, and can produce bioactive metabolites while mitigating antinutritional factors and improving shelf life.",{"name":120,"@type":111,"acceptedAnswer":121},"What role do bioactive peptides and probiotics play in systemic health modulation?",{"text":122,"@type":114},"Bioactive peptides released from dietary proteins and probiotics act synergistically via the gut microbiome, influencing metabolic and immune networks and producing signaling molecules such as short-chain fatty acids.","https://schema.org",{"og:url":83,"og:type":125,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":127,"canonical":83},"index,follow",{"doc_id":129,"site_id":62},461258,1791156667,{"code":4,"msg":5,"data":132},{"doc_id":129,"user_id":133,"nickname":92,"user_avatar":134,"doc_module":4,"category_id":34,"category_name":35,"doc_title":65,"doc_description":67,"doc_content":135,"file_id":136,"file_url":137,"file_type":138,"file_size":139,"view_count":105,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":24,"language":140,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":141,"faqs":142,"seo_title":143,"seo_description":67,"update_tm":144,"read_time":145,"preview_page_count":4},7971474921005,"https://ap-avatar.wpscdn.com/davatar_29158cc5080c5b710cf443261637dec0","Editorial  \nBioactive Peptides and Probiotic Bacteria: Modulators of Human Health  \nQi Wang 1, * and Yafeng Zheng 2  \nReceived: 8 December 2025  \nAccepted: 15 December 2025  \nPublished: 23 December 2025  \nCopyright: © 2025 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license.  \n1 Institute of Food Science and Technology, Fujian Academy of Agricultural Sciences, Fuzhou 350003, China  \n2 College of Food Science, Fujian Agriculture and Forestry University, Fuzhou 350002, China; [zyffst@163.com](zyffst@163.com)  \n* Correspondence: [faaswq@163.com](faaswq@163.com)  \nThe global functional food market is experiencing an unprecedented expansion, driven by escalating consumer demand for dietary solutions that deliver health benefits beyond basic nutrition [1] . This surge reflects a fundamental paradigm shift from reactive disease treatment to proactive wellness management, where food is increasingly recognized as a primary modulator in physiological homeostasis and chronic disease prevention [2] . Contemporary consumers show heightened health literacy, demanding clean-label products with scientifically substantiated efficacy, natural origins, and minimal processing—preferences that compel innovation in bioactive ingredient discovery, sustainable production, and advanced delivery systems [3,4] .  \nFermentation technology has re-emerged as a cornerstone of modern functional food development, offering sustainable and efficient biotransformation pathways that simultaneously enhance nutritional value, safety, and sensory acceptability [5,6] . The strategic application of lactic acid bacteria (LAB), bifidobacteria, and tailored yeast consortia enables the production of bioactive metabolites—including peptides, polyphenols, andoligosaccharides—while mitigating antinutritional factors and extending product shelf life [7–9] . Recent breakthroughs in precision fermentation and synthetic biology have catalyzed a revolution in this space, transforming microbial cell factories into efficient biomanufacturing platforms for the sustainable production of high-value compounds, while substantially reducing environmental footprints [10] . This microbial mastery aligns seamlessly with circular economy principles, valorizing underutilized agricultural byproducts and marine resources into premium functional ingredients.  \nCentral to this evolving landscape are bioactive peptides and probiotics, which function synergistically through the gut microbiome to modulate systemic health. Bioactive peptides, encrypted within dietary proteins, exhibit pleiotropic activities—including antihypertensive, antioxidant, immunomodulatory, and antidiabetic effects—upon liberation via enzymatic hydrolysis or probiotic fermentation [6,11] . Marine-derived proteins, particularly from fish processing waste and microalgal biomass, represent sustainable reservoirs of potent bioactive peptides targeting metabolic syndrome and cardiovascular risk [12] . Concurrently, probiotics operate as dynamic therapeutic agents, reshaping gut microbial ecology, fortifying intestinal barrier integrity, and producing signaling molecules such as short-chain fatty acids (SCFAs) and neurotransmitter analogs [13] . The emerging gut– peptide–probiotic axis exemplifies personalized nutrition potential, wherein strain-specific proteolytic systems release tailored peptide profiles that interact with host receptors and microbial consortia to influence metabolic and immune networks.  \nAccelerating these advances is the integration of multi-omics platforms and artificial intelligence (AI) in food innovation. Metagenomics, metabolomics, and peptidomics  \nunravel complex microbe–host interactions, enabling the rational design of fermented products with optimized bioactivity [14] . AI-driven predictive modeling streamlines strain selection, fermentation optimization, and peptide s","cbCaijhcD8h5NFKH","https://ap.wps.com/l/cbCaijhcD8h5NFKH","pdf",175244,"English","# Editorial\n## Special Issue focus\n## Fermentation as a catalyst for quality and nutrition\n## Bioactive peptides and probiotics: gut–peptide–probiotic axis\n## Multi-omics and AI in food innovation","[{\"question\":\"Why are functional foods expanding worldwide according to the editorial?\",\"answer\":\"They expand due to rising consumer demand for dietary solutions that provide health benefits beyond basic nutrition, reflecting a shift toward proactive wellness management.\"},{\"question\":\"How does fermentation technology support functional food development in the article?\",\"answer\":\"Fermentation enables sustainable biotransformation, enhances nutritional value and safety, and can produce bioactive metabolites while mitigating antinutritional factors and improving shelf life.\"},{\"question\":\"What role do bioactive peptides and probiotics play in systemic health modulation?\",\"answer\":\"Bioactive peptides released from dietary proteins and probiotics act synergistically via the gut microbiome, influencing metabolic and immune networks and producing signaling molecules such as short-chain fatty acids.\"}]","Bioactive Peptides and Probiotic Bacteria: Modulators of Human Health | PDF",1790761111,13]