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This report describes a 22-year-old woman initially diagnosed with bilateral breast fibroadenoma. Postoperative pathology confirmed coexisting bilateral mammary fibroadenomas with DCIS, where benign clinical and imaging features can obscure malignant components. The case emphasizes improving clinician awareness of breast lesion complexity and refining diagnostic and therapeutic protocols to reduce missed diagnoses and adverse outcomes.",{"@graph":69,"@context":122},[70,84,105],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":35,"@type":76,"position":81},"https://docshare.wps.com/document/healthcare/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/bilateral-breast-fibroadenoma-with-bilateral-ductal-carcinoma-in-situ-a-case-report/440421/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/bilateral-breast-fibroadenoma-with-bilateral-ductal-carcinoma-in-situ-a-case-report/440421.png","ImageObject",300,407,{"name":92,"@type":93},"jayni","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-10-30","2026-09-29",true,{"@type":102,"interactionType":103,"userInteractionCount":19},"InteractionCounter",{"@type":104},"ViewAction",{"@type":106,"mainEntity":107},"FAQPage",[108,114,118],{"name":109,"@type":110,"acceptedAnswer":111},"Why is bilateral fibroadenoma with DCIS considered difficult to diagnose?","Question",{"text":112,"@type":113},"Benign clinical and imaging features of fibroadenoma can mask the malignant DCIS component. Bilateral concurrent occurrence further increases diagnostic complexity.","Answer",{"name":115,"@type":110,"acceptedAnswer":116},"What were the key diagnostic findings in this case?",{"text":117,"@type":113},"Ultrasound showed hypoechoic nodules with regular morphology and BI-RADS 3 classification, while pathology after surgery confirmed fibroadenoma coexisting with DCIS in both breasts.",{"name":119,"@type":110,"acceptedAnswer":120},"How was the patient treated and what was the follow-up outcome?",{"text":121,"@type":113},"The patient underwent bilateral mastectomy, followed by expansion of resection margins due to uncertain boundaries. She agreed to tamoxifen endocrine therapy, declined radiotherapy, and had no recurrence signs during 12 months of follow-up.","https://schema.org",{"og:url":83,"og:type":124,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":126,"canonical":83},"index,follow",{"doc_id":128,"site_id":62},440421,1790766127,{"code":4,"msg":5,"data":131},{"doc_id":128,"user_id":132,"nickname":92,"user_avatar":133,"doc_module":4,"category_id":34,"category_name":35,"doc_title":65,"doc_description":67,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":19,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":19,"language":139,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":140,"faqs":141,"seo_title":142,"seo_description":67,"update_tm":143,"read_time":52,"preview_page_count":4},3985747859343,"https://ap-avatar.wpscdn.com/davatar_276721f389ce27ea32af1340a28f341c","Clinical Case Reports  \nCASE REPORT  OPEN ACCESS   \nBilateral Breast Fibroadenoma With Bilateral Ductal Carcinoma In Situ: A Case Report  \nSiyang Wang | Xiaohua Zhang | Wuguo Tian   \nDepartment of Breast and Thyroid Surgery, Daping Hospital, Army Military Medical University, Chongqing, China Correspondence: Xiaohua Zhang ([29780293@qq.com](29780293@qq.com)) | Wuguo Tian ([tianwuguogood@126.com](tianwuguogood@126.com))  \nReceived: 13 November 2025 | Revised: 7 December 2025 | Accepted: 19 December 2025  \nKeywords: bilateral | breast cancer | breast fibroadenoma | ductal carcinoma in situ  \nABSTRACT  \nBreast fibroadenoma coexisting with ductal carcinoma in situ (DCIS) is clinically rare, with bilateral concurrent occurrence presenting greater diagnostic complexity. This report describes a young female patient who was initially diagnosed with bilateral breast fibroadenoma. Postoperative pathological examination revealed coexisting bilateral mammary fibroadenomas with DCIS. While mammary fibroadenomas are common benign lesions, their coexistence with DCIS often leads to missed diagnoses, potentially resulting in serious consequences. This case study highlights the importance of enhancing clinicians' understanding of breast lesion complexity and optimizing diagnostic and therapeutic protocols.  \n1 | Introduction  \nBreast fibroadenoma is a common benign tumor in women, with an incidence rate of approximately 10%[1] . However, cases involving ductal carcinoma in situ (DCIS) within the tumor are relatively rare, with reported incidence rates below 1% in the literature [2] . DCIS refers to malignant proliferation of epithelial cells confined to the ducts, which has the potential to develop into invasive cancer [3] . When DCIS occurs within a fibroadenoma, its benign clinical and imaging features often mask the malignant component, leading to diagnostic challenges before surgery. Currently, most reported cases worldwide are unilateral [4, 5] . The mechanism of coexistence of DCIS and fibroadenoma is still unknown. It may be that the two are two independent tumors coexisting by chance. It may also be that the ductal epithelium in fibroadenoma undergoes malignant transformation under the action of long-term hormone stimulation or other factors. The occurrence of DCIS in both breast fibroadenomas seems to support the latter theory. This article presents a detailed case of DCIS identified within a bilateral breast fibroadenoma confirmed by pathology, exploring its  \nclinical-pathological characteristics, diagnostic approaches, and treatment strategies to enhance clinicians' understanding and improve management of such rare case.  \n2 | Case History/Examination  \nA 22-year-old unmarried woman without children, with no prior medical history or family history of breast cancer, was admitted for “discovery of bilateral breast masses over one month.”The patient had incidentally detected a mass in each upper outer quadrant of both breasts one month prior, without accompanying symptoms such as pain, nipple discharge, or skin changes. Clinical examination revealed symmetrical breasts with normal skin. Palpable masses were found in the upper outer quadrants: approximately 2.0 cm × 1.5 cm on the right and 2.5 cm × 2.0 cm on the left, with firm texture, well-defined borders, and good mobility. No enlarged lymph nodes were detected in the axillary region. Breast ultrasound showed hypoechoic nodules in the upper outer quadrants, with regular morphology, clear margins, and BI-RADS 3 classification.  \nThis is an open access article under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.  \n© 2026 The Author(s). Clinical Case Reports published by John Wiley & Sons Ltd.  \nClinical Case Reports, 2026; 14:e71794 1 of 4  \n[https://doi.org/10.1002/ccr3.71794](https://doi.","cbCaitG3lyA0Fhgl","https://ap.wps.com/l/cbCaitG3lyA0Fhgl","pdf",516819,"English","# Introduction\n# Case History/Examination\n# Differential Diagnosis, Investigations and Treatment\n# Outcome and Follow-Up\n# Discussion","[{\"question\":\"Why is bilateral fibroadenoma with DCIS considered difficult to diagnose?\",\"answer\":\"Benign clinical and imaging features of fibroadenoma can mask the malignant DCIS component. Bilateral concurrent occurrence further increases diagnostic complexity.\"},{\"question\":\"What were the key diagnostic findings in this case?\",\"answer\":\"Ultrasound showed hypoechoic nodules with regular morphology and BI-RADS 3 classification, while pathology after surgery confirmed fibroadenoma coexisting with DCIS in both breasts.\"},{\"question\":\"How was the patient treated and what was the follow-up outcome?\",\"answer\":\"The patient underwent bilateral mastectomy, followed by expansion of resection margins due to uncertain boundaries. She agreed to tamoxifen endocrine therapy, declined radiotherapy, and had no recurrence signs during 12 months of follow-up.\"}]","Bilateral Breast Fibroadenoma With Bilateral Ductal Carcinoma In Situ - A Case Report | PDF",1790692157]