[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"doc-detail-114918-en":3,"doc-seo-114918-105":30,"detail-sidebar-cat-0-en-105":92},{"code":4,"msg":5,"data":6},0,"success",{"doc_id":7,"user_id":8,"nickname":9,"user_avatar":10,"doc_module":4,"category_id":11,"category_name":12,"doc_title":13,"doc_description":14,"doc_content":15,"file_id":16,"file_url":17,"file_type":18,"file_size":19,"view_count":20,"is_deleted":4,"is_public":20,"is_downloadable":20,"audit_status":20,"page_count":21,"language":22,"language_code":23,"site_id":24,"html_lang":23,"table_of_contents":25,"faqs":26,"seo_title":27,"seo_description":14,"update_tm":28,"read_time":29},114918,1099513958607,"Jiven","https://ap-avatar.wpscdn.com/avatar/100002390cf8733938c?x-image-process=image/resize,m_fixed,w_180,h_180&k=1778829742770036399",8,"Research & Report","Bidirectional association between non-alcoholic fatty liver disease and fatty pancreas - A systematic review and meta-analysis","Accumulating evidence suggests a possible link between non-alcoholic fatty liver disease (NAFLD) and fatty pancreas, since both involve fat deposition in the liver and pancreas. This systematic review and meta-analysis evaluated the bidirectional association between NAFLD and fatty pancreas and assessed impacts on disease severity using observational studies from EMBASE and MEDLINE through August 2022.","Bidirectional association between non-alcoholic fatty liver disease and fatty pancreas: a systematic review and meta-analysis  \nWasit Wongtrakula ,b,* , Suvijak Untaaveesupa,* , Nonthalee Pausawadia and Phunchai Charatcharoenwitthayaa  \n\n| Background Accumulating evidence suggests a potential relationship between non-alcoholic fatty liver disease (NAFLD) and fatty pancreas, as both conditions are associated with fat deposition in the liver and pancreas, respectively. The meta-analysis aimed to investigate the bidirectional association between NAFLD and fatty pancreas, as well as their respective effects on disease severity.\u003Cbr>Methods A systematic search of the EMBASE and MEDLINE databases from inception to August 2022 was conducted |\n| --- |\n| , ,\u003Cbr>to identify observational studies examining the association between NAFLD and fatty pancreas, as well as their impact on disease severity. The pooled odds ratio (OR) with a 95% confidence interval (CI) was estimated using a random-effects model. Results Our analysis included 26 case-control or cross-sectional studies, comprising 67,803 participants. We observed a significant association between NAFLD and an increased odds of having fatty pancreas (OR, 6. 18; 95% CI, 4.49–8.51; I2 = 92%) . Similarly, fatty pancreas was significantly associated with an increased odds of having NAFLD (OR, 9.56; 95% CI, 5.09–17.95; I2 = 83%) . Furthermore, the presence of fatty pancreas was associated with a 1.75-fold increased risk of severe NAFLD based on ultrasonographic classification (95% CI, 1.46–2. 10; I2 = 0%) . Among NAFLD patients, the coexistence of fatty pancreas was associated with a trend towards increased odds of having non-alcoholic steatohepatitis (OR, 3.52; 95% CI, 0.65–18.93; I2 = 82%) and advanced fibrosis (OR, 2.47; 95% CI, 0.52–11.80; I2 = 76%) .\u003Cbr>Conclusion This meta-analysis discloses a bidirectional association between NAFLD and fatty pancreas, emphasizing the importance of understanding the intricate relationship between these two conditions. Eur J Gastroenterol Hepatol 35 :\u003Cbr>1107–1116\u003Cbr> Copyright © 2023 Wolters Kluwer Health, Inc. All rights reserved.  |\n\nIntroduction  \nCardiometabolic disorders, particularly obesity and type 2 diabetes mellitus become a global pandemic, affecting 20–30% of the adult population as a consequence of physical inactivity and excessive consumption of the Western diet [1] . These metabolic disorders increased the amount of free fatty acids in the blood, which then accumulated in visceral adipose tissues and other organs including the liver [2,3] . Intrahepatic fat accumulation causes non-alcoholic fatty liver disease (NAFLD), one of the most prevalent chronic liver diseases with a 30% global prevalence [3] . Through intrahepatic lipotoxicity, NAFLD  \nEuropean Journal of Gastroenterology & Hepatology 2023, 35:1107–1116 Keywords: advanced fibrosis, fatty pancreas, meta-analysis, non-alcoholic fatty liver disease, non-alcoholic steatohepatitis  \naDivision of Gastroenterology, Department of Medicine, Faculty of Medicine Siriraj Hospital, Mahidol University and bDepartment of Research and Development, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand Correspondence to Phunchai Charatcharoenwitthaya, MD, Division of Gastroenterology, Department of Medicine, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand  \nTel: +662 4197282; fax: +662 4115013; e-mail: [phunchai@yahoo.com](phunchai@yahoo.com)[ ](phunchai@yahoo.com)[Received](Received 4 July 2023 Accepted 17 July 2023)[ 4 July 2023](Received 4 July 2023 Accepted 17 July 2023)[ Accepted](Received 4 July 2023 Accepted 17 July 2023)[ 17 July 2023](Received 4 July 2023 Accepted 17 July 2023) .  \n*Wasit Wongtrakul and Suvijak Untaaveesup contributed equally to the writing of this article.  \nSupplemental Digital Content is available for this article. Direct URL citations appear in the printed text and are provided in the HTML and PDF versions of this ","cbCaibQNxWyi8Th2","https://ap.wps.com/l/cbCaibQNxWyi8Th2","pdf",940972,1,10,"English","en",105,"# Abstract\n## Background\n## Methods\n## Results\n## Conclusion","[{\"question\":\"What was the goal of this systematic review and meta-analysis?\",\"answer\":\"To investigate the bidirectional association between NAFLD and fatty pancreas and evaluate their respective effects on disease severity.\"},{\"question\":\"How was the evidence collected?\",\"answer\":\"A systematic search of EMBASE and MEDLINE was performed from inception to August 2022 to identify observational studies examining the association between NAFLD and fatty pancreas and their impact on severity.\"},{\"question\":\"What main associations were reported between NAFLD and fatty pancreas?\",\"answer\":\"NAFLD was associated with increased odds of fatty pancreas, and fatty pancreas was also associated with increased odds of NAFLD; fatty pancreas additionally related to higher risk of severe NAFLD based on ultrasonographic classification.\"}]","Bidirectional association between non-alcoholic fatty liver disease and fatty pancreas - A systematic review and meta-analysis | PDF",1785445265,25,{"code":4,"msg":31,"data":32},"ok",{"site_id":24,"language":23,"slug":33,"title":13,"keywords":34,"description":14,"schema_data":35,"social_meta":87,"head_meta":89,"extra_data":91,"updated_unix":28},"bidirectional-association-between-non-alcoholic-fatty-liver-disease-and-fatty-pancreas-a-systematic-review-and-meta-analysis","",{"@graph":36,"@context":86},[37,54,69],{"@type":38,"itemListElement":39},"BreadcrumbList",[40,44,48,51],{"item":41,"name":42,"@type":43,"position":20},"https://docshare.wps.com","Home","ListItem",{"item":45,"name":46,"@type":43,"position":47},"https://docshare.wps.com/document/","Document",2,{"item":49,"name":12,"@type":43,"position":50},"https://docshare.wps.com/document/research-report/",3,{"item":52,"name":13,"@type":43,"position":53},"https://docshare.wps.com/document/bidirectional-association-between-non-alcoholic-fatty-liver-disease-and-fatty-pancreas-a-systematic-review-and-meta-analysis/114918/",4,{"url":52,"name":13,"@type":55,"author":56,"headline":13,"publisher":58,"fileFormat":61,"inLanguage":23,"description":14,"dateModified":62,"datePublished":63,"encodingFormat":61,"isAccessibleForFree":64,"interactionStatistic":65},"DigitalDocument",{"name":9,"@type":57},"Person",{"url":41,"name":59,"@type":60},"DocShare","Organization","application/pdf","2026-08-01","2026-07-30",true,{"@type":66,"interactionType":67,"userInteractionCount":20},"InteractionCounter",{"@type":68},"ViewAction",{"@type":70,"mainEntity":71},"FAQPage",[72,78,82],{"name":73,"@type":74,"acceptedAnswer":75},"What was the goal of this systematic review and meta-analysis?","Question",{"text":76,"@type":77},"To investigate the bidirectional association between NAFLD and fatty pancreas and evaluate their respective effects on disease severity.","Answer",{"name":79,"@type":74,"acceptedAnswer":80},"How was the evidence collected?",{"text":81,"@type":77},"A systematic search of EMBASE and MEDLINE was performed from inception to August 2022 to identify observational studies examining the association between NAFLD and fatty pancreas and their impact on severity.",{"name":83,"@type":74,"acceptedAnswer":84},"What main associations were reported between NAFLD and fatty pancreas?",{"text":85,"@type":77},"NAFLD was associated with increased odds of fatty pancreas, and fatty pancreas was also associated with increased odds of NAFLD; 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