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Research status and expression profiles are compared across TNBC, non-TNBC, and normal breast tissue using bibliometrics from Web of Science and integrated bioinformatic analyses. Publication trends, keyword frequency, cooperation networks, differential gene and pathway enrichment, diagnostic performance, and prognostic significance are evaluated alongside protein-protein interaction and hub gene identification.",{"@graph":14,"@context":72},[15,34,55],{"@type":16,"itemListElement":17},"BreadcrumbList",[18,23,27,31],{"item":19,"name":20,"@type":21,"position":22},"https://docshare.wps.com","Home","ListItem",1,{"item":24,"name":25,"@type":21,"position":26},"https://docshare.wps.com/document/","Document",2,{"item":28,"name":29,"@type":21,"position":30},"https://docshare.wps.com/document/research-report/","Research & Report",3,{"item":32,"name":10,"@type":21,"position":33},"https://docshare.wps.com/document/bibliometric-analysis-of-phosphoglycerate-kinase-1-expression-in-breast-cancer-and-its-distinct-upregulation-in-triple-negative-breast-cancer/331035/",4,{"url":32,"name":10,"@type":35,"image":36,"author":41,"headline":10,"publisher":44,"fileFormat":47,"inLanguage":8,"description":12,"dateModified":48,"datePublished":49,"encodingFormat":47,"isAccessibleForFree":50,"interactionStatistic":51},"DigitalDocument",{"url":37,"@type":38,"width":39,"height":40},"https://docshare.wps.com/thumbnails/bibliometric-analysis-of-phosphoglycerate-kinase-1-expression-in-breast-cancer-and-its-distinct-upregulation-in-triple-negative-breast-cancer/331035.png","ImageObject",300,407,{"name":42,"@type":43},"Noah","Person",{"url":19,"name":45,"@type":46},"DocShare","Organization","application/pdf","2026-10-29","2026-09-21",true,{"@type":52,"interactionType":53,"userInteractionCount":33},"InteractionCounter",{"@type":54},"ViewAction",{"@type":56,"mainEntity":57},"FAQPage",[58,64,68],{"name":59,"@type":60,"acceptedAnswer":61},"What is the study’s primary focus regarding PGK1 in breast cancer?","Question",{"text":62,"@type":63},"The study evaluates PGK1 as a possible biomarker by analyzing breast cancer research status and comparing PGK1 expression and mechanisms among TNBC, non-TNBC, and normal breast tissue.","Answer",{"name":65,"@type":60,"acceptedAnswer":66},"How were bibliometric and expression analyses performed?",{"text":67,"@type":63},"Relevant literature was downloaded from the Web of Science Core Collection, and publication counts, keyword frequency, cooperation networks, and theme trends were analyzed. Normal, TNBC, and non-TNBC mRNA datasets were compiled to identify differentially expressed genes.",{"name":69,"@type":60,"acceptedAnswer":70},"What does the study conclude about PGK1 in TNBC?",{"text":71,"@type":63},"PGK1 expression is identified as a research hotspot and frontier direction, and PGK1 is suggested to promote TNBC progression by mediating metabolism and HIF-1 signaling pathways.","https://schema.org",{"og:url":32,"og:type":74,"og:title":10,"og:site_name":45,"og:description":12},"article",{"robots":76,"canonical":32},"index,follow",{"doc_id":78,"site_id":7},331035,1790986532,{"code":4,"msg":81,"data":82},"success",[83,87,91,95,100,105,110,114,119,122,126],{"id":22,"doc_module":4,"doc_module_name":25,"category_name":84,"show_sort_weight":85,"slug":86},"Story & Novel",90,"story-novel",{"id":26,"doc_module":4,"doc_module_name":25,"category_name":88,"show_sort_weight":89,"slug":90},"Literature",80,"literature",{"id":33,"doc_module":4,"doc_module_name":25,"category_name":92,"show_sort_weight":93,"slug":94},"Exam",70,"exam",{"id":96,"doc_module":4,"doc_module_name":25,"category_name":97,"show_sort_weight":98,"slug":99},5,"Comic",60,"comic",{"id":101,"doc_module":4,"doc_module_name":25,"category_name":102,"show_sort_weight":103,"slug":104},6,"Technology",50,"technology",{"id":106,"doc_module":4,"doc_module_name":25,"category_name":107,"show_sort_weight":108,"slug":109},7,"Healthcare",40,"healthcare",{"id":111,"doc_module":4,"doc_module_name":25,"category_name":29,"show_sort_weight":112,"slug":113},8,30,"research-report",{"id":115,"doc_module":4,"doc_module_name":25,"category_name":116,"show_sort_weight":117,"slug":118},9,"Religion & Spirituality",20,"religion-spirituality",{"id":117,"doc_module":4,"doc_module_name":25,"category_name":120,"show_sort_weight":117,"slug":121},"World Cup","world-cup",{"id":123,"doc_module":4,"doc_module_name":25,"category_name":124,"show_sort_weight":123,"slug":125},10,"Lifestyle","lifestyle",{"id":127,"doc_module":4,"doc_module_name":25,"category_name":128,"show_sort_weight":96,"slug":129},19,"General","general",{"code":4,"msg":81,"data":131},{"doc_id":78,"user_id":132,"nickname":42,"user_avatar":133,"doc_module":4,"category_id":111,"category_name":29,"doc_title":10,"doc_description":12,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":33,"is_deleted":4,"is_public":22,"is_downloadable":22,"audit_status":22,"page_count":139,"language":140,"language_code":8,"site_id":7,"html_lang":8,"table_of_contents":141,"faqs":142,"seo_title":143,"seo_description":12,"update_tm":144,"read_time":145,"preview_page_count":4},8796095462418,"https://ap-avatar.wpscdn.com/avatar/80000253c1241d02b47?x-image-process=image/resize,m_fixed,w_180,h_180&k=1778826106357471780","| W | J | C | O | World Journal of\u003Cbr>Clinical Oncology |\n| --- | --- | --- | --- | --- |\n\nSubmit a Manuscript: [https://www.f6publishing.com](https://www.f6publishing.com) World J Clin Oncol 2024 July 24; 15(7): 867-894  \nDOI: 10.5306/wjco.v15.i7.867 ISSN 2218-4333 (online)  \nORIGINAL ARTICLE  \nClinical and Translational Research  \nBibliometric analysis of phosphoglycerate kinase 1 expression in breast cancer and its distinct upregulation in triple-negative breast cancer  \nJing-Yu Chen, Jian-Di Li, Rong-Quan He, Zhi-Guang Huang, Gang Chen, Wen Zou  \nSpecialty type: Oncology  \nProvenance and peer review:  \nUnsolicited article; Externally peer reviewed.  \nPeer-review model: Single blind  \nPeer-review report’s classification Scientific Quality: Grade B  \nNovelty: Grade B  \nCreativity or Innovation: Grade B  \nScientific Significance: Grade B  \nP-Reviewer: Uz Zaman M  \nReceived: February 8, 2024  \nRevised: May 27, 2024  \nAccepted: June 24, 2024  \nPublished online: July 24, 2024  \nProcessing time: 158 Days and 20.5 Hours  \nJing-Yu Chen, Jian-Di Li, Zhi-Guang Huang, Gang Chen, Wen Zou, Department of Pathology, First Affiliated Hospital of Guangxi Medical University, Nanning 530021, Guangxi Zhuang Autonomous Region, China  \nRong-Quan He, Department of Medical Oncology, First Affiliated Hospital of Guangxi Medical University, Nanning 530021, Guangxi Zhuang Autonomous Region, China  \nCorresponding author: Wen Zou, MM, Doctor, Department of Pathology, First Affiliated Hospital of Guangxi Medical University, No. 6 Shuangyong Road, Nanning 530021, Guangxi Zhuang Autonomous Region, [China.](China. pathologyzw@sr.gxmu.edu.cn)[ pathologyzw@sr.gxmu.edu.cn](China. pathologyzw@sr.gxmu.edu.cn)  \nAbstract  \nBACKGROUND  \nPhosphoglycerate kinase 1 (PGK1) has been identified as a possible biomarker for breast cancer (BC) and may play a role in the development and advancement of triple-negative BC (TNBC) .  \nAIM  \nTo explore the PGK1 and BC research status and PGK1 expression and mechanism differences among TNBC, non-TNBC, and normal breast tissue.  \nMETHODS  \nPGK1 and BC related literature was downloaded from Web of Science Core Collection Core Collection. Publication counts, key-word frequency, cooperation networks, and theme trends were analyzed. Normal breast, TNBC, and nonTNBC mRNA data were gathered, and differentially expressed genes obtained. Area under the summary receiver operating characteristic curves, sensitivity and specificity of PGK1 expression were determined. Kaplan Meier revealed PGK1’s prognostic implication. PGK1 co-expressed genes were explored, and Gene Ontology, Kyoto Encyclopedia of Genes and Genomes, and Disease Ontology applied. Protein-protein interaction networks were constructed. Hub genes identified.  \nRESULTS  \nPGK1 and BC related publications have surged since 2020, with China leading the way. The most frequent keyword was “Expression”. Collaborative networks were found among co-citations, countries, institutions, and authors. PGK1 expression  \n WJCO  [https://www.wjgnet.com](https://www.wjgnet.com) 867 July 24, 2024  Volume 15  Issue 7   \nChen JY et al. PGK1 in TNBC  \nand BC progression were research hotspots, and PGK1 expression and BC survival were research frontiers. In 16 TNBC vs non-cancerous breast and 15 TNBC vs non-TNBC datasets, PGK1 mRNA levels were higher in 1159 TNBC than 1205 non-cancerous breast cases [standardized mean differences (SMD): 0.85, 95% confidence interval (95%CI): 0.54-1.16, I² = 86%, P \u003C 0.001] . PGK1 expression was higher in 1520 TNBC than 7072 non-TNBC cases (SMD: 0.25, 95%CI: 0.03-0.47, I² = 91%, P = 0.02) . Recurrence free survival was lower in PGK1-high-expression than PGK1-low-expression group (hazard ratio: 1.282, P = 0.023) . PGK1 co-expressed genes were concentrated in ATP metabolic process, HIF-1 signaling, and glycolysis/gluconeogenesis pathways.  \nCONCLUSION  \nPGK1 expression is a research hotspot and frontier direction in the BC field. PGK1 may play a strong role in promoting ","cbCairL53G57qtCU","https://ap.wps.com/l/cbCairL53G57qtCU","pdf",17886736,29,"English","# Abstract\n## Background\n## Aim\n## Methods\n## Results\n## Conclusion\n# Main Text Highlights","[{\"question\":\"What is the study’s primary focus regarding PGK1 in breast cancer?\",\"answer\":\"The study evaluates PGK1 as a possible biomarker by analyzing breast cancer research status and comparing PGK1 expression and mechanisms among TNBC, non-TNBC, and normal breast tissue.\"},{\"question\":\"How were bibliometric and expression analyses performed?\",\"answer\":\"Relevant literature was downloaded from the Web of Science Core Collection, and publication counts, keyword frequency, cooperation networks, and theme trends were analyzed. Normal, TNBC, and non-TNBC mRNA datasets were compiled to identify differentially expressed genes.\"},{\"question\":\"What does the study conclude about PGK1 in TNBC?\",\"answer\":\"PGK1 expression is identified as a research hotspot and frontier direction, and PGK1 is suggested to promote TNBC progression by mediating metabolism and HIF-1 signaling pathways.\"}]","Bibliometric analysis of phosphoglycerate kinase 1 expression in breast cancer and its distinct upregulation in triple-negative breast cancer | PDF",1789991266,73]