[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"detail-sidebar-cat-0-en-105":3,"doc-seo-332093-105":59,"doc-detail-332093-en":130},{"code":4,"msg":5,"data":6},0,"success",[7,13,18,23,28,33,38,43,48,51,55],{"id":8,"doc_module":4,"doc_module_name":9,"category_name":10,"show_sort_weight":11,"slug":12},1,"Document","Story & Novel",90,"story-novel",{"id":14,"doc_module":4,"doc_module_name":9,"category_name":15,"show_sort_weight":16,"slug":17},2,"Literature",80,"literature",{"id":19,"doc_module":4,"doc_module_name":9,"category_name":20,"show_sort_weight":21,"slug":22},4,"Exam",70,"exam",{"id":24,"doc_module":4,"doc_module_name":9,"category_name":25,"show_sort_weight":26,"slug":27},5,"Comic",60,"comic",{"id":29,"doc_module":4,"doc_module_name":9,"category_name":30,"show_sort_weight":31,"slug":32},6,"Technology",50,"technology",{"id":34,"doc_module":4,"doc_module_name":9,"category_name":35,"show_sort_weight":36,"slug":37},7,"Healthcare",40,"healthcare",{"id":39,"doc_module":4,"doc_module_name":9,"category_name":40,"show_sort_weight":41,"slug":42},8,"Research & Report",30,"research-report",{"id":44,"doc_module":4,"doc_module_name":9,"category_name":45,"show_sort_weight":46,"slug":47},9,"Religion & Spirituality",20,"religion-spirituality",{"id":46,"doc_module":4,"doc_module_name":9,"category_name":49,"show_sort_weight":46,"slug":50},"World Cup","world-cup",{"id":52,"doc_module":4,"doc_module_name":9,"category_name":53,"show_sort_weight":52,"slug":54},10,"Lifestyle","lifestyle",{"id":56,"doc_module":4,"doc_module_name":9,"category_name":57,"show_sort_weight":24,"slug":58},19,"General","general",{"code":4,"msg":60,"data":61},"ok",{"site_id":62,"language":63,"slug":64,"title":65,"keywords":66,"description":67,"schema_data":68,"social_meta":123,"head_meta":125,"extra_data":127,"updated_unix":129},105,"en","bia-alcl-and-bia-scc-updates-on-clinical-features-and-genetic-mutations-for-latest-recommendations","BIA-ALCL and BIA-SCC: Updates on Clinical Features and Genetic Mutations for Latest Recommendations","","Breast Implant-Associated Anaplastic Large Cell Lymphoma (BIA-ALCL) and Breast Implant-Associated Squamous Cell Carcinoma (BIA-SCC) are emerging malignancies linked to breast implants. Evidence supports a clinical need to understand chronic inflammation and genetics as contributors, while implant-type association is clearer for BIA-ALCL than for BIA-SCC. Recent studies outline dominant JAK-STAT pathway activation in BIA-ALCL and identify multiple molecular players. Overlapping presentations require ultrasound and cytological evaluation first, with MRI and CT-PET for staging, and implant removal with en-bloc capsulectomy as standard therapy.",{"@graph":69,"@context":122},[70,84,105],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":35,"@type":76,"position":81},"https://docshare.wps.com/document/healthcare/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/bia-alcl-and-bia-scc-updates-on-clinical-features-and-genetic-mutations-for-latest-recommendations/332093/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/bia-alcl-and-bia-scc-updates-on-clinical-features-and-genetic-mutations-for-latest-recommendations/332093.png","ImageObject",300,407,{"name":92,"@type":93},"Ivy","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-10-29","2026-09-21",true,{"@type":102,"interactionType":103,"userInteractionCount":39},"InteractionCounter",{"@type":104},"ViewAction",{"@type":106,"mainEntity":107},"FAQPage",[108,114,118],{"name":109,"@type":110,"acceptedAnswer":111},"What are BIA-ALCL and BIA-SCC?","Question",{"text":112,"@type":113},"BIA-ALCL and BIA-SCC are neoplastic complications associated with breast implants. They arise from the breast implant capsule and represent distinct cancers with different genetic and clinical features.","Answer",{"name":115,"@type":110,"acceptedAnswer":116},"Are BIA-SCC and BIA-ALCL associated with specific implant types?",{"text":117,"@type":113},"The text states that BIA-ALCL is often linked to macrotextured implants, while current evidence does not suggest an implant-type association for BIA-SCC.",{"name":119,"@type":110,"acceptedAnswer":120},"What is the recommended diagnostic and initial evaluation approach?",{"text":121,"@type":113},"The document highlights that the clinical presentation overlaps and that ultrasound and cytological examinations are the first recommended steps in the diagnostic work-up. MRI and CT-PET are recommended depending on the clinical presentation for disease staging.","https://schema.org",{"og:url":83,"og:type":124,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":126,"canonical":83},"index,follow",{"doc_id":128,"site_id":62},332093,1790025744,{"code":4,"msg":5,"data":131},{"doc_id":128,"user_id":132,"nickname":92,"user_avatar":133,"doc_module":4,"category_id":34,"category_name":35,"doc_title":65,"doc_description":67,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":39,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":139,"language":140,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":141,"faqs":142,"seo_title":143,"seo_description":67,"update_tm":144,"read_time":145},549758252649,"https://ap-avatar.wpscdn.com/avatar/8000253669c5317157?_k=1778319167496531819","medicina  \nReview  \nBIA-ALCL and BIA-SCC: Updates on Clinical Features and Genetic Mutations for Latest Recommendations  \nGennaro D’Orsi 1, Martina Giacalone 2, Alessio Calicchia 2, Elettra Gagliano 2, Lisa Vannucchi 2, Gianluca Vanni 3, Oreste Claudio Buonomo 3, Valerio Cervelli 2 and Benedetto Longo 2, *  \nCitation: D’Orsi, G.; Giacalone, M.; Calicchia, A.; Gagliano, E.; Vannucchi, L.; Vanni, G.; Buonomo, O.C.; Cervelli, V.; Longo, B. BIA-ALCL and BIA-SCC: Updates on Clinical Features and Genetic Mutations for Latest Recommendations. Medicina 2024, 60, 793. [https://doi.org/10.3390/](https://doi.org/10.3390/)[ ](https://doi.org/10.3390/)medicina60050793  \nAcademic Editors: Pier Camillo Parodi, Glenda Giorgia Caputo and Rossella Sgarzani  \nReceived: 24 March 2024  \nRevised: 3 May 2024  \nAccepted: 7 May 2024  \nPublished: 10 May 2024  \nCopyright: © 2024 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license ([https://](https://)[ ](https://)[creativecommons.org/licenses/by/](creativecommons.org/licenses/by/)[ ](creativecommons.org/licenses/by/)[4.0/](4.0/)) .  \n1 PhD School of Applied Medical-Surgical Sciences, Tor Vergata University of Rome, Via Montpellier 1,  \n00133 Rome, Italy  \n2 Plastic and Reconstructive Surgery at Department of Surgical Science, Tor Vergata University of Rome, Via Montpellier 1, 00133 Rome, Italy  \n3 Division of Breast Unit, Department of Surgical Sciences, School of Medicine and Surgery, Tor Vergata University of Rome, Via Montpellier 1, 00133 Rome, Italy  \n* [Correspondence: benedetto.longo@uniroma2.it](Correspondence: benedetto.longo@uniroma2.it); Tel.: +39-062318851  \nAbstract: Breast Implant-Associated Anaplastic Large Cell Lymphoma (BIA-ALCL) and Breast Implant-Associated Squamous Cell Carcinoma (BIA-SCC) are emerging neoplastic complications related to breast implants. While BIA-ALCL is often linked to macrotextured implants, current evidence does not suggest an implant-type association for BIA-SCC. Chronic inflammation and genetics have been hypothesized as key pathogenetic players, although for both conditions, the exact mechanismsand specific risks related to breast implants are yet to be established. While the genetic alterations in BIA-SCC are still unknown, JAK-STAT pathway activation has been outlined as a dominant signature of BIA-ALCL. Recent genetic investigation has uncovered various molecular players, including MEK-ERK, PI3K/AKT, CDK4-6, and PDL1 . The clinical presentation of BIA-ALCL and BIA-SCCoverlaps, including most commonly late seroma and breast swelling, warranting ultrasound and cytological examinations, which are the first recommended steps as part of the diagnostic work-up. While the role of mammography is still limited, MRI and CT-PET are recommended according to the clinical presentation and for disease staging. To date, the mainstay of treatment for BIA-ALCLand BIA-SCC is implant removal with en-bloc capsulectomy. Chemotherapy and radiation therapy have also been used for advanced-stage BIA-ALCL and BIA-SCC. In-depth characterization of the tumor genetics is key for the development of novel therapeutic strategies, especially for advanced stage BIA-ALCL and BIA-SCC, which show a more aggressive course and poor prognosis.  \nKeywords: BIA-ALCL; BIA-SCC; breast implants; breast reconstruction  \n1. Introduction  \nNowadays, breast implants are in common use for both reconstruction purposes following mastectomy and aesthetic breast augmentation or remodeling. Despite initial concerns, several studies have shown that breast implants do not increase the risk of breast tissue cancer [1] . Nonetheless, the past decades have made the risk of breast implant capsule-associated tumors ever more evident [2] . The first report on Breast ImplantAssociated Anaplastic Large Cell Lymphoma (BIA-ALCL) dates to 1997 when Keech and Creech first described the occurrenc","cbCairo8qOpBeWJJ","https://ap.wps.com/l/cbCairo8qOpBeWJJ","pdf",947160,13,"English","# Abstract\n# Introduction\n## Breast implant-associated tumor background\n## Epidemiology and reported cases\n## Rationale for genetic investigation\n# Diagnostic work-up and clinical presentation\n## Overlapping symptoms and initial testing\n## Role of imaging and staging","[{\"question\":\"What are BIA-ALCL and BIA-SCC?\",\"answer\":\"BIA-ALCL and BIA-SCC are neoplastic complications associated with breast implants. They arise from the breast implant capsule and represent distinct cancers with different genetic and clinical features.\"},{\"question\":\"Are BIA-SCC and BIA-ALCL associated with specific implant types?\",\"answer\":\"The text states that BIA-ALCL is often linked to macrotextured implants, while current evidence does not suggest an implant-type association for BIA-SCC.\"},{\"question\":\"What is the recommended diagnostic and initial evaluation approach?\",\"answer\":\"The document highlights that the clinical presentation overlaps and that ultrasound and cytological examinations are the first recommended steps in the diagnostic work-up. MRI and CT-PET are recommended depending on the clinical presentation for disease staging.\"}]","BIA-ALCL and BIA-SCC: Updates on Clinical Features and Genetic Mutations for Latest Recommendations | PDF",1789996719,33]