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The observational population-based analysis estimates HPV-attributable cancer incidence from 1990–2023 and forecasts trends to 2038, separating cervical squamous cell carcinoma and adenocarcinoma and other HPV-related sites. Findings show rising HPV-attributable cancer incidence in men, fastest for oropharyngeal SCC, while cervical SCC declines in women after 2018; prevention needs to expand beyond screening.",{"@graph":69,"@context":122},[70,84,105],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":35,"@type":76,"position":81},"https://docshare.wps.com/document/healthcare/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/beyond-womens-health-long-term-human-papillomavirusrelated-cancer-trends-in-norway/368989/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/beyond-womens-health-long-term-human-papillomavirusrelated-cancer-trends-in-norway/368989.png","ImageObject",300,407,{"name":92,"@type":93},"OmBimo","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-10-29","2026-09-23",true,{"@type":102,"interactionType":103,"userInteractionCount":52},"InteractionCounter",{"@type":104},"ViewAction",{"@type":106,"mainEntity":107},"FAQPage",[108,114,118],{"name":109,"@type":110,"acceptedAnswer":111},"Why is estimating HPV-attributable cancer burden beyond cervical cancer important in Norway?","Question",{"text":112,"@type":113},"Because organized cervical cancer screening and HPV vaccination do not fully cover other HPV-related cancer sites, understanding the total burden is needed to improve prevention strategies.","Answer",{"name":115,"@type":110,"acceptedAnswer":116},"What data and approach were used to estimate HPV-related cancer trends?",{"text":117,"@type":113},"The study used high-quality Norwegian Cancer Registry data, calculated the proportion of cancers at each site attributed to HPV from existing literature, estimated incidence from 1990–2023, and forecasted to 2038.",{"name":119,"@type":110,"acceptedAnswer":120},"What were the key trend differences between men and women?",{"text":121,"@type":113},"In men, HPV-attributable cancer incidence increased, with male oropharyngeal SCC showing the fastest rise; in women, cervical cancer remained most common, but cervical SCC decreased annually from 2018–2023.","https://schema.org",{"og:url":83,"og:type":124,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":126,"canonical":83},"index,follow",{"doc_id":128,"site_id":62},368989,1790219564,{"code":4,"msg":5,"data":131},{"doc_id":128,"user_id":132,"nickname":92,"user_avatar":133,"doc_module":4,"category_id":34,"category_name":35,"doc_title":65,"doc_description":67,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":52,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":44,"language":139,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":140,"faqs":141,"seo_title":142,"seo_description":67,"update_tm":143,"read_time":144},962090893581,"https://ap-avatar.wpscdn.com/davatar_276721f389ce27ea32af1340a28f341c","The Journal of Infectious Diseases  \nMAJOR ARTICLE  \nBeyond Women’s Health: Long-Term Human Papillomavirus–Related Cancer Trends in Norway  \nThea E. Hetland Falkenthal, Ståle Nygård,a, and Mari Nygårda,  \nDepartment of Research, Cancer Registry of Norway, Norwegian Institute of Public Health, Oslo, Norway  \nBackground. Understanding the total burden of human papillomavirus (HPV)–related cancers is crucial for improving prevention strategies. While organized cervical cancer (CC) screening has been implemented for many years, other HPV-related cancers lacked screening programs. Primary prevention through HPV vaccination has been implemented through national programs, initially for girls and later for boys. To analyze changes in HPV-attributable cancer incidence for both men and women, we used data from the Cancer Registry of Norway (CRN) .  \nMethods. This was an observational population-based study using high-quality data from the CRN. The proportion of cancersat each site attributed to HPV was calculated based on existing literature. We estimated HPV cancer incidence rates from 1990 to 2023 and forecasted incidences until 2038 for cervical squamous cell carcinoma (SCC) and adenocarcinoma, along with other HPVrelated SCCs.  \nResults. Among men, HPV-attributable cancer incidence was rising, with male oropharyngeal SCC showing the fastest increase (annual percentage change [APC], 4.5; P \u003C .01) . Overall, the incidence of HPV-attributable cancers not prevented by screening steadily increased (APC, 2.8; P \u003C .01), surpassing CC incidence and projected to continue rising until 2038. In women, CC remains the most common HPV cancer. However, after an increasing trend since 2004, cervical SCC incidence rates decreased 6% annually from 2018 to 2023 (95% confidence interval [CI], −9.9 to −1.9; P \u003C .01) .  \nConclusions. The burden of HPV-related cancers beyond CC is increasing in Norway, whereas CC incidence is declining. Addressing the rising total burden of HPV-attributable cancers requires additional preventive measures.  \nKeywords. Human Papilloma virus; Cancer; Cervical cancer; oropharyngeal cancer.  \nHuman papillomavirus (HPV) is a common sexually transmitted infection (STI) . There are > 100 types of HPV, and 13 of these are considered high-risk (HR-HPV) types for which persistent infection may lead to precancer and cancer [ 1] . The most frequent cancer caused by HPV is cervical cancer (CC), with all squamous cell carcinomas (SCCs) and most adenocarcinomas (ACs) being caused by HR-HPV infection [ 1, 2] . A considerable proportion of oropharyngeal and anal cancer in both sexes, penile cancer in men, and vulvar and vaginal cancers in women are also caused by HR-HPV [3] .  \nIn this study, we define “HPV-related cancers” as cancer types for which HPV is a known cause, irrespective of the  \nReceived 04 April 2025; editorial decision 22 June 2025; accepted 27 June 2025; published online 9 July 2025  \nPresented in part: EUROGIN, Stockholm, Sweden, March 2024 (abstract \\#6903) .  \naS. N. and M. N. contributed equally to this work.  \nCorrespondence: Thea Eline Hetland Falkenthal, MD, PhD, Department of Research, Cancer Registry of Norway, Norwegian Institute of Public Health, Postboks 5313 Majorstuen, Oslo 0304, Norway ([tehd@fhi.no](tehd@fhi.no)); Ståle Nygård, PhD, Department of Research, Cancer Registry of Norway, Norwegian Institute of Public Health, Postboks 5313 Majorstuen, Oslo 0304, Norway ([stny@fhi.no](stny@fhi.no)) .  \nThe Journal of Infectious Diseases® 2025;232:e897–905  \n© The Author(s) 2025. Published by Oxford University Press on behalf of Infectious Diseases Society of America.  \nThis is an Open Access article distributed under the terms of the Creative Commons Attribution License ([https://creativecommons.org/licenses/by/4.0/](https://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse,)[), which permits unrestricted reuse,](https://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse,","cbCaidwy3VQvsC9I","https://ap.wps.com/l/cbCaidwy3VQvsC9I","pdf",1023763,"English","# Background\n# Methods\n# Results\n# Conclusions","[{\"question\":\"Why is estimating HPV-attributable cancer burden beyond cervical cancer important in Norway?\",\"answer\":\"Because organized cervical cancer screening and HPV vaccination do not fully cover other HPV-related cancer sites, understanding the total burden is needed to improve prevention strategies.\"},{\"question\":\"What data and approach were used to estimate HPV-related cancer trends?\",\"answer\":\"The study used high-quality Norwegian Cancer Registry data, calculated the proportion of cancers at each site attributed to HPV from existing literature, estimated incidence from 1990–2023, and forecasted to 2038.\"},{\"question\":\"What were the key trend differences between men and women?\",\"answer\":\"In men, HPV-attributable cancer incidence increased, with male oropharyngeal SCC showing the fastest rise; in women, cervical cancer remained most common, but cervical SCC decreased annually from 2018–2023.\"}]","Beyond Women’s Health - Long-Term Human Papillomavirus–Related Cancer Trends in Norway | PDF",1790180058,23]