[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"detail-sidebar-cat-0-en-105":3,"doc-seo-435682-105":59,"doc-detail-435682-en":130},{"code":4,"msg":5,"data":6},0,"success",[7,13,18,23,28,33,38,43,48,51,55],{"id":8,"doc_module":4,"doc_module_name":9,"category_name":10,"show_sort_weight":11,"slug":12},1,"Document","Story & Novel",90,"story-novel",{"id":14,"doc_module":4,"doc_module_name":9,"category_name":15,"show_sort_weight":16,"slug":17},2,"Literature",80,"literature",{"id":19,"doc_module":4,"doc_module_name":9,"category_name":20,"show_sort_weight":21,"slug":22},4,"Exam",70,"exam",{"id":24,"doc_module":4,"doc_module_name":9,"category_name":25,"show_sort_weight":26,"slug":27},5,"Comic",60,"comic",{"id":29,"doc_module":4,"doc_module_name":9,"category_name":30,"show_sort_weight":31,"slug":32},6,"Technology",50,"technology",{"id":34,"doc_module":4,"doc_module_name":9,"category_name":35,"show_sort_weight":36,"slug":37},7,"Healthcare",40,"healthcare",{"id":39,"doc_module":4,"doc_module_name":9,"category_name":40,"show_sort_weight":41,"slug":42},8,"Research & Report",30,"research-report",{"id":44,"doc_module":4,"doc_module_name":9,"category_name":45,"show_sort_weight":46,"slug":47},9,"Religion & Spirituality",20,"religion-spirituality",{"id":46,"doc_module":4,"doc_module_name":9,"category_name":49,"show_sort_weight":46,"slug":50},"World Cup","world-cup",{"id":52,"doc_module":4,"doc_module_name":9,"category_name":53,"show_sort_weight":52,"slug":54},10,"Lifestyle","lifestyle",{"id":56,"doc_module":4,"doc_module_name":9,"category_name":57,"show_sort_weight":24,"slug":58},19,"General","general",{"code":4,"msg":60,"data":61},"ok",{"site_id":62,"language":63,"slug":64,"title":65,"keywords":66,"description":67,"schema_data":68,"social_meta":123,"head_meta":125,"extra_data":127,"updated_unix":129},105,"en","beyond-glasses-fda-approval-of-vizz-aceclidine-transforming-presbyopia-management","Beyond glasses - FDA approval of VIZZ (aceclidine) transforming presbyopia management","","Editorial on presbyopia explains age-related loss of accommodative capacity and lens rigidity that leads to blurred near vision, headaches, and eye strain, with global prevalence projected to rise substantially. It reviews conventional optical, contact lens, and surgical strategies that primarily manage symptoms while leaving patients dependent on spectacles and exposing them to side effects. It discusses pharmacologic efforts, noting pilocarpine eyedrops, while emphasizing continuing unmet need for safer, longer-lasting therapies.",{"@graph":69,"@context":122},[70,84,105],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":35,"@type":76,"position":81},"https://docshare.wps.com/document/healthcare/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/beyond-glasses-fda-approval-of-vizz-aceclidine-transforming-presbyopia-management/435682/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/beyond-glasses-fda-approval-of-vizz-aceclidine-transforming-presbyopia-management/435682.png","ImageObject",300,407,{"name":92,"@type":93},"ahduag","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-10-30","2026-09-29",true,{"@type":102,"interactionType":103,"userInteractionCount":24},"InteractionCounter",{"@type":104},"ViewAction",{"@type":106,"mainEntity":107},"FAQPage",[108,114,118],{"name":109,"@type":110,"acceptedAnswer":111},"What causes presbyopia according to the editorial?","Question",{"text":112,"@type":113},"Presbyopia results from age-related loss of accommodative capacity driven primarily by progressive stiffening and reduced elasticity of the crystalline lens, limiting its ability to change shape for near focus.","Answer",{"name":115,"@type":110,"acceptedAnswer":116},"How do conventional presbyopia corrections address the problem?",{"text":117,"@type":113},"They compensate for lost accommodation rather than reversing the underlying lens sclerosis, relying on spectacles, contact lenses, or surgical options with potential limitations and side effects.",{"name":119,"@type":110,"acceptedAnswer":120},"What pharmacologic option does the editorial highlight before VIZZ?",{"text":121,"@type":113},"It highlights pilocarpine hydrochloride 1.25% (VUITY), an eyedrop approved in 2021 that increases depth of field via pupil constriction and improves near acuity for several hours, with mostly mild side effects reported.","https://schema.org",{"og:url":83,"og:type":124,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":126,"canonical":83},"index,follow",{"doc_id":128,"site_id":62},435682,1791361536,{"code":4,"msg":5,"data":131},{"doc_id":128,"user_id":132,"nickname":92,"user_avatar":133,"doc_module":4,"category_id":34,"category_name":35,"doc_title":65,"doc_description":67,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":24,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":19,"language":139,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":140,"faqs":141,"seo_title":142,"seo_description":67,"update_tm":143,"read_time":52,"preview_page_count":4},3985747870414,"https://ap-avatar.wpscdn.com/davatar_9964176cb1d06d4a9deccf72a44ae3dc","Editorial  \n# Beyond glasses: FDA approval of VIZZ (aceclidine)transforming presbyopia management\n\nSyed Mohsin Raza Bukhari, MBBSa , Hassan Mehdi, MBBSa , Ghazi Abdullah, MBBSa , Muhammad Ans, MBBSa ,Mohsin Raza, MBBSb ,*  \n## Introduction, epidemiology, and pathophysiology\n\nPresbyopia, derived from the Greek words for “old eye,” ischaracterized by the progressive inability to focus on nearobjects. This occurs because of age-related loss of accommoda -tive capacity due to decreased elasticity of the crystalline lensand reduced efficiency of the ciliary muscle[1,2] . Functionally, theeye loses its ability to rapidly alter the lens curvature, leading toblurry near vision, headaches, and eye strain, particularly underconditions of low illumination[2] . It typically becomes sympto -maticin the mid-40s and, by age 50, virtually all adults exhibitsome degree of near-blur. About 85% of individuals over 40require near correction[3] . Globally, an estimated 1.8 billionpeople had presbyopia in 2015, and this number is projectedto exceed 2.1 billion by 2030[2,3] . The burden is substantial:roughly 128 million U.S. adults (about half of the 40 + popula -tion) are affected[4,5], and unmet need remains high, especially inunderserved regions. Uncorrected presbyopia profoundlyimpairs daily activities (difficulty reading fine print, eye strain,headaches) and quality of life[3] . As life expectancy rises, thesocietal impact of this near-vision deficit is growing.  \nPresbyopia’s pathophysiology centers on progressive stiffen -ing of the crystalline lens. The lens loses elasticity and enlargeswith age, diminishing its ability to change shape for nearfocus[2,6] . Although earlier theories invoked ciliary muscle weak -ness, evidence now strongly favors lens rigidity as the primarymechanism[3] . The net effect is a reduced “amplitude of accom -modation” such that patients cannot achieve the refractivepower needed for near tasks.  \nThis editorial has been written in line with the TITAN(Transparency In The reporting of Artificial Intelligence)Guidelines 2025[7] .  \naNishtar Medical University and Hospital, Multan, Pakistan and bAvicenna TajikState Medical University, Dushanbe, Tajikistan  \nSponsorships or competing interests that maybe relevant to content are disclosedatthe end of this article.  \n*Corresponding author. Address: Avicenna Tajik State Medical University, 734003,RT, Dushanbe, dist.Sino, str.Sino 29-31, Tajikistan. Tel.: + 992078601001.  \nE-mail: mohsinsadaqat100@gmail.com (M. Raza).  \nCopyright © 2025 The Author(s). Published by Wolters Kluwer Health, Inc. This is anopen access article distributed under the terms of the Creative CommonsAttribution-Non Commercial-No Derivatives License 4.0 (CCBY-NC-ND), where itispermissible to download and share the work provided itis properly cited. The workcannot be changed in any way or used commercially without permission from thejournal.  \nAnnals of Medicine & Surgery (2026) 88:61–64Received 20 August 2025; Accepted 4 December 2025Published online 15 December 2025http://dx.doi.org/10.1097/MS9.0000000000004593  \n## Traditional management approaches\n\nConventional presbyopia corrections all compensate for lostaccommodation rather than reverse its cause. These includespectacles (reading glasses, bifocals, progressives), contact lenses(single-vision or multifocal), and various surgical options(monovision LASIK or PRK, corneal inlays, multifocal/extendeddepth-of-focus intraocular lenses, and even scleral expansionprocedures)[8] . While optical appliances are widely availableand effective, they impose limitations. For example, multifocalor progressive glasses often induce peripheral blur anda restricted visual field, which has been linked to increased fallrisk in older adults [3] .  \nMultifocal contact lenses can restore near vision but may beimpractical for some presbyopes due to age-related dry eye andmanual dexterity issues[3] . Surgical interventions can reducedependence on spectacles, but they carry ri","cbCaieRdnNuiYUIy","https://ap.wps.com/l/cbCaieRdnNuiYUIy","pdf",199191,"English","# Introduction, epidemiology, and pathophysiology\n# Traditional management approaches","[{\"question\":\"What causes presbyopia according to the editorial?\",\"answer\":\"Presbyopia results from age-related loss of accommodative capacity driven primarily by progressive stiffening and reduced elasticity of the crystalline lens, limiting its ability to change shape for near focus.\"},{\"question\":\"How do conventional presbyopia corrections address the problem?\",\"answer\":\"They compensate for lost accommodation rather than reversing the underlying lens sclerosis, relying on spectacles, contact lenses, or surgical options with potential limitations and side effects.\"},{\"question\":\"What pharmacologic option does the editorial highlight before VIZZ?\",\"answer\":\"It highlights pilocarpine hydrochloride 1.25% (VUITY), an eyedrop approved in 2021 that increases depth of field via pupil constriction and improves near acuity for several hours, with mostly mild side effects reported.\"}]","Beyond glasses - FDA approval of VIZZ (aceclidine) transforming presbyopia management | PDF",1790674736]