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Despite existing HPV vaccination and standard chemo/radiotherapy, off-target toxicity and persistent disease burden drive interest in safer natural compounds. Proteomic analysis of cervical carcinoma cells treated with bergenin showed effects across multiple cancer hallmarks, including apoptosis and angiogenesis, while further study indicated molecular docking support for stronger affinity of MMP-9 for bergenin than Galectin-3. Overall results suggest bergenin as a promising anti-angiogenic anticancer candidate warranting further development.",{"@graph":69,"@context":123},[70,84,106],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":40,"@type":76,"position":81},"https://docshare.wps.com/document/research-report/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/bergenin-inhibits-growth-of-human-cervical-cancer-cells-by-decreasing-galectin-3-and-mmp-9-expression/332196/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/bergenin-inhibits-growth-of-human-cervical-cancer-cells-by-decreasing-galectin-3-and-mmp-9-expression/332196.png","ImageObject",300,407,{"name":92,"@type":93},"Maeve","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-10-27","2026-09-21",true,{"@type":102,"interactionType":103,"userInteractionCount":105},"InteractionCounter",{"@type":104},"ViewAction",12,{"@type":107,"mainEntity":108},"FAQPage",[109,115,119],{"name":110,"@type":111,"acceptedAnswer":112},"Why is bergenin considered a candidate for cervical cancer therapy?","Question",{"text":113,"@type":114},"Bergenin is a natural polyphenol with a favorable safety profile and potential anticancer activity. The study focuses on its ability to interfere with angiogenesis by altering proteins such as Galectin-3 and MMP-9.","Answer",{"name":116,"@type":111,"acceptedAnswer":117},"What did proteomic analysis reveal after treating cervical carcinoma cells with bergenin?",{"text":118,"@type":114},"Proteomic analysis indicated that bergenin influences multiple cancer-related hallmarks, including apoptosis and angiogenesis. It also affected several cellular processes beyond cancer pathways.",{"name":120,"@type":111,"acceptedAnswer":121},"How did molecular docking support bergenin’s mechanism in inhibiting angiogenesis?",{"text":122,"@type":114},"Molecular docking suggested that MMP-9 has higher affinity for bergenin than Galectin-3. This aligns with the observed reduction of angiogenic proteins Galectin-3 and MMP-9 in treated cells.","https://schema.org",{"og:url":83,"og:type":125,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":127,"canonical":83},"index,follow",{"doc_id":129,"site_id":62},332196,1790169232,{"code":4,"msg":5,"data":132},{"doc_id":129,"user_id":133,"nickname":92,"user_avatar":134,"doc_module":4,"category_id":39,"category_name":40,"doc_title":65,"doc_description":67,"doc_content":135,"file_id":136,"file_url":137,"file_type":138,"file_size":139,"view_count":105,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":140,"language":141,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":142,"faqs":143,"seo_title":144,"seo_description":67,"update_tm":145,"read_time":146,"preview_page_count":4},5909877438554,"https://ap-avatar.wpscdn.com/avatar/5600025385ad2bf12a7?_k=1778553567797529272","[www. nature.com/scientificreports](www. nature.com/scientificreports)  \nOPEN  \nBergenin inhibits growth of human cervical cancer cells by decreasing Galectin‑3 and MMP‑9 expression  \nRavi Chauhan1, Lakshay Malhotra3,4, Ashna Gupta1, Gunjan Dagar1, Mohini Mendiratta2, Tariq Masoodi 5, Sheema Hashem6, Sara Al Marzooqi7, Dayasagar Das8, Shahab Uddin9, Abdul Samath Ethayathulla 3, Muzafar A. Macha10, Ammira Al‑ShabeebAkil7,  \nRanjit Kumar Sahoo2, Ekta Rai11, AjazA. Bhat7 & Mayank Singh1*  \nCervical cancer is still the leading cause of cancer mortality worldwide even after introduction of vaccine against Human papillomavirus (HPV), due to low vaccine coverage, especially in the developing world. Cervical cancer is primarily treated by Chemo/Radiotherapy, depending on the disease stage, with Carboplatin/Cisplatin‑based drug regime. These drugs being non‑specific, target rapidly dividing cells, including normal cells, so safer options are needed for lower off‑target toxicity. Natural products offer an attractive option compared to synthetic drugs due to their well‑established safety profile and capacity to target multiple oncogenic hallmarks of cancer like inflammation, angiogenesis, etc. In the current study, we investigated the effect of Bergenin (C‑glycoside of 4‑O‑methylgallic acid), a natural polyphenol compound that is isolated from medicinal plants such as Bergenia crassifolia, Caesalpinia digyna, and Flueggea leucopyrus. Bergenin has been shown to have anti‑inflammatory, anti‑ulcerogenic, and wound healing properties but its anticancer potential has been realized only recently. We performed a proteomic analysis of cervical carcinoma cells treated with bergenin and found it to influence multiple hallmarks of cancers, including apoptosis, angiogenesis, and tumor suppressor proteins. It was also involved in many different cellular processes unrelated to cancer, as shown by our proteomic analysis. Further analysis showed bergeninto bea potent‑angiogenic agent by reducing key angiogenic proteins like Galectin 3 and MMP‑9 (Matrix Metalloprotease 9) in cervical carcinoma cells. Further understanding of this interaction was carried out using molecular docking analysis, which indicated MMP‑9 has more affinity for bergenin as compared to Galectin‑3. Cumulatively, our data provide novel insight into the anti‑angiogenic mechanism of bergenin in cervical carcinoma cells by modulation of multiple angiogenic proteins like Galectin‑3 and MMP‑9 which warrant its further development as an anticancer agent in cervical cancer.  \nKeywords Bergenin, Cervical cancer, HPV, Galectin 3, Matrix metallo protease 9  \nCervical cancer poses a significant threat to the health of women and is leading cause of mortality in womens worldwide. Cervical cancer is primarily associated with high-risk human papillomavirus (HPV) infection, among other risk factors1. According to the Globacon 2020 cancer facts, 6,04,127 new cervical cancer cases and 3,41,831 deaths were reported among all age groups worldwide. Furthermore, cervical cancer is the fourth most common malignancy among females, with a 13.3% incidence rate and a 7.3% mortality rate. The risk factors besides infection with HPV for cervical cancer include early sexual maturity, polygamy, early pregnancy, multiple pregnancies,  \n1Department of Medical Oncology (Lab.), Dr. BRAIRCH, All India Institute of Medical Sciences (AIIMS), New Delhi 110029, India. 2Department of Medical Oncology, Dr. BRAIRCH, All India Institute of Medical Sciences (AIIMS), New Delhi, India. 3Department of Biophysics, All India Institute of Medical Sciences, New Delhi, India. 4Department of Biochemistry, Sri Venkateswara College, University of Delhi, New Delhi, India. 5Laboratory of Cancer Immunology and Genetics, Sidra Medicine, Doha, Qatar. 6Department of Human Genetics, Sidra Medicine, Doha, Qatar. 7Department of Human Genetics-Precision Medicine in Diabetes, Obesity and Cancer Program, Sidra Medicine, Doha, Qatar. 8Department of Med","cbCaidx5Gd75onIq","https://ap.wps.com/l/cbCaidx5Gd75onIq","pdf",4821674,15,"English","# Introduction\n## Rationale for targeting angiogenesis\n# Methods and Findings\n## Proteomic analysis of bergenin-treated cells\n## Impact on apoptosis and angiogenesis proteins\n## Molecular docking affinity for MMP-9 vs Galectin-3\n# Conclusion","[{\"question\":\"Why is bergenin considered a candidate for cervical cancer therapy?\",\"answer\":\"Bergenin is a natural polyphenol with a favorable safety profile and potential anticancer activity. The study focuses on its ability to interfere with angiogenesis by altering proteins such as Galectin-3 and MMP-9.\"},{\"question\":\"What did proteomic analysis reveal after treating cervical carcinoma cells with bergenin?\",\"answer\":\"Proteomic analysis indicated that bergenin influences multiple cancer-related hallmarks, including apoptosis and angiogenesis. It also affected several cellular processes beyond cancer pathways.\"},{\"question\":\"How did molecular docking support bergenin’s mechanism in inhibiting angiogenesis?\",\"answer\":\"Molecular docking suggested that MMP-9 has higher affinity for bergenin than Galectin-3. This aligns with the observed reduction of angiogenic proteins Galectin-3 and MMP-9 in treated cells.\"}]","Bergenin inhibits growth of human cervical cancer cells by decreasing Galectin-3 and MMP-9 expression | PDF",1789997273,38]