[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"detail-sidebar-cat-0-en-105":3,"doc-seo-336923-105":59,"doc-detail-336923-en":130},{"code":4,"msg":5,"data":6},0,"success",[7,13,18,23,28,33,38,43,48,51,55],{"id":8,"doc_module":4,"doc_module_name":9,"category_name":10,"show_sort_weight":11,"slug":12},1,"Document","Story & Novel",90,"story-novel",{"id":14,"doc_module":4,"doc_module_name":9,"category_name":15,"show_sort_weight":16,"slug":17},2,"Literature",80,"literature",{"id":19,"doc_module":4,"doc_module_name":9,"category_name":20,"show_sort_weight":21,"slug":22},4,"Exam",70,"exam",{"id":24,"doc_module":4,"doc_module_name":9,"category_name":25,"show_sort_weight":26,"slug":27},5,"Comic",60,"comic",{"id":29,"doc_module":4,"doc_module_name":9,"category_name":30,"show_sort_weight":31,"slug":32},6,"Technology",50,"technology",{"id":34,"doc_module":4,"doc_module_name":9,"category_name":35,"show_sort_weight":36,"slug":37},7,"Healthcare",40,"healthcare",{"id":39,"doc_module":4,"doc_module_name":9,"category_name":40,"show_sort_weight":41,"slug":42},8,"Research & Report",30,"research-report",{"id":44,"doc_module":4,"doc_module_name":9,"category_name":45,"show_sort_weight":46,"slug":47},9,"Religion & Spirituality",20,"religion-spirituality",{"id":46,"doc_module":4,"doc_module_name":9,"category_name":49,"show_sort_weight":46,"slug":50},"World Cup","world-cup",{"id":52,"doc_module":4,"doc_module_name":9,"category_name":53,"show_sort_weight":52,"slug":54},10,"Lifestyle","lifestyle",{"id":56,"doc_module":4,"doc_module_name":9,"category_name":57,"show_sort_weight":24,"slug":58},19,"General","general",{"code":4,"msg":60,"data":61},"ok",{"site_id":62,"language":63,"slug":64,"title":65,"keywords":66,"description":67,"schema_data":68,"social_meta":123,"head_meta":125,"extra_data":127,"updated_unix":129},105,"en","benign-tumors-and-non-melanoma-skin-cancers-in-patients-with-fanconi-anemia","Benign tumors and non-melanoma skin cancers in patients with Fanconi anemia","","Fanconi anemia (FA) is an inherited bone marrow failure syndrome caused by pathogenic variants in the FA/BRCA DNA repair pathway. People with FA have increased risks of myelodysplastic syndrome, acute myeloid leukemia, and solid tumors, yet information on benign tumors and non-melanoma skin cancers (NMSC) in FA is limited. Using medical records from 200 FA patients in the National Cancer Institute IBMFS Study, researchers identified 30 with NMSC and/or benign tumors and compared them with 170 controls, summarizing tumor types, ages, genotypes, and the implications for consistent surveillance after onset.",{"@graph":69,"@context":122},[70,84,105],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":35,"@type":76,"position":81},"https://docshare.wps.com/document/healthcare/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/benign-tumors-and-non-melanoma-skin-cancers-in-patients-with-fanconi-anemia/336923/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/benign-tumors-and-non-melanoma-skin-cancers-in-patients-with-fanconi-anemia/336923.png","ImageObject",300,407,{"name":92,"@type":93},"Skyler","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-10-27","2026-09-21",true,{"@type":102,"interactionType":103,"userInteractionCount":29},"InteractionCounter",{"@type":104},"ViewAction",{"@type":106,"mainEntity":107},"FAQPage",[108,114,118],{"name":109,"@type":110,"acceptedAnswer":111},"What genetic pathway is involved in Fanconi anemia and why does it matter for cancer risk?","Question",{"text":112,"@type":113},"Fanconi anemia is caused by pathogenic variants in genes of the FA/BRCA DNA repair pathway. This pathway defect contributes to an elevated susceptibility to malignancies, including hematologic disorders and solid tumors.","Answer",{"name":115,"@type":110,"acceptedAnswer":116},"How many FA patients had non-melanoma skin cancers or benign tumors in this study?",{"text":117,"@type":113},"Among 200 enrolled FA patients, 30 had at least one non-melanoma skin cancer (squamous or basal cell carcinoma) and/or a benign tumor, while the remaining 170 formed the control group.",{"name":119,"@type":110,"acceptedAnswer":120},"What does the study suggest about monitoring patients with Fanconi anemia?",{"text":121,"@type":113},"The findings emphasize the need for consistent monitoring in FA due to early-onset NMSC compared with the general population, and the value of comprehensive surveillance because benign tumors occurred across diverse anatomical locations.","https://schema.org",{"og:url":83,"og:type":124,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":126,"canonical":83},"index,follow",{"doc_id":128,"site_id":62},336923,1790325700,{"code":4,"msg":5,"data":131},{"doc_id":128,"user_id":132,"nickname":92,"user_avatar":133,"doc_module":4,"category_id":34,"category_name":35,"doc_title":65,"doc_description":67,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":29,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":39,"language":139,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":140,"faqs":141,"seo_title":142,"seo_description":67,"update_tm":143,"read_time":46},2336464648746,"https://ap-avatar.wpscdn.com/davatar_276721f389ce27ea32af1340a28f341c","Familial Cancer  \n[https://doi.org/10.1007/s10689-024-00410-2](https://doi.org/10.1007/s10689-024-00410-2)  \nORIGINAL PAPER  \nBenign tumors and non-melanoma skin cancers in patients with Fanconi anemia  \nAura Enache1 · Bia Sajjad1 · Burak Altintas1 · Neelam Giri1 · Lisa J. McReynolds1 · Edward W. Cowen1  \nReceived: 3 April 2024 / Accepted: 13 June 2024  \nThis is a U.S. Government work and not under copyright protection in the US; foreign copyright protection may apply 2024, corrected publication 2024  \nAbstract  \nFanconi anemia (FA) is an inherited bone marrow failure syndrome (IBMFS) characterized by pathogenic variants in the FA/BRCA DNA repair pathway genes. Individuals with FA have an elevated risk of developing myelodysplastic syndrome, acute myeloid leukemia, and solid tumors. Hematopoietic cell transplantation (HCT) is the most effective treatment for FA related bone marrow failure but can increase the risk of cancer development. Information on benign tumors and NMSC is lacking in patients with FA. Our objective was to characterize patients with FA enrolled in the National Cancer Institute IBMFS Study who have experienced non-melanoma skin cancers (NMSC) and/or benign tumors (BT) . A total of 200 patients diagnosed with FA were enrolled in the Institutional Review Board approved study “Etiologic Investigation of Cancer Susceptibility in IBMFS: A Natural History Study”(NCT00027274) . Through medical records review, we identified 30 patients with at least one NMSC, either squamous or basal cell carcinoma, or benign tumor. The remaining 170 patients comprised the control group. Out of 200 patients, 12 had NMSC, 25 had benign tumors, with an age range of 11–64 and 0–56 years, respectively. The median age at HCT was 30.5 years for NMSC patients, 9 years for benign tumor patients, and 9.1 years for controls. The most common genotype observed was FANCA, followed by FANCC and FANCI. Benign tumors spanned diverse anatomical locations. Early onset NMSC in patients with FA compared to the general population emphasizes the need for consistent monitoring in patients with FA, while the diverse anatomical locations of benign tumors underscore the importance of comprehensive surveillance for timely interventions in managing symptomatology and heightened cancer risk.  \nKeywords Fanconi anemia · Basal cell carcinoma · Squamous cell carcinoma · Skin cancer · Benign tumor  \nIntroduction  \nFanconi anemia (FA) is a rare genetic disorder that is generally characterized by physical abnormalities, inherited bone marrow failure (BMF), and an increased susceptibility to malignancies [1, 2] . FA is caused by pathogenic variants in the genes making up the FA/BRCA DNA repair pathway, which consists of 22 proteins, organized into complementation groups based on their position in the FA pathway [3] . Inheritance patterns for most FA genes are biallelic,  \nA. Enache and B. Sajjad contributed equally to this work.  \n􀀍 Lisa J. McReynolds [lisa.mcreynolds@nih.gov](lisa.mcreynolds@nih.gov)  \n1 Division of Cancer Epidemiology and Genetics, Clinical Genetics Branch, National Cancer Institute, 9609 Medical Center Drive 6E434, Bethesda, MD 20892, USA  \nautosomal recessive, except FANCB which is X-linked and FANCR (RAD51), which is autosomal dominant [4, 5] . Patients with FA exhibit a diverse range of clinical presentations, typically diagnosed around the age of 7 years [1, 6] . These clinical presentations include pancytopenia, skin abnormalities, upper limb abnormalities, and short stature [1] . A common curative treatment for BMF secondary to FA is hematopoietic cell transplantation (HCT) . However, the risk of developing cancer is additionally heightened for individuals who undergo transplant [7] .  \nPatients with FA face a heightened risk of developing cancer, particularly hematological disorders such as myelodysplastic syndrome (MDS) and acute myeloid leukemia (AML), with cumulative incidence rates of 40% and 10% respectively by the age of 50 [6, 8] . Th","cbCaijnWHyk28Y2Z","https://ap.wps.com/l/cbCaijnWHyk28Y2Z","pdf",889108,"English","# Abstract\n# Introduction\n# Methods","[{\"question\":\"What genetic pathway is involved in Fanconi anemia and why does it matter for cancer risk?\",\"answer\":\"Fanconi anemia is caused by pathogenic variants in genes of the FA/BRCA DNA repair pathway. This pathway defect contributes to an elevated susceptibility to malignancies, including hematologic disorders and solid tumors.\"},{\"question\":\"How many FA patients had non-melanoma skin cancers or benign tumors in this study?\",\"answer\":\"Among 200 enrolled FA patients, 30 had at least one non-melanoma skin cancer (squamous or basal cell carcinoma) and/or a benign tumor, while the remaining 170 formed the control group.\"},{\"question\":\"What does the study suggest about monitoring patients with Fanconi anemia?\",\"answer\":\"The findings emphasize the need for consistent monitoring in FA due to early-onset NMSC compared with the general population, and the value of comprehensive surveillance because benign tumors occurred across diverse anatomical locations.\"}]","Benign tumors and non-melanoma skin cancers in patients with Fanconi anemia | PDF",1790017076]