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This review summarizes key studies to clarify the latest published evidence and identify areas gaining academic attention. Recent advances emphasize emerging imaging and biomarkers for early lung cancer diagnosis, and evolving pleural disease strategies, including more conservative pneumothorax care, aggressive pleural infection management, and updated approaches beyond drainage in malignant pleural effusion and mesothelioma.",{"@graph":69,"@context":127},[70,84,106],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":40,"@type":76,"position":81},"https://docshare.wps.com/document/research-report/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/bedside-to-bench-and-back-again-translational-research-in-interventional-pulmonology/332834/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/bedside-to-bench-and-back-again-translational-research-in-interventional-pulmonology/332834.png","ImageObject",300,407,{"name":92,"@type":93},"Evangeline","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-11-01","2026-09-21",true,{"@type":102,"interactionType":103,"userInteractionCount":105},"InteractionCounter",{"@type":104},"ViewAction",11,{"@type":107,"mainEntity":108},"FAQPage",[109,115,119,123],{"name":110,"@type":111,"acceptedAnswer":112},"What is the main purpose of this review?","Question",{"text":113,"@type":114},"To summarize key translational research studies in interventional pulmonology, reflect the latest published evidence, and highlight areas of increasing academic interest.","Answer",{"name":116,"@type":111,"acceptedAnswer":117},"How does the review describe the research approach in interventional pulmonology?",{"text":118,"@type":114},"It notes that interventional pulmonology has used an inverted strategy, “bedside-to-bench and back,” rather than a classical “bench-to-bedside” path.",{"name":120,"@type":111,"acceptedAnswer":121},"Which diagnostic focus is highlighted for lung cancer?",{"text":122,"@type":114},"The review emphasizes risk stratification and diagnosis of early-stage lung cancer, including advances in imaging, biopsy techniques, and biomarkers, particularly for detecting peripheral pulmonary nodules.",{"name":124,"@type":111,"acceptedAnswer":125},"What bronchoscopic advances are discussed?",{"text":126,"@type":114},"It covers computed tomography-guided transthoracic needle biopsy as a reference standard and describes newer technologies such as robotic-assisted navigation bronchoscopy combined with peri-operative imaging.","https://schema.org",{"og:url":83,"og:type":129,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":131,"canonical":83},"index,follow",{"doc_id":133,"site_id":62},332834,1790280153,{"code":4,"msg":5,"data":136},{"doc_id":133,"user_id":137,"nickname":92,"user_avatar":138,"doc_module":4,"category_id":39,"category_name":40,"doc_title":65,"doc_description":67,"doc_content":139,"file_id":140,"file_url":141,"file_type":142,"file_size":143,"view_count":105,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":29,"language":144,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":145,"faqs":146,"seo_title":147,"seo_description":67,"update_tm":148,"read_time":149,"preview_page_count":4},13056703019662,"https://ap-avatar.wpscdn.com/avatar/be000253a8e92610077?_k=1778726343310543188","REVIEW  \nUPRI RNIENTON Bedside to bench and back again-translational  \nresearch in interventional pulmonology  \nBeenish Iqbala, Hee Jae Choib, Nikolaos I. Kanellakisc, Jason Akuliand and Najib M. Rahman e  \nPurpose of review  \nTranslational research in Interventional Pulmonology has made significant advances in recent years, ranging from novel biomarkers and imaging to practice-changing clinical trials in lung cancer and pleural disease. This review article aims to summarize key research studies in the field to understand the latest published evidence and to highlight areas of growing academic interest.  \nRecent findings  \nIn lung cancer, the role of novel imaging and biomarkers and their potential utility in early lung cancer diagnosis will be highlighted. In pleural disease, less invasive/conservative treatment in pneumothorax, early aggressive treatment in pleural infection along with novel biomarkers, and the shift beyond drainage strategies in malignant pleural effusion and mesothelioma will be discussed.  \nSummary  \nThis overview of translational research in the field of interventional pulmonology will ultimately help to highlight the gaps in current evidence to promote research in areas of clinical significance.  \nKeywords  \ninterventional pulmonology, lung cancer diagnostics, pleural disease, translation  \nINTRODUCTION  \nThe recognition of interventional pulmonology (IP), as a subspecialty of respiratory medicine is a relatively recent phenomenon but the proceduresand practices of IP have been around for centuries [1] . Hence, research in IP has not followed a classical‘bench-to-bedside approach’ and has rather utilized an inverted approach of ‘bedside-to-bench and back’. In the last few decades, the focus of IP research was experiential reports of new technology use and refinement of diagnostic and therapeutic methods. More recently, research efforts have begun to better understand the pathophysiological underpinnings of diseases which are playing a foundational role in guiding newer diagnostic and therapeutic approaches. This article will aim to summarize key recent and current translational research, both early (basic sciences) and late (clinical), in the field of lung cancer diagnostics and pleural disease [2] .  \nRESEARCH IN LUNG CANCER DIAGNOSTICS  \nLung cancer remains the leading cause of cancer death, accounting for 20.4% of all cancer deaths in 2024 [3] . Efforts to screen for, diagnose, and treat  \nlung cancer in its early stages have led to an increase in peripheral pulmonary nodule (PPN) detection [4] . Although low-risk PPNs may be observed, current guidelines recommend that intermediate and highrisk PPNs should undergo biopsy and/or resection to establish a diagnosis of early-stage lung cancer, improving cancer-specific and overall mortality. Given the significant impact on patient survival,  \naOxford Respiratory Trials Unit, University of Oxford, Oxford, UK, bPGY-5, Division of Pulmonary and Critical Care, University of North Carolina, Chapel Hill, North Carolina, USA, cChinese Oxford Institute, University of Oxford, Oxford, UK, dInterventional Pulmonology and Pulmonary Oncology, Division of Pulmonary and Critical Care, Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, North Carolina, USA and eProfessor of Respiratory Medicine, Director Oxford Respiratory Trials Unit, Nuffield Department of Medicine, University of Oxford, Oxford, UK  \nCorrespondence to Dr Beenish Iqbal, MBBS, MRCP, FCPS, Pleural Research Fellow, Oxford Respiratory Trials Unit, University of Oxford, Oxford OX3 7LJ, UK. Tel: +447732760538;  \ne-mail: [beenish.iqbal@ndm.ox.ac.uk](beenish.iqbal@ndm.ox.ac.uk)  \n[Curr Opin Pulm Med](Curr Opin Pulm Med 2025)[ 2025](Curr Opin Pulm Med 2025), [31:59](31:59)–[64](64)  \n[DOI:10.1097/MCP.0000000000001125](DOI:10.1097/MCP.0000000000001125)  \nThis is an open access article distributed under the Creative Commons Attribution License 4.0 (CCBY), which permits unrestricted ","cbCaifStUBhi2PST","https://ap.wps.com/l/cbCaifStUBhi2PST","pdf",184650,"English","# Purpose of review\n# Recent findings\n# Summary\n# Introduction\n# Research in lung cancer diagnostics\n## Bronchoscopic advances","[{\"question\":\"What is the main purpose of this review?\",\"answer\":\"To summarize key translational research studies in interventional pulmonology, reflect the latest published evidence, and highlight areas of increasing academic interest.\"},{\"question\":\"How does the review describe the research approach in interventional pulmonology?\",\"answer\":\"It notes that interventional pulmonology has used an inverted strategy, “bedside-to-bench and back,” rather than a classical “bench-to-bedside” path.\"},{\"question\":\"Which diagnostic focus is highlighted for lung cancer?\",\"answer\":\"The review emphasizes risk stratification and diagnosis of early-stage lung cancer, including advances in imaging, biopsy techniques, and biomarkers, particularly for detecting peripheral pulmonary nodules.\"},{\"question\":\"What bronchoscopic advances are discussed?\",\"answer\":\"It covers computed tomography-guided transthoracic needle biopsy as a reference standard and describes newer technologies such as robotic-assisted navigation bronchoscopy combined with peri-operative imaging.\"}]","Bedside to bench and back again - translational research in interventional pulmonology | PDF",1789999681,15]