[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"detail-sidebar-cat-0-en-105":3,"doc-seo-332155-105":59,"doc-detail-332155-en":130},{"code":4,"msg":5,"data":6},0,"success",[7,13,18,23,28,33,38,43,48,51,55],{"id":8,"doc_module":4,"doc_module_name":9,"category_name":10,"show_sort_weight":11,"slug":12},1,"Document","Story & Novel",90,"story-novel",{"id":14,"doc_module":4,"doc_module_name":9,"category_name":15,"show_sort_weight":16,"slug":17},2,"Literature",80,"literature",{"id":19,"doc_module":4,"doc_module_name":9,"category_name":20,"show_sort_weight":21,"slug":22},4,"Exam",70,"exam",{"id":24,"doc_module":4,"doc_module_name":9,"category_name":25,"show_sort_weight":26,"slug":27},5,"Comic",60,"comic",{"id":29,"doc_module":4,"doc_module_name":9,"category_name":30,"show_sort_weight":31,"slug":32},6,"Technology",50,"technology",{"id":34,"doc_module":4,"doc_module_name":9,"category_name":35,"show_sort_weight":36,"slug":37},7,"Healthcare",40,"healthcare",{"id":39,"doc_module":4,"doc_module_name":9,"category_name":40,"show_sort_weight":41,"slug":42},8,"Research & Report",30,"research-report",{"id":44,"doc_module":4,"doc_module_name":9,"category_name":45,"show_sort_weight":46,"slug":47},9,"Religion & Spirituality",20,"religion-spirituality",{"id":46,"doc_module":4,"doc_module_name":9,"category_name":49,"show_sort_weight":46,"slug":50},"World Cup","world-cup",{"id":52,"doc_module":4,"doc_module_name":9,"category_name":53,"show_sort_weight":52,"slug":54},10,"Lifestyle","lifestyle",{"id":56,"doc_module":4,"doc_module_name":9,"category_name":57,"show_sort_weight":24,"slug":58},19,"General","general",{"code":4,"msg":60,"data":61},"ok",{"site_id":62,"language":63,"slug":64,"title":65,"keywords":66,"description":67,"schema_data":68,"social_meta":123,"head_meta":125,"extra_data":127,"updated_unix":129},105,"en","basement-membrane-associated-gene-expression-as-a-predictor-of-survival-in-oral-cancer","Basement membrane-associated gene expression as a predictor of survival in oral cancer","","Investigates whether basement membrane (BM)-associated gene expressions can predict survival in oral cancer. Public repository data were integrated for BM-associated genes, oral cancer transcriptomes, and clinical records; differential expression was identified and Cox and Lasso models were used to build an overall-survival risk score across time intervals, then validated with the GSE42743 cohort. Prognostic value was assessed alongside clinical associations, with pathway enrichment, immune infiltration, and immune checkpoint analyses, and validation of LAMA3 expression in tissues using qRT-PCR and immunohistochemistry.",{"@graph":69,"@context":122},[70,84,105],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":40,"@type":76,"position":81},"https://docshare.wps.com/document/research-report/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/basement-membrane-associated-gene-expression-as-a-predictor-of-survival-in-oral-cancer/332155/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/basement-membrane-associated-gene-expression-as-a-predictor-of-survival-in-oral-cancer/332155.png","ImageObject",300,407,{"name":92,"@type":93},"Hazel","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-11-03","2026-09-21",true,{"@type":102,"interactionType":103,"userInteractionCount":34},"InteractionCounter",{"@type":104},"ViewAction",{"@type":106,"mainEntity":107},"FAQPage",[108,114,118],{"name":109,"@type":110,"acceptedAnswer":111},"What question does the study address about oral cancer survival?","Question",{"text":112,"@type":113},"The study evaluates the prognostic value of basement membrane-associated gene expressions for survival in oral cancer patients.","Answer",{"name":115,"@type":110,"acceptedAnswer":116},"How was the BM-associated gene risk score constructed and validated?",{"text":117,"@type":113},"Differentially expressed BM-associated genes were used with Cox and Lasso regression to build a risk score, which was then validated using the GSE42743 cohort.",{"name":119,"@type":110,"acceptedAnswer":120},"Which BM-associated genes showed notable prognostic significance?",{"text":121,"@type":113},"LAMA3, MMP14, and GPC2 demonstrated notable prognostic significance and supported construction of the BM-based risk score.","https://schema.org",{"og:url":83,"og:type":124,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":126,"canonical":83},"index,follow",{"doc_id":128,"site_id":62},332155,1791103801,{"code":4,"msg":5,"data":131},{"doc_id":128,"user_id":132,"nickname":92,"user_avatar":133,"doc_module":4,"category_id":39,"category_name":40,"doc_title":65,"doc_description":67,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":34,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":139,"language":140,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":141,"faqs":142,"seo_title":143,"seo_description":67,"update_tm":144,"read_time":145,"preview_page_count":4},137441390410,"https://ap-avatar.wpscdn.com/avatar/2000252f4ab5702993?_k=1776741390130283984","Wang et al. BMC Cancer (2024) 24:731 BMC Cancer  \n[https://doi.org/10.1186/s12885-024-12485-2](https://doi.org/10.1186/s12885-024-12485-2)  \nRESEARCH Open Access  \nBasement membrane-associated gene expression as a predictor of survival in oral cancer  \nXu Wang 1†, Chaoge Liu2,3†, HuiFang Wu 1, Yulu Gu 1, Le Zhang4, Rongqing Xu 1 and Qing Lin 1*  \nAbstract  \nBackground This study sought to investigate the prognostic value of basement membrane (BM)-associated gene expressions in oral cancer.  \nMethods We harvested and integrated data on BM-associated genes (BMGs), the oral cancer transcriptome, and clinical information from public repositories. After identifying differential ly expressed BMGs, we used Cox and Lasso regression analyses to create a BMG-based risk score for overall survival at various intervals. We then validated this score using the GSE42743 cohort as a validation set. The prognostic potential of the risk scores and their relations to clinical features were assessed. Further, we conducted functional pathway enrichment, immune cell infiltration, and immune checkpoint analyses to elucidate the immunological implications and therapeutic potential of the BMGbased risk score and constituent genes. To confirm the expression levels of the BMG LAMA3 in clinical samples of oral cancer tissue, we performed quantitative real-time PCR (qRT-PCR) and immunohistochemical staining.  \nResults The BMGs LAMA3, MMP14, and GPC2 demonstrated notable prognostic significance, facilitating the construction of a BMG-based risk score. A higher risk score derived from BMGs correlated with a poorer survival prognosis for oral cancer patients. Moreover, the risk-associated BMGs exhibited a significant relationship with immune function variability (P \u003C 0. 05), discrepancies in infiltrating immune cell fractions, and immune checkpoint expressions (P \u003C 0. 05) . The upregulated expression levels of LAMA3 in oral cancer tissues were substantiated through qRT-PCR and immunohistochemical staining.  \nConclusion The BMG-based risk score emerged as a reliable prognostic tool for oral cancer, meriting further research for validation and potential clinical application.  \nKeywords Oral cancer, Basement membrane, Risk model, Immune checkpoint  \n†Xu Wang and Chaoge Liu contributed equally to this work.  \n*Correspondence: Qing Lin [linqing522@126.com](linqing522@126.com)  \n1Fujian Provincial Key Laboratory of Brain Aging and Neurodegenerative Diseases, Laboratory of Clinical Applied Anatomy, School of Basic Medical Sciences, Fujian Medical University, Fuzhou 350122, China  \n2Department of Oramaxillofacial-Head and Neck Surgery, School of Medicine, Tianjin Stomatological Hospital, Nankai University,  \nTianjin 300041, China  \n3Tianjin Key Laboratory of Oral and Maxillofacial Function Reconstruction, Tianjin 300041, China  \n4Department of Oral Pathology, School of Medicine, Tianjin Stomatological Hospital, Nankai University, Tianjin 300041, China  \n© The Author(s) 2024. Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit [http://creativecommons.org/l](http://creativecommons.org/l)icenses/by/4.0/. The Creative Commons Public Domain Dedication waiver ([http://creativecommons.org/publicdomain/zero/1.0/](http://creativecommons","cbCaicaN0omVebMd","https://ap.wps.com/l/cbCaicaN0omVebMd","pdf",5260313,15,"English","# Abstract\n## Background\n## Methods\n## Results\n## Conclusion\n# Background\n## Clinical burden and current treatment\n## Need for biomarkers\n## Role of basement membranes in OSCC","[{\"question\":\"What question does the study address about oral cancer survival?\",\"answer\":\"The study evaluates the prognostic value of basement membrane-associated gene expressions for survival in oral cancer patients.\"},{\"question\":\"How was the BM-associated gene risk score constructed and validated?\",\"answer\":\"Differentially expressed BM-associated genes were used with Cox and Lasso regression to build a risk score, which was then validated using the GSE42743 cohort.\"},{\"question\":\"Which BM-associated genes showed notable prognostic significance?\",\"answer\":\"LAMA3, MMP14, and GPC2 demonstrated notable prognostic significance and supported construction of the BM-based risk score.\"}]","Basement membrane-associated gene expression as a predictor of survival in oral cancer | PDF",1789997082,38]