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This poster examines whether baseline lateral ventricle volume predicts subsequent cognitive decline in clinical patients with memory complaints using CDR, neuropsychometric, CSF, and neuroimaging assessments from 1990 to 2018.",{"@graph":14,"@context":73},[15,34,56],{"@type":16,"itemListElement":17},"BreadcrumbList",[18,23,27,31],{"item":19,"name":20,"@type":21,"position":22},"https://docshare.wps.com","Home","ListItem",1,{"item":24,"name":25,"@type":21,"position":26},"https://docshare.wps.com/document/","Document",2,{"item":28,"name":29,"@type":21,"position":30},"https://docshare.wps.com/document/healthcare/","Healthcare",3,{"item":32,"name":10,"@type":21,"position":33},"https://docshare.wps.com/document/baseline-lateral-ventricle-volume-predict-cognitive-decline-in-a-clinical-cohort/456212/",4,{"url":32,"name":10,"@type":35,"image":36,"author":41,"headline":10,"publisher":44,"fileFormat":47,"inLanguage":8,"description":12,"dateModified":48,"datePublished":49,"encodingFormat":47,"isAccessibleForFree":50,"interactionStatistic":51},"DigitalDocument",{"url":37,"@type":38,"width":39,"height":40},"https://docshare.wps.com/thumbnails/baseline-lateral-ventricle-volume-predict-cognitive-decline-in-a-clinical-cohort/456212.png","ImageObject",300,407,{"name":42,"@type":43},"Elsa","Person",{"url":19,"name":45,"@type":46},"DocShare","Organization","application/pdf","2026-11-07","2026-09-30",true,{"@type":52,"interactionType":53,"userInteractionCount":55},"InteractionCounter",{"@type":54},"ViewAction",9,{"@type":57,"mainEntity":58},"FAQPage",[59,65,69],{"name":60,"@type":61,"acceptedAnswer":62},"What biomarker does the study focus on for predicting Alzheimer-related cognitive decline?","Question",{"text":63,"@type":64},"The study evaluates baseline lateral ventricle volume as an imaging biomarker. It compares its predictive utility in a clinical cohort and relates it to cognitive change.","Answer",{"name":66,"@type":61,"acceptedAnswer":67},"How were brain volumes and cognition measured in the clinical cohort?",{"text":68,"@type":64},"Lateral ventricle and hippocampal volumes were extracted with FreeSurfer (5.3) and adjusted for intracranial volume. Cognitive performance used a composite score derived from z-scores of Verbal Fluency, Trail Making B Seconds, and Digit Symbol Errors.",{"name":70,"@type":61,"acceptedAnswer":71},"What do the results indicate about the relationship between lateral ventricle volume and cognitive outcomes?",{"text":72,"@type":64},"Baseline lateral ventricle volume significantly predicted cognitive decline (p = 0.01). It also correlated with the rate of change in the cognitive composite score and showed associations with baseline hippocampal volume.","https://schema.org",{"og:url":32,"og:type":75,"og:title":10,"og:site_name":45,"og:description":12},"article",{"robots":77,"canonical":32},"index,follow",{"doc_id":79,"site_id":7},456212,1791100514,{"code":4,"msg":82,"data":83},"success",[84,88,92,96,101,106,110,115,119,122,126],{"id":22,"doc_module":4,"doc_module_name":25,"category_name":85,"show_sort_weight":86,"slug":87},"Story & Novel",90,"story-novel",{"id":26,"doc_module":4,"doc_module_name":25,"category_name":89,"show_sort_weight":90,"slug":91},"Literature",80,"literature",{"id":33,"doc_module":4,"doc_module_name":25,"category_name":93,"show_sort_weight":94,"slug":95},"Exam",70,"exam",{"id":97,"doc_module":4,"doc_module_name":25,"category_name":98,"show_sort_weight":99,"slug":100},5,"Comic",60,"comic",{"id":102,"doc_module":4,"doc_module_name":25,"category_name":103,"show_sort_weight":104,"slug":105},6,"Technology",50,"technology",{"id":107,"doc_module":4,"doc_module_name":25,"category_name":29,"show_sort_weight":108,"slug":109},7,40,"healthcare",{"id":111,"doc_module":4,"doc_module_name":25,"category_name":112,"show_sort_weight":113,"slug":114},8,"Research & Report",30,"research-report",{"id":55,"doc_module":4,"doc_module_name":25,"category_name":116,"show_sort_weight":117,"slug":118},"Religion & Spirituality",20,"religion-spirituality",{"id":117,"doc_module":4,"doc_module_name":25,"category_name":120,"show_sort_weight":117,"slug":121},"World Cup","world-cup",{"id":123,"doc_module":4,"doc_module_name":25,"category_name":124,"show_sort_weight":123,"slug":125},10,"Lifestyle","lifestyle",{"id":127,"doc_module":4,"doc_module_name":25,"category_name":128,"show_sort_weight":97,"slug":129},19,"General","general",{"code":4,"msg":82,"data":131},{"doc_id":79,"user_id":132,"nickname":42,"user_avatar":133,"doc_module":4,"category_id":107,"category_name":29,"doc_title":10,"doc_description":12,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":55,"is_deleted":4,"is_public":22,"is_downloadable":22,"audit_status":22,"page_count":30,"language":139,"language_code":8,"site_id":7,"html_lang":8,"table_of_contents":140,"faqs":141,"seo_title":142,"seo_description":12,"update_tm":143,"read_time":111,"preview_page_count":4},137455077381,"https://ap-avatar.wpscdn.com/davatar_994ba38a5ba835b3df7d355c54d3ed8d","DOI: 10. 1002/alz70856_105116  \nBIOMARKERS  \nPOSTER PRESENTATION  \nNEUROIMAGING  \nBaseline Lateral Ventricle Volume Predict Cognitive Decline ina clinical cohort  \nGengsheng Chen1  Nicole S. McKay 1  Nelly Joseph-Mathurin2   \nParinaz Massoumzadeh 1  Brian A. Gordon 1  Jingxia Liu 1  Pamela J. LaMontagne3  Sarah J. Keefe2  Suzanne E. Schindler4  Jason J. Hassenstab 1  Carlos Cruchaga 1  John C. Morris 1  Tammie L.S. Benzinger4  \n1Washington University in St. Louis, School of Medicine, St. Louis, MO, USA  \n2Washington University School of Medicine, St. Louis, MO, USA  \n3Washington University in St. Louis School of Medicine, St. Louis, MO, USA  \n4Washington University in St. Louis, St. Louis, MO, USA  \nCorrespondence  \nGengsheng Chen, Washington University in St. Louis, School of Medicine, St. Louis, MO, USA. Email: [allisonchen@wustl.edu](allisonchen@wustl.edu)  \nAbstract  \nBackground: Biomarkers are essential for the early detection of Alzheimer disease (AD) to develop effective treatments. As neurons die, hippocampal shrinkage and lateral ventricle expansion occur. Measuring hippocampal volume is challenging due to its small size, while lateral ventricle volume is easier to quantify. Our previous research showed that baseline and longitudinal changes in lateral ventricle volume predicted cognitive decline in a research cohort. However, its utility as a biomarker in clinical populations remains underexplored. This study investigated whether lateral ventricle volume predicts cognitive decline in clinical patients with memory complaints who underwent Clinical Dementia Rating (CDR©), neuropsychometric, cerebrospinal fluid (CSF) and imaging assessments between 1990 and 2018.  \nMethod: This study included 344 participants from the OASIS4 clinical cohort ([https://sites.wustl.edu/oasisbrains/home/oasis-4/](https://sites.wustl.edu/oasisbrains/home/oasis-4/)) who had at least two cognitive assessmentsand corresponding MRI scans. Lateral ventricle and hippocampal volumes were extracted using FreeSurfer (5.3) software and adjusted for intracranial volume. Cognitive performance was measured using a composite score based on z-scores from Verbal Fluency, Trailmaking B Seconds, and Digit Symbol Errors—tests commonly used to study early AD-related changes. A random coefficient model examined whether baseline lateral ventricle volume predicted cognitive decline, controlling for age, sex, and education. Linear regression analyzed correlations between baseline hippocampal volume and baseline lateral ventricle volume, and the relationship between baseline lateral ventricle volume and changes in cognitive composite scores.  \nResult: Demographic characteristics of the participants at baseline were presented in Table 1. Baseline lateral ventricle volume was a significant predictor of the cognitive  \nThis is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.  \n© 2025 The Alzheimer’s Association. Alzheimer’s & Dementia published by Wiley Periodicals LLC on behalf of Alzheimer’s Association.  \nAlzheimer’s Dement. 2025;21(Suppl. 2):e105116.  \n[https://doi.org/10.1002/alz70856_105116](https://doi.org/10.1002/alz70856_105116)  \nwi[leyonlinelibrary.com/journal/alz](leyonlinelibrary.com/journal/alz)  \n1of3  \nBIOMARKERS  \ndecline as measured by the cognitive composite scores(Table2, p = 0.01). Additionally, baseline lateral ventricles volume is significantly correlated with the rate of changes in cognitive composite scores (Figure 2A, R2 =0.0368, p = 0.0003) and baseline hippocampal volume (Figure 2B, R2 = 0. 1631, p \u003C 0.0001).  \nConclusion: These findings suggest that the lateral ventricle volume may be used as a robust and easily measurable imaging biomarker in clinical setting. Its significant predictive value for cognitive decline, along with its strong association with hippocampal volume in a clinical cohort, hig","cbCaikoUNuQLuBde","https://ap.wps.com/l/cbCaikoUNuQLuBde","pdf",741718,"English","# Abstract\n## Background\n## Method\n## Result\n## Conclusion","[{\"question\":\"What biomarker does the study focus on for predicting Alzheimer-related cognitive decline?\",\"answer\":\"The study evaluates baseline lateral ventricle volume as an imaging biomarker. It compares its predictive utility in a clinical cohort and relates it to cognitive change.\"},{\"question\":\"How were brain volumes and cognition measured in the clinical cohort?\",\"answer\":\"Lateral ventricle and hippocampal volumes were extracted with FreeSurfer (5.3) and adjusted for intracranial volume. Cognitive performance used a composite score derived from z-scores of Verbal Fluency, Trail Making B Seconds, and Digit Symbol Errors.\"},{\"question\":\"What do the results indicate about the relationship between lateral ventricle volume and cognitive outcomes?\",\"answer\":\"Baseline lateral ventricle volume significantly predicted cognitive decline (p = 0.01). It also correlated with the rate of change in the cognitive composite score and showed associations with baseline hippocampal volume.\"}]","Baseline Lateral Ventricle Volume Predict Cognitive Decline in a clinical cohort | PDF",1790745352]