[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"detail-sidebar-cat-0-en-105":3,"doc-seo-468140-105":59,"doc-detail-468140-en":130},{"code":4,"msg":5,"data":6},0,"success",[7,13,18,23,28,33,38,43,48,51,55],{"id":8,"doc_module":4,"doc_module_name":9,"category_name":10,"show_sort_weight":11,"slug":12},1,"Document","Story & Novel",90,"story-novel",{"id":14,"doc_module":4,"doc_module_name":9,"category_name":15,"show_sort_weight":16,"slug":17},2,"Literature",80,"literature",{"id":19,"doc_module":4,"doc_module_name":9,"category_name":20,"show_sort_weight":21,"slug":22},4,"Exam",70,"exam",{"id":24,"doc_module":4,"doc_module_name":9,"category_name":25,"show_sort_weight":26,"slug":27},5,"Comic",60,"comic",{"id":29,"doc_module":4,"doc_module_name":9,"category_name":30,"show_sort_weight":31,"slug":32},6,"Technology",50,"technology",{"id":34,"doc_module":4,"doc_module_name":9,"category_name":35,"show_sort_weight":36,"slug":37},7,"Healthcare",40,"healthcare",{"id":39,"doc_module":4,"doc_module_name":9,"category_name":40,"show_sort_weight":41,"slug":42},8,"Research & Report",30,"research-report",{"id":44,"doc_module":4,"doc_module_name":9,"category_name":45,"show_sort_weight":46,"slug":47},9,"Religion & Spirituality",20,"religion-spirituality",{"id":46,"doc_module":4,"doc_module_name":9,"category_name":49,"show_sort_weight":46,"slug":50},"World Cup","world-cup",{"id":52,"doc_module":4,"doc_module_name":9,"category_name":53,"show_sort_weight":52,"slug":54},10,"Lifestyle","lifestyle",{"id":56,"doc_module":4,"doc_module_name":9,"category_name":57,"show_sort_weight":24,"slug":58},19,"General","general",{"code":4,"msg":60,"data":61},"ok",{"site_id":62,"language":63,"slug":64,"title":65,"keywords":66,"description":67,"schema_data":68,"social_meta":123,"head_meta":125,"extra_data":127,"updated_unix":129},105,"en","basal-cell-nevus-syndrome-treated-with-laser-therapy-novel-approach-for-young-adults","Basal Cell Nevus Syndrome Treated With Laser Therapy: Novel Approach for Young Adults","","Basal cell nevus syndrome (BCNS), also known as Gorlin-Goltz syndrome, is an autosomal dominant disorder causing early-onset basal cell carcinomas alongside multiple systemic features. Standard therapies can be highly effective but may cause scarring and limit use in young adults due to side effects and contraindications. A reported 36-year-old woman with genetically confirmed BCNS underwent non-invasive laser treatment using pulsed dye laser for superficial lesions and Nd:YAG for nodular lesions, achieving lesion clearance with minimal healing complications and favorable cosmetic outcomes at one year.",{"@graph":69,"@context":122},[70,84,105],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":35,"@type":76,"position":81},"https://docshare.wps.com/document/healthcare/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/basal-cell-nevus-syndrome-treated-with-laser-therapy-novel-approach-for-young-adults/468140/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/basal-cell-nevus-syndrome-treated-with-laser-therapy-novel-approach-for-young-adults/468140.png","ImageObject",300,407,{"name":92,"@type":93},"Liam","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-10-22","2026-09-30",true,{"@type":102,"interactionType":103,"userInteractionCount":29},"InteractionCounter",{"@type":104},"ViewAction",{"@type":106,"mainEntity":107},"FAQPage",[108,114,118],{"name":109,"@type":110,"acceptedAnswer":111},"Why is systemic therapy often difficult for young adults with BCNS?","Question",{"text":112,"@type":113},"European guidelines recommend hedgehog pathway inhibitors for multiple BCCs, but side effects such as muscle cramps, dysgeusia, and weight loss, plus pregnancy contraindications, restrict their use in young adults.","Answer",{"name":115,"@type":110,"acceptedAnswer":116},"What lasers were used for different types of basal cell carcinoma in the case?",{"text":117,"@type":113},"Pulsed dye laser (PDL, 595 nm) was used for superficial BCCs, while Nd:YAG (1064 nm) was used for nodular lesions, with specific treatment parameters and cooling settings described.",{"name":119,"@type":110,"acceptedAnswer":120},"What cosmetic and safety outcomes were observed after one year?",{"text":121,"@type":113},"After six sessions over 12 months, no scarring was observed at one year; mild short-term pain and local side effects such as erythema, swelling, and crusting occurred, and diffuse depigmentation was reported.","https://schema.org",{"og:url":83,"og:type":124,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":126,"canonical":83},"index,follow",{"doc_id":128,"site_id":62},468140,1791066430,{"code":4,"msg":5,"data":131},{"doc_id":128,"user_id":132,"nickname":92,"user_avatar":133,"doc_module":4,"category_id":34,"category_name":35,"doc_title":65,"doc_description":67,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":29,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":81,"language":139,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":140,"faqs":141,"seo_title":142,"seo_description":67,"update_tm":143,"read_time":39,"preview_page_count":4},8796095461564,"https://ap-avatar.wpscdn.com/davatar_155a257f0dc6eb9ab79c44ca47cae57d","International Journal of Dermatology  \nSHORT COMMUNICATION  OPEN ACCESS   \nBasal Cell Nevus Syndrome Treated With Laser Therapy: Novel Approach for Young Adults  \nGiulia Briatico1 | Camila Scharf1 | Eugenia Veronica Di Brizzi1 | Gabriella Brancaccio1  | Nikola Drmac2  \n1University of Campania, Naples, Italy | 2European Institute of Dermatology, Milan, Italy Correspondence: Giulia Briatico ([giulia.briatico@unicampania.it](giulia.briatico@unicampania.it))  \nReceived: 28 March 2025 | Revised: 29 April 2025 | Accepted: 2 May 2025  \nFunding: The authors received no specific funding for this work.  \nKeywords: dermato-oncology | laser treatment | skin cancer | basal cell nevus syndrome | basal cell carcinoma | Gorlin-Goltz syndrome  \nBasal cell nevus syndrome (BCNS), also known as Gorlin-Goltz syndrome, is a rare inherited disorder with an autosomal dominant pattern that causes early-onset basal cell carcinomas (BCCs). Its associated features include keratocysts, palmoplantar pits, falxcerebri calcification, skeletal abnormalities, frontal bossing, fibromas (in the heart and ovaries), medulloblastoma, glaucoma, and cleft lip/palate [1]. The syndrome arises from an overactive Sonic hedgehog signaling pathway, promoting tumor growth.  \nStandard treatments encompass surgery, Mohs surgery, electrodessication, curettage, photodynamic therapy, cryotherapy, radiotherapy, and topical agents such as imiquimod or 5-fluorouracil. Despite their high efficacy, these methods often lead to scarring, which can affect patients' psychosocial well-being. The European Association of Dermato-Oncology (EADO) guideline [2] recommends treating multiple BCCs in BCNS patients with hedgehog pathway inhibitors (sonidegib, vismodegib), shown to reduce the size of existing BCCs and the rate of new surgically eligible BCCs. However, side effects like muscle cramps, dysgeusia, and weight loss, as well as contraindications in pregnancy, restrict their use in young adults. The management of BCNS remains a topic of debate, necessitating a multidisciplinary approach.  \nLaser therapy has emerged as a promising alternative, with studies supporting the pulsed dye laser (PDL, 595 nm) [3] and the neodymium-doped yttrium aluminium garnet laser (Nd:YAG, 1064 nm) [4] .  \nA 36-year-old woman with genetically confirmed BCNS, diagnosed 15 years earlier, presented in December 2022. She had  \nundergone multiple excisions but refused systemic treatment due to psychological distress and her desire for pregnancy. After signing the informed consent, the proposed treatment included PDL for superficial BCCs and Nd:YAG for nodular ones.  \nTreatment parameters were based on prior studies:  \n• PDL (VBeam, Candela Corporation): 7 mm, 0.45 ms, 13 J, Dynamic Cooling Device (DCD) off, treating with a 3 mm margin.  \n• Nd:YAG (Candela Corporation): 6 mm, 170 J, 3 ms, DCD off.  \nEach lesion required 1 to 3 treatments, with sessions every 2 months for a total of six sessions over 12 months. The treatment endpoint was achieving gray-purple purpura after each session, while dermoscopy assessed the absence of BCCs during follow-up (Figures 1 and 2) . PDL caused mild, short-term pain, whereas Nd:YAG needed local anesthesia. Side effects includederythema, swelling, and crusting. Lesions healed within 2 weeks without infection or bleeding. After 1 year, no scarring was observed; however, diffuse depigmentation did occur. The patient was satisfied with the cosmetic outcomes.  \nThis case highlights the necessity of effective non-invasive treatments for young BCNS patients concerned about aesthetics. Carbon dioxide (CO2) laser ablation was not proposed, as it showed no improved cosmetic outcomes compared to cryotherapy. Additionally, it was not recommended in a systematic review of laser treatments for nonmelanoma skin cancer due to its lower effectiveness compared to Nd:YAG [5] .  \nThis is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution a","cbCaibFbtAK4nZG5","https://ap.wps.com/l/cbCaibFbtAK4nZG5","pdf",328405,"English","# Short Communication\n## Background and treatment considerations\n## Laser therapy approach\n## Case description and outcomes\n## Discussion and conclusion","[{\"question\":\"Why is systemic therapy often difficult for young adults with BCNS?\",\"answer\":\"European guidelines recommend hedgehog pathway inhibitors for multiple BCCs, but side effects such as muscle cramps, dysgeusia, and weight loss, plus pregnancy contraindications, restrict their use in young adults.\"},{\"question\":\"What lasers were used for different types of basal cell carcinoma in the case?\",\"answer\":\"Pulsed dye laser (PDL, 595 nm) was used for superficial BCCs, while Nd:YAG (1064 nm) was used for nodular lesions, with specific treatment parameters and cooling settings described.\"},{\"question\":\"What cosmetic and safety outcomes were observed after one year?\",\"answer\":\"After six sessions over 12 months, no scarring was observed at one year; mild short-term pain and local side effects such as erythema, swelling, and crusting occurred, and diffuse depigmentation was reported.\"}]","Basal Cell Nevus Syndrome Treated With Laser Therapy: Novel Approach for Young Adults | PDF",1790773802]