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The study evaluates high dose rate (HDR) brachytherapy as a non-surgical option and examines dermoscopy as a bridge between clinical and pathological assessment. The work addresses limited evidence on how dermoscopic patterns change during and after irradiation, using structured before-, end-, and 24-week follow-up observations.",{"@graph":69,"@context":123},[70,84,106],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":35,"@type":76,"position":81},"https://docshare.wps.com/document/healthcare/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/basal-cell-carcinoma-after-high-dose-rate-brachytherapy-medium-term-dermoscopic-evaluation-of-cancers-response/377141/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/basal-cell-carcinoma-after-high-dose-rate-brachytherapy-medium-term-dermoscopic-evaluation-of-cancers-response/377141.png","ImageObject",300,407,{"name":92,"@type":93},"Aditya","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-11-02","2026-09-24",true,{"@type":102,"interactionType":103,"userInteractionCount":105},"InteractionCounter",{"@type":104},"ViewAction",12,{"@type":107,"mainEntity":108},"FAQPage",[109,115,119],{"name":110,"@type":111,"acceptedAnswer":112},"Why is basal cell carcinoma in the facial region considered challenging?","Question",{"text":113,"@type":114},"It is difficult because facial aesthetics and nearby critical structures must be protected while achieving effective tumor control.","Answer",{"name":116,"@type":111,"acceptedAnswer":117},"What follow-up time points were used to assess changes?",{"text":118,"@type":114},"Patients were evaluated clinically and dermoscopically before treatment, at the end of treatment (3rd week), and 24 weeks after therapy.",{"name":120,"@type":111,"acceptedAnswer":121},"How did HDR brachytherapy affect dermoscopic and clinical patterns?",{"text":122,"@type":114},"Logistic regression showed a reduction in the number of clinical and dermoscopic patterns typical for basal cell carcinoma, with changes linked to scar tissue formation.","https://schema.org",{"og:url":83,"og:type":125,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":127,"canonical":83},"index,follow",{"doc_id":129,"site_id":62},377141,1790342606,{"code":4,"msg":5,"data":132},{"doc_id":129,"user_id":133,"nickname":92,"user_avatar":134,"doc_module":4,"category_id":34,"category_name":35,"doc_title":65,"doc_description":67,"doc_content":135,"file_id":136,"file_url":137,"file_type":138,"file_size":139,"view_count":105,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":140,"language":141,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":142,"faqs":143,"seo_title":144,"seo_description":67,"update_tm":145,"read_time":36},962085564549,"https://ap-avatar.wpscdn.com/davatar_085a072bc5b1113ac321206ff7593b45","Dermatol Ther (Heidelb) (2023) 13:2063–2078 [https://doi.org/10.1007/s13555-023-00981-5](https://doi.org/10.1007/s13555-023-00981-5)  \nORIGINAL RESEARCH  \nBasal Cell Carcinoma After High Dose Rate Brachytherapy: Medium-term Dermoscopic Evaluation of Cancer’s Response  \nTomasz Krzysztofiak  . Magdalena Suchorzepka  .  \nAndrzej Tukiendorf  . Piotr Wojcieszek  . Grayna Kami´nska-Winciorek   \nReceived: May 5, 2023 / Accepted: July 10, 2023 / Published online: August 9, 2023 􀀂 The Author(s) 2023  \nABSTRACT  \nIntroduction: Basal cell carcinoma of the facial region remains a challenge for contemporary oncology due to the presence of aesthetic regions and critical organs. Surgery is not always the optimal solution, and high dose rate (HDR) brachytherapy has emerged as an organ-sparing treatment method whose effectiveness has been proven by a growing number of publications. Dermoscopy is a diagnostic tool that bridges clinical and pathological examination of skin lesions. It is routinely used for diagnosis, monitoring of treatment, and post-treatment evaluation; however, the literature lacks data concerning changes in dermoscopic patterns of skin cancers during and after irradiation.  \nT. Krzysztofiak 􀀂 P. Wojcieszek  \nBrachytherapy Department, Maria SklodowskaCurie National Research Institute of Oncology (MSCNRIO), Gliwice Branch, Poland ul. Wybrzee Armii Krajowej 15, 44-100 Gliwice, Poland  \nT. Krzysztofiak  \ne-mail: tomasz.krzysztofi[ak@io.gliwice.pl](ak@io.gliwice.pl)  \n[P. Wojcieszek](P. Wojcieszek)  \ne-mail: [piotr.wojcieszek@io.gliwice.pl](piotr.wojcieszek@io.gliwice.pl)  \n[M. Suchorzepka](M. Suchorzepka)  \nPathology Tumor Department, Maria Sklodowska, Curie National Research Institute of Oncology, Gliwice Branch, Poland ul. Wybrzee Armii Krajowej 15, 44-100 Gliwice, Poland [e-mail: m.suchorzepka@gmail.com](e-mail: m.suchorzepka@gmail.com)  \nMethods: Our team conducted a prospective non-randomized trial of 39 patients with highrisk basal cell carcinomas (BCCs), mostly localized within the high-risk zone (H-zone) of the facial region, and who qualified for HDRbrachytherapy. HDR contact brachytherapy with custom-made surface molds was introduced, delivering a dose of 45 Gy in 9 fractions prescribed to the tumor. Every patient was observed clinically and dermoscopically at three observational points: before treatment, at the end of treatment (3rd week), and 24 weeks after the end of therapy. The evolution of clinical and dermoscopic patterns was observed by two independent dermoscopists using current diagnostic criteria. A database of 12,088 photographic observations was evaluated.  \nA. Tukiendorf  \nInstitute of Health Sciences, University of Opole, ul. Katowicka 68, 45-060 Opole, Poland  \ne-mail: [andrzej.tukiendorf@gmail.com](andrzej.tukiendorf@gmail.com)  \nG. Kami´nska-Winciorek (&)  \nDepartment of Bone Marrow Transplantation and Haematology-Oncology, Skin Cancer and Melanoma Team, Maria Sklodowska-Curie National Research Institute o_ f Oncology, Gliwice Branch, Poland ul. Wybrzeze Armii Krajowej 15, 44-100  \nGliwice, Poland  \ne-mail: [dermatolog.pl@gmail.com](dermatolog.pl@gmail.com)  \nResults: Univariate logistic regression proved that brachytherapy decreases the number of clinical and dermoscopic patterns typical for basal cell carcinoma, as well as dermoscopic features not related to BCC, presumably due to the formation of scar tissue. In addition, univariate logistic regression with random effects proved a positive correlation between tumor size and presence of various dermoscopic patterns typical for BCC.  \nConclusion: Dermoscopy is proven to be easy to perform and an adequate monitoring tool for patients with BCCs undergoing HDRbrachytherapy.  \nKeywords: Basal cell carcinoma; Dermoscopy; Dermatoscopy; HDR brachytherapy; Skin cancer  \nKey Summary Points  \nWhy carry out this study?  \nSearched literature lacks data regarding evolution of dermoscopic patterns among patients undergoing HDR brachytherapy.  \nWhat have We learned from","cbCaiqJH0nk2XYdi","https://ap.wps.com/l/cbCaiqJH0nk2XYdi","pdf",1810795,16,"English","# Abstract\n## Introduction\n## Methods\n## Results\n## Conclusion\n## Keywords\n## Key Summary Points\n# Introduction","[{\"question\":\"Why is basal cell carcinoma in the facial region considered challenging?\",\"answer\":\"It is difficult because facial aesthetics and nearby critical structures must be protected while achieving effective tumor control.\"},{\"question\":\"What follow-up time points were used to assess changes?\",\"answer\":\"Patients were evaluated clinically and dermoscopically before treatment, at the end of treatment (3rd week), and 24 weeks after therapy.\"},{\"question\":\"How did HDR brachytherapy affect dermoscopic and clinical patterns?\",\"answer\":\"Logistic regression showed a reduction in the number of clinical and dermoscopic patterns typical for basal cell carcinoma, with changes linked to scar tissue formation.\"}]","Basal Cell Carcinoma After High Dose Rate Brachytherapy - Medium-term Dermoscopic Evaluation of Cancer’s Response | PDF",1790223355]