[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"doc-seo-328942-105":3,"detail-sidebar-cat-0-en-105":81,"doc-detail-328942-en":130},{"code":4,"msg":5,"data":6},0,"ok",{"site_id":7,"language":8,"slug":9,"title":10,"keywords":11,"description":12,"schema_data":13,"social_meta":74,"head_meta":76,"extra_data":78,"updated_unix":80},105,"en","bacterial-outer-membrane-vesicles-in-the-fight-against-cancer","Bacterial outer membrane vesicles in the fight against cancer","","Bacterial outer membrane vesicles (OMVs) are small vesicles naturally released by Gram-negative bacteria, attracting interest for cancer therapy. OMVs can deliver therapeutic agents to tumor sites to reduce exposure to healthy cells and lower systemic toxicity, while also activating immune responses to help recognize and eliminate cancer cells. OMVs can be engineered to carry antigens, immunomodulatory factors, and small interfering RNAs, and they may synergize with chemotherapy and radiation. This review emphasizes their promise as targeted therapy vectors.",{"@graph":14,"@context":73},[15,34,56],{"@type":16,"itemListElement":17},"BreadcrumbList",[18,23,27,31],{"item":19,"name":20,"@type":21,"position":22},"https://docshare.wps.com","Home","ListItem",1,{"item":24,"name":25,"@type":21,"position":26},"https://docshare.wps.com/document/","Document",2,{"item":28,"name":29,"@type":21,"position":30},"https://docshare.wps.com/document/research-report/","Research & Report",3,{"item":32,"name":10,"@type":21,"position":33},"https://docshare.wps.com/document/bacterial-outer-membrane-vesicles-in-the-fight-against-cancer/328942/",4,{"url":32,"name":10,"@type":35,"image":36,"author":41,"headline":10,"publisher":44,"fileFormat":47,"inLanguage":8,"description":12,"dateModified":48,"datePublished":49,"encodingFormat":47,"isAccessibleForFree":50,"interactionStatistic":51},"DigitalDocument",{"url":37,"@type":38,"width":39,"height":40},"https://docshare.wps.com/thumbnails/bacterial-outer-membrane-vesicles-in-the-fight-against-cancer/328942.png","ImageObject",300,407,{"name":42,"@type":43},"Miles","Person",{"url":19,"name":45,"@type":46},"DocShare","Organization","application/pdf","2026-10-23","2026-09-21",true,{"@type":52,"interactionType":53,"userInteractionCount":55},"InteractionCounter",{"@type":54},"ViewAction",6,{"@type":57,"mainEntity":58},"FAQPage",[59,65,69],{"name":60,"@type":61,"acceptedAnswer":62},"What are bacterial outer membrane vesicles (OMVs) and how are they formed?","Question",{"text":63,"@type":64},"OMVs are small vesicles released spontaneously by Gram-negative bacteria during development. They are fragments of the bacterial outer membrane and typically range from 20 to 200 nanometers.","Answer",{"name":66,"@type":61,"acceptedAnswer":67},"How can OMVs be used to fight cancer therapeutically?",{"text":68,"@type":64},"OMVs can deliver drugs directly to tumor sites, minimizing damage to healthy cells and reducing systemic toxicity. They can also activate immune recognition and elimination of cancer cells, and be engineered to carry antigens, immunomodulatory compounds, or small interfering RNAs.",{"name":70,"@type":61,"acceptedAnswer":71},"What evidence suggests OMVs could also promote cancer?",{"text":72,"@type":64},"New evidence indicates OMVs may facilitate inflammation and angiogenesis, processes that can support tumor growth and spread. Studies cited in the text report pro-inflammatory effects that promote colorectal cancer growth, along with potential immune cell suppression.","https://schema.org",{"og:url":32,"og:type":75,"og:title":10,"og:site_name":45,"og:description":12},"article",{"robots":77,"canonical":32},"index,follow",{"doc_id":79,"site_id":7},328942,1790690733,{"code":4,"msg":82,"data":83},"success",[84,88,92,96,101,105,110,114,119,122,126],{"id":22,"doc_module":4,"doc_module_name":25,"category_name":85,"show_sort_weight":86,"slug":87},"Story & Novel",90,"story-novel",{"id":26,"doc_module":4,"doc_module_name":25,"category_name":89,"show_sort_weight":90,"slug":91},"Literature",80,"literature",{"id":33,"doc_module":4,"doc_module_name":25,"category_name":93,"show_sort_weight":94,"slug":95},"Exam",70,"exam",{"id":97,"doc_module":4,"doc_module_name":25,"category_name":98,"show_sort_weight":99,"slug":100},5,"Comic",60,"comic",{"id":55,"doc_module":4,"doc_module_name":25,"category_name":102,"show_sort_weight":103,"slug":104},"Technology",50,"technology",{"id":106,"doc_module":4,"doc_module_name":25,"category_name":107,"show_sort_weight":108,"slug":109},7,"Healthcare",40,"healthcare",{"id":111,"doc_module":4,"doc_module_name":25,"category_name":29,"show_sort_weight":112,"slug":113},8,30,"research-report",{"id":115,"doc_module":4,"doc_module_name":25,"category_name":116,"show_sort_weight":117,"slug":118},9,"Religion & Spirituality",20,"religion-spirituality",{"id":117,"doc_module":4,"doc_module_name":25,"category_name":120,"show_sort_weight":117,"slug":121},"World Cup","world-cup",{"id":123,"doc_module":4,"doc_module_name":25,"category_name":124,"show_sort_weight":123,"slug":125},10,"Lifestyle","lifestyle",{"id":127,"doc_module":4,"doc_module_name":25,"category_name":128,"show_sort_weight":97,"slug":129},19,"General","general",{"code":4,"msg":82,"data":131},{"doc_id":79,"user_id":132,"nickname":42,"user_avatar":133,"doc_module":4,"category_id":111,"category_name":29,"doc_title":10,"doc_description":12,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":55,"is_deleted":4,"is_public":22,"is_downloadable":22,"audit_status":22,"page_count":139,"language":140,"language_code":8,"site_id":7,"html_lang":8,"table_of_contents":141,"faqs":142,"seo_title":143,"seo_description":12,"update_tm":144,"read_time":145,"preview_page_count":4},13056703019404,"https://ap-avatar.wpscdn.com/davatar_29158cc5080c5b710cf443261637dec0","Bacterial outer membrane vesicles in the fight against cancer  \nYiming Meng1, Cuicui Kong1, Yushu Ma1, Jing Sun2, Guirong Zhang1  \n1Department of Central Laboratory, Cancer Hospital of Dalian University of Technology, Liaoning Cancer Hospital & Institute, Shenyang, Liaoning 110042, China; 2Department of Biobank, Cancer Hospital of Dalian University of Technology, Liaoning Cancer Hospital & Institute, Shenyang, Liaoning 110042, China.  \nAbstract  \nBacterial outer membrane vesicles (OMVs) are diminutive vesicles naturally released by Gram-negative bacteria. These vesicles possess distinctive characteristics that attract attention for their potential use in drug administration and immunotherapy in cancer treatment. Therapeutic medicines may be delivered via OMVs directly to the tumor sites, thereby minimizing exposure to healthy cells and lowering the risk of systemic toxicity. Furthermore, the activation of the immune system by OMVs has been demonstrated to facilitate the recognition and elimination of cancer cells, which makes them a desirable tool for immunotherapy. They can also be genetically modified to carry specific antigens, immunomodulatory compounds, and small interfering RNAs, enhancing the immune response to cancerous cells and silencing genes associated with disease progression. Combining OMVs with other cancer treatments like chemotherapy and radiation has shown promising synergistic effects. This review highlights the crucial role of bacterial OMVs in cancer, emphasizing their potential as vectors for novel cancer targeted therapies. As researchers delve deeper into the complexities of these vesicles and their interactions with tumors, there is a growing sense of optimism that this avenue of study will bring positive outcomes and renewed hope to cancer patients in the foreseeable future.  \nKeywords: Bacterial outer membrane vesicles; Tumor microenvironment; Immunotherapy; Phototherapy; Nanoparticle  \nIntroduction  \nThe tumor microenvironment (TME) encompasses an intricate assemblage of cells and extracellular matrix constituents, exerting a pivotal influence on cancer biology. This entity includes malignant cells and a diverse array of non-malignant cells, such as immune cells, fibroblasts, bacteria, and endothelial cells. [1] Interactions occurring inside the TME are characterized by their intricate and diverse nature, as many cell types play distinct roles in facilitating tumor development and progression. Recognizing the importance oftheTME in cancer research, thereis a growing emphasis on developing approaches to target this intricate system. Recent studies have highlighted the role of the microbiome, a collection of microorganisms inhabiting the human body, in cancer development and progression. [2] Bacterial organisms have been found to promote tumor growth and metastasis, but they also hold potential for therapeutic applications, such as the utilization of bacterial outer membrane vesicles (OMVs) . [3]  \nOMVs are fragments of the bacterial membrane released by Gram-negative bacteria spontaneously during their development. Typically ranging in size from 20 to 200 nanometers, the small size of OMVs allows them to swiftly distribute throughout the intercellular gap and even enter  \n\n| Access this article online |  |\n| --- | --- |\n| Quick Response Code: | Website:\u003Cbr>[www.cmj.org](www.cmj.org) |\n|  | DOI:\u003Cbr>10.1097/CM9.0000000000003234 |\n\ninto the cell’s interior. [4] OMVs possess distinct biological functions while maintaining the primary components of the original bacteria, including lipids, proteins, and pathogen-associated molecular patterns (PAMPs) such aslipopolysaccharides (LPS), lipoproteins, peptidoglycans, DNA, RNA, and more. [5] The lipid bilayer constitutes the OMVs, with phospholipids and LPS accounting for the majority of OMVs’ lipid composition [Figure 1] . The structure of OMVs confers stability and facilitates drug delivery. Simultaneously, it also offers the potential for cell interaction, en","cbCaiezARQPF1kkh","https://ap.wps.com/l/cbCaiezARQPF1kkh","pdf",914695,13,"English","# Introduction\n## Tumor microenvironment and microbiome links\n## OMVs: origin, size, and composition\n## OMVs in tumor inhibition and tumor promotion","[{\"question\":\"What are bacterial outer membrane vesicles (OMVs) and how are they formed?\",\"answer\":\"OMVs are small vesicles released spontaneously by Gram-negative bacteria during development. They are fragments of the bacterial outer membrane and typically range from 20 to 200 nanometers.\"},{\"question\":\"How can OMVs be used to fight cancer therapeutically?\",\"answer\":\"OMVs can deliver drugs directly to tumor sites, minimizing damage to healthy cells and reducing systemic toxicity. They can also activate immune recognition and elimination of cancer cells, and be engineered to carry antigens, immunomodulatory compounds, or small interfering RNAs.\"},{\"question\":\"What evidence suggests OMVs could also promote cancer?\",\"answer\":\"New evidence indicates OMVs may facilitate inflammation and angiogenesis, processes that can support tumor growth and spread. Studies cited in the text report pro-inflammatory effects that promote colorectal cancer growth, along with potential immune cell suppression.\"}]","Bacterial outer membrane vesicles in the fight against cancer | PDF",1789981723,33]