[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"detail-sidebar-cat-0-en-105":3,"doc-seo-370036-105":59,"doc-detail-370036-en":130},{"code":4,"msg":5,"data":6},0,"success",[7,13,18,23,28,33,38,43,48,51,55],{"id":8,"doc_module":4,"doc_module_name":9,"category_name":10,"show_sort_weight":11,"slug":12},1,"Document","Story & Novel",90,"story-novel",{"id":14,"doc_module":4,"doc_module_name":9,"category_name":15,"show_sort_weight":16,"slug":17},2,"Literature",80,"literature",{"id":19,"doc_module":4,"doc_module_name":9,"category_name":20,"show_sort_weight":21,"slug":22},4,"Exam",70,"exam",{"id":24,"doc_module":4,"doc_module_name":9,"category_name":25,"show_sort_weight":26,"slug":27},5,"Comic",60,"comic",{"id":29,"doc_module":4,"doc_module_name":9,"category_name":30,"show_sort_weight":31,"slug":32},6,"Technology",50,"technology",{"id":34,"doc_module":4,"doc_module_name":9,"category_name":35,"show_sort_weight":36,"slug":37},7,"Healthcare",40,"healthcare",{"id":39,"doc_module":4,"doc_module_name":9,"category_name":40,"show_sort_weight":41,"slug":42},8,"Research & Report",30,"research-report",{"id":44,"doc_module":4,"doc_module_name":9,"category_name":45,"show_sort_weight":46,"slug":47},9,"Religion & Spirituality",20,"religion-spirituality",{"id":46,"doc_module":4,"doc_module_name":9,"category_name":49,"show_sort_weight":46,"slug":50},"World Cup","world-cup",{"id":52,"doc_module":4,"doc_module_name":9,"category_name":53,"show_sort_weight":52,"slug":54},10,"Lifestyle","lifestyle",{"id":56,"doc_module":4,"doc_module_name":9,"category_name":57,"show_sort_weight":24,"slug":58},19,"General","general",{"code":4,"msg":60,"data":61},"ok",{"site_id":62,"language":63,"slug":64,"title":65,"keywords":66,"description":67,"schema_data":68,"social_meta":123,"head_meta":125,"extra_data":127,"updated_unix":129},105,"en","bacteria-in-neoplastic-diseases-a-brief-note-on-wilms-tumor","Bacteria in neoplastic diseases - A brief note on Wilms tumor","","Bacteria participate in cancer pathology through multiple mechanisms, acting as etiological or predisposing factors, contributing to secondary infections, and supplying modified bacteria or bacterial products for therapy. Etiological connections and predisposing roles are emphasized for adult cancers, whereas pediatric tumorigenesis is more associated with genetic abnormalities. Secondary infections worsen morbidity and mortality in pediatric cancer despite precautions. Bacterial toxins are presented as targeted therapeutic molecules, and strategies targeting Wilms tumor 1 protein are reviewed alongside Wilms tumor pathological and clinical characteristics and relevant secondary infections.",{"@graph":69,"@context":122},[70,84,105],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":35,"@type":76,"position":81},"https://docshare.wps.com/document/healthcare/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/bacteria-in-neoplastic-diseases-a-brief-note-on-wilms-tumor/370036/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/bacteria-in-neoplastic-diseases-a-brief-note-on-wilms-tumor/370036.png","ImageObject",300,407,{"name":92,"@type":93},"mieayamfan","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-10-24","2026-09-23",true,{"@type":102,"interactionType":103,"userInteractionCount":39},"InteractionCounter",{"@type":104},"ViewAction",{"@type":106,"mainEntity":107},"FAQPage",[108,114,118],{"name":109,"@type":110,"acceptedAnswer":111},"How do bacteria contribute to cancer development according to this review?","Question",{"text":112,"@type":113},"Bacteria can act as etiological factors or predisposing factors, drive secondary infections, and influence cancer therapy through modified bacteria or bacterial products such as toxins.","Answer",{"name":115,"@type":110,"acceptedAnswer":116},"Why are secondary bacterial infections important in pediatric cancer patients?",{"text":117,"@type":113},"Secondary infections significantly affect morbidity and mortality in pediatric cancer patients even when precautionary measures are taken.",{"name":119,"@type":110,"acceptedAnswer":120},"What is the significance of Wilms tumor 1 (WT1) in Wilms tumor?",{"text":121,"@type":113},"WT1 dysregulation is described as fundamentally responsible for Wilms tumor pathogenesis, and WT1-targeted therapeutic strategies are highlighted as potential areas in cancer therapy.","https://schema.org",{"og:url":83,"og:type":124,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":126,"canonical":83},"index,follow",{"doc_id":128,"site_id":62},370036,1790247166,{"code":4,"msg":5,"data":131},{"doc_id":128,"user_id":132,"nickname":92,"user_avatar":133,"doc_module":4,"category_id":34,"category_name":35,"doc_title":65,"doc_description":67,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":39,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":52,"language":139,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":140,"faqs":141,"seo_title":142,"seo_description":67,"update_tm":143,"read_time":144},962090893677,"https://ap-avatar.wpscdn.com/davatar_3d24733baf745e90a7e4bdd5f77d97b2","| W | J | E | M | World Journal of\u003Cbr>Experimental Medicine |\n| --- | --- | --- | --- | --- |\n\nSubmit a Manuscript: [https://www.f6publishing.com](https://www.f6publishing.com) World J Exp Med 2025 December 20; 15(4): 108221  \nDOI: 10.5493/wjem.v15.i4.108221 ISSN 2220-315x (online)  \nMINIREVIEWS  \nBacteria in neoplastic diseases: A brief note on Wilms tumor  \nAdam Burke, Adekunle Sanyaolu, Amitabha Ray  \nSpecialty type: Medicine, research and experimental  \nProvenance and peer review:  \nInvited article; Externally peer reviewed.  \nPeer-review model: Single blind  \nPeer-review report’s classification Scientific Quality: Grade D  \nNovelty: Grade C  \nCreativity or Innovation: Grade C  \nScientific Significance: Grade D  \nP-Reviewer: Başaranoğlu M, Research Assistant Professor, Türkiye  \nReceived: April 9, 2025  \nRevised: May 12, 2025  \nAccepted: August 4, 2025  \nPublished online: December 20, 2025  \nProcessing time: 255 Days and 10.3 Hours  \nAdam Burke, Department of Family Medicine, Independence Health System, Latrobe, PA 15650, United States  \nAdekunle Sanyaolu, Amitabha Ray, Biomedical Sciences, School of Health Professions, D’Youville University, Buffalo, NY 14201, United States  \nCo-corresponding authors: Adekunle Sanyaolu and Amitabha Ray.  \nCorresponding author: Adekunle Sanyaolu, PhD, Professor, Biomedical Sciences, D’Youville University, 320 Porter Ave, Buffalo, NY 14201, [United States.](United States. sanyakunle@hotmail.com)[ sanyakunle@hotmail.com](United States. sanyakunle@hotmail.com)  \nAbstract  \nBacteria can be involved in the pathological processes of cancer in different manners-for instance, as an etiological factor or predisposing factor, in secondary infection, as well as modified bacteria or bacterial products in cancer treatment. The bacterial etiological connection or its role as a predisposing factor is mainly relevant to adult cancers, which are primarily associated with individual lifestylesand/or environmental issues. In contrast, genetic abnormalities are perhaps linked with tumorigenesis in the pediatric age group. Nonetheless, secondary infections significantly affect morbidity and mortality among pediatric cancer patients in spite of precautionary measures. On the other hand, bacterial products, i.e., toxins, are potential molecules for targeted cancer therapy. These therapeutic agents have two parts: Usually a receptor-binding antibody (e.g., anti-HER2 antibody) and a toxin (e.g., Pseudomonas exotoxin A) . Similarly, several investigators have been trying to develop therapeutic approaches that target Wilms tumor 1 protein, whose dysregulation is thought to be fundamentally responsible for the pathogenesis of Wilms tumor, the most common kidney tumor of childhood. However, the overexpression of Wilms tumor 1 protein has been documented in many cancer tissues-both solid tumors and hematological malignancies. This article briefly reviews both the pathological and clinical characteristics of Wilms tumor along with relevant secondary infections.  \nKey Words: Bacteria; Cancer; Infectious complications; Wilms tumor; Wilms tumor 1 vaccine  \n©The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved.  \n WJEM  [https://www.wjgnet.com](https://www.wjgnet.com) 1 December 20, 2025  Volume 15  Issue 4   \nBurke A et al. Wilms tumor: Issues and applications  \nCore Tip: This review describes different aspects of Wilms tumor, e.g., pathogenesis, epidemiology, immune responses, and complications, particularly secondary bacterial infections. The pertinent Wilms tumor 1 (WT1) gene and its protein play an important role in the embryogenesis of the kidney and the development of Wilms tumor. Interestingly, WT1 functions both as a tumor suppressor as well as an oncogenic factor, probably depending on the biological circumstances. Nevertheless, WT1 is overexpressed in several tumor tissues. For this reason, WT1-targeted strategies are potential areas in cancer therapy.  \nCitation: Burke A, Sanyaol","cbCailSssvyYZf4B","https://ap.wps.com/l/cbCailSssvyYZf4B","pdf",1253348,"English","# Abstract\n## Core Tip\n## Introduction","[{\"question\":\"How do bacteria contribute to cancer development according to this review?\",\"answer\":\"Bacteria can act as etiological factors or predisposing factors, drive secondary infections, and influence cancer therapy through modified bacteria or bacterial products such as toxins.\"},{\"question\":\"Why are secondary bacterial infections important in pediatric cancer patients?\",\"answer\":\"Secondary infections significantly affect morbidity and mortality in pediatric cancer patients even when precautionary measures are taken.\"},{\"question\":\"What is the significance of Wilms tumor 1 (WT1) in Wilms tumor?\",\"answer\":\"WT1 dysregulation is described as fundamentally responsible for Wilms tumor pathogenesis, and WT1-targeted therapeutic strategies are highlighted as potential areas in cancer therapy.\"}]","Bacteria in neoplastic diseases - A brief note on Wilms tumor | PDF",1790186379,25]