[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"detail-sidebar-cat-0-en-105":3,"doc-detail-426846-en":59,"doc-seo-426846-105":80},{"code":4,"msg":5,"data":6},0,"success",[7,13,18,23,28,33,38,43,48,51,55],{"id":8,"doc_module":4,"doc_module_name":9,"category_name":10,"show_sort_weight":11,"slug":12},1,"Document","Story & Novel",90,"story-novel",{"id":14,"doc_module":4,"doc_module_name":9,"category_name":15,"show_sort_weight":16,"slug":17},2,"Literature",80,"literature",{"id":19,"doc_module":4,"doc_module_name":9,"category_name":20,"show_sort_weight":21,"slug":22},4,"Exam",70,"exam",{"id":24,"doc_module":4,"doc_module_name":9,"category_name":25,"show_sort_weight":26,"slug":27},5,"Comic",60,"comic",{"id":29,"doc_module":4,"doc_module_name":9,"category_name":30,"show_sort_weight":31,"slug":32},6,"Technology",50,"technology",{"id":34,"doc_module":4,"doc_module_name":9,"category_name":35,"show_sort_weight":36,"slug":37},7,"Healthcare",40,"healthcare",{"id":39,"doc_module":4,"doc_module_name":9,"category_name":40,"show_sort_weight":41,"slug":42},8,"Research & Report",30,"research-report",{"id":44,"doc_module":4,"doc_module_name":9,"category_name":45,"show_sort_weight":46,"slug":47},9,"Religion & Spirituality",20,"religion-spirituality",{"id":46,"doc_module":4,"doc_module_name":9,"category_name":49,"show_sort_weight":46,"slug":50},"World Cup","world-cup",{"id":52,"doc_module":4,"doc_module_name":9,"category_name":53,"show_sort_weight":52,"slug":54},10,"Lifestyle","lifestyle",{"id":56,"doc_module":4,"doc_module_name":9,"category_name":57,"show_sort_weight":24,"slug":58},19,"General","general",{"code":4,"msg":5,"data":60},{"doc_id":61,"user_id":62,"nickname":63,"user_avatar":64,"doc_module":4,"category_id":39,"category_name":40,"doc_title":65,"doc_description":66,"doc_content":67,"file_id":68,"file_url":69,"file_type":70,"file_size":71,"view_count":19,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":8,"language":72,"language_code":73,"site_id":74,"html_lang":73,"table_of_contents":75,"faqs":76,"seo_title":77,"seo_description":66,"update_tm":78,"read_time":79},426846,3985747859343,"jayni","https://ap-avatar.wpscdn.com/davatar_276721f389ce27ea32af1340a28f341c","AVERAGE LIFETIME WORK EXPOSURES AND IMMUNE FUNCTION AMONG OLDER ADULTS","Overall immune health and functioning shape the emergence of aging-related chronic conditions across the life course. Differences in later-life immune function are socially patterned, yet the role of work-related factors has received limited attention. Using a new dataset that integrates O*NET occupation-level work exposures, individuals’ work histories, and immune measures from the Health and Retirement Study, OLS regression assesses links after age 65. Results show stress-, physical-, and environmental-related average lifetime work exposures relate to immune indicators, with differential effects by sex.","1218 Innovation in Aging, 2025, Vol. 9, No. S2  \nexposures (e.g., decision freedom) and immune function are dependent on sex, suggesting that for some occupational exposures, the same level of exposure influences immune function outcomes differently for men and women. Based on these findings, we determine that work exposures may be an important social determinant of immune function as people age over the life course  \nAbstract citation ID: igaf122.4075  \nAVERAGE LIFETIME WORK EXPOSURES AND  \nIMMUNE FUNCTION AMONG OLDER ADULTS  \nRebekah Carpenter1, Dawn Carr1, and Grace Noppert2,  \n1. Florida State University, Tallahassee, Florida, United States, 2. University of Michigan, Ann Arbor, Michigan, United States  \nOverall immune health and functioning plays a critical role in the development of aging-related chronic conditions and diseases over the life course. Recent research shows that differences in immune function in later life are socially patterned and shaped by lifetime exposures. However, limited attention has been given to the potential impact of work-related factors on later-life immune health. Given that the average adult spends approximately one-third of their life working, occupational conditions may have long-term influences on immune function as people age over time.We use a new dataset that leverages occupation-level work exposures from the Occupational Information Network (O*NET), individual-level work history data, and individual immune function data from the Health and Retirement Study (HRS) . Ordinary Least Square (OLS) regression models were assessed to evaluate associations between three domains of lifetime work exposures and eight indicators (e.g., Cytomegalovirus IgG antibody levels) of immune function after age 65. We find that we find that multiple stress- (e.g., job demands), physical-(e.g. frequency of bending and twisting the body), and environmental-related (e.g., exposure to contaminants) average lifetime work exposures are associated with later life immune health. We also find that the association between some work","cbCaimPvVQE7YqGg","https://ap.wps.com/l/cbCaimPvVQE7YqGg","pdf",1068403,"English","en",105,"# Study background\n## Immune health and aging-related disease\n# Data and methods\n## Work exposure data sources\n## Regression approach and immune indicators\n# Findings\n## Stress-, physical-, and environmental-related exposures\n## Sex differences in associations","[{\"question\":\"What question does the study address about immune function in older adults?\",\"answer\":\"It examines whether average lifetime work exposures are associated with immune health after age 65, beyond broader social patterns of immune function.\"},{\"question\":\"Which data sources and methods are used to test the associations?\",\"answer\":\"The study builds a dataset combining O*NET occupation-level work exposures, individual work history, and immune function data from the Health and Retirement Study, then uses OLS regression to evaluate associations with multiple immune indicators.\"},{\"question\":\"What kinds of work exposures show links to immune function after age 65?\",\"answer\":\"Average lifetime work exposures related to stress (job demands), physical demands (frequency of bending and twisting), and environmental factors (exposure to contaminants) are associated with later-life immune health.\"}]","AVERAGE LIFETIME WORK EXPOSURES AND IMMUNE FUNCTION AMONG OLDER ADULTS | PDF",1790642006,3,{"code":4,"msg":81,"data":82},"ok",{"site_id":74,"language":73,"slug":83,"title":65,"keywords":84,"description":66,"schema_data":85,"social_meta":138,"head_meta":140,"extra_data":142,"updated_unix":143},"average-lifetime-work-exposures-and-immune-function-among-older-adults","",{"@graph":86,"@context":137},[87,100,120],{"@type":88,"itemListElement":89},"BreadcrumbList",[90,94,96,98],{"item":91,"name":92,"@type":93,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":95,"name":9,"@type":93,"position":14},"https://docshare.wps.com/document/",{"item":97,"name":40,"@type":93,"position":79},"https://docshare.wps.com/document/research-report/",{"item":99,"name":65,"@type":93,"position":19},"https://docshare.wps.com/document/average-lifetime-work-exposures-and-immune-function-among-older-adults/426846/",{"url":99,"name":65,"@type":101,"image":102,"author":107,"headline":65,"publisher":109,"fileFormat":112,"inLanguage":73,"description":66,"dateModified":113,"datePublished":114,"encodingFormat":112,"isAccessibleForFree":115,"interactionStatistic":116},"DigitalDocument",{"url":103,"@type":104,"width":105,"height":106},"https://docshare.wps.com/thumbnails/average-lifetime-work-exposures-and-immune-function-among-older-adults/426846.png","ImageObject",300,407,{"name":63,"@type":108},"Person",{"url":91,"name":110,"@type":111},"DocShare","Organization","application/pdf","2026-10-07","2026-09-29",true,{"@type":117,"interactionType":118,"userInteractionCount":19},"InteractionCounter",{"@type":119},"ViewAction",{"@type":121,"mainEntity":122},"FAQPage",[123,129,133],{"name":124,"@type":125,"acceptedAnswer":126},"What question does the study address about immune function in older adults?","Question",{"text":127,"@type":128},"It examines whether average lifetime work exposures are associated with immune health after age 65, beyond broader social patterns of immune function.","Answer",{"name":130,"@type":125,"acceptedAnswer":131},"Which data sources and methods are used to test the associations?",{"text":132,"@type":128},"The study builds a dataset combining O*NET occupation-level work exposures, individual work history, and immune function data from the Health and Retirement Study, then uses OLS regression to evaluate associations with multiple immune indicators.",{"name":134,"@type":125,"acceptedAnswer":135},"What kinds of work exposures show links to immune function after age 65?",{"text":136,"@type":128},"Average lifetime work exposures related to stress (job demands), physical demands (frequency of bending and twisting), and environmental factors (exposure to contaminants) are associated with later-life immune health.","https://schema.org",{"og:url":99,"og:type":139,"og:title":65,"og:site_name":110,"og:description":66},"article",{"robots":141,"canonical":99},"index,follow",{"doc_id":61,"site_id":74},1790930954]