[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"doc-detail-36537-en":3,"doc-seo-36537-105":29,"detail-sidebar-cat-0-en-105":90},{"code":4,"msg":5,"data":6},0,"success",{"doc_id":7,"user_id":8,"nickname":9,"user_avatar":10,"doc_module":4,"category_id":11,"category_name":12,"doc_title":13,"doc_description":14,"doc_content":15,"file_id":16,"file_url":17,"file_type":18,"file_size":19,"view_count":20,"is_deleted":4,"is_public":20,"is_downloadable":20,"audit_status":20,"page_count":21,"language":22,"language_code":23,"site_id":24,"html_lang":23,"table_of_contents":25,"faqs":26,"seo_title":13,"seo_description":14,"update_tm":27,"read_time":28},36537,1099513958607,"Jiven","https://ap-avatar.wpscdn.com/avatar/100002390cf8733938c?x-image-process=image/resize,m_fixed,w_180,h_180&k=1778829742770036399",8,"Research & Report","Autophagy: Controlling Cell Fate in Rheumatic Diseases","Autophagy, an endogenous process required for organelle turnover, preserves cellular homeostasis and shapes cell fate. Dysregulated autophagy drives progression of systemic lupus erythematosus, rheumatoid arthritis, osteoarthritis, and systemic sclerosis through cell-type specific effects on survival, maturation, immune responses, and fibrosis. The review links autophagy to immune signaling and cellular fates and summarizes how current and investigational therapies modulate autophagy within these rheumatic diseases.","","cbCainxpccEMHAIF","https://ap.wps.com/l/cbCainxpccEMHAIF","pdf",609500,1,15,"English","en",105,"# Abstract\n# Mechanisms of autophagy\n## ULK1 complex\n# Autophagy and rheumatic disease cell types\n## SLE\n## RA\n## OA\n## SSc\n# Therapeutic modulation of autophagy","[{\"question\":\"What role does autophagy play in rheumatic diseases?\",\"answer\":\"Autophagy regulates cellular homeostasis and cell fate. Altered autophagy contributes to disease progression across SLE, RA, OA, and SSc through dysregulated immune responses, fibrosis-related pathways, and abnormal cellular functions.\"},{\"question\":\"How can autophagy differ across cell types in these diseases?\",\"answer\":\"Cell-type specific responses affect autophagy differently in each condition. Examples include decreased autophagy in OA chondrocytes, restricted autophagy in SSc fibroblasts, altered autophagy in RA synoviocytes, and dysregulated autophagy in SLE hematopoietic lineage cells.\"},{\"question\":\"Which signaling systems regulate autophagy initiation and maturation?\",\"answer\":\"Autophagy is positively regulated by complexes including the ULK1 complex and beclin 1 complex, with AMPK among key activators. mTOR signaling acts as a negative regulator via mTORC1 and mTORC2.\"}]",1782939803,38,{"code":4,"msg":30,"data":31},"ok",{"site_id":24,"language":23,"slug":32,"title":13,"keywords":15,"description":14,"schema_data":33,"social_meta":85,"head_meta":87,"extra_data":89,"updated_unix":27},"autophagy-controlling-cell-fate-in-rheumatic-diseases",{"@graph":34,"@context":84},[35,52,67],{"@type":36,"itemListElement":37},"BreadcrumbList",[38,42,46,49],{"item":39,"name":40,"@type":41,"position":20},"https://docshare.wps.com","Home","ListItem",{"item":43,"name":44,"@type":41,"position":45},"https://docshare.wps.com/document/","Document",2,{"item":47,"name":12,"@type":41,"position":48},"https://docshare.wps.com/document/research-report/",3,{"item":50,"name":13,"@type":41,"position":51},"https://docshare.wps.com/document/autophagy-controlling-cell-fate-in-rheumatic-diseases/36537/",4,{"url":50,"name":13,"@type":53,"author":54,"headline":13,"publisher":56,"fileFormat":59,"inLanguage":23,"description":14,"dateModified":60,"datePublished":61,"encodingFormat":59,"isAccessibleForFree":62,"interactionStatistic":63},"DigitalDocument",{"name":9,"@type":55},"Person",{"url":39,"name":57,"@type":58},"DocShare","Organization","application/pdf","2026-07-10","2026-07-01",true,{"@type":64,"interactionType":65,"userInteractionCount":20},"InteractionCounter",{"@type":66},"ViewAction",{"@type":68,"mainEntity":69},"FAQPage",[70,76,80],{"name":71,"@type":72,"acceptedAnswer":73},"What role does autophagy play in rheumatic diseases?","Question",{"text":74,"@type":75},"Autophagy regulates cellular homeostasis and cell fate. Altered autophagy contributes to disease progression across SLE, RA, OA, and SSc through dysregulated immune responses, fibrosis-related pathways, and abnormal cellular functions.","Answer",{"name":77,"@type":72,"acceptedAnswer":78},"How can autophagy differ across cell types in these diseases?",{"text":79,"@type":75},"Cell-type specific responses affect autophagy differently in each condition. Examples include decreased autophagy in OA chondrocytes, restricted autophagy in SSc fibroblasts, altered autophagy in RA synoviocytes, and dysregulated autophagy in SLE hematopoietic lineage cells.",{"name":81,"@type":72,"acceptedAnswer":82},"Which signaling systems regulate autophagy initiation and maturation?",{"text":83,"@type":75},"Autophagy is positively regulated by complexes including the ULK1 complex and beclin 1 complex, with AMPK among key activators. mTOR signaling acts as a negative regulator via mTORC1 and mTORC2.","https://schema.org",{"og:url":50,"og:type":86,"og:title":13,"og:site_name":57,"og:description":14},"article",{"robots":88,"canonical":50},"index,follow",{"doc_id":7,"site_id":24},{"code":4,"msg":5,"data":91},[92,96,100,104,109,114,119,122,127,130,134],{"id":20,"doc_module":4,"doc_module_name":44,"category_name":93,"show_sort_weight":94,"slug":95},"Story & Novel",90,"story-novel",{"id":45,"doc_module":4,"doc_module_name":44,"category_name":97,"show_sort_weight":98,"slug":99},"Literature",80,"literature",{"id":51,"doc_module":4,"doc_module_name":44,"category_name":101,"show_sort_weight":102,"slug":103},"Exam",70,"exam",{"id":105,"doc_module":4,"doc_module_name":44,"category_name":106,"show_sort_weight":107,"slug":108},5,"Comic",60,"comic",{"id":110,"doc_module":4,"doc_module_name":44,"category_name":111,"show_sort_weight":112,"slug":113},6,"Technology",50,"technology",{"id":115,"doc_module":4,"doc_module_name":44,"category_name":116,"show_sort_weight":117,"slug":118},7,"Healthcare",40,"healthcare",{"id":11,"doc_module":4,"doc_module_name":44,"category_name":12,"show_sort_weight":120,"slug":121},30,"research-report",{"id":123,"doc_module":4,"doc_module_name":44,"category_name":124,"show_sort_weight":125,"slug":126},9,"Religion & Spirituality",20,"religion-spirituality",{"id":125,"doc_module":4,"doc_module_name":44,"category_name":128,"show_sort_weight":125,"slug":129},"World Cup","world-cup",{"id":131,"doc_module":4,"doc_module_name":44,"category_name":132,"show_sort_weight":131,"slug":133},10,"Lifestyle","lifestyle",{"id":135,"doc_module":4,"doc_module_name":44,"category_name":136,"show_sort_weight":105,"slug":137},19,"General","general"]