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The role of autophagy in their etiology and progression has attracted major attention. The paper evaluates the impact and mechanisms of autophagy in gastrointestinal disorders by synthesizing recent research, covering inflammation-related conditions and gastrointestinal cancers, and offering updated perspectives on mechanisms and therapeutic strategies while noting complexity and unresolved points.",{"@graph":69,"@context":122},[70,84,105],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":35,"@type":76,"position":81},"https://docshare.wps.com/document/healthcare/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/autophagy-and-its-role-in-gastrointestinal-diseases/340172/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/autophagy-and-its-role-in-gastrointestinal-diseases/340172.png","ImageObject",300,407,{"name":92,"@type":93},"Rowan","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-10-30","2026-09-21",true,{"@type":102,"interactionType":103,"userInteractionCount":52},"InteractionCounter",{"@type":104},"ViewAction",{"@type":106,"mainEntity":107},"FAQPage",[108,114,118],{"name":109,"@type":110,"acceptedAnswer":111},"What does the paper focus on regarding autophagy?","Question",{"text":112,"@type":113},"It evaluates the impact and mechanisms of autophagy in gastrointestinal disorders and discusses how autophagy relates to disease etiology and progression.","Answer",{"name":115,"@type":110,"acceptedAnswer":116},"Which gastrointestinal conditions are highlighted?",{"text":117,"@type":113},"The discussion covers inflammation-related diseases such as ulcerative colitis, Crohn’s disease, and pancreatitis, as well as gastrointestinal cancers including esophageal, gastric, and colorectal cancers.",{"name":119,"@type":110,"acceptedAnswer":120},"Why does the paper call for more research on autophagy?",{"text":121,"@type":113},"It states that autophagy’s role is complex and, at times, contentious, with precise roles and underlying mechanisms not fully understood.","https://schema.org",{"og:url":83,"og:type":124,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":126,"canonical":83},"index,follow",{"doc_id":128,"site_id":62},340172,1790813092,{"code":4,"msg":5,"data":131},{"doc_id":128,"user_id":132,"nickname":92,"user_avatar":133,"doc_module":4,"category_id":34,"category_name":35,"doc_title":65,"doc_description":67,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":52,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":39,"language":139,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":140,"faqs":141,"seo_title":142,"seo_description":67,"update_tm":143,"read_time":46},1099514067415,"https://ap-avatar.wpscdn.com/avatar/100002539d78ffe74a7?x-image-process=image/resize,m_fixed,w_180,h_180&k=1779092875211072502","| W | J | G | World Journal of\u003Cbr>Gastroenterology |\n| --- | --- | --- | --- |\n\nSubmit a Manuscript: [https://www.f6publishing.com](https://www.f6publishing.com) World J Gastroenterol 2024 September 28; 30(36): 4014-4020  \nDOI: 10.3748/wjg.v30.i36.4014 ISSN 1007-9327 (print) ISSN 2219-2840 (online)  \nEDITORIAL  \nAutophagy and its role in gastrointestinal diseases  \nBo-Zong Shao, Wen-Gang Zhang, Zhen-Yu Liu, En-Qiang Linghu  \nSpecialty type: Gastroenterology and hepatology  \nProvenance and peer review:  \nInvited article; Externally peer reviewed.  \nPeer-review model: Single blind  \nPeer-review report’s classification Scientific Quality: Grade C, Grade C  \nNovelty: Grade C, Grade C  \nCreativity or Innovation: Grade C, Grade C  \nScientific Significance: Grade B, Grade C  \nP-Reviewer: Durairajan SSK  \nReceived: March 12, 2024  \nRevised: August 25, 2024  \nAccepted: September 9, 2024  \nPublished online: September 28, 2024  \nProcessing time: 192 Days and 3.5 Hours  \nBo-Zong Shao, Wen-Gang Zhang, Zhen-Yu Liu, En-Qiang Linghu, Department of Gastroenterology, First Medical Center of Chinese People’s Liberation Army General Hospital, Beijing 100853, China  \nCo-first authors: Bo-Zong Shao and Wen-Gang Zhang.  \nCorresponding author: En-Qiang Linghu, MD, PhD, Professor, Chief, Department of Gastroenterology, First Medical Center of Chinese People’s Liberation Army General Hospital, No. 28 Fuxing Road, Beijing 100853, [China.](China. linghuenqiang@vip.sina.com)[ linghuenqiang@vip.sina.com](China. linghuenqiang@vip.sina.com)  \nAbstract  \nGastrointestinal disorders encompass a spectrum of conditions affecting various organs within the digestive system, such as the esophagus, stomach, colon, rectum, pancreas, liver, small intestine, and bile ducts. The role of autophagy in the etiology and progression of gastrointestinal diseases has garnered significant attention. This paper seeks to evaluate the impact and mechanisms of autophagyin gastrointestinal disorders by synthesizing recent research findings. Specifically, we delve into inflammation-related gastrointestinal conditions, including ulcerative colitis, Crohn’s disease, and pancreatitis, as well as gastrointestinal cancers such as esophageal, gastric, and colorectal cancers. Additionally, we provide commentary on a recent publication by Chang et al in the World Journal of Gastroenterology. Our objective is to offer fresh perspectives on the mechanismsand therapeutic approaches for these gastrointestinal ailments. This review aims to offer new perspectives on the mechanisms and therapeutic strategies for gastrointestinal disorders by critically analyzing relevant publications. As discussed, the role of autophagy in gastrointestinal diseases is complex and, at times, contentious. To harness the full therapeutic potential of autophagy in treating these conditions, more in-depth research is imperative.  \nKey Words: Autophagy; Inflammation; Cancer; Inflammatory bowel disease; Pancreatitis  \n©The Author(s) 2024. Published by Baishideng Publishing Group Inc. All rights reserved.  \nCore Tip: Extensive research has implicated autophagy in the pathogenesis and advancement of diverse gastrointestinal disorders. Nevertheless, the precise role of autophagy in these ailments remains incompletely understood, and the specific underlying mechanisms remain elusive. Consequently, further investigation is warranted to address these gaps in knowledge.  \n WJG  [https://www.wjgnet.com](https://www.wjgnet.com) 4014 September 28, 2024  Volume 30  Issue 36   \nShao BZ et al. Autophagy in gastrointestinal diseases  \nCitation: Shao BZ, Zhang WG, Liu ZY, Linghu EQ. Autophagy and its role in gastrointestinal diseases. World J Gastroenterol 2024;  \n30(36): 4014-4020  \nURL: [https://www.wjgnet.com/1007-9327/full/v30/i36/4014.htm](https://www.wjgnet.com/1007-9327/full/v30/i36/4014.htm)  \nDOI: [https://dx.doi.org/10.3748/wjg.v30.i36.4014](https://dx.doi.org/10.3748/wjg.v30.i36.4014)  \nINTRODUCTION  \nThe term “autophagy” was ","cbCaie7pHIkOonYQ","https://ap.wps.com/l/cbCaie7pHIkOonYQ","pdf",1717815,"English","# Editorial\n## Abstract\n## Core Tip\n## Introduction","[{\"question\":\"What does the paper focus on regarding autophagy?\",\"answer\":\"It evaluates the impact and mechanisms of autophagy in gastrointestinal disorders and discusses how autophagy relates to disease etiology and progression.\"},{\"question\":\"Which gastrointestinal conditions are highlighted?\",\"answer\":\"The discussion covers inflammation-related diseases such as ulcerative colitis, Crohn’s disease, and pancreatitis, as well as gastrointestinal cancers including esophageal, gastric, and colorectal cancers.\"},{\"question\":\"Why does the paper call for more research on autophagy?\",\"answer\":\"It states that autophagy’s role is complex and, at times, contentious, with precise roles and underlying mechanisms not fully understood.\"}]","Autophagy and its role in gastrointestinal diseases | PDF",1790034649]