[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"doc-seo-337316-105":3,"detail-sidebar-cat-0-en-105":81,"doc-detail-337316-en":131},{"code":4,"msg":5,"data":6},0,"ok",{"site_id":7,"language":8,"slug":9,"title":10,"keywords":11,"description":12,"schema_data":13,"social_meta":74,"head_meta":76,"extra_data":78,"updated_unix":80},105,"en","autoimmune-gastritis-in-korean-patients-with-gastric-tumors-clinicopathologic-correlations-and-diagnostic-histological-features","Autoimmune Gastritis in Korean Patients with Gastric Tumors - Clinicopathologic Correlations and Diagnostic Histological Features","","Autoimmune gastritis (AIG) is a corpus-dominant atrophic gastritis associated with antiparietal cell antibody and/or anti-intrinsic factor antibody. A study assessed the frequency of AIG among 624 Korean patients with gastric tumors and evaluated clinicopathologic correlations and diagnostic histological features. Eleven met AIG criteria (5.9% APCA-positive; 1.8% AIG overall), with AIG frequency lower in gastric cancer than in neuroendocrine tumors. H. pylori antibodies were often positive in AIG with gastric cancer, and pepsinogen markers differed by AIG status.",{"@graph":14,"@context":73},[15,34,56],{"@type":16,"itemListElement":17},"BreadcrumbList",[18,23,27,31],{"item":19,"name":20,"@type":21,"position":22},"https://docshare.wps.com","Home","ListItem",1,{"item":24,"name":25,"@type":21,"position":26},"https://docshare.wps.com/document/","Document",2,{"item":28,"name":29,"@type":21,"position":30},"https://docshare.wps.com/document/healthcare/","Healthcare",3,{"item":32,"name":10,"@type":21,"position":33},"https://docshare.wps.com/document/autoimmune-gastritis-in-korean-patients-with-gastric-tumors-clinicopathologic-correlations-and-diagnostic-histological-features/337316/",4,{"url":32,"name":10,"@type":35,"image":36,"author":41,"headline":10,"publisher":44,"fileFormat":47,"inLanguage":8,"description":12,"dateModified":48,"datePublished":49,"encodingFormat":47,"isAccessibleForFree":50,"interactionStatistic":51},"DigitalDocument",{"url":37,"@type":38,"width":39,"height":40},"https://docshare.wps.com/thumbnails/autoimmune-gastritis-in-korean-patients-with-gastric-tumors-clinicopathologic-correlations-and-diagnostic-histological-features/337316.png","ImageObject",300,407,{"name":42,"@type":43},"Valentina","Person",{"url":19,"name":45,"@type":46},"DocShare","Organization","application/pdf","2026-10-30","2026-09-21",true,{"@type":52,"interactionType":53,"userInteractionCount":55},"InteractionCounter",{"@type":54},"ViewAction",14,{"@type":57,"mainEntity":58},"FAQPage",[59,65,69],{"name":60,"@type":61,"acceptedAnswer":62},"How was autoimmune gastritis (AIG) diagnosed in the study cohort?","Question",{"text":63,"@type":64},"Patients with positive antiparietal cell antibody underwent review of endoscopy and histology findings to establish AIG according to diagnostic criteria.","Answer",{"name":66,"@type":61,"acceptedAnswer":67},"What was the frequency of AIG among Korean patients with different gastric tumors?",{"text":68,"@type":64},"AIG was present in 1.3% of gastric cancer patients (8/612) and 25.0% of neuroendocrine tumor patients (3/12).",{"name":70,"@type":61,"acceptedAnswer":71},"What relationships were found between AIG and Helicobacter pylori in patients with gastric cancer?",{"text":72,"@type":64},"Among AIG patients, serum Helicobacter pylori antibody was positive in 6/11 (54.5%), and all of these positives occurred in patients with gastric cancer. Histology showed pure AIG, concurrent AIG with H. pylori gastritis, and cases indefinite for AIG.","https://schema.org",{"og:url":32,"og:type":75,"og:title":10,"og:site_name":45,"og:description":12},"article",{"robots":77,"canonical":32},"index,follow",{"doc_id":79,"site_id":7},337316,1790128024,{"code":4,"msg":82,"data":83},"success",[84,88,92,96,101,106,110,115,120,123,127],{"id":22,"doc_module":4,"doc_module_name":25,"category_name":85,"show_sort_weight":86,"slug":87},"Story & Novel",90,"story-novel",{"id":26,"doc_module":4,"doc_module_name":25,"category_name":89,"show_sort_weight":90,"slug":91},"Literature",80,"literature",{"id":33,"doc_module":4,"doc_module_name":25,"category_name":93,"show_sort_weight":94,"slug":95},"Exam",70,"exam",{"id":97,"doc_module":4,"doc_module_name":25,"category_name":98,"show_sort_weight":99,"slug":100},5,"Comic",60,"comic",{"id":102,"doc_module":4,"doc_module_name":25,"category_name":103,"show_sort_weight":104,"slug":105},6,"Technology",50,"technology",{"id":107,"doc_module":4,"doc_module_name":25,"category_name":29,"show_sort_weight":108,"slug":109},7,40,"healthcare",{"id":111,"doc_module":4,"doc_module_name":25,"category_name":112,"show_sort_weight":113,"slug":114},8,"Research & Report",30,"research-report",{"id":116,"doc_module":4,"doc_module_name":25,"category_name":117,"show_sort_weight":118,"slug":119},9,"Religion & Spirituality",20,"religion-spirituality",{"id":118,"doc_module":4,"doc_module_name":25,"category_name":121,"show_sort_weight":118,"slug":122},"World Cup","world-cup",{"id":124,"doc_module":4,"doc_module_name":25,"category_name":125,"show_sort_weight":124,"slug":126},10,"Lifestyle","lifestyle",{"id":128,"doc_module":4,"doc_module_name":25,"category_name":129,"show_sort_weight":97,"slug":130},19,"General","general",{"code":4,"msg":82,"data":132},{"doc_id":79,"user_id":133,"nickname":42,"user_avatar":134,"doc_module":4,"category_id":107,"category_name":29,"doc_title":10,"doc_description":12,"doc_content":135,"file_id":136,"file_url":137,"file_type":138,"file_size":139,"view_count":55,"is_deleted":4,"is_public":22,"is_downloadable":22,"audit_status":22,"page_count":140,"language":141,"language_code":8,"site_id":7,"html_lang":8,"table_of_contents":142,"faqs":143,"seo_title":144,"seo_description":12,"update_tm":145,"read_time":113},13056703020460,"https://ap-avatar.wpscdn.com/avatar/be000253dac470eee5d?_k=1778207105932848923","Gut and Liver  \n[https://doi.org/10.5009/gnl240223](https://doi.org/10.5009/gnl240223)[ ](https://doi.org/10.5009/gnl240223)[pISSN 1976-2283 eISSN 2005-1212](pISSN 1976-2283 eISSN 2005-1212)  \nOriginal Article  \n\n| Autoimmune Gastritis in Korean Patients with Gastric Tumors: Clinicopathologic Correlations and Diagnostic Histological Features\u003Cbr>Soomin Ahn1 , Tae-Se Kim2 , Ryoji Kushima3 , Jun Haeng Lee2 , Kyoung-Mee Kim1\u003Cbr>1Department of Pathology and Translational Genomics, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea; 2Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea; 3Department of Pathology, Shiga University of Medical Science, Otsu, Japan |  |  |\n| --- | --- | --- |\n| \u003Cbr>See editorial on page 145.\u003Cbr>Article Info\u003Cbr>Received May 17, 2024\u003Cbr>Revised July 29, 2024\u003Cbr>Accepted August 1, 2024\u003Cbr>Published online November 7, 2024\u003Cbr>Corresponding Author\u003Cbr>Kyoung-Mee Kim\u003Cbr>ORCID [https://orcid.org/0000-0002-1162-9205](https://orcid.org/0000-0002-1162-9205)[ ](https://orcid.org/0000-0002-1162-9205)[E-mail](E-mail kkmkys@skku.edu)[ kkmkys@skku.edu](E-mail kkmkys@skku.edu)\u003Cbr>Jun Haeng Lee\u003Cbr>ORCID [https://orcid.org/0000-0002-5272-1841](https://orcid.org/0000-0002-5272-1841)[ ](https://orcid.org/0000-0002-5272-1841)[E-mail](E-mail stomachlee@gmail.com)[ stomachlee@gmail.com](E-mail stomachlee@gmail.com)\u003Cbr>Soomin Ahn and Tae-Se Kim contributed equally to the work as first authors. | Background/Aims: Autoimmune gastritis (AIG) is a corpus-dominant atrophic gastritis in which patients are positive for antiparietal cell antibody (APCA) and/or anti-intrinsic factor antibody. The risk of developing gastric cancer in patients withAIG remains unclear, and reliable frequency data of AIG in patients with gastric cancer are lacking.\u003Cbr>Methods: We included 624 Korean patients with gastric tumors (612 gastric cancers and 12 neuroendocrine tumors) who hadAPCA results and were available for AIG evaluation. In patients with positive APCA results, endoscopy and histology findings were reviewed to diagnose AIG. Results: Of the 624 patients, 37 (5 .9%) tested positive for APCA, and ultimately, 11 (1 .8%) met the diagnostic criteria for AIG (5 both endoscopy and histology findings, 4 endoscopy-only findings, 2 histology-only findings) . The frequency of AIG in patients with gastric cancer was 1.3%(8/612), and that in patients with neuroendocrine tumors was 25.0%(3/12) . Of the 11 patients withAIG, serum Helicobacter pylori antibody was positive in six patients (54 .5%), all of whom had gastric cancer. Histologically, three patients showed pure AIG, four patients exhibited concurrent AIG and H. pylori gastritis, and the findings for four were indefinite for AIG. The pepsinogen (PG) I levels and PG I/II ratio were significantly lower in patients with gastric cancer with AIG than inpatients with gastric cancer without AIG (p=0 .042 and p=0 .016, respectively) .\u003Cbr>Conclusions: The frequency of AIG in gastric cancer patients was very low compared to that inpatients with neuroendocrine tumors. Rather, concurrent AIG and H. pylori gastritis was common in patients withAIG with gastric cancer. (Gut Liver 2025;19:177-188)\u003Cbr>Key Words: Stomach neoplasms; Autoimmune diseases; Gastritis, atrophic; Diagnosis |  |\n| \u003Cbr>INTRODUCTION |  | to 2% .1 In Asia, the frequency of AIG is considered rare and was previously underestimated; however, its frequency |\n| Atrophic gastritis can be classified into two types based |  | has steadily increased with the rising awareness of this |\n| on etiology: type A (autoimmune) and type B (environmental) . Type B gastritis, with Helicobacter pylori being |  | condition.2,3 Additionally, AIG concurrent with previous or current H. pylori infection has been reported in various |\n| the most common agent of gastritis, is much more com- |  | ranges, and potential links between the two conditions are |\n| mon and is characterized by antrum-pr","cbCaicPvoa1gPBZ0","https://ap.wps.com/l/cbCaicPvoa1gPBZ0","pdf",30383296,12,"English","# Introduction\n# Methods\n# Results\n# Conclusions\n# Article Info\n## Received, Revised, Accepted, Published online\n## Corresponding Authors","[{\"question\":\"How was autoimmune gastritis (AIG) diagnosed in the study cohort?\",\"answer\":\"Patients with positive antiparietal cell antibody underwent review of endoscopy and histology findings to establish AIG according to diagnostic criteria.\"},{\"question\":\"What was the frequency of AIG among Korean patients with different gastric tumors?\",\"answer\":\"AIG was present in 1.3% of gastric cancer patients (8/612) and 25.0% of neuroendocrine tumor patients (3/12).\"},{\"question\":\"What relationships were found between AIG and Helicobacter pylori in patients with gastric cancer?\",\"answer\":\"Among AIG patients, serum Helicobacter pylori antibody was positive in 6/11 (54.5%), and all of these positives occurred in patients with gastric cancer. Histology showed pure AIG, concurrent AIG with H. pylori gastritis, and cases indefinite for AIG.\"}]","Autoimmune Gastritis in Korean Patients with Gastric Tumors - Clinicopathologic Correlations and Diagnostic Histological Features | PDF",1790018562]