[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"detail-sidebar-cat-0-en-105":3,"doc-seo-435830-105":59,"doc-detail-435830-en":130},{"code":4,"msg":5,"data":6},0,"success",[7,13,18,23,28,33,38,43,48,51,55],{"id":8,"doc_module":4,"doc_module_name":9,"category_name":10,"show_sort_weight":11,"slug":12},1,"Document","Story & Novel",90,"story-novel",{"id":14,"doc_module":4,"doc_module_name":9,"category_name":15,"show_sort_weight":16,"slug":17},2,"Literature",80,"literature",{"id":19,"doc_module":4,"doc_module_name":9,"category_name":20,"show_sort_weight":21,"slug":22},4,"Exam",70,"exam",{"id":24,"doc_module":4,"doc_module_name":9,"category_name":25,"show_sort_weight":26,"slug":27},5,"Comic",60,"comic",{"id":29,"doc_module":4,"doc_module_name":9,"category_name":30,"show_sort_weight":31,"slug":32},6,"Technology",50,"technology",{"id":34,"doc_module":4,"doc_module_name":9,"category_name":35,"show_sort_weight":36,"slug":37},7,"Healthcare",40,"healthcare",{"id":39,"doc_module":4,"doc_module_name":9,"category_name":40,"show_sort_weight":41,"slug":42},8,"Research & Report",30,"research-report",{"id":44,"doc_module":4,"doc_module_name":9,"category_name":45,"show_sort_weight":46,"slug":47},9,"Religion & Spirituality",20,"religion-spirituality",{"id":46,"doc_module":4,"doc_module_name":9,"category_name":49,"show_sort_weight":46,"slug":50},"World Cup","world-cup",{"id":52,"doc_module":4,"doc_module_name":9,"category_name":53,"show_sort_weight":52,"slug":54},10,"Lifestyle","lifestyle",{"id":56,"doc_module":4,"doc_module_name":9,"category_name":57,"show_sort_weight":24,"slug":58},19,"General","general",{"code":4,"msg":60,"data":61},"ok",{"site_id":62,"language":63,"slug":64,"title":65,"keywords":66,"description":67,"schema_data":68,"social_meta":123,"head_meta":125,"extra_data":127,"updated_unix":129},105,"en","auditory-pathway-abnormalities-in-parkinsons-disease-abstract","Auditory pathway abnormalities in Parkinson’s disease - Abstract","","This study characterizes audiometric responses and auditory evoked potential measures—auditory brainstem response (ABR) and cortical auditory evoked potentials (CAEP)—in individuals with Parkinson’s disease (PD). Thirty-two participants aged 40–81 were assessed: 16 with PD and 16 without PD, matched by sex and age. Pure-tone audiometry, ABR (click stimuli), and CAEP (oddball paradigm with tone-burst and speech) were analyzed with repeated-measures ANOVA. PD showed higher hearing thresholds at 6 and 8 kHz, no ABR group differences, and reduced CAEP P1-N1, P2-N2, and N2-P3 amplitudes, indicating impaired cortical processing of acoustic stimuli.",{"@graph":69,"@context":122},[70,84,105],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":35,"@type":76,"position":81},"https://docshare.wps.com/document/healthcare/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/auditory-pathway-abnormalities-in-parkinsons-disease-abstract/435830/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/auditory-pathway-abnormalities-in-parkinsons-disease-abstract/435830.png","ImageObject",300,407,{"name":92,"@type":93},"Jiven","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-10-30","2026-09-29",true,{"@type":102,"interactionType":103,"userInteractionCount":29},"InteractionCounter",{"@type":104},"ViewAction",{"@type":106,"mainEntity":107},"FAQPage",[108,114,118],{"name":109,"@type":110,"acceptedAnswer":111},"What was the objective of the study on Parkinson’s disease and auditory pathways?","Question",{"text":112,"@type":113},"To characterize audiometric responses and both auditory brainstem response (ABR) and cortical auditory evoked potentials (CAEP) in individuals with Parkinson’s disease.","Answer",{"name":115,"@type":110,"acceptedAnswer":116},"How were participants assessed in this study?",{"text":117,"@type":113},"Participants underwent pure tone audiometry, ABR using click stimuli, and CAEP using an oddball paradigm with tone burst and speech stimuli.",{"name":119,"@type":110,"acceptedAnswer":120},"What were the main findings regarding hearing thresholds and evoked potentials?",{"text":121,"@type":113},"PD participants had significantly higher hearing thresholds at 6 and 8 kHz, ABR showed no between-group differences, and CAEP revealed smaller amplitudes (P1-N1, P2-N2, and N2-P3) in the PD group.","https://schema.org",{"og:url":83,"og:type":124,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":126,"canonical":83},"index,follow",{"doc_id":128,"site_id":62},435830,1791033378,{"code":4,"msg":5,"data":131},{"doc_id":128,"user_id":132,"nickname":92,"user_avatar":133,"doc_module":4,"category_id":34,"category_name":35,"doc_title":65,"doc_description":67,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":29,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":139,"language":140,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":141,"faqs":142,"seo_title":143,"seo_description":67,"update_tm":144,"read_time":145,"preview_page_count":4},1099513958607,"https://ap-avatar.wpscdn.com/avatar/100002390cf8733938c?x-image-process=image/resize,m_fixed,w_180,h_180&k=1778829742770036399","Article published online: 2025-02-06  \nOriginal Article 1  \nAuditory pathway abnormalities in Parkinson’s disease  \nRafaela Valiengo de Souza 1 Liliane Aparecida Fagundes Silva 1 Carla Gentile Matas 1  \n1 Universidade de São Paulo, Faculdade de Medicina, Departamento de Fisioterapia, Fonoaudiologia e Terapia Ocupacional, São Paulo SP, Brazil.  \nArq. Neuro-Psiquiatr. 2025;83(1):s00451801844 .  \nAddress for correspondence Liliane Aparecida Fagundes Silva (email: [liliane.a.fagundes@gmail.com](liliane.a.fagundes@gmail.com))  \nAbstract  \nKeywords  \n► Auditory Cortex  \n► Parkinson Disease  \n► Hearing Loss  \n► Evoked Potentials, Auditory  \n► Event-Related Potentials, P300  \nBackground Parkinson’s disease (PD) is a degenerative, progressive, chronic disease that mainly affects the central nervous system, caused by dopamine deficiency. One of the ways to evaluate the central nervous system is with auditory evoked potentials (AEP) .  \nObjective To characterize the audiometric responses, and the auditory brainstem response (ABR), and cortical auditory evoked potentials (CAEP) in individuals with PD. Methods Thirty-two patients aged between 40 and 81 of both sexes were assessed, 16 with PD (study group [SG]) and 16 without PD (control group [CG]) matched for sex and age. The subjects were assessed using pure tone audiometry, ABR with click stimuli, and CAEP using the oddball paradigm with tone burst and speech stimuli. The results were compared between the groups using a repeated measures analysis of variance (ANOVA) test.  \nResults In pure-tone audiometry, significantly higher hearing thresholds were found in the SG at 6 and 8 kHz. For the ABR, no differences were observed between groups. The CAEP analysis did not find statistical differences in the latencies between the groups, however, the SG presented smaller amplitudes of P1-N1, P2-N2, and N2-P3 than the CG.  \nConclusion The results of this study showed a significantly higher threshold in higher frequencies in PD. Although no differences were observed at the brainstem level, the decrease in amplitude of all components in patients with PD in the CAEP suggests adeficit in both automatic and attentional cortical processing of acoustic stimuli.  \nINTRODUCTION  \nIncreased life expectancy is a preponderant factor in epidemiological transition, requiring greater attention to agingrelated chronic and degenerative diseases, 1 including Parkinson’s disease (PD),2,3 whose predominance is 1 to 2 per 1000 people in the general population and 1 per 100 in those over than 65 years old.  \nPD was described by James Parkinson in 1917 as a paralysis agitans,4 and its classic clinical condition is characterized by motor signs such as tremors, stiffness, bradykinesia, and postural instability, due to the degeneration of nigrostriatal dopaminergic neurons at the brain nuclei.5 PD is currently recognized as a disease with a broader and more diffuse spectrum involving not only the dopaminergic neurodegeneration of the motor system but also the impairment of  \nreceived April 5, 2024  \nreceived in its final form October 8, 2024  \naccepted  \nOctober 26, 2024  \nDOI [https://doi.org/](https://doi.org/)[ ](https://doi.org/)10.1055/s-0045-1801844 . ISSN 0004-282X.  \nEditor-in-Chief: Hélio A. G. Teive.  \nAssociate Editor: Laura SilveiraMoriyama.  \n© 2025 . The Author(s) .  \nThis is an open access article published by Thieme under the terms of the Creative Commons Attribution 4.0 International License, permitting copying and reproduction so long as the original work is given appropriate credit ([https://creativecommons.org/licenses/by/4.0/](https://creativecommons.org/licenses/by/4.0/)).  \nThieme Revinter Publicações Ltda., Rua do Matoso 170, Rio de Janeiro, RJ, CEP 20270-135, Brazil  \n2 Hearing in Parkinson’s disease Souza et al.  \nvarious organs and systems manifested with nonmotor signs and symptoms.6–8  \nAlthough clinical manifestations are the basis for diagnosis and analysis of the progression of the disease, the p","cbCaiedyrdbTl9Er","https://ap.wps.com/l/cbCaiedyrdbTl9Er","pdf",787092,11,"English","# Abstract\n## Background\n## Objective\n## Methods\n## Results\n## Conclusion\n# Introduction\n## Epidemiology and disease description\n## Hearing complaints and clinical relevance\n## Central auditory system and electrophysiological assessment","[{\"question\":\"What was the objective of the study on Parkinson’s disease and auditory pathways?\",\"answer\":\"To characterize audiometric responses and both auditory brainstem response (ABR) and cortical auditory evoked potentials (CAEP) in individuals with Parkinson’s disease.\"},{\"question\":\"How were participants assessed in this study?\",\"answer\":\"Participants underwent pure tone audiometry, ABR using click stimuli, and CAEP using an oddball paradigm with tone burst and speech stimuli.\"},{\"question\":\"What were the main findings regarding hearing thresholds and evoked potentials?\",\"answer\":\"PD participants had significantly higher hearing thresholds at 6 and 8 kHz, ABR showed no between-group differences, and CAEP revealed smaller amplitudes (P1-N1, P2-N2, and N2-P3) in the PD group.\"}]","Auditory pathway abnormalities in Parkinson’s disease - Abstract | PDF",1790675519,28]