[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"doc-seo-432149-105":3,"doc-detail-432149-en":81,"detail-sidebar-cat-0-en-105":98},{"code":4,"msg":5,"data":6},0,"ok",{"site_id":7,"language":8,"slug":9,"title":10,"keywords":11,"description":12,"schema_data":13,"social_meta":74,"head_meta":76,"extra_data":78,"updated_unix":80},105,"en","atypical-presentation-of-macular-serpiginous-choroiditis-masquerading-as-age-related-macular-degeneration-research-report-overview","Atypical presentation of macular serpiginous choroiditis masquerading as age related macular degeneration - Research report overview","","Purpose: Describe a case of macular serpiginous choroiditis masquerading as age-related macular degeneration. Method: Multimodal imaging with ultra-widefield fundus autofluorescence and fluorescein/indocyanine green angiography, plus cross-sectional en face OCT and OCT angiography, to establish the correct diagnosis. Results: A 57-year-old woman presented with acute right-eye loss and long-standing left-eye loss; OCT showed drusenoid lesions and atrophic scarring, while OCTA demonstrated inner choroidal ischemia. Immunomodulatory therapy improved vision and resolved OCT lesions, with OCTA regression of ischemia. Conclusion: Placoid disorders can mimic AMD; OCTA is crucial for accurate diagnosis and treatment guidance.",{"@graph":14,"@context":73},[15,34,56],{"@type":16,"itemListElement":17},"BreadcrumbList",[18,23,27,31],{"item":19,"name":20,"@type":21,"position":22},"https://docshare.wps.com","Home","ListItem",1,{"item":24,"name":25,"@type":21,"position":26},"https://docshare.wps.com/document/","Document",2,{"item":28,"name":29,"@type":21,"position":30},"https://docshare.wps.com/document/healthcare/","Healthcare",3,{"item":32,"name":10,"@type":21,"position":33},"https://docshare.wps.com/document/atypical-presentation-of-macular-serpiginous-choroiditis-masquerading-as-age-related-macular-degeneration-research-report-overview/432149/",4,{"url":32,"name":10,"@type":35,"image":36,"author":41,"headline":10,"publisher":44,"fileFormat":47,"inLanguage":8,"description":12,"dateModified":48,"datePublished":49,"encodingFormat":47,"isAccessibleForFree":50,"interactionStatistic":51},"DigitalDocument",{"url":37,"@type":38,"width":39,"height":40},"https://docshare.wps.com/thumbnails/atypical-presentation-of-macular-serpiginous-choroiditis-masquerading-as-age-related-macular-degeneration-research-report-overview/432149.png","ImageObject",300,407,{"name":42,"@type":43},"Dipper","Person",{"url":19,"name":45,"@type":46},"DocShare","Organization","application/pdf","2026-10-30","2026-09-29",true,{"@type":52,"interactionType":53,"userInteractionCount":55},"InteractionCounter",{"@type":54},"ViewAction",6,{"@type":57,"mainEntity":58},"FAQPage",[59,65,69],{"name":60,"@type":61,"acceptedAnswer":62},"How was the correct diagnosis established in this case?","Question",{"text":63,"@type":64},"The diagnosis relied on multimodal imaging, including OCT and OCT angiography, to detect inner choroidal ischemia and characterize the lesions beyond typical AMD findings.","Answer",{"name":66,"@type":61,"acceptedAnswer":67},"What key imaging findings suggested macular serpiginous choroiditis rather than AMD?",{"text":68,"@type":64},"OCT showed drusenoid lesions and atrophic macular scarring, while OCTA demonstrated inner choroidal ischemia corresponding to the drusenoid lesions without relevant shadow artifact.",{"name":70,"@type":61,"acceptedAnswer":71},"What treatment was used and what was the outcome?",{"text":72,"@type":64},"The patient received immunomodulatory therapy, including oral steroids and escalating mycophenolate dosing. After three months, visual acuity improved, drusenoid lesions resolved on OCT, and choroidal ischemia regressed on OCTA.","https://schema.org",{"og:url":32,"og:type":75,"og:title":10,"og:site_name":45,"og:description":12},"article",{"robots":77,"canonical":32},"index,follow",{"doc_id":79,"site_id":7},432149,1790760564,{"code":4,"msg":82,"data":83},"success",{"doc_id":79,"user_id":84,"nickname":42,"user_avatar":85,"doc_module":4,"category_id":86,"category_name":29,"doc_title":10,"doc_description":12,"doc_content":87,"file_id":88,"file_url":89,"file_type":90,"file_size":91,"view_count":55,"is_deleted":4,"is_public":22,"is_downloadable":22,"audit_status":22,"page_count":33,"language":92,"language_code":8,"site_id":7,"html_lang":8,"table_of_contents":93,"faqs":94,"seo_title":95,"seo_description":12,"update_tm":96,"read_time":97,"preview_page_count":4},1374404997633,"https://ap-avatar.wpscdn.com/davatar_a8503ba1806abce46bf441b54a3ca4cd",7,"American Journal of Ophthalmology Case Reports 41 (2026) 102491  \nContents lists available at ScienceDirect  \nAmerican Journal of Ophthalmology Case Reports  \njournal [homepage:](homepage: www.ajocasereports.com/)[ www.ajocasereports.com/](homepage: www.ajocasereports.com/)  \n| Atypical presentation of macular serpiginous choroiditis masquerading as age related macular degeneration\u003Cbr>Shahin Faghihi a , Tal Eshkoly-Lior a, Alessandro Feoa,b, David Sarrafa,c,*\u003Cbr>a Retinal Division, Stein Eye Institute, University of California of Los Angeles, David Geffen School of Medicine at UCLA, Los Angeles, CA, United States b Department of Biomedical Sciences, Humanitas University, Via Rita Levi Montalcini 4, Pieve Emanuele, 20072, Milan, Italy\u003Cbr>c Greater Los Angeles VA Healthcare Center, Los Angeles, CA, United States |  |  |\n| --- | --- | --- |\n| A R T I C L E I N F O |  | A B S T R A C T |\n| Keywords:\u003Cbr>Serpiginous choroiditis Multimodal imaging Prednisone treatment Mycophenolate mofetil treatment Anti VEGF intravitreal injection OCT-A |  | Purpose: To describe a case of macular serpiginous choroiditis (SC) masquerading as age related macular degeneration.\u003Cbr>Method: Multimodal imaging (MMI), including ultra-widefield fundus autofluorescence and fluorescein and indocyanine green angiography werer performed. Cross-sectional and en face optical coherence tomography (OCT) and OCT angiography (OCTA) facilitated the correct diagnosis of this masquerade condition.\u003Cbr>Results: A 57-year-old woman, with a history of long-standing vision loss in the left eye (OS), presented with acute vision loss in the right eye (OD). Color fundus photography showed a focal macular lesion central OD and an irregular atrophic macular scar central OS. OCT OD displayed large drusenoid lesions in the macula OD and amacular scar OS. OCTA showed evidence of inner choroidal ischemia central OD corresponding to the drusenoid lesions without shadow artifact OD. A diagnosis of macular serpiginous choroiditis was rendered OD and the patient was started on immunomodulatory therapy (IMT) including oral steroids and increasing dosages of mycophenolate therapy. After three months of follow-up, the visual acuity remarkably improved, the drusenoid lesions completely resolved on OCT, and choroidal ischemia completely regressed on OCTA OD.\u003Cbr>Conclusion: Placoid disorders can masquerade as AMD. We present an unusual case of macular serpiginouschoroiditis with new onset drusenoid lesions driven by inner choroidal ischemia on OCTA and with resolution following IMT. OCTA can be an invaluable tool to correctly diagnose placoid conditions which is essential to guide therapeutic considerations. |\n\n1. Introduction  \nThe spectrum of placoid disorders is broad and includes well known conditions such as acute posterior macular placoid pigment epitheliopathy (APMPPE) and rarer diseases such as persistent placoid chorioretinitis (PPC). These disorders are driven by inner choroidal orchoriocapillaris (CC) ischemia1 which can be effectively captured with dye-based angiography such as fluorescein (FA) or indocyanine angiography (ICGA). However, OCTA is a more recent advanced tool that can detect CC ischemia with greater ease and simplicity.1  \nSerpiginous choroiditis (SC) is a more severe placoid disease that can be associated with progressive recurrent infiltrates and severe chorioretinal scarring. The lesions classically progress in a helicoid pattern away from the disc but rarer presentations include macular serpiginouschoroiditis (MSC) in which the process is more centrally located.2,3  \nPlacoid disorders such as APMPPE and SC and MSC can develop in middle-aged patients.4 Various retinal pigment epithelium (RPE) distuirbances, including drusenoid lesions and macular neovascularization (MNV), can complicate these placoid disorders and masquerade as more common entities such as age-related macular degeneration (AMD).  \nWe describe a remarkable case of MSC in a patient with new onset drus","cbCaidjv8yJxX174","https://ap.wps.com/l/cbCaidjv8yJxX174","pdf",3842169,"English","# Purpose\n# Method\n# Results\n# Conclusion\n# Introduction\n## Placid disorders and inner choroidal ischemia\n## Serpiginous choroiditis and macular variants\n## Masquerade as age-related macular degeneration\n# Case report\n## Baseline presentation\n## Examination and imaging findings","[{\"question\":\"How was the correct diagnosis established in this case?\",\"answer\":\"The diagnosis relied on multimodal imaging, including OCT and OCT angiography, to detect inner choroidal ischemia and characterize the lesions beyond typical AMD findings.\"},{\"question\":\"What key imaging findings suggested macular serpiginous choroiditis rather than AMD?\",\"answer\":\"OCT showed drusenoid lesions and atrophic macular scarring, while OCTA demonstrated inner choroidal ischemia corresponding to the drusenoid lesions without relevant shadow artifact.\"},{\"question\":\"What treatment was used and what was the outcome?\",\"answer\":\"The patient received immunomodulatory therapy, including oral steroids and escalating mycophenolate dosing. After three months, visual acuity improved, drusenoid lesions resolved on OCT, and choroidal ischemia regressed on OCTA.\"}]","Atypical presentation of macular serpiginous choroiditis masquerading as age related macular degeneration - Research report overview | PDF",1790658277,10,{"code":4,"msg":82,"data":99},[100,104,108,112,117,121,124,129,134,137,140],{"id":22,"doc_module":4,"doc_module_name":25,"category_name":101,"show_sort_weight":102,"slug":103},"Story & Novel",90,"story-novel",{"id":26,"doc_module":4,"doc_module_name":25,"category_name":105,"show_sort_weight":106,"slug":107},"Literature",80,"literature",{"id":33,"doc_module":4,"doc_module_name":25,"category_name":109,"show_sort_weight":110,"slug":111},"Exam",70,"exam",{"id":113,"doc_module":4,"doc_module_name":25,"category_name":114,"show_sort_weight":115,"slug":116},5,"Comic",60,"comic",{"id":55,"doc_module":4,"doc_module_name":25,"category_name":118,"show_sort_weight":119,"slug":120},"Technology",50,"technology",{"id":86,"doc_module":4,"doc_module_name":25,"category_name":29,"show_sort_weight":122,"slug":123},40,"healthcare",{"id":125,"doc_module":4,"doc_module_name":25,"category_name":126,"show_sort_weight":127,"slug":128},8,"Research & Report",30,"research-report",{"id":130,"doc_module":4,"doc_module_name":25,"category_name":131,"show_sort_weight":132,"slug":133},9,"Religion & Spirituality",20,"religion-spirituality",{"id":132,"doc_module":4,"doc_module_name":25,"category_name":135,"show_sort_weight":132,"slug":136},"World Cup","world-cup",{"id":97,"doc_module":4,"doc_module_name":25,"category_name":138,"show_sort_weight":97,"slug":139},"Lifestyle","lifestyle",{"id":141,"doc_module":4,"doc_module_name":25,"category_name":142,"show_sort_weight":113,"slug":143},19,"General","general"]