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Morphologic and molecular genetic findings supported aCML, and azacitidine produced a favorable response with reduced eosinophil-related organ injury.",{"@graph":14,"@context":73},[15,34,56],{"@type":16,"itemListElement":17},"BreadcrumbList",[18,23,27,31],{"item":19,"name":20,"@type":21,"position":22},"https://docshare.wps.com","Home","ListItem",1,{"item":24,"name":25,"@type":21,"position":26},"https://docshare.wps.com/document/","Document",2,{"item":28,"name":29,"@type":21,"position":30},"https://docshare.wps.com/document/research-report/","Research & Report",3,{"item":32,"name":10,"@type":21,"position":33},"https://docshare.wps.com/document/atypical-chronic-myeloid-leukemia-found-in-a-patient-with-eosinophilia-for-six-years-a-case-report/332225/",4,{"url":32,"name":10,"@type":35,"image":36,"author":41,"headline":10,"publisher":44,"fileFormat":47,"inLanguage":8,"description":12,"dateModified":48,"datePublished":49,"encodingFormat":47,"isAccessibleForFree":50,"interactionStatistic":51},"DigitalDocument",{"url":37,"@type":38,"width":39,"height":40},"https://docshare.wps.com/thumbnails/atypical-chronic-myeloid-leukemia-found-in-a-patient-with-eosinophilia-for-six-years-a-case-report/332225.png","ImageObject",300,407,{"name":42,"@type":43},"Aria","Person",{"url":19,"name":45,"@type":46},"DocShare","Organization","application/pdf","2026-11-02","2026-09-21",true,{"@type":52,"interactionType":53,"userInteractionCount":55},"InteractionCounter",{"@type":54},"ViewAction",7,{"@type":57,"mainEntity":58},"FAQPage",[59,65,69],{"name":60,"@type":61,"acceptedAnswer":62},"Why is eosinophilia unusual in atypical chronic myeloid leukemia (aCML)?","Question",{"text":63,"@type":64},"Eosinophilia is commonly observed in hematologic malignancies, but it is rarely seen in aCML. aCML is primarily characterized by neutrophilia and dysplastic features within the MDS/MPN spectrum.","Answer",{"name":66,"@type":61,"acceptedAnswer":67},"How was the diagnosis of aCML established in the reported case?",{"text":68,"@type":64},"The patient had persistent eosinophilia for six years with other primary and secondary diseases ruled out. Over time, increased white blood cells and primarily neutrophils emerged, and the final diagnosis relied on combined morphologic and molecular genetic findings.",{"name":70,"@type":61,"acceptedAnswer":71},"What treatment was tried initially, and what was the eventual response?",{"text":72,"@type":64},"Corticosteroids and hydroxyurea were ineffective for the patient. After later diagnostic clarification, the patient responded well to azacitidine, with significant reduction in eosinophil infiltration-related end-organ damage.","https://schema.org",{"og:url":32,"og:type":75,"og:title":10,"og:site_name":45,"og:description":12},"article",{"robots":77,"canonical":32},"index,follow",{"doc_id":79,"site_id":7},332225,1790194329,{"code":4,"msg":82,"data":83},"success",[84,88,92,96,101,106,110,114,119,122,126],{"id":22,"doc_module":4,"doc_module_name":25,"category_name":85,"show_sort_weight":86,"slug":87},"Story & Novel",90,"story-novel",{"id":26,"doc_module":4,"doc_module_name":25,"category_name":89,"show_sort_weight":90,"slug":91},"Literature",80,"literature",{"id":33,"doc_module":4,"doc_module_name":25,"category_name":93,"show_sort_weight":94,"slug":95},"Exam",70,"exam",{"id":97,"doc_module":4,"doc_module_name":25,"category_name":98,"show_sort_weight":99,"slug":100},5,"Comic",60,"comic",{"id":102,"doc_module":4,"doc_module_name":25,"category_name":103,"show_sort_weight":104,"slug":105},6,"Technology",50,"technology",{"id":55,"doc_module":4,"doc_module_name":25,"category_name":107,"show_sort_weight":108,"slug":109},"Healthcare",40,"healthcare",{"id":111,"doc_module":4,"doc_module_name":25,"category_name":29,"show_sort_weight":112,"slug":113},8,30,"research-report",{"id":115,"doc_module":4,"doc_module_name":25,"category_name":116,"show_sort_weight":117,"slug":118},9,"Religion & Spirituality",20,"religion-spirituality",{"id":117,"doc_module":4,"doc_module_name":25,"category_name":120,"show_sort_weight":117,"slug":121},"World Cup","world-cup",{"id":123,"doc_module":4,"doc_module_name":25,"category_name":124,"show_sort_weight":123,"slug":125},10,"Lifestyle","lifestyle",{"id":127,"doc_module":4,"doc_module_name":25,"category_name":128,"show_sort_weight":97,"slug":129},19,"General","general",{"code":4,"msg":82,"data":131},{"doc_id":79,"user_id":132,"nickname":42,"user_avatar":133,"doc_module":4,"category_id":111,"category_name":29,"doc_title":10,"doc_description":12,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":55,"is_deleted":4,"is_public":22,"is_downloadable":22,"audit_status":22,"page_count":55,"language":139,"language_code":8,"site_id":7,"html_lang":8,"table_of_contents":140,"faqs":141,"seo_title":142,"seo_description":12,"update_tm":143,"read_time":144,"preview_page_count":4},2336464648322,"https://ap-avatar.wpscdn.com/avatar/2200025388227c56fec?_k=1778556882303663488","Jiang et al. BMC Geriatrics (2024) 24:595 [https://doi.org/10.1186/s12877-024-05196-7](https://doi.org/10.1186/s12877-024-05196-7)  \nBMC Geriatrics  \nCASE REPORT Open Access  \nAtypical chronic myeloid leukemia found in a patient with eosinophilia for six years: a case report  \nMoqin Jiang 1,2, Meng Chen 1,2, Lixiang Yan 1,2, Ying Zhang 1,2, Xiangdong Yang 1,2 and Weifeng Zhang 1,2*  \nAbstract  \nBackground Atypical chronic myeloid leukemia (aCML) is a highly aggressive type of blood cancer that falls under the category of myelodysplastic/myeloproliferative neoplasms (MDS/MPN) . In the fifth edition of the WHO classification of tumors, this category has been renamed MDS/MPN with neutrophilia. Although eosinophilia is commonly observed in blood cancers, it is rarely seen in aCML.  \nCase presentation This study presents a case of aCML that was diagnosed six years after the patient developed eosinophilia. The patient had undergone tests to rule out other primary and secondary diseases, but the eosinophilia remained unexplained. Treatment with corticosteroids and hydroxyurea had proven ineffective. Six years later, the patient experienced an increase in white blood cells, primarily neutrophils. After ruling out other possible diagnoses, a combination of morphologic and molecular genetic findings led to the diagnosis of aCML. The patient responded well to treatment with azacitidine.  \nConclusions This study summarizes the current state of aCML diagnosis and management and discusses the possible connection between eosinophilia and aCML.  \nKeywords Atypical chronic myeloid leukemia, MDS/MPN with neutrophilia, Eosinophilia, Molecular genetics, Myelodysplastic/myeloproliferative neoplasms  \nBackground  \nAtypical chronic myeloid leukemia (aCML) is a rare and aggressive hematopoietic stem cell malignancy. Its incidence is approximately 1–2 cases per 100 cases of BCR::ABL1−positive chronic myeloid leukemia (CML) [1, 2]. Clinically and biologically heterogeneous, aCML carries a high risk of progression to acute myeloid leukemia  \n*Correspondence: Weifeng Zhang [wf031@163.com](wf031@163.com)  \n1Department of Hematology, First Teaching Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin 300381, China  \n2National Clinical Research Center for Chinese Medicine Acupuncture and Moxibustion, Tianjin 300381, China  \n(AML) and a poor prognosis due to the lack of standardized treatment protocols. Due to overlapping bone marrow (BM) developmental abnormalities and hyperplastic features, aCML is classified as a subtype of myelodysplastic/myeloproliferative neoplasms (MDS/MPN) [3]. The term “aCML” was retained in the 2022 International Consensus Classification (ICC) of Myeloid Neoplasms and Acute Leukemia and was redefined in the 5th edition of the World Health Organization (WHO) classification of tumors of hematopoietic and lymphoid tissues as MDS/MPN with neutrophilia [3, 4].  \nThe characteristics of aCML are indicated by white blood cell (WBC) counts ≥ 13 × 109/L with increased neutrophils (NEU) and dysplasia, as well as immature BM  \n© The Author(s) 2024. Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit [http://creativecommons.org/l](http://creativecommons.org/l)icenses/by/4.0/. The Creati","cbCaiaZhIAogcB9r","https://ap.wps.com/l/cbCaiaZhIAogcB9r","pdf",2783089,"English","# Abstract\n## Background\n## Case presentation\n## Conclusions\n# Background\n## Definition and classification of aCML\n## Diagnostic features and exclusion criteria\n# Case presentation\n## Initial presentation and eosinophilia over six years","[{\"question\":\"Why is eosinophilia unusual in atypical chronic myeloid leukemia (aCML)?\",\"answer\":\"Eosinophilia is commonly observed in hematologic malignancies, but it is rarely seen in aCML. aCML is primarily characterized by neutrophilia and dysplastic features within the MDS/MPN spectrum.\"},{\"question\":\"How was the diagnosis of aCML established in the reported case?\",\"answer\":\"The patient had persistent eosinophilia for six years with other primary and secondary diseases ruled out. Over time, increased white blood cells and primarily neutrophils emerged, and the final diagnosis relied on combined morphologic and molecular genetic findings.\"},{\"question\":\"What treatment was tried initially, and what was the eventual response?\",\"answer\":\"Corticosteroids and hydroxyurea were ineffective for the patient. After later diagnostic clarification, the patient responded well to azacitidine, with significant reduction in eosinophil infiltration-related end-organ damage.\"}]","Atypical chronic myeloid leukemia found in a patient with eosinophilia for six years - a case report | PDF",1789997428,18]