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A retrospective cross-sectional study evaluated adults with thyrotoxicosis using clinical, biochemical, and electrocardiographic records, applying generalized linear models with robust errors. Among 801 patients, 65 had AF (prevalence 8.1%, 95% CI 6.3–10.2). AF patients were older, more often male, and had higher frequencies of chronic kidney disease, dyslipidemia, diabetes, heart failure, cerebrovascular disease, and thyroid crisis. Multivariable determinants were age 35–60, age >60, male sex, heart failure, and thyroid crisis; thyroid hormone levels were not independently associated.",{"@graph":69,"@context":122},[70,84,105],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":35,"@type":76,"position":81},"https://docshare.wps.com/document/healthcare/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/atrial-fibrillation-in-the-context-of-thyrotoxicosis-prevalence-and-clinical-determinants/416618/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/atrial-fibrillation-in-the-context-of-thyrotoxicosis-prevalence-and-clinical-determinants/416618.png","ImageObject",300,407,{"name":92,"@type":93},"Blitz","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-11-06","2026-09-28",true,{"@type":102,"interactionType":103,"userInteractionCount":52},"InteractionCounter",{"@type":104},"ViewAction",{"@type":106,"mainEntity":107},"FAQPage",[108,114,118],{"name":109,"@type":110,"acceptedAnswer":111},"What was the prevalence of atrial fibrillation among patients with thyrotoxicosis?","Question",{"text":112,"@type":113},"Among 801 patients, 65 had atrial fibrillation, giving a prevalence of 8.1% (95% CI: 6.3–10.2).","Answer",{"name":115,"@type":110,"acceptedAnswer":116},"Which factors were independently associated with atrial fibrillation in multivariable analysis?",{"text":117,"@type":113},"Independent determinants included age 35–60 years, age >60 years, male sex, heart failure, and thyroid crisis.",{"name":119,"@type":110,"acceptedAnswer":120},"Were thyroid hormone levels independently associated with atrial fibrillation?",{"text":121,"@type":113},"No. Thyroid hormone levels were not independently associated with atrial fibrillation in this study.","https://schema.org",{"og:url":83,"og:type":124,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":126,"canonical":83},"index,follow",{"doc_id":128,"site_id":62},416618,1790906154,{"code":4,"msg":5,"data":131},{"doc_id":128,"user_id":132,"nickname":92,"user_avatar":133,"doc_module":4,"category_id":34,"category_name":35,"doc_title":65,"doc_description":67,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":52,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":52,"language":139,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":140,"faqs":141,"seo_title":142,"seo_description":67,"update_tm":143,"read_time":144,"preview_page_count":4},24464137899374,"https://us-avatar.wpscdn.com/davatar_3d24733baf745e90a7e4bdd5f77d97b2","Original Article J Clin Med Res. 2025;17(12):716-725  \nAtrial Fibrillation in the Context of Thyrotoxicosis: Prevalence and Clinical Determinants  \nSukrisd Koowattanatianchaia, Arwarit Pocathikorna, Vimonsri Rangsrisaeneepitakb,  \nKiraphol Kaladeec, Chatchai Kreepalad, e  \nAbstract  \nBackground: Atrial fibrillation (AF) is a frequent but variably reported complication of thyrotoxicosis, with mechanisms that extend beyond thyroid hormone excess. Clarifying its prevalence and determinants may guide early detection and management.  \nMethods: We conducted a retrospective cross-sectional study of adults with thyrotoxicosis. Clinical, biochemical, and electrocardiographic data were reviewed. Associations between variables and AF were assessed using generalized linear models with robust errors, and results expressed as adjusted odds ratios (ORs) with 95% confidence intervals (CIs) .  \nResults: Among 801 patients with thyrotoxicosis, 65 had AF, yielding a prevalence of 8.1%(95% CI: 6.3-10.2) . Compared with nonAF patients, those with AF were older, more often male (48% vs. 20%), and more frequently had chronic kidney disease, dyslipidemia, diabetes, heart failure (HF), cerebrovascular disease, and thyroid crisis (all P \u003C 0.01) . In multivariable analysis, independent determinants included age 35-60 years (adjusted OR 5.48; 95% CI: 2.03-14.83), age > 60 years (adjusted OR 11.39; 95% CI: 3.43-37.76), male sex (adjusted OR 3.38; 95% CI: 1.70 - 6.30), HF (adjusted OR 11.25; 95% CI: 2.85 -44.54), and thyroid crisis (adjusted OR 61.84; 95% CI: 21.89-181.32) . Thyroid hormone levels were not independently associated with AF.  \nConclusion: AF was observed in approximately 8% of patients with thyrotoxicosis. The findings suggested that clinical vulnerabilities -  \nManuscript submitted October 3, 2025, accepted December 1, 2025 Published online December 24, 2025  \naDivision of Cardiology, Department of Internal Medicine, Burapha University, Chonburi, Thailand  \nbDivision of Endocrinology, Department of Internal Medicine, Burapha University, Chonburi, Thailand  \ncSchool of Health Science, Sukhothai Thammathirat Open University, Nonthaburi, Thailand  \ndNephrology Unit, School of Internal Medicine, Institute of Medicine, Suranaree University of Technology, Nakhon Ratchasima, Thailand eCorresponding Author: Chatchai Kreepala, Nephrology Unit, School of Internal Medicine, Institute of Medicine, Suranaree University of Technology,  \nNakhon Ratchasima 30000, Thailand. Email: [chatchaikree@gmail.com](chatchaikree@gmail.com)  \ndoi: [https://doi.org/10.14740/jocmr6413](https://doi.org/10.14740/jocmr6413)  \nolder age, male sex, HF, and thyroid crisis-were more strongly associated with AF than thyroid hormone levels. These results supported targeted AF screening in high-risk thyrotoxic patients and indicated that rhythm management should consider patient susceptibility alongside restoring euthyroidism.  \nKeywords: Atrial fibrillation; Thyrotoxicosis; Hyperthyroidism; Risk factors; Prevalence  \nIntroduction  \nAtrial fibrillation (AF) is the most common sustained cardiac arrhythmia worldwide, contributing substantially to morbidity and mortality through heart failure (HF) and thromboembolic complications [1-3] . Its risk factors are diverse, including advancing age, hypertension, diabetes, structural heart disease, and endocrine disorders, among which thyrotoxicosis has long been recognized as a precipitating condition [2, 3] .  \nThe association between thyrotoxicosis and AF, however, is complex and not universal. Not all patients with thyrotoxicosis develop AF. Clinical severity, such as marked hormone excess, thyroid crisis, or long-term exposure, may increase arrhythmic risk through sympathetic activation and atrial electrical remodeling, yet evidence for direct causality remains inconclusive [3-5] . Similarly, whenAF is observed in the context of thyrotoxicosis, it cannot be assumed that thyroid dysfunction is the sole trigger. Other risk factors, such a","cbCairvr3dwGc552","https://ap.wps.com/l/cbCairvr3dwGc552","pdf",829627,"English","# Abstract\n## Background\n## Methods\n## Results\n## Conclusion\n# Introduction\n## Association and complexity\n## Reversibility and clinical relevance\n## Epidemiology and study objective","[{\"question\":\"What was the prevalence of atrial fibrillation among patients with thyrotoxicosis?\",\"answer\":\"Among 801 patients, 65 had atrial fibrillation, giving a prevalence of 8.1% (95% CI: 6.3–10.2).\"},{\"question\":\"Which factors were independently associated with atrial fibrillation in multivariable analysis?\",\"answer\":\"Independent determinants included age 35–60 years, age \\u003e60 years, male sex, heart failure, and thyroid crisis.\"},{\"question\":\"Were thyroid hormone levels independently associated with atrial fibrillation?\",\"answer\":\"No. Thyroid hormone levels were not independently associated with atrial fibrillation in this study.\"}]","Atrial Fibrillation in the Context of Thyrotoxicosis - Prevalence and Clinical Determinants | PDF",1790606063,25]