[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"doc-seo-455974-105":3,"detail-sidebar-cat-0-en-105":81,"doc-detail-455974-en":130},{"code":4,"msg":5,"data":6},0,"ok",{"site_id":7,"language":8,"slug":9,"title":10,"keywords":11,"description":12,"schema_data":13,"social_meta":74,"head_meta":76,"extra_data":78,"updated_unix":80},105,"en","atrial-cardiomyopathy-markers-and-outcomes-clinical-research-key-findings","Atrial cardiomyopathy: markers and outcomes - Clinical research - Key findings","","A study in the UK Biobank evaluates atrial cardiomyopathy (AtCM) markers and related risk factors, linking them to incident atrial fibrillation (AF), heart failure (HF), and stroke. Individuals with cardiac magnetic resonance imaging and electrocardiographic data are analyzed using logistic regression, Cox regression, and cumulative incidence models. Among 26,467 participants, 15.7% show at least one AtCM marker and 2.3% show two or more, with strong associations to AF, HF, and stroke and improved AF risk reclassification by integrating clinical and genetic risk.",{"@graph":14,"@context":73},[15,34,56],{"@type":16,"itemListElement":17},"BreadcrumbList",[18,23,27,31],{"item":19,"name":20,"@type":21,"position":22},"https://docshare.wps.com","Home","ListItem",1,{"item":24,"name":25,"@type":21,"position":26},"https://docshare.wps.com/document/","Document",2,{"item":28,"name":29,"@type":21,"position":30},"https://docshare.wps.com/document/healthcare/","Healthcare",3,{"item":32,"name":10,"@type":21,"position":33},"https://docshare.wps.com/document/atrial-cardiomyopathy-markers-and-outcomes-clinical-research-key-findings/455974/",4,{"url":32,"name":10,"@type":35,"image":36,"author":41,"headline":10,"publisher":44,"fileFormat":47,"inLanguage":8,"description":12,"dateModified":48,"datePublished":49,"encodingFormat":47,"isAccessibleForFree":50,"interactionStatistic":51},"DigitalDocument",{"url":37,"@type":38,"width":39,"height":40},"https://docshare.wps.com/thumbnails/atrial-cardiomyopathy-markers-and-outcomes-clinical-research-key-findings/455974.png","ImageObject",300,407,{"name":42,"@type":43},"วิน","Person",{"url":19,"name":45,"@type":46},"DocShare","Organization","application/pdf","2026-10-30","2026-09-30",true,{"@type":52,"interactionType":53,"userInteractionCount":55},"InteractionCounter",{"@type":54},"ViewAction",20,{"@type":57,"mainEntity":58},"FAQPage",[59,65,69],{"name":60,"@type":61,"acceptedAnswer":62},"What markers of atrial cardiomyopathy (AtCM) were evaluated in this study?","Question",{"text":63,"@type":64},"AtCM markers included left atrial dilation, left atrial mechanical dysfunction, P-wave prolongation, and abnormal P-wave terminal force.","Answer",{"name":66,"@type":61,"acceptedAnswer":67},"How common were AtCM markers in the UK Biobank cohort?",{"text":68,"@type":64},"Among 26,467 individuals, 15.7% had at least one AtCM marker and 2.3% had two or more markers.",{"name":70,"@type":61,"acceptedAnswer":71},"What outcomes were AtCM markers associated with?",{"text":72,"@type":64},"AtCM markers were associated with incident atrial fibrillation (AF), heart failure (HF), and stroke, with higher event rates in participants with two or more markers.","https://schema.org",{"og:url":32,"og:type":75,"og:title":10,"og:site_name":45,"og:description":12},"article",{"robots":77,"canonical":32},"index,follow",{"doc_id":79,"site_id":7},455974,1790928364,{"code":4,"msg":82,"data":83},"success",[84,88,92,96,101,106,110,115,119,122,126],{"id":22,"doc_module":4,"doc_module_name":25,"category_name":85,"show_sort_weight":86,"slug":87},"Story & Novel",90,"story-novel",{"id":26,"doc_module":4,"doc_module_name":25,"category_name":89,"show_sort_weight":90,"slug":91},"Literature",80,"literature",{"id":33,"doc_module":4,"doc_module_name":25,"category_name":93,"show_sort_weight":94,"slug":95},"Exam",70,"exam",{"id":97,"doc_module":4,"doc_module_name":25,"category_name":98,"show_sort_weight":99,"slug":100},5,"Comic",60,"comic",{"id":102,"doc_module":4,"doc_module_name":25,"category_name":103,"show_sort_weight":104,"slug":105},6,"Technology",50,"technology",{"id":107,"doc_module":4,"doc_module_name":25,"category_name":29,"show_sort_weight":108,"slug":109},7,40,"healthcare",{"id":111,"doc_module":4,"doc_module_name":25,"category_name":112,"show_sort_weight":113,"slug":114},8,"Research & Report",30,"research-report",{"id":116,"doc_module":4,"doc_module_name":25,"category_name":117,"show_sort_weight":55,"slug":118},9,"Religion & Spirituality","religion-spirituality",{"id":55,"doc_module":4,"doc_module_name":25,"category_name":120,"show_sort_weight":55,"slug":121},"World Cup","world-cup",{"id":123,"doc_module":4,"doc_module_name":25,"category_name":124,"show_sort_weight":123,"slug":125},10,"Lifestyle","lifestyle",{"id":127,"doc_module":4,"doc_module_name":25,"category_name":128,"show_sort_weight":97,"slug":129},19,"General","general",{"code":4,"msg":82,"data":131},{"doc_id":79,"user_id":132,"nickname":42,"user_avatar":133,"doc_module":4,"category_id":107,"category_name":29,"doc_title":10,"doc_description":12,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":55,"is_deleted":4,"is_public":22,"is_downloadable":22,"audit_status":22,"page_count":139,"language":140,"language_code":8,"site_id":7,"html_lang":8,"table_of_contents":141,"faqs":142,"seo_title":143,"seo_description":12,"update_tm":144,"read_time":113,"preview_page_count":4},2336475104736,"https://ap-avatar.wpscdn.com/avatar/22000c4c5e0e5b17e70?x-image-process=image/resize,m_fixed,w_180,h_180&k=1786591360781797222","European Heart Journal (2026) 47, 235–246 [https://doi.org/10.1093/eurheartj/ehaf793](https://doi.org/10.1093/eurheartj/ehaf793)  \nCLINICAL RESEARCH  \nArrhythmias  \nAtrial cardiomyopathy: markers and outcomes  \nOliver B. Vad  1,2,3,*, Nick van Vreeswijk  1, Ahmed S. Yassin  1, Yuri Blaauw1, Christian Paludan-Müller  2,4, Jørgen K. Kanters  3,5, Claus Graff  6,  \nUlrich Schotten  7, Emelia J. Benjamin  8,9, Jesper H. Svendsen  2,10, and Michiel Rienstra  1  \n1Department of Cardiology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands; 2Department of Cardiology, Copenhagen University Hospital—Rigshospitalet, Copenhagen, Denmark; 3Department of Biomedical Sciences, University of Copenhagen, Copenhagen, Denmark; 4Department of Cardiothoracic Surgery, Copenhagen University Hospital—Rigshospitalet, Copenhagen, Denmark; 5Center of Biosignal Research, University of California, San Francisco, CA, USA; 6Department of Health Science and Technology, Aalborg University, Aalborg, Denmark; 7Department of Physiology, Cardiovascular Research Institute Maastricht, Maastricht, The Netherlands; 8Department of Medicine, Chobanian and Avedisian School of Medicine, Boston Medical Center, Boston University, Boston, MA, USA; 9Department of Epidemiology, Boston University School of Public Health, Boston, MA, USA; and 10Department of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark  \nReceived 31 January 2025; revised 25 May 2025; accepted 18 September 2025; online publish-ahead-of-print 15 October 2025  \nSee the editorial comment for this article ‘Understanding atrial cardiomyopathy: a missing link in the prevention of atrial fibrillation, heart failure, and stroke?’, by M.R. Schubert and M.F. Sinner, [https://doi.org/10.1093/eurheartj/ehaf832](https://doi.org/10.1093/eurheartj/ehaf832).  \nMethods Individuals from the UK Biobank with cardiac magnetic resonance imaging and electrocardiographic information were  \nincluded. Atrial cardiomyopathy markers included left atrial dilation, left atrial mechanical dysfunction, P-wave prolongation, and abnormal P-wave terminal force. Risk factors for AtCM were assessed using logistic regressions. Incident AF, HF, and stroke according to AtCM markers were assessed in multivariable Cox-regression and cumulative incidence models. AF risk according to AtCM markers, clinical and genetic risk factors was evaluated by integrating the HARMS2-AF score and a polygenic risk score for AF. We used net reclassification improvement (NRI) to evaluate reclassification of risk when considering AtCM markers.  \nResults Among 26 467 individuals, 4145 (15 . 7%) had ≥1 marker and 619 (2 . 3%) had ≥2 markers of AtCM. Age, coronary artery  \ndisease, and hypertension were consistently associated with AtCM. Having one AtCM marker conferred a hazard ratio (HR) for AF of 1.88 [95% confidence interval (CI): 1.54–2.31; P \u003C .001], with higher rates observed in individuals with ≥2 markers (HR: 4.59; 95% CI: 3.52–5.99; P \u003C .001) . Addition of AtCM markers was associated with an NRI of 13.7%(95% CI: 9.2%–18.3%) . Integration of clinical and genetic risk factors indicated an additive effect on AF rates. Having ≥2 markers associated with HF (HR: 3.08, 95% CI: 2.03–4.66, P \u003C .001), and stroke (HR: 3.07, 95% CI: 1.78–5.28, P \u003C .001) .  \nConclusions One in seven individuals had at least one marker of AtCM. Atrial cardiomyopathy markers were associated with AF, HF, and stroke, supporting AtCM as a common substrate for all three outcomes.  \nAbstract  \nBackground and Aims  \nAtrial cardiomyopathy (AtCM) is increasingly recognized as an important substrate for atrial fibrillation (AF) . This study aimed to examine potential markers and risk factors of AtCM, and associations with incident AF, heart failure (HF), and stroke.  \n* Corresponding author. Emails: [o.t.b.vad@umcg.nl](o.t.b.vad@umcg.nl), [ovad0004@regionh.dk](ovad0004@regionh.dk)  \n© The Author(s) 2025. Published by Oxford University Press on beha","cbCaimtYv1umktiG","https://ap.wps.com/l/cbCaimtYv1umktiG","pdf",2055853,12,"English","# Background and Aims\n# Methods\n# Results\n# Conclusions\n# Structured Graphical Abstract\n## Key Question\n## Key Finding\n## Take Home Message","[{\"question\":\"What markers of atrial cardiomyopathy (AtCM) were evaluated in this study?\",\"answer\":\"AtCM markers included left atrial dilation, left atrial mechanical dysfunction, P-wave prolongation, and abnormal P-wave terminal force.\"},{\"question\":\"How common were AtCM markers in the UK Biobank cohort?\",\"answer\":\"Among 26,467 individuals, 15.7% had at least one AtCM marker and 2.3% had two or more markers.\"},{\"question\":\"What outcomes were AtCM markers associated with?\",\"answer\":\"AtCM markers were associated with incident atrial fibrillation (AF), heart failure (HF), and stroke, with higher event rates in participants with two or more markers.\"}]","Atrial cardiomyopathy: markers and outcomes - Clinical research - Key findings | PDF",1790744819]