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Using data from the China Health and Retirement Longitudinal Study (CHARLS), this study evaluated whether the atherogenic index of plasma (AIP) predicts subsequent cognitive impairment in middle-aged and older adults with hypertension. Baseline AIP was analyzed with logistic regression, dose-response modeling, and ROC-based comparisons against traditional lipid markers.",{"@graph":69,"@context":122},[70,84,105],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":40,"@type":76,"position":81},"https://docshare.wps.com/document/research-report/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/atherogenic-index-of-plasma-and-cognitive-impairment-risk-among-hypertensive-adults-evidence-from-a-nationwide-cohort-study/450283/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/atherogenic-index-of-plasma-and-cognitive-impairment-risk-among-hypertensive-adults-evidence-from-a-nationwide-cohort-study/450283.png","ImageObject",300,407,{"name":92,"@type":93},"River Wang","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-10-05","2026-09-30",true,{"@type":102,"interactionType":103,"userInteractionCount":81},"InteractionCounter",{"@type":104},"ViewAction",{"@type":106,"mainEntity":107},"FAQPage",[108,114,118],{"name":109,"@type":110,"acceptedAnswer":111},"What is the main objective of the study?","Question",{"text":112,"@type":113},"To examine whether the atherogenic index of plasma (AIP) is associated with the risk of cognitive impairment among middle-aged and older adults with hypertension.","Answer",{"name":115,"@type":110,"acceptedAnswer":116},"Which data source and study design were used?",{"text":117,"@type":113},"Data came from the CHARLS baseline wave in 2011 and the follow-up wave in 2018, assessing cognitive impairment using multivariable logistic regression.",{"name":119,"@type":110,"acceptedAnswer":120},"How did AIP relate to cognitive impairment risk?",{"text":121,"@type":113},"Higher AIP quartiles were associated with increased cognitive impairment risk compared with the lowest quartile, and AIP showed stronger predictive performance than traditional lipid markers.","https://schema.org",{"og:url":83,"og:type":124,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":126,"canonical":83},"index,follow",{"doc_id":128,"site_id":62},450283,1790794838,{"code":4,"msg":5,"data":131},{"doc_id":128,"user_id":132,"nickname":92,"user_avatar":133,"doc_module":4,"category_id":39,"category_name":40,"doc_title":65,"doc_description":67,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":81,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":139,"language":140,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":141,"faqs":142,"seo_title":143,"seo_description":67,"update_tm":144,"read_time":145},1099514067438,"https://ap-avatar.wpscdn.com/avatar/100002539ee87300030?x-image-process=image/resize,m_fixed,w_180,h_180&k=1780474512215547542","Aging Clinical and Experimental Research (2026) 38:36  \n[https://doi.org/10.1007/s40520-025-03290-3](https://doi.org/10.1007/s40520-025-03290-3)  \nRESEARCH  \nAtherogenic index of plasma and cognitive impairment risk among hypertensive adults: evidence from a nationwide cohort study  \nWeimin Bai1 · Bing Feng2 · Yaowen Li2 · Raoman Feng3 · Lijie Qin1  \nReceived: 31 May 2025 / Revised: 20 October 2025 / Accepted: 8 December 2025 © The Author(s) 2025  \nAbstract  \nBackground Cognitive impairment is a major complication in individuals with hypertension. Emerging evidence suggests that metabolic abnormalities may contribute to its pathogenesis. This study examined the association between the atherogenic index of plasma (AIP) and risk of cognitive impairment in middle-aged and older adults with hypertension.  \nMethods Data were from the 2011 baseline and 2018 follow-up waves of the China Health and Retirement Longitudinal Study (CHARLS) . Multivariable logistic regression was used to assess the association between baseline AIP and subsequent cognitive impairment. Dose-response patterns were explored using restricted cubic spline (RCS) models, and subgroup analyses evaluated effect modification. Predictive performance of AIP versus traditional lipids was assessed by receiver operating characteristic (ROC) curves.  \nResults Among 3,739 hypertensive participants (mean age: 60.5 ± 9.1 years; 50.0% female), 43.0% developed cognitive impairment. Compared with quartile 1 (Q1), higher AIP quartiles were significantly associated with increased risk ofcognitive impairment: Q2 (odds ratio [OR], 1.44; 95% confidence interval [CI], 1.15–1.80), Q3 (OR, 1.76; 95% CI, 1.40–2.20), and Q4 (OR, 1.85; 95% CI, 1.45–2.37). RCS indicated a linear dose-response (P for nonlinearity =0.061) . Subgroup analyses showed consistent associations across age, gender, body mass index, residence, and diabetes, with no significant interactions detected. AIP outperformed traditional lipid markers in predicting cognitive impairment.  \nConclusion Elevated AIP was independently associated with an increased risk of cognitive impairment among middle-aged and older adults with hypertension, suggesting its potential as a practical biomarker for early identification of cognitive risk in this high-risk population.  \nKeywords Atherogenic index of plasma · Hypertension · Cognitive impairment · CHARLS · Risk factors  \nWeimin Bai and Bing Feng contributed equally to this work.  \n􀀍 Raoman Feng [18808925821@163.com](18808925821@163.com)  \n􀀍 Lijie Qin [qinlijie1819@163.com](qinlijie1819@163.com)  \n1 Department of Emergency, Henan Provincial People’s Hospital, People’s Hospital of Zhengzhou University, People’s Hospital of Henan University, Zhengzhou 450003, China  \n2 Department of Traditional Chinese Medicine Rehabilitation, The 966th Hospital of The PLA Joint Logistic Support Force of China, Dandong 118000, China  \n3 The Nephrology Department of the Second Affiliated Hospital of Hainan, Medical University, Haikou 570311, China  \nIntroduction  \nCognitive impairment represents a major contributor to functional decline among middle-aged and older adults and has become a growing global public health concern [1, 2] . It is primarily characterized by deficits in multiple cognitive domains, including memory, comprehension, attention, and calculation, and is widely recognized as a prodromal stage of dementia [1, 2] . Given the absence of effective treatments, early identification of individuals at elevated risk and the implementation of timely interventions are critical for delaying disease progression and improving long-term outcomes [1, 3, 4] .  \nHypertension is one of the most prevalent chronic conditions in aging populations. Despite its high prevalence, treatment and control rates remain suboptimal. A robust body of literature has demonstrated a strong association  \n1 3  \nbetween hypertension and cognitive decline [5, 6]. Notably, hypertension beginning in midlife has been shown to exert ","cbCaikYexlp49v6c","https://ap.wps.com/l/cbCaikYexlp49v6c","pdf",1185869,11,"English","# Abstract\n## Background\n## Methods\n## Results\n## Conclusion\n# Introduction","[{\"question\":\"What is the main objective of the study?\",\"answer\":\"To examine whether the atherogenic index of plasma (AIP) is associated with the risk of cognitive impairment among middle-aged and older adults with hypertension.\"},{\"question\":\"Which data source and study design were used?\",\"answer\":\"Data came from the CHARLS baseline wave in 2011 and the follow-up wave in 2018, assessing cognitive impairment using multivariable logistic regression.\"},{\"question\":\"How did AIP relate to cognitive impairment risk?\",\"answer\":\"Higher AIP quartiles were associated with increased cognitive impairment risk compared with the lowest quartile, and AIP showed stronger predictive performance than traditional lipid markers.\"}]","Atherogenic index of plasma and cognitive impairment risk among hypertensive adults - evidence from a nationwide cohort study | PDF",1790732739,28]