[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"detail-sidebar-cat-0-en-105":3,"doc-seo-438006-105":59,"doc-detail-438006-en":131},{"code":4,"msg":5,"data":6},0,"success",[7,13,18,23,28,33,38,43,48,51,55],{"id":8,"doc_module":4,"doc_module_name":9,"category_name":10,"show_sort_weight":11,"slug":12},1,"Document","Story & Novel",90,"story-novel",{"id":14,"doc_module":4,"doc_module_name":9,"category_name":15,"show_sort_weight":16,"slug":17},2,"Literature",80,"literature",{"id":19,"doc_module":4,"doc_module_name":9,"category_name":20,"show_sort_weight":21,"slug":22},4,"Exam",70,"exam",{"id":24,"doc_module":4,"doc_module_name":9,"category_name":25,"show_sort_weight":26,"slug":27},5,"Comic",60,"comic",{"id":29,"doc_module":4,"doc_module_name":9,"category_name":30,"show_sort_weight":31,"slug":32},6,"Technology",50,"technology",{"id":34,"doc_module":4,"doc_module_name":9,"category_name":35,"show_sort_weight":36,"slug":37},7,"Healthcare",40,"healthcare",{"id":39,"doc_module":4,"doc_module_name":9,"category_name":40,"show_sort_weight":41,"slug":42},8,"Research & Report",30,"research-report",{"id":44,"doc_module":4,"doc_module_name":9,"category_name":45,"show_sort_weight":46,"slug":47},9,"Religion & Spirituality",20,"religion-spirituality",{"id":46,"doc_module":4,"doc_module_name":9,"category_name":49,"show_sort_weight":46,"slug":50},"World Cup","world-cup",{"id":52,"doc_module":4,"doc_module_name":9,"category_name":53,"show_sort_weight":52,"slug":54},10,"Lifestyle","lifestyle",{"id":56,"doc_module":4,"doc_module_name":9,"category_name":57,"show_sort_weight":24,"slug":58},19,"General","general",{"code":4,"msg":60,"data":61},"ok",{"site_id":62,"language":63,"slug":64,"title":65,"keywords":66,"description":67,"schema_data":68,"social_meta":124,"head_meta":126,"extra_data":128,"updated_unix":130},105,"en","associations-of-biotin-levels-in-serum-and-follicular-fluid-with-icsi-success-a-cross-sectional-study-from-iraq","Associations of Biotin Levels in Serum and Follicular Fluid With ICSI Success: A Cross-Sectional Study From Iraq","","Biotin (vitamin B7) is evaluated as a potential metabolic marker in infertile women undergoing IVF with ICSI. In an observational cross-sectional study of 50 patients, serum and follicular fluid biotin levels were measured at egg retrieval and analyzed against ovarian responsiveness categorized by AMH and number of retrieved oocytes. No significant differences in biotin were found across normal, poor, and hyper-responder groups, while follicular biotin showed inverse correlations with AMH and BMI. Biotin levels were not associated with pregnancy outcome, whereas higher numbers of total and mature oocytes related significantly to pregnancy results.",{"@graph":69,"@context":123},[70,84,106],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":35,"@type":76,"position":81},"https://docshare.wps.com/document/healthcare/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/associations-of-biotin-levels-in-serum-and-follicular-fluid-with-icsi-success-a-cross-sectional-study-from-iraq/438006/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/associations-of-biotin-levels-in-serum-and-follicular-fluid-with-icsi-success-a-cross-sectional-study-from-iraq/438006.png","ImageObject",300,407,{"name":92,"@type":93},"Indoniesian Boy","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-10-30","2026-09-29",true,{"@type":102,"interactionType":103,"userInteractionCount":105},"InteractionCounter",{"@type":104},"ViewAction",11,{"@type":107,"mainEntity":108},"FAQPage",[109,115,119],{"name":110,"@type":111,"acceptedAnswer":112},"What was the study purpose regarding biotin and IVF outcomes?","Question",{"text":113,"@type":114},"To evaluate biotin levels in serum and follicular fluid of infertile women undergoing IVF-ICSI and compare them with ovarian responsiveness and pregnancy outcomes.","Answer",{"name":116,"@type":111,"acceptedAnswer":117},"How were participants grouped in the study?",{"text":118,"@type":114},"Women were classified based on ovarian responsiveness using AMH levels and the number of retrieved eggs.",{"name":120,"@type":111,"acceptedAnswer":121},"Did serum or follicular fluid biotin correlate with pregnancy outcomes?",{"text":122,"@type":114},"No significant effect was found; higher serum or follicular fluid biotin levels did not show significant associations with pregnancy outcomes.","https://schema.org",{"og:url":83,"og:type":125,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":127,"canonical":83},"index,follow",{"doc_id":129,"site_id":62},438006,1790766215,{"code":4,"msg":5,"data":132},{"doc_id":129,"user_id":133,"nickname":92,"user_avatar":134,"doc_module":4,"category_id":34,"category_name":35,"doc_title":65,"doc_description":67,"doc_content":135,"file_id":136,"file_url":137,"file_type":138,"file_size":139,"view_count":105,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":39,"language":140,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":141,"faqs":142,"seo_title":143,"seo_description":67,"update_tm":144,"read_time":46,"preview_page_count":4},962090760608,"https://ap-avatar.wpscdn.com/davatar_276721f389ce27ea32af1340a28f341c","Wiley  \nObstetrics and Gynecology International Volume 2025, Article ID 8841801, 8 pages [https://doi.org/10.1155/ogi/8841801](https://doi.org/10.1155/ogi/8841801)  \nResearch Article  \nAssociations of Biotin Levels in Serum and Follicular Fluid With ICSI Success: A Cross-Sectional Study From Iraq  \nZainab Abdul Ameer Jaafar , 1 Nawal Aziz Bakir,2 and Dina Akeel Salman1  \n1 Department of Obstetrics and Gynecology, College of Medicine, Al-Mustansiriya University, Baghdad, Iraq  \n2 Heet General Hospital, Anbar, Iraq  \nCorrespondence should be addressed to Zainab Abdul Ameer Jaafar; [zainabjaafar@uomustansiriyah.edu.iq](zainabjaafar@uomustansiriyah.edu.iq)  \nReceived 4 May 2025; Revised 24 September 2025; Accepted 7 November 2025  \nAcademic Editor: Manvinder Singh  \nCopyright © 2025 Zainab Abdul Ameer Jaafar et al. Obstetrics and Gynecology International published by John Wiley & Sons Ltd. Tis is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.  \nBackground: Biotin (vitamin B7) has been identifed as an essential cofactor within metabolism and gene expression. Te purpose of this study is to evaluate the level of biotin within serum and follicular fuid aspirates among infertile women undergoing IVF cycles and to compare these levels with ovulation sensitivity and rates of pregnancy.  \nMethods: In this observational study with 50 patients with infertility receiving intracytoplasmic sperm injection (ICSI) treatment, women were classifed according to ovarian responsiveness to anti-Mullerian hormone (AMH) levels and the number of retrieved eggs. At the time of egg retrieval, the levels of biotin in the blood and the ovarian fuid were tested. Te study maintained strict reporting according to the STROBE criteria.  \nResults: Tere was no signifcant diference with respect to either serum levels or follicular fuids’ biotin among normal responders, poor responders, and hyperresponders. In contrast, there was an inverse correlation between the values of follicular biotin and AMH (p 􀂈 0.033) and BMI (p 􀂈 0.022) . Te data revealed that higher numbers of total and mature oocytes had signifcant infuences on the outcome of pregnancies (p 􀂈 0.032 and p 􀂈 0.014), respectively; however, higher values of either serum fuids’ biotin or follicular fuids’ biotin had no signifcant efect.  \nConclusion: Concentrations in serum and follicular fuid ofbiotin do not play any role in IVF outcome. Te negative correlation with AMH and BMI levels might indicate the role of biotin in the ovaries as an indicator of ovarian metabolism. Te result provides valuable data in understanding the possible role of biotin in the microenvironment of the ovaries and the need to study it further.  \nKeywords: biotin; follicular fuid; metabolic markers; ovarian response; pregnancy outcomes  \n1. Introduction  \nInfertility has been quoted to occur in one out of every six couples in the world [1]. Female factors that lead to infertility are numerous and include ovulation disorders, tube damage, any form of lesions within the vagina and uterus, and endocrine disorders [2] . Recent studies indicate that micronutrients are essential in “reproductive health” and act either singularly or in conjunction with assisted reproductive technologies (ARTs) [3] . Micronutrients such as “antineoplastic factors”(such as antioxidants), B-complex vitamins,  \nvitamin D3, and essential fatty acids (EFAs), among others, are believed to “improve fertility rates” [4] .  \nOf these, biotin (vitamin B7), one of the water-soluble Bvitamins, is pivotal in crucial metabolic processes such as fatty acid synthesis, gluconeogenesis, and amino acid catabolism. Biotin is also crucial in mitochondrial function, gene regulation, and cell proliferation, processes that are essential for follicular development as well as for oocyte competence [5] . Tough it has signifcant biological f","cbCainWtGhQv60RU","https://ap.wps.com/l/cbCainWtGhQv60RU","pdf",484619,"English","# Introduction\n# Methods\n# Results\n# Conclusion\n# Keywords","[{\"question\":\"What was the study purpose regarding biotin and IVF outcomes?\",\"answer\":\"To evaluate biotin levels in serum and follicular fluid of infertile women undergoing IVF-ICSI and compare them with ovarian responsiveness and pregnancy outcomes.\"},{\"question\":\"How were participants grouped in the study?\",\"answer\":\"Women were classified based on ovarian responsiveness using AMH levels and the number of retrieved eggs.\"},{\"question\":\"Did serum or follicular fluid biotin correlate with pregnancy outcomes?\",\"answer\":\"No significant effect was found; higher serum or follicular fluid biotin levels did not show significant associations with pregnancy outcomes.\"}]","Associations of Biotin Levels in Serum and Follicular Fluid With ICSI Success: A Cross-Sectional Study From Iraq | PDF",1790683851]