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Methods: Associations were tested between antemortem PET uptake and digitally quantified tau and TDP-43 neuropathology. Participants spanned no/low, intermediate, and high AD neuropathologic change, with hippocampal and entorhinal segmentation from T1 MRI and postmortem immunostaining plus weakly supervised learning quantification.",{"@graph":69,"@context":126},[70,84,105],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":35,"@type":76,"position":81},"https://docshare.wps.com/document/healthcare/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/associations-of-18-f-flortaucipir-tau-pet-with-quantitative-tau-histopathology-in-the-medial-temporal-lobe-poster-presentation/459432/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/associations-of-18-f-flortaucipir-tau-pet-with-quantitative-tau-histopathology-in-the-medial-temporal-lobe-poster-presentation/459432.png","ImageObject",300,407,{"name":92,"@type":93},"Genevieve","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-11-06","2026-09-30",true,{"@type":102,"interactionType":103,"userInteractionCount":29},"InteractionCounter",{"@type":104},"ViewAction",{"@type":106,"mainEntity":107},"FAQPage",[108,114,118,122],{"name":109,"@type":110,"acceptedAnswer":111},"What was the study’s main objective?","Question",{"text":112,"@type":113},"To determine how antemortem 18 F-Flortaucipir PET uptake relates to digitally quantified tau and TDP-43 neuropathology in medial temporal lobe regions.","Answer",{"name":115,"@type":110,"acceptedAnswer":116},"How were PET uptake values calculated and analyzed?",{"text":117,"@type":113},"18 F-Flortaucipir SUVRs were computed relative to inferior cerebellar grey matter and averaged across hemispheres, then non-parametric correlations were run between SUVRs and pathology measures with false discovery rate correction.",{"name":119,"@type":110,"acceptedAnswer":120},"What did the results show about tau tangles and PET signal?",{"text":121,"@type":113},"Tau tangles showed significant associations with SUVRs in BA35/entorhinal cortex, and mean hippocampal tangle measures were associated with SUVRs in both anterior and posterior hippocampus.",{"name":123,"@type":110,"acceptedAnswer":124},"Did PET SUVRs relate to TDP-43 pathology?",{"text":125,"@type":113},"No. PET SUVRs were not associated with somatic or neuritic pTDP-43 measures.","https://schema.org",{"og:url":83,"og:type":128,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":130,"canonical":83},"index,follow",{"doc_id":132,"site_id":62},459432,1790755912,{"code":4,"msg":5,"data":135},{"doc_id":132,"user_id":136,"nickname":92,"user_avatar":137,"doc_module":4,"category_id":34,"category_name":35,"doc_title":65,"doc_description":67,"doc_content":138,"file_id":139,"file_url":140,"file_type":141,"file_size":142,"view_count":29,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":19,"language":143,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":144,"faqs":145,"seo_title":146,"seo_description":67,"update_tm":133,"read_time":52,"preview_page_count":4},1374391974585,"https://ap-avatar.wpscdn.com/davatar_276721f389ce27ea32af1340a28f341c","DOI: 10. 1002/alz70856_107115  \nBIOMARKERS  \nPOSTER PRESENTATION  \nNEUROIMAGING  \nAssociations of 18 F-flortaucipir tau PET with quantitative tau histopathology in the medial temporal lobe  \nJeffrey S Phillips1  \nLaura E. M. Wisse3 Ricardo Insausti6  \n Amanda E Denning2  Lisa M Levorse2  Christopher A Brown2  Sanaz Arezoumandan4  Sandhitsu R. Das2  Eddie B. Lee5   John L. Robinson2  Ranjit Ittyerah2  Sílvia Porta7   \nCorey T. McMillan8  Daniel T Ohm 1  David J. Irwin8  Ilya M. Nasrallah9  Paul A. Yushkevich 10  DavidA. Wolk 10  \n1 Penn Frontotemporal Degeneration Center, Department of Neurology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA  \n2 University of Pennsylvania, Philadelphia, PA, USA  \n3 Diagnostic Radiology, Department of Clinical Sciences Lund, Lund University, Lund, Sweden  \n4 Cleveland Clinic FL, Fort Lauderdale, FL, USA  \n5 Department of Pathology & Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA  \n6 University of Castilla-La Mancha, Albacete, Spain  \n7 Center for Neurodegenerative Disease Research, Department of Pathology and Laboratory Medicine, University of Pennsylvania, Perelman School of Medicine, Philadelphia, PA, USA  \n8 Penn Frontotemporal Degeneration Center, Department of Neurology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA  \n9 Department of Radiology, University of Pennsylvania, Philadelphia, PA, USA  \n10 Penn Alzheimer’s Disease Research Center, University of Pennsylvania, Philadelphia, PA, USA  \nCorrespondence  \nJeffrey S Phillips, Penn Frontotemporal Degeneration Center, Department of Neurology, Perelman School of Medicine,  \nAbstract  \nBackground: 18 F-Flortaucipir is widely used for positron emission tomography (PET) imaging of Alzheimer’s disease (AD)-type tau, but its sensitivity in early Braak stages has been questioned, and hippocampal uptake is at least partially confounded by offtarget binding. We investigated associations between antemortem PET uptake and digitally-quantified tau and TDP-43 neuropathology.  \nMethods: Participants (n = 14, Figure 1) included 5 people with no/low AD neuropathologic change (ADNC) at autopsy, 2 intermediate, and 7 high. Clinical diagnoses included normal cognition (n = 2), AD (n = 5), dementia with Lewy bodies (n = 2), Parkinson’s disease dementia (n = 1), corticobasal syndrome (n = 2), and posterior cortical atrophy (n = 2). We used the Automated Segmentation of Hippocampal Subfields T1 MRI pipeline to segment anterior and posterior hippocampus, Brodmann’s areas (BA) 35 (transentorhinal cortex) & 36, and entorhinal cortex. 18 F-Flortaucipir standardized uptake value ratios (SUVRs) were computed relative to inferior cerebellar grey matter and averaged across hemispheres. Postmortem sampling comprised hippocampal subiculum, CA1, CA2, CA3, and dentate gyrus; BA35 and BA36; and entorhinal cortex. FFPE-brain tissue was immunostained using PHF1 and phospho-specific TDP-43 antibodies and digitally imaged. Two different weakly supervised learning algorithms, Wildcat, were trained to identify tau tangles and threads; or somatic and neuritic phosphorylated TDP-43 (pTDP-43) inclusions. Each pathology type was quantified by summary statistics on Wildcat heatmaps, averaged over hippocampal subfields; and over BA35/entorhinal cortex  \nThis is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.  \n© 2025 The Alzheimer’s Association. Alzheimer’s & Dementia published by Wiley Periodicals LLC on behalf of Alzheimer’s Association.  \nAlzheimer’s Dement. 2025;21(Suppl. 2):e107115.  \n[https://doi.org/10.1002/alz70856_107115](https://doi.org/10.1002/alz70856_107115)  \nwi[leyonlinelibrary.com/journal/alz](leyonlinelibrary.com/journal/alz)  \n1of4  \nBIOMARKERS  \nUniversity of Pennsylvania, Philadelphia, PA, USA.  \n[Email:](Em","cbCaiqNyNmmtzBLQ","https://ap.wps.com/l/cbCaiqNyNmmtzBLQ","pdf",892811,"English","# Abstract\n## Background\n## Methods\n## Results\n## Conclusion","[{\"question\":\"What was the study’s main objective?\",\"answer\":\"To determine how antemortem 18 F-Flortaucipir PET uptake relates to digitally quantified tau and TDP-43 neuropathology in medial temporal lobe regions.\"},{\"question\":\"How were PET uptake values calculated and analyzed?\",\"answer\":\"18 F-Flortaucipir SUVRs were computed relative to inferior cerebellar grey matter and averaged across hemispheres, then non-parametric correlations were run between SUVRs and pathology measures with false discovery rate correction.\"},{\"question\":\"What did the results show about tau tangles and PET signal?\",\"answer\":\"Tau tangles showed significant associations with SUVRs in BA35/entorhinal cortex, and mean hippocampal tangle measures were associated with SUVRs in both anterior and posterior hippocampus.\"},{\"question\":\"Did PET SUVRs relate to TDP-43 pathology?\",\"answer\":\"No. PET SUVRs were not associated with somatic or neuritic pTDP-43 measures.\"}]","Associations of 18 F-flortaucipir Tau PET with Quantitative Tau Histopathology in the Medial Temporal Lobe - Poster Presentation | PDF"]