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A total of 260 hospitalized participants had vitamin D concentration and biomarkers, SUD severity, psychiatric disorders, cognitive functioning, and impulsivity measured at admission (T0). Negative affectivity and craving for the main substance and food were assessed at T0 and discharge (T1). Vitamin D deficiency was highly prevalent and showed univariate links with higher body weight and altered calcium at T0, and greater craving intensity at T1, with multivariate models showing no significant effects.",{"@graph":69,"@context":126},[70,84,105],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":35,"@type":76,"position":81},"https://docshare.wps.com/document/healthcare/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/associations-between-vitamin-d-status-and-clinical-presentation-among-french-inpatients-with-substance-use-disorders-original-article-addiction-biology/458296/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/associations-between-vitamin-d-status-and-clinical-presentation-among-french-inpatients-with-substance-use-disorders-original-article-addiction-biology/458296.png","ImageObject",300,407,{"name":92,"@type":93},"WPS_1786070896","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-11-08","2026-09-30",true,{"@type":102,"interactionType":103,"userInteractionCount":34},"InteractionCounter",{"@type":104},"ViewAction",{"@type":106,"mainEntity":107},"FAQPage",[108,114,118,122],{"name":109,"@type":110,"acceptedAnswer":111},"What was the main objective of the study?","Question",{"text":112,"@type":113},"To explore differences in addiction-related, psychopathological, and biological characteristics among inpatients treated for substance use disorders based on vitamin D status.","Answer",{"name":115,"@type":110,"acceptedAnswer":116},"How were participants and measurements organized over time?",{"text":117,"@type":113},"Data were collected at hospital admission (T0) for vitamin D and biomarkers, SUD severity, psychiatric disorders, cognitive functioning, and impulsivity, and negative affectivity and craving were reassessed at discharge (T1).",{"name":119,"@type":110,"acceptedAnswer":120},"What associations did vitamin D deficiency show in the results?",{"text":121,"@type":113},"Vitamin D deficiency was very common (about 89.3%) and was associated in univariate analyses with higher body weight and lower plasma calcium at T0, and higher craving intensity for both the treated substance and food at T1.",{"name":123,"@type":110,"acceptedAnswer":124},"Did the study find independent links between vitamin D/calcium and craving at T1?",{"text":125,"@type":113},"Multivariate regression analyses did not find significant associations between vitamin D or calcium levels and craving intensities at T1.","https://schema.org",{"og:url":83,"og:type":128,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":130,"canonical":83},"index,follow",{"doc_id":132,"site_id":62},458296,1790752505,{"code":4,"msg":5,"data":135},{"doc_id":132,"user_id":136,"nickname":92,"user_avatar":137,"doc_module":4,"category_id":34,"category_name":35,"doc_title":65,"doc_description":67,"doc_content":138,"file_id":139,"file_url":140,"file_type":141,"file_size":142,"view_count":34,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":143,"language":144,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":145,"faqs":146,"seo_title":147,"seo_description":67,"update_tm":133,"read_time":148,"preview_page_count":4},549768072016,"https://ap-avatar.wpscdn.com/davatar_155a257f0dc6eb9ab79c44ca47cae57d","Addiction Biology  \nORIGINAL ARTICLE  OPEN ACCESS   \nAssociations Between Vitamin D Status and Clinical Presentation Among French Inpatients With Substance Use Disorders  \nLuca Pavirani1,2,3  | Bibi Aliya Seelarbokus1  | Léa Marinelli2,4  | Pauline Desnavailles3 | Sylvie Berthoz1,5  | Melina Fatseas1,2,3   \n1Univ. Bordeaux, INCIA CNRS-UMR 5287, Bordeaux, France | 2CHU Bordeaux, Bordeaux, France | 3CH Charles Perrens, Bordeaux, France | 4Univ. Bordeaux LabPsy, Bordeaux, France | 5Department of Psychiatry for Adolescents and Young Adults, Institut Mutualiste Montsouris, Paris, France Correspondence: Sylvie Berthoz ([sylvie.berthoz-landron@inserm.fr](sylvie.berthoz-landron@inserm.fr))  \nReceived: 26 July 2025 | Revised: 10 November 2025 | Accepted: 26 November 2025  \nKeywords: calcium | craving for drugs | craving for food | C-reactive protein | micronutrients | substance use disorders  \nABSTRACT  \nBackground: Numerous studies have demonstrated that vitamin D plays a crucial role in modulating dopaminergic pathways, suggesting a potential role in the pathophysiology of addictive disorders. However, among individuals with substance use disorders (SUDs), the link between vitamin D and addiction-related symptoms has not been sufficiently studied.  \nObjective: This study aims to explore among inpatients treated for various types of SUDs differences in addiction-related, psychopathological and biological characteristics based on vitamin D status.  \nMethods: The sample included 260 participants hospitalized in a French addiction treatment unit. Vitamin D concentration and other biomarkers, SUDs severity and other psychiatric disorders, cognitive functioning and impulsivity were collected at hospital admission (T0) . Perceived negative affectivity and craving (for the main substance and food) were collected at T0 and hospital discharge (T1) .  \nResults: About 89.3% of the participants had a vitamin D deficiency as defined by French recommendations (\u003C30 ng/mL). Using univariate between-group analyses, vitamin D deficiency was associated with higher body weight and lower calcium plasma levels at T0, as well as increased craving intensity for both the substance at the origin of the treatment and food at T1 . Multivariate regression analyses showed no significant associations between vitamin D or calcium levels and craving intensities at T1 . Conclusion: This study confirms the high prevalence of vitamin D deficiency among inpatients treated for SUDs. Although preliminary, our findings highlight the importance of assessing vitamin D levels in SUDs. They call for further research on its role in relapse vulnerability and the potential benefits of its supplementation during drug withdrawal treatment.  \n1 | Introduction  \nVitamin D status has been the focus of growing interest in the past decade, with increasing evidence implicating serum 5-hydroxyvitamin D (25(OH)D) in neuroprotection and neurodevelopment, beyond its well-known effects on calcium and phosphate metabolism [1]. After the discovery and validation of  \nvitamin D receptors (VDRs) in diverse brain regions and their interaction with the transcriptional machinery inside target cells [2], an increasing number of experimental animal studies have demonstrated direct interactions between vitamin D and neurotrophic factors such as nerve growth factor (NGF) and glial cell line-derived neurotrophic factor (GDNF), both of which are crucial for cell proliferation and neurodevelopment [3] .  \nThis is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.  \n© 2026 The Author(s). Addiction Biology published by John Wiley & Sons Ltd on behalf of Society for the Study of Addiction.  \nAddiction Biology, 2026; 31:e70110 1 of 11  \n[https://doi.org/10.1111/adb.70110](https://doi.org/10.1111/adb.70110)  \nIn animal models, vitamin D administration has been shown to en","cbCaibLoGCsLL0sV","https://ap.wps.com/l/cbCaibLoGCsLL0sV","pdf",340892,11,"English","# Background\n## Objective\n## Methods\n## Results\n## Conclusion\n# Introduction\n## Vitamin D and neurobiology\n## Vitamin D and psychiatric conditions\n## Rationale for studying SUDs","[{\"question\":\"What was the main objective of the study?\",\"answer\":\"To explore differences in addiction-related, psychopathological, and biological characteristics among inpatients treated for substance use disorders based on vitamin D status.\"},{\"question\":\"How were participants and measurements organized over time?\",\"answer\":\"Data were collected at hospital admission (T0) for vitamin D and biomarkers, SUD severity, psychiatric disorders, cognitive functioning, and impulsivity, and negative affectivity and craving were reassessed at discharge (T1).\"},{\"question\":\"What associations did vitamin D deficiency show in the results?\",\"answer\":\"Vitamin D deficiency was very common (about 89.3%) and was associated in univariate analyses with higher body weight and lower plasma calcium at T0, and higher craving intensity for both the treated substance and food at T1.\"},{\"question\":\"Did the study find independent links between vitamin D/calcium and craving at T1?\",\"answer\":\"Multivariate regression analyses did not find significant associations between vitamin D or calcium levels and craving intensities at T1.\"}]","Associations Between Vitamin D Status and Clinical Presentation Among French Inpatients With Substance Use Disorders - Original Article - Addiction Biology | PDF",28]