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Findings show significant links between specific CCL5 and CXCR2 polymorphisms and increased cancer risk. Reported associations remained statistically significant after adjustments for age, diabetes, hypertension, or endometrial thickening above 5 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Chemokine Receptor and an Increased Risk of Endometrial Cancer  \nWioletta Izabela Wujcicka 1, *, Agnieszka Zaja˛c 2, Krzysztof Szyłło 2,3, Hanna Romanowicz 4, Beata Smolarz 5 and Grzegorz Stachowiak 2  \nCitation: Wujcicka, W.I.; Zaja˛c, A.; Szyłło, K.; Romanowicz, H.; Smolarz, B.; Stachowiak, G. Associations between Single Nucleotide Polymorphisms from the Genes of Chemokines and the CXCR2  \nChemokine Receptor and an Increased Risk of Endometrial Cancer. Cancers 2023, 15, 5416. [https://](https://)[ ](https://)[doi.org/10.3390/cancers15225416](doi.org/10.3390/cancers15225416)  \nAcademic Editor: Elena Bonora  \nReceived: 12 October 2023  \nRevised: 9 November 2023  \nAccepted: 10 November 2023  \nPublished: 14 November 2023  \nCopyright: © 2023 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license ([https://](https://)[ ](https://)[creativecommons.org/licenses/by/](creativecommons.org/licenses/by/)[ ](creativecommons.org/licenses/by/)[4.0/](4.0/)) .  \n1 Scientific Laboratory of the Center of Medical Laboratory Diagnostics and Screening, Polish Mother's Memorial Hospital—Research Institute, 93-338 Lodz, Poland  \n2 Department of Operative Gynecology and Gynecologic Oncology, Polish Mother's Memorial Hospital—Research Institute, 93-338 Lodz, Poland; [agnieszka.zajac@icloud.com](agnieszka.zajac@icloud.com) (A.Z.); [krzysztof.szyllo@iczmp.edu.pl](krzysztof.szyllo@iczmp.edu.pl) (K.S.); [gstach23@interia.pl](gstach23@interia.pl) (G.S.)  \n3 Department of Operative and Endoscopic Gynecology, Medical University of Lodz, 93-338 Lodz, Poland  \n4 Department of Clinical Pathomorphology, Polish Mother's Memorial Hospital—Research Institute, 93-338 Lodz, Poland; [hanna.romanowicz@iczmp.edu.pl](hanna.romanowicz@iczmp.edu.pl)  \n5 Laboratory of Cancer Genetics of the Department of Clinical Pathomorphology, Polish Mother's Memorial Hospital—Research Institute, 93-338 Lodz, Poland; [beata.smolarz@iczmp.edu.pl](beata.smolarz@iczmp.edu.pl)  \n* [Correspondence: wwujcicka@yahoo.com](Correspondence: wwujcicka@yahoo.com); Tel.: +48-422711520; Fax: +48-422711510  \nSimple Summary: Endometrial cancer is the second most common tumor of the female reproductive organs in the world. Taking into account the immunological mechanisms of defense against cancer, an important role is attributed to cytokines. In this case-control study, we aimed to identify the possible associations between selected single nucleotide polymorphisms (SNPs), localized in the CCL2, CCL5, CXCL8, and CXCR2 genes, and the onset and progression of endometrial cancer. We found that CCL5 and CXCR2 polymorphisms were associated with increased cancer risk, while the relationships remained significant after adjustments for age, diabetes, hypertension, or endometrial thickening. The selected haplotypes for CCL5 and CCL2 SNPs also correlated with an increased risk of cancer. We concluded that the four polymorphisms studied were significantly associated with an increased risk of endometrial cancer. The obtained results may be useful for identifying the signaling pathways involved in observed genetic changes, which is important for the tumorigenesis of endometrial cancer.  \nAbstract: Significant relationships with endometrial cancer were demonstrated, both for CCL2, CCL5, and CXCL8 chemokines and for the chemokine receptor CXCR2 . The reported case-control study of genetic associations was designed to establish the role of selected single nucleotide polymorphisms (SNPs) of the CCL2, CCL5, CXCL8, and CXCR2 genes in the onset and progression of endometrial cancer. This study was conducted on 282 women, including 132 (46.8%) patients with endometrial cancer and 150 (53.2%) non-cancerous controls. The genotypes for CCL2 rs4586, CCL5 rs2107538 andrs2280789, CXCL8 rs222753","cbCaivX9vS1WcB6O","https://ap.wps.com/l/cbCaivX9vS1WcB6O","pdf",1416056,16,"English","# Introduction\n## Study background\n# Abstract\n## Study aim and design\n## Key results\n## Conclusions","[{\"question\":\"What is the main research question of the study?\",\"answer\":\"The study examines whether specific SNPs in chemokine-related genes (CCL2, CCL5, CXCL8, CXCR2) are associated with the onset and progression of endometrial cancer.\"},{\"question\":\"How was the study designed and how many participants were included?\",\"answer\":\"A case-control study was conducted with 282 women, including 132 endometrial cancer patients and 150 non-cancer controls.\"},{\"question\":\"Which genetic variants were associated with increased endometrial cancer risk?\",\"answer\":\"CCL5 and CXCR2 polymorphisms showed significant associations with increased cancer risk, and certain haplotypes for CCL5 and CCL2 were also linked to higher risk.\"}]","Associations between Single Nucleotide Polymorphisms from the Genes of Chemokines and the CXCR2 Chemokine Receptor and an Increased Risk of Endometrial Cancer | PDF",1790230132]