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This cohort study examined whether adherence to DASH, MEDAS, and MIND dietary patterns is associated with incident IPF and whether phenotypic age acceleration mediates this relationship. Analyses included 196,473 UK Biobank participants using repeated 24-h recalls and Cox models, with mediation analysis for phenotypic age acceleration.",{"@graph":69,"@context":122},[70,84,105],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":35,"@type":76,"position":81},"https://docshare.wps.com/document/healthcare/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/associations-between-dietary-patterns-and-the-incidence-of-idiopathic-pulmonary-fibrosis-a-cohort-study/432725/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/associations-between-dietary-patterns-and-the-incidence-of-idiopathic-pulmonary-fibrosis-a-cohort-study/432725.png","ImageObject",300,407,{"name":92,"@type":93},"Fans","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-09-30","2026-09-29",true,{"@type":102,"interactionType":103,"userInteractionCount":14},"InteractionCounter",{"@type":104},"ViewAction",{"@type":106,"mainEntity":107},"FAQPage",[108,114,118],{"name":109,"@type":110,"acceptedAnswer":111},"What was the main research question of this cohort study on IPF?","Question",{"text":112,"@type":113},"Whether adherence to healthy dietary patterns (DASH, MEDAS, and MIND) is associated with the incidence of idiopathic pulmonary fibrosis, and whether phenotypic age acceleration mediates the association.","Answer",{"name":115,"@type":110,"acceptedAnswer":116},"How were dietary intake and adherence measured?",{"text":117,"@type":113},"Dietary intake was assessed using repeated 24-hour recall questionnaires, and adherence scores were calculated for the DASH, MEDAS, and MIND dietary patterns.",{"name":119,"@type":110,"acceptedAnswer":120},"What did the study find about dietary adherence and incident IPF risk?",{"text":121,"@type":113},"Higher adherence to all three dietary patterns was significantly associated with a reduced risk of incident IPF, with hazard ratios indicating lower risk for the highest versus lowest quartiles in fully adjusted models.","https://schema.org",{"og:url":83,"og:type":124,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":126,"canonical":83},"index,follow",{"doc_id":128,"site_id":62},432725,1790766221,{"code":4,"msg":5,"data":131},{"doc_id":128,"user_id":132,"nickname":92,"user_avatar":133,"doc_module":4,"category_id":34,"category_name":35,"doc_title":65,"doc_description":67,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":14,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":34,"language":139,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":140,"faqs":141,"seo_title":142,"seo_description":67,"update_tm":143,"read_time":144},5909892330395,"https://ap-avatar.wpscdn.com/davatar_6f874abed73319feea01a86fa6f0fab8","The Journal of nutrition, health and aging 30 (2026) 100755  \nContents lists available at ScienceDirect  \nThe Journal of nutrition, health and aging  \njournal [homepage:](homepage: www.elsevier.com/locate/jnha)[ www.elsevier.com/locate/jnha](homepage: www.elsevier.com/locate/jnha)  \n| Original Article\u003Cbr>Associations between dietary patterns and the incidence of idiopathic pulmonary fibrosis: A cohort study |  |  | |\n| --- | --- | --- | --- |\n| Yonghao Lia,1, Xinran Doua,1, Hui Lia, Xuan Lia, Luqin Yanga, Jiawei Chena, Fengqin Zhang a, Huihui Yuea, Ruihan Donga, Jianhan He a, Xuewen Wang a, Wei Weib,*, Li Liuc,*,\u003Cbr>Huilan Zhang a,*\u003Cbr>a The Center for Biomedical Research, Department of Respiratory and Critical Care Medicine, National Health Commission (NHC) Key Laboratory of Respiratory Diseases, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, 430030, China\u003Cbr>b School of Computer Science and Technology, Huazhong University of Science and Technology, Wuhan, Hubei, 430030, China\u003Cbr>c Department of Epidemiology and Biostatistics, Ministry of Education Key Lab of Environment and Health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, 430030, China |  |  |  |\n| A R T I C L E I N F O |  | A B S T R A C T |  |\n| Keywords\u003Cbr>Dietary patterns\u003Cbr>Phenotypic age\u003Cbr>Idiopathic pulmonary fibrosis Prospective study\u003Cbr>Cohort study |  | Background: Idiopathic pulmonary fibrosis (IPF) is a progressive, age-related lung disease with few modifiable risk factors. While healthy dietary patterns have been associated with reduced risk of chronic diseases, their impact on IPF remains unclear. This study investigated the relationship between adherence to healthy dietary patterns and incident IPF and explored whether phenotypic age acceleration mediates this association. Methods: We analyzed 196,473 participants from the UK Biobank. Dietary intake was assessed via repeated 24-h recall questionnaires, and adherence scores were calculated for the DASH, MEDAS, and MIND dietary patterns. Cox proportional hazards models were used to estimate the association between dietary scores and incident IPF. Mediation analysis was conducted to examine the role of phenotypic age acceleration.\u003Cbr>Results: During a median follow-up of 12.4 years, 516 IPF cases were identified. Higher adherence to all three dietary patterns was significantly associated with a reduced risk of IPF. In fully adjusted models, hazard ratios for the highest vs. lowest quartiles were 0.75 (95% CI: 0.59–0.95) for DASH, 0.53 (0.37–0.75) for MEDAS, and 0.66 (0.51–0.86) for MIND. Phenotypic age acceleration partially mediated these associations.\u003Cbr>Conclusions: Higher dietary scores were associated with a lower risk of incident IPF, partially mediated by reduced phenotypic age acceleration. These findings suggest that promoting healthy eating habits may contribute to reducing age-related lung disease burden in older adults. |  |\n\n1. Introduction  \nPulmonary fibrosis is a group of diseases characterized by diffuse exudation, infiltration, and fibrosis in the interstitial space of the lungs. Idiopathic pulmonary fibrosis (IPF) is a serious type of pulmonary fibrosis for which the etiology is unknown. The process of fibrosis is irreversible, and the lung function of patients deteriorates rapidly over a short period, with a poor prognosis. The median survival after diagnosis is only 3–5 years [1]. Epidemiologically, IPF is recognized as a rare disorder worldwide, with a pooled global incidence of approximately 5.8 cases per 100,000 persons per year and a prevalence of 17.7 cases per 100,000, although considerable regional variation has been  \nobserved [2]. Recent analyses based on the World Health Organization Mortality Database indicate that global crude mortality for IPF increased from about 2.10 per 100,000 in 2001 to 3.14 per 100,000 in 2022, with higher mortality consistently obser","cbCaif0vx3cDPp2n","https://ap.wps.com/l/cbCaif0vx3cDPp2n","pdf",2112802,"English","# Introduction\n# Methods\n# Results\n# Conclusions","[{\"question\":\"What was the main research question of this cohort study on IPF?\",\"answer\":\"Whether adherence to healthy dietary patterns (DASH, MEDAS, and MIND) is associated with the incidence of idiopathic pulmonary fibrosis, and whether phenotypic age acceleration mediates the association.\"},{\"question\":\"How were dietary intake and adherence measured?\",\"answer\":\"Dietary intake was assessed using repeated 24-hour recall questionnaires, and adherence scores were calculated for the DASH, MEDAS, and MIND dietary patterns.\"},{\"question\":\"What did the study find about dietary adherence and incident IPF risk?\",\"answer\":\"Higher adherence to all three dietary patterns was significantly associated with a reduced risk of incident IPF, with hazard ratios indicating lower risk for the highest versus lowest quartiles in fully adjusted models.\"}]","Associations between dietary patterns and the incidence of idiopathic pulmonary fibrosis - A cohort study | PDF",1790660985,18]