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Results: SMC4 is upregulated in cancer tissues versus normal tissues and confirmed in synovial sarcoma by immunohistochemistry; higher SMC4 associates with worse outcomes in multiple cancers and with positive immune cell infiltration patterns, including distinct monocyte and TAM, M1, M2 marker profiles. Conclusion: SMC4 links to prognosis and sarcoma immunological status and may serve as a biomarker.",{"@graph":69,"@context":122},[70,84,105],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":35,"@type":76,"position":81},"https://docshare.wps.com/document/healthcare/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/association-of-smc4-with-prognosis-and-immune-infiltration-of-sarcoma/382100/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/association-of-smc4-with-prognosis-and-immune-infiltration-of-sarcoma/382100.png","ImageObject",300,407,{"name":92,"@type":93},"acoobca","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-10-31","2026-09-24",true,{"@type":102,"interactionType":103,"userInteractionCount":29},"InteractionCounter",{"@type":104},"ViewAction",{"@type":106,"mainEntity":107},"FAQPage",[108,114,118],{"name":109,"@type":110,"acceptedAnswer":111},"What is the main aim of the study about SMC4 and sarcoma?","Question",{"text":112,"@type":113},"To assess whether SMC4 has prognostic relevance in pan-cancer and to evaluate the association between SMC4 and immune infiltration in sarcoma.","Answer",{"name":115,"@type":110,"acceptedAnswer":116},"What did the study find regarding SMC4 expression in cancer tissues?",{"text":117,"@type":113},"SMC4 expression was elevated in cancer tissues compared with normal tissues, and this was confirmed in synovial sarcoma using immunohistochemistry.",{"name":119,"@type":110,"acceptedAnswer":120},"How does SMC4 relate to immune infiltration and patient outcomes in sarcoma?",{"text":121,"@type":113},"Higher SMC4 expression correlates with worse outcomes and shows positive associations with immune cell infiltration patterns, including differences in immune marker profiles such as monocytes, TAM, and M1/M2.","https://schema.org",{"og:url":83,"og:type":124,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":126,"canonical":83},"index,follow",{"doc_id":128,"site_id":62},382100,1791452095,{"code":4,"msg":5,"data":131},{"doc_id":128,"user_id":132,"nickname":92,"user_avatar":133,"doc_module":4,"category_id":34,"category_name":35,"doc_title":65,"doc_description":67,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":29,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":139,"language":140,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":141,"faqs":142,"seo_title":143,"seo_description":67,"update_tm":144,"read_time":36},3985747870733,"https://ap-avatar.wpscdn.com/davatar_a8503ba1806abce46bf441b54a3ca4cd","[www.aging-us.com](www.aging-us.com) AGING 2023, Vol. 15, No. 2  \nResearch Paper  \nAssociation of SMC4 with prognosis and immune infiltration of sarcoma  \nGuangyao Jiang1, Junjie Chen2, Yan Li1, Jian Zhou3, Wanchun Wang3, Gen Wu4, Yupeng Zhang5  \n1 Department of Orthopedics, People's Hospital of Pingchang County, Pingchang, Sichuan 636400, China 2 Department of Orthopedics, Longhui People’s Hospital, Shaoyang, Hunan 422200, China  \n3 Department of Orthopedics, The Second Xiangya Hospital, Central South University, Changsha, Hunan 410011, China  \n4 Department of Orthopedics, The Fifth Affiliated Hospital, Southern Medical University, Guangzhou, Guangdong 510900, China  \n5 Department of Spine Surgery, The Second Xiangya Hospital of Central South University, Changsha, Hunan 410011, China  \nCorrespondence to: Yupeng Zhang; email: [zyp666@csu.edu.cn](zyp666@csu.edu.cn)  \n[Keywords:](Keywords: SMC4)[ SMC4](Keywords: SMC4), sarcoma, prognosis, immune infiltrates, biomarker  \nReceived: August 13, 2022 Accepted: January 23, 2023 Published: January 30, 2023  \nCopyright: © 2023 Jiang et al. This is an open access article distributed under the terms of the Creative Commons Attribution License (CC BY 3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.  \nABSTRACT  \nObjective: This study was performed to explore the prognostic relevance of structural maintenance of chromosomes 4 (SMC4) in pan-cancer and explore the association between SMC4 and immune infiltration of sarcoma.  \nResults: Elevated expression of SMC4 was detected in cancer tissues compared to normal tissue, which was confirmed in synovial sarcoma tissues with immunohistochemistry (IHC). Additionally, higher expression of SMC4 was connected to worse outcomes of sarcoma, gastric cancer, breast cancer, liver cancer or ovarian cancer. Moreover, SMC4 was positively connected to immune cell infiltrates in sarcoma. In addition, infiltrating immune cell markers including monocyte, TAM, M1 and M2 presented different SMC4-associated immune infiltration patterns.  \nConclusion: The results from our study showed that SMC4 was positively related to the prognosis and immunological status of sarcoma. SMC4 could be a potential biomarker for prognosis and immune cell infiltratesin sarcoma.  \nMethods: Several databases including ONCOMINE, GEPIA, and Kaplan-Meier Plotter were adopted to explore the expression pattern of SMC4 in sarcoma, which was confirmed by IHC. The GEPIA and TIMER datasets were adopted to investigate the associations between SMC4 and prognosis in various cancers, especially in sarcoma.  \nINTRODUCTION  \nSarcoma is a type of tumor that originates from human mesenchymal cells [1] . Depending on where the tumor is located, sarcomas can be divided into more than 50 different types, such as osteosarcoma, liposarcoma and myxosarcoma. A report issued by the World Health Organization in the 2016 year showed that the incidence  \nof sarcomas continues to increase [2] . In the United States, newly diagnosed sarcomas contribute to 19–21% of cancer-related deaths in childhood and adolescence [3] . Although most sarcomas are localized tumors that are typically treated with surgical resection and radiation therapy, the metastasis rate can be as high as 50% over the first five years after diagnosis (depending on the location, grade, and subtype) . The five-year  \nrelative survival rate of patients with distant metastases is 16% due mainly to the limited efficacy of current systemic treatment programs [4] .  \nThe immune system can recognize and control the growth of cancer, but tumor cells can avoid recognition and elimination by the immune system to survive in the host. In previous studies, how cancer evades the immune system has been well-studied, which provides a helpful insight into preventing cancer immune evasion and eliminating cancer cells [5] . The diversity behind sarcomas has historically led to the d","cbCaifBIMQXnHkHP","https://ap.wps.com/l/cbCaifBIMQXnHkHP","pdf",2818554,16,"English","# Abstract\n## Objective\n## Results\n## Conclusion\n## Methods\n# Introduction\n# Results\n## mRNA expression level of SMC4 in pan-cancer","[{\"question\":\"What is the main aim of the study about SMC4 and sarcoma?\",\"answer\":\"To assess whether SMC4 has prognostic relevance in pan-cancer and to evaluate the association between SMC4 and immune infiltration in sarcoma.\"},{\"question\":\"What did the study find regarding SMC4 expression in cancer tissues?\",\"answer\":\"SMC4 expression was elevated in cancer tissues compared with normal tissues, and this was confirmed in synovial sarcoma using immunohistochemistry.\"},{\"question\":\"How does SMC4 relate to immune infiltration and patient outcomes in sarcoma?\",\"answer\":\"Higher SMC4 expression correlates with worse outcomes and shows positive associations with immune cell infiltration patterns, including differences in immune marker profiles such as monocytes, TAM, and M1/M2.\"}]","Association of SMC4 with prognosis and immune infiltration of sarcoma | PDF",1790249048]