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Sarcopenia was defined using bioelectrical impedance–derived muscle mass relative to BMI, and pain and function were measured with AUSCAN and DASH. Male patients with lower muscle mass/BMI showed significantly higher DASH and AUSCAN scores; female associations were not significant. The results support muscle preservation in hand OA 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10.5152/ArchRheumatol.2025.25088  \nAssociation of Sarcopenia with Pain and Disability in Hand Osteoarthritis: A Retrospective, Cross-Sectional, Single-Center Study  \nABSTRACT  \nBackground/Aims: Sarcopenia is known to worsen clinical outcomes in osteoarthritis, particularly in weight-bearing joints, yet its relationship with symptom burden in hand osteoarthritis has not been well established. This study explored the relationship between sarcopenia, hand pain, and functional status in patients with hand osteoarthritis.  \nMaterials and Methods: A retrospective analysis was conducted on 1139 patients aged ≥40 years with radiographically confirmed hand osteoarthritis. Sarcopenia was defined as the ratio of muscle mass to body mass index, measured via bioelectrical impedance analysis. Hand pain and function were assessed using the Australian/Canadian Osteoarthritis Hand Index, and the Disabilities of the Arm, Shoulder and Hand (DASH) questionnaires. Sex-specific multivariable linear regression models were constructed, adjusting for demographic and lifestyle covariates.  \nResults: In males, lower appendicular skeletal muscle mass/body mass index was significantly associated with higher DASH scores (estimate:−10.664, P = .006) . A significant association with higher Australian/Canadian Osteoarthritis Hand Index scores was also observed (estimate: −26 .236, P = .030) . Lower upper-extremity muscle mass/body mass index was likewise associated with higher DASH scores in males (estimate: −41 .074, P =.013) . In females, none of the associations reached statistical significance.  \nConclusion: These findings suggest that sarcopenia contributes to increased pain and disability in hand osteoarthritis, highlighting the clinical importance of preserving muscle mass in its management.  \nKeywords: Bioelectrical impedance analysis, functional disability, hand osteoarthritis, muscle mass, sarcopenia  \nIntroduction  \nOsteoarthritis (OA) is a common degenerative joint disease affecting multiple joints, particularly the knees and hands, and is a leading cause of pain, functional disability, and reduced quality of life in older adults.1,2 The hands are frequently used in daily activities, and degenerative changes accompanied by pain in these joints can significantly impair functional performance.2,3 To assess pain and functional limitations in hand OA, validated instruments such as the Australian/Canadian Osteoarthritis Hand Index (AUSCAN) and the Disabilities of the Arm, Shoulder and Hand (DASH) questionnaire are commonly used.4 ,5 Although several factors—advanced age, increased body  \nCopyright@Author(s) -[Available online at archivesof rheumatology.com](Available online at archivesof rheumatology.com). Content of this journal is licensed under a Creative Commons Attribution (CC BY) 4.0 International License.  \nHanna Lee1,2 Sang-Il Lee3 Yun-Hong Cheon3 Hyunjin Lim3 Ki Soo Park4 Hyun-Ok Kim1,2  \n1Division of Rheumatology, Department of Internal Medicine, Gyeongsang National University Hospital, changwon, South Korea 2Department of Medicine, Gyeongsang National University, Jinju, South Korea  \n3Division of Rheumatology, Department of Internal Medicine, Gyeongsang National University Hospital, Jinju, South Korea  \n4Department of Preventive Medicine, Gyeongsang National University College of Medicine Institute of Health Sciences, Jinju, Korea  \nCorresponding author: Hyun-Ok Kim  \n􀀍 [galleonok@hanmail. net](galleonok@hanmail. net)  \nReceived: August 12, 2025  \nRevision requested:  \nSeptember 6, 2025  \nLast revision received:  \nSeptember 9, 2025  \nAccepted: October 20, 2025  \nPublication Date: December 1, 2025  \nCite this article as: Lee H, Lee S-I, Cheon Y-H, et al. Association of sarcopenia with pain and disability in hand osteoarthritis: a retrospective, cross-sectional, single-center study. Arch Rheumatol. 2025;40(4):492-498 .  \n492  \nLee et al. Sarcopenia and Hand Osteoarthritis Disa","cbCaiusBItU8jqIZ","https://ap.wps.com/l/cbCaiusBItU8jqIZ","pdf",449598,"English","# Abstract\n## Background/Aims\n## Materials and Methods\n## Results\n## Conclusion\n# Introduction\n# Main Points","[{\"question\":\"How was sarcopenia defined in the study?\",\"answer\":\"Sarcopenia was defined as the ratio of muscle mass to body mass index measured by bioelectrical impedance analysis.\"},{\"question\":\"Which assessment tools were used to evaluate pain and function?\",\"answer\":\"Hand pain and function were assessed with the Australian/Canadian Osteoarthritis Hand Index (AUSCAN) and the Disabilities of the Arm, Shoulder and Hand (DASH) questionnaire.\"},{\"question\":\"What were the key findings by sex?\",\"answer\":\"In males, lower muscle mass/body mass index was significantly associated with higher DASH and AUSCAN scores, while none of the associations reached statistical significance in females.\"}]","Association of Sarcopenia with Pain and Disability in Hand Osteoarthritis - A Retrospective, Cross-Sectional, Single-Center Study | PDF",1790679917,18]