[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"detail-sidebar-cat-0-en-105":3,"doc-seo-426345-105":59,"doc-detail-426345-en":130},{"code":4,"msg":5,"data":6},0,"success",[7,13,18,23,28,33,38,43,48,51,55],{"id":8,"doc_module":4,"doc_module_name":9,"category_name":10,"show_sort_weight":11,"slug":12},1,"Document","Story & Novel",90,"story-novel",{"id":14,"doc_module":4,"doc_module_name":9,"category_name":15,"show_sort_weight":16,"slug":17},2,"Literature",80,"literature",{"id":19,"doc_module":4,"doc_module_name":9,"category_name":20,"show_sort_weight":21,"slug":22},4,"Exam",70,"exam",{"id":24,"doc_module":4,"doc_module_name":9,"category_name":25,"show_sort_weight":26,"slug":27},5,"Comic",60,"comic",{"id":29,"doc_module":4,"doc_module_name":9,"category_name":30,"show_sort_weight":31,"slug":32},6,"Technology",50,"technology",{"id":34,"doc_module":4,"doc_module_name":9,"category_name":35,"show_sort_weight":36,"slug":37},7,"Healthcare",40,"healthcare",{"id":39,"doc_module":4,"doc_module_name":9,"category_name":40,"show_sort_weight":41,"slug":42},8,"Research & Report",30,"research-report",{"id":44,"doc_module":4,"doc_module_name":9,"category_name":45,"show_sort_weight":46,"slug":47},9,"Religion & Spirituality",20,"religion-spirituality",{"id":46,"doc_module":4,"doc_module_name":9,"category_name":49,"show_sort_weight":46,"slug":50},"World Cup","world-cup",{"id":52,"doc_module":4,"doc_module_name":9,"category_name":53,"show_sort_weight":52,"slug":54},10,"Lifestyle","lifestyle",{"id":56,"doc_module":4,"doc_module_name":9,"category_name":57,"show_sort_weight":24,"slug":58},19,"General","general",{"code":4,"msg":60,"data":61},"ok",{"site_id":62,"language":63,"slug":64,"title":65,"keywords":66,"description":67,"schema_data":68,"social_meta":123,"head_meta":125,"extra_data":127,"updated_unix":129},105,"en","association-of-oral-health-and-genetic-risk-with-incidence-of-dementia","ASSOCIATION OF ORAL HEALTH AND GENETIC RISK WITH INCIDENCE OF DEMENTIA","","Genetic predisposition and oral health problems both contribute to dementia risk, yet whether poor oral health shows similar risk patterns across genetic susceptibility levels remains uncertain. This study evaluates the joint effect of oral health problems—painful gums, bleeding gums, loose teeth, toothache, and dentures—and genetic risk on incident dementia. In a UK Biobank cohort, participants free of dementia at baseline were followed until 2022, and models estimated associations for all-cause dementia, Alzheimer’s disease, and vascular dementia.",{"@graph":69,"@context":122},[70,84,105],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":40,"@type":76,"position":81},"https://docshare.wps.com/document/research-report/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/association-of-oral-health-and-genetic-risk-with-incidence-of-dementia/426345/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/association-of-oral-health-and-genetic-risk-with-incidence-of-dementia/426345.png","ImageObject",300,407,{"name":92,"@type":93},"Mimi","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-10-22","2026-09-29",true,{"@type":102,"interactionType":103,"userInteractionCount":29},"InteractionCounter",{"@type":104},"ViewAction",{"@type":106,"mainEntity":107},"FAQPage",[108,114,118],{"name":109,"@type":110,"acceptedAnswer":111},"How were genetic risk and dementia outcomes defined in the study?","Question",{"text":112,"@type":113},"Genetic risk was defined using a polygenic risk score (categorized into low, intermediate, and high) and APOE ε4 carrier status. Outcomes included all-cause dementia and major subtypes: Alzheimer’s disease and vascular dementia.","Answer",{"name":115,"@type":110,"acceptedAnswer":116},"What oral health problems were linked to higher dementia risk?",{"text":117,"@type":113},"Oral health problems, especially painful gums and dentures, were associated with increased risk of all-cause dementia, Alzheimer’s disease, and vascular dementia during follow-up.",{"name":119,"@type":110,"acceptedAnswer":120},"Did oral health modify the effect of genetic risk on dementia?",{"text":121,"@type":113},"Joint-effect analyses showed additive interactions between painful gums/dentures and genetic risk, indicating worsening burden among genetically susceptible individuals. No multiplicative interaction was observed.","https://schema.org",{"og:url":83,"og:type":124,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":126,"canonical":83},"index,follow",{"doc_id":128,"site_id":62},426345,1790851603,{"code":4,"msg":5,"data":131},{"doc_id":128,"user_id":132,"nickname":92,"user_avatar":133,"doc_module":4,"category_id":39,"category_name":40,"doc_title":65,"doc_description":67,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":29,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":8,"language":139,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":140,"faqs":141,"seo_title":142,"seo_description":67,"update_tm":143,"read_time":81},2336477974920,"https://ap-avatar.wpscdn.com/davatar_155a257f0dc6eb9ab79c44ca47cae57d","Innovation in Aging, 2025, Vol. 9, No. S2 1159  \nUK Biobank cohort. Participants (N = 364,557) free of dementia at baseline (2006–2010) were followed until 2022. Genetic risk was defined by polygenic risk score (PRS; categorized as low, intermediate, and high) and APOE ε4 carrier status. Cox proportional hazards and competing risk regression models were used to estimate associations with all-cause dementia (ACD) and its major subtypes, Alzheimer’s disease (AD) and vascular dementia (VaD), adjusting for demographic, socioeconomic and health-related factors. During follow-up, 1,915 cases of ACD, 3,278 AD, and 1,581 VaD were identified. Oral health problems, particularly painful gums and dentures, were associated with increased risk of ACD, AD, and VaD. Higher genetic risk, assessed by both PRS and APOE ε4, was also strongly associated with incident dementia. Analyses of joint effects indicated that painful gums and dentures demonstrated additive interactions with genetic risk, although no multiplicative interaction was observed. These findings suggest that poor oral health is independently associated with elevated dementia risk and may exacerbate the burden among genetically susceptible individuals. Improving oral health care could represent a modifiable strategy for dementia prevention.  \nAbstract citation ID: igaf122.3885  \nASSOCIATION OF ORAL HEALTH AND GENETIC RISK  \nWITH INCIDENCE OF DEMENTIA  \nYunrui Liu1, Xiang Qi1, Ruotong Mona Liu1, Sophie Zhijing Xu1, Huabin Luo2, and Bei Wu3, 1. New York University, New York, New York, United States, 2. East Carolina University, Greenville, North Carolina, United States, 3. NYU Shanghai, Shanghai, China (People’s Republic)  \nGenetic predisposition and oral health problems both contribute to the risk of dementia, yet it remains unclear whether poor oral health confers similar risk across different levels of genetic susceptibility. We investigated the joint effect of oral health problems (painful gums, bleeding gums, loose teeth, toothache, and dentures) and genetic risk on incident dementia in the","cbCaidqcNGGX7Lv6","https://ap.wps.com/l/cbCaidqcNGGX7Lv6","pdf",1026790,"English","# Study design and cohort\n## Genetic risk measures and outcomes\n## Statistical modeling and adjustments\n## Oral health associations\n## Joint effects and interaction patterns\n## Conclusions and prevention implications","[{\"question\":\"How were genetic risk and dementia outcomes defined in the study?\",\"answer\":\"Genetic risk was defined using a polygenic risk score (categorized into low, intermediate, and high) and APOE ε4 carrier status. Outcomes included all-cause dementia and major subtypes: Alzheimer’s disease and vascular dementia.\"},{\"question\":\"What oral health problems were linked to higher dementia risk?\",\"answer\":\"Oral health problems, especially painful gums and dentures, were associated with increased risk of all-cause dementia, Alzheimer’s disease, and vascular dementia during follow-up.\"},{\"question\":\"Did oral health modify the effect of genetic risk on dementia?\",\"answer\":\"Joint-effect analyses showed additive interactions between painful gums/dentures and genetic risk, indicating worsening burden among genetically susceptible individuals. No multiplicative interaction was observed.\"}]","ASSOCIATION OF ORAL HEALTH AND GENETIC RISK WITH INCIDENCE OF DEMENTIA | PDF",1790640265]