[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"doc-seo-443951-105":3,"detail-sidebar-cat-0-en-105":81,"doc-detail-443951-en":130},{"code":4,"msg":5,"data":6},0,"ok",{"site_id":7,"language":8,"slug":9,"title":10,"keywords":11,"description":12,"schema_data":13,"social_meta":74,"head_meta":76,"extra_data":78,"updated_unix":80},105,"en","association-of-mmp-9-and-timp-1-concentration-with-neurological-outcome-after-cardiac-arrest-and-resuscitation-a-substudy-of-the-comacare-trial","Association of MMP-9 and TIMP-1 concentration with neurological outcome after cardiac arrest and resuscitation - a substudy of the COMACARE trial","","Out-of-hospital cardiac arrest (OHCA) triggers an inflammatory response that includes altered concentrations of matrix metalloproteinase (MMP)-9 and tissue inhibitor of matrix metalloproteinase (TIMP)-1. Plasma levels of MMP-9 and TIMP-1 were measured in 112 OHCA patients at ICU admission and at 24, 48, and 72 hours, with 40 elective cardiac surgery patients as controls. MMP-9 and TIMP-1 were elevated after OHCA but showed no association with six-month neurological outcome.",{"@graph":14,"@context":73},[15,34,56],{"@type":16,"itemListElement":17},"BreadcrumbList",[18,23,27,31],{"item":19,"name":20,"@type":21,"position":22},"https://docshare.wps.com","Home","ListItem",1,{"item":24,"name":25,"@type":21,"position":26},"https://docshare.wps.com/document/","Document",2,{"item":28,"name":29,"@type":21,"position":30},"https://docshare.wps.com/document/research-report/","Research & Report",3,{"item":32,"name":10,"@type":21,"position":33},"https://docshare.wps.com/document/association-of-mmp-9-and-timp-1-concentration-with-neurological-outcome-after-cardiac-arrest-and-resuscitation-a-substudy-of-the-comacare-trial/443951/",4,{"url":32,"name":10,"@type":35,"image":36,"author":41,"headline":10,"publisher":44,"fileFormat":47,"inLanguage":8,"description":12,"dateModified":48,"datePublished":49,"encodingFormat":47,"isAccessibleForFree":50,"interactionStatistic":51},"DigitalDocument",{"url":37,"@type":38,"width":39,"height":40},"https://docshare.wps.com/thumbnails/association-of-mmp-9-and-timp-1-concentration-with-neurological-outcome-after-cardiac-arrest-and-resuscitation-a-substudy-of-the-comacare-trial/443951.png","ImageObject",300,407,{"name":42,"@type":43},"Angel","Person",{"url":19,"name":45,"@type":46},"DocShare","Organization","application/pdf","2026-10-03","2026-09-29",true,{"@type":52,"interactionType":53,"userInteractionCount":55},"InteractionCounter",{"@type":54},"ViewAction",6,{"@type":57,"mainEntity":58},"FAQPage",[59,65,69],{"name":60,"@type":61,"acceptedAnswer":62},"What was the main objective of this substudy?","Question",{"text":63,"@type":64},"To determine whether plasma MMP-9 and TIMP-1 concentrations in OHCA patients are elevated and whether they relate to neurological outcome after cardiac arrest and resuscitation.","Answer",{"name":66,"@type":61,"acceptedAnswer":67},"How were MMP-9 and TIMP-1 measured, and when were samples collected?",{"text":68,"@type":64},"MMP-9 and TIMP-1 concentrations were measured in 112 OHCA patients at ICU admission and at 24, 48, and 72 hours.",{"name":70,"@type":61,"acceptedAnswer":71},"Did MMP-9 or TIMP-1 concentrations predict neurological outcome?",{"text":72,"@type":64},"No. Logistic regression showed that neither biomarker demonstrated an association with neurological outcome.","https://schema.org",{"og:url":32,"og:type":75,"og:title":10,"og:site_name":45,"og:description":12},"article",{"robots":77,"canonical":32},"index,follow",{"doc_id":79,"site_id":7},443951,1790864993,{"code":4,"msg":82,"data":83},"success",[84,88,92,96,101,105,110,114,119,122,126],{"id":22,"doc_module":4,"doc_module_name":25,"category_name":85,"show_sort_weight":86,"slug":87},"Story & Novel",90,"story-novel",{"id":26,"doc_module":4,"doc_module_name":25,"category_name":89,"show_sort_weight":90,"slug":91},"Literature",80,"literature",{"id":33,"doc_module":4,"doc_module_name":25,"category_name":93,"show_sort_weight":94,"slug":95},"Exam",70,"exam",{"id":97,"doc_module":4,"doc_module_name":25,"category_name":98,"show_sort_weight":99,"slug":100},5,"Comic",60,"comic",{"id":55,"doc_module":4,"doc_module_name":25,"category_name":102,"show_sort_weight":103,"slug":104},"Technology",50,"technology",{"id":106,"doc_module":4,"doc_module_name":25,"category_name":107,"show_sort_weight":108,"slug":109},7,"Healthcare",40,"healthcare",{"id":111,"doc_module":4,"doc_module_name":25,"category_name":29,"show_sort_weight":112,"slug":113},8,30,"research-report",{"id":115,"doc_module":4,"doc_module_name":25,"category_name":116,"show_sort_weight":117,"slug":118},9,"Religion & Spirituality",20,"religion-spirituality",{"id":117,"doc_module":4,"doc_module_name":25,"category_name":120,"show_sort_weight":117,"slug":121},"World Cup","world-cup",{"id":123,"doc_module":4,"doc_module_name":25,"category_name":124,"show_sort_weight":123,"slug":125},10,"Lifestyle","lifestyle",{"id":127,"doc_module":4,"doc_module_name":25,"category_name":128,"show_sort_weight":97,"slug":129},19,"General","general",{"code":4,"msg":82,"data":131},{"doc_id":79,"user_id":132,"nickname":42,"user_avatar":133,"doc_module":4,"category_id":111,"category_name":29,"doc_title":10,"doc_description":12,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":55,"is_deleted":4,"is_public":22,"is_downloadable":22,"audit_status":22,"page_count":111,"language":139,"language_code":8,"site_id":7,"html_lang":8,"table_of_contents":140,"faqs":141,"seo_title":142,"seo_description":12,"update_tm":143,"read_time":117},687207412472,"https://ap-avatar.wpscdn.com/davatar_155a257f0dc6eb9ab79c44ca47cae57d","R E S U S C I T A T I O N P L U S 27 (20 26) 1011 87  \nOriginal Article  \nAssociation of MMP-9 and TIMP-1 concentration with neurological outcome after cardiac arrest and resuscitation – a substudy of the COMACARE trial  \nEmilia Kortesuo a,*, Joonas Tirkkonena,b, Matti Reinikainenc, Pirkka T. Pekkarinend, Eeva Moilanena,e, Liisa Pet¨aj¨ad, Markus B Skrifvarsd, Johanna H¨astbackaa,b  \nAbstract  \nBackground and aim: Out-of-hospital cardiac arrest (OHCA) leads to an inflammatory response, including alterations in matrix metalloproteinase (MMP)-9 and tissue inhibitor of matrix metalloproteinase (TIMP)-1 concentrations. We investigated whether the MMP-9 and TIMP-1 plasma concentrations of OHCA patients are elevated and associated with outcome among OHCA patients.  \nMethods: This was a substudy of the prospective COMACARE trial (NCT02698917) . We included 112 OHCA patients and measured MMP-9 and TIMP-1 concentrations at ICU admission, 24, 48 and at 72 h. Preoperative blood samples from 40 age-and sex-matched elective cardiac surgery patients were used as controls. We defined favourable outcome as a Cerebral Performance Category (CPC) 1–2 at six months.  \nResults: The median (interquartile range) MMP-9 concentrations at admission for OHCA patients and for controls were 369 (228–619) ng/mL and 66 (41–114) ng/mL, respectively, p \u003C 0.001 . The TIMP-1 concentrations for OHCA patients at admission and for controls were 137 (104–163) ng/mLand 79 (71–96) ng/mL, respectively, p \u003C 0.001 . The MMP-9 levels peaked at admission; 448 (241–700) ng/mL in patients with CPC 􀀁 3 as compared with 340 (224–563) ng/mL in patients with CPC 1–2 (p = 0.103) . TIMP-1 concentrations peaked at 48 h; 223 (174–323) ng/mL in patients with CPC 􀀁 3 as compared with 201 (148–273) ng/mL in patients with CPC 1–2 (p = 0.104) . In a logistic regression model, neither biomarker demonstrated association with outcome.  \nConclusion: OHCA patients had higher plasma concentrations of MMP-9 and TIMP-1 than elective surgery patients. However, the concentrations showed no association with outcome.  \nKeywords: Out-of-hospital cardiac arrest, OHCA, MMP-9, TIMP-1, Inflammation  \nIntroduction  \nCardiac arrest leads to sudden loss of circulation and causes ischemia to which especially the central nervous system is sensitive.1 After successful resuscitation from cardiac arrest, a multi-organ dysfunction called post-cardiac arrest syndrome (PCAS) occurs in some patients.2 It is likely caused by multiple factors, but inflammatory response resembling septic shock, following whole-body ischemia and reperfusion at return of spontaneous circulation (ROSC), plays a substantial part.3 Therefore, inflammatory biomarkers are interesting regarding the development of organ dysfunction and brain injury.4,5  \nAfter out-of-hospital cardiac arrest (OHCA), blood concentrations of matrix metalloproteinase (MMP)-9 are increased,6 but their role has not been properly investigated. In a previous study, MMP-9 and TIMP-1 concentrations were compared between patients treated with therapeutic hypothermia and a control group without targeted temperature management.6 The main finding was that MMP-9 levels decreased during hypothermia but increased again after rewarming. However, only two sampling time points were available, and no admission samples were collected. In addition, the study lacked a control group with underlying cardiovascular pathology, which would have been important for assessing the magnitude of MMP-9 and TIMP-1 changes during acute global ischaemia.6 MMPs are a group of zinc-dependent endopeptidases with collagen cleaving capability  \n* Corresponding author.  \nE-mail address: emilia. kortesuo@tuni.fi (E. Kortesuo) .  \n[https://doi.org/10.1016/j.resplu.2025.101187](https://doi.org/10.1016/j.resplu.2025.101187)  \nReceived 5 September 2025; Received in revised form 30 November 2025; Accepted 2 December 2025  \n2666-5204/􀀁 2025 The Authors. Published by Elsevier B.V. This is an open access article under","cbCaieKCBhS23bda","https://ap.wps.com/l/cbCaieKCBhS23bda","pdf",663033,"English","# Abstract\n# Background and aim\n# Methods\n# Results\n# Conclusion\n# Keywords\n# Introduction\n# Materials and methods","[{\"question\":\"What was the main objective of this substudy?\",\"answer\":\"To determine whether plasma MMP-9 and TIMP-1 concentrations in OHCA patients are elevated and whether they relate to neurological outcome after cardiac arrest and resuscitation.\"},{\"question\":\"How were MMP-9 and TIMP-1 measured, and when were samples collected?\",\"answer\":\"MMP-9 and TIMP-1 concentrations were measured in 112 OHCA patients at ICU admission and at 24, 48, and 72 hours.\"},{\"question\":\"Did MMP-9 or TIMP-1 concentrations predict neurological outcome?\",\"answer\":\"No. Logistic regression showed that neither biomarker demonstrated an association with neurological outcome.\"}]","Association of MMP-9 and TIMP-1 concentration with neurological outcome after cardiac arrest and resuscitation - a substudy of the COMACARE trial | PDF",1790706200]