[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"detail-sidebar-cat-0-en-105":3,"doc-seo-331661-105":59,"doc-detail-331661-en":130},{"code":4,"msg":5,"data":6},0,"success",[7,13,18,23,28,33,38,43,48,51,55],{"id":8,"doc_module":4,"doc_module_name":9,"category_name":10,"show_sort_weight":11,"slug":12},1,"Document","Story & Novel",90,"story-novel",{"id":14,"doc_module":4,"doc_module_name":9,"category_name":15,"show_sort_weight":16,"slug":17},2,"Literature",80,"literature",{"id":19,"doc_module":4,"doc_module_name":9,"category_name":20,"show_sort_weight":21,"slug":22},4,"Exam",70,"exam",{"id":24,"doc_module":4,"doc_module_name":9,"category_name":25,"show_sort_weight":26,"slug":27},5,"Comic",60,"comic",{"id":29,"doc_module":4,"doc_module_name":9,"category_name":30,"show_sort_weight":31,"slug":32},6,"Technology",50,"technology",{"id":34,"doc_module":4,"doc_module_name":9,"category_name":35,"show_sort_weight":36,"slug":37},7,"Healthcare",40,"healthcare",{"id":39,"doc_module":4,"doc_module_name":9,"category_name":40,"show_sort_weight":41,"slug":42},8,"Research & Report",30,"research-report",{"id":44,"doc_module":4,"doc_module_name":9,"category_name":45,"show_sort_weight":46,"slug":47},9,"Religion & Spirituality",20,"religion-spirituality",{"id":46,"doc_module":4,"doc_module_name":9,"category_name":49,"show_sort_weight":46,"slug":50},"World Cup","world-cup",{"id":52,"doc_module":4,"doc_module_name":9,"category_name":53,"show_sort_weight":52,"slug":54},10,"Lifestyle","lifestyle",{"id":56,"doc_module":4,"doc_module_name":9,"category_name":57,"show_sort_weight":24,"slug":58},19,"General","general",{"code":4,"msg":60,"data":61},"ok",{"site_id":62,"language":63,"slug":64,"title":65,"keywords":66,"description":67,"schema_data":68,"social_meta":123,"head_meta":125,"extra_data":127,"updated_unix":129},105,"en","association-of-cardiovascular-disease-on-cancer-observational-and-mendelian-randomization-analyses","Association of cardiovascular disease on cancer - observational and mendelian randomization analyses","","Extensive research is needed to clarify how cardiovascular disease (CVD) relates to cancer. The observational analysis uses data from the 2005–2018 National Health and Nutrition Examination Survey (NHANES) and applies weighted multivariable logistic regression with numerous confounders. Mendelian randomization (MR) is used to infer an unbiased causal relationship, with primary results from inverse variance weighted methods.",{"@graph":69,"@context":122},[70,84,105],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":40,"@type":76,"position":81},"https://docshare.wps.com/document/research-report/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/association-of-cardiovascular-disease-on-cancer-observational-and-mendelian-randomization-analyses/331661/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/association-of-cardiovascular-disease-on-cancer-observational-and-mendelian-randomization-analyses/331661.png","ImageObject",300,407,{"name":92,"@type":93},"Theodora","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-10-23","2026-09-21",true,{"@type":102,"interactionType":103,"userInteractionCount":44},"InteractionCounter",{"@type":104},"ViewAction",{"@type":106,"mainEntity":107},"FAQPage",[108,114,118],{"name":109,"@type":110,"acceptedAnswer":111},"What datasets and statistical approaches are used to study the CVD–cancer relationship?","Question",{"text":112,"@type":113},"The observational component relies on NHANES data from 2005–2018 and uses weighted multivariable logistic regression with many confounding factors. The causal component uses Mendelian randomization, primarily the inverse variance weighted approach.","Answer",{"name":115,"@type":110,"acceptedAnswer":116},"What did observational analysis show about the CVD–cancer association?",{"text":117,"@type":113},"A positive cross-sectional correlation was reported between CVD and cancer in the specified model results (Model 3), including an odds ratio with a statistically significant p value.",{"name":119,"@type":110,"acceptedAnswer":120},"How did Mendelian randomization change the interpretation of causality between CVD and cancer?",{"text":121,"@type":113},"MR indicated a negative causal relationship for certain CVD subtypes with specific cancers, and it found a reverse direction where prostate cancer showed a positive correlation with angina pectoris. The overall implication is that genetically informed risk estimates can differ from observational associations.","https://schema.org",{"og:url":83,"og:type":124,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":126,"canonical":83},"index,follow",{"doc_id":128,"site_id":62},331661,1790190590,{"code":4,"msg":5,"data":131},{"doc_id":128,"user_id":132,"nickname":92,"user_avatar":133,"doc_module":4,"category_id":39,"category_name":40,"doc_title":65,"doc_description":67,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":44,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":139,"language":140,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":141,"faqs":142,"seo_title":143,"seo_description":67,"update_tm":144,"read_time":41,"preview_page_count":4},687197207919,"https://ap-avatar.wpscdn.com/avatar/a000253d6f5f7c60be?x-image-process=image/resize,m_fixed,w_180,h_180&k=1779446848396160552","[www. nature.com/scientificreports](www. nature.com/scientificreports)  \nOPEN  \nAssociation of cardiovascular disease on cancer: observational and mendelian randomization analyses  \nTongtong Bai1 & ChengyuWu2􀀍  \nExtensive research is needed to examine the association between cardiovascular disease (CVD) and cancer. The observational study is based on data collected from the 2005–2018 National Health and Nutrition Examination Survey (NHANES). To assess the connection between CVDs and cancer, we used a weighted multivariable logistic regression analysis with as many confounding factors as feasible included in the model. By employing Mendelian randomization (MR), the unbiased causal relationship between CVDs and cancers was ascertained. The primary analytical approach employed the Inverse Variance Weighted methodology. In cross-sectional study, a positive correlation was observed between CVD and cancer (Model 3, Odds ratio 1.26, 95% confidence interval 1.01 ~ 1.57, p = 0.040) . However, MR analysis indicated a negative causal relationship between certain subtypes ofCVD and specific cancers, with effect sizes for coronary heart disease and lung cancer (β = − 4.759, p = 0.002), breast cancer (β = − 2.684, p = 0.026), colorectal cancer (β = − 4.581, p = 0.042), liver cancers (β =− 19.264, p = 0.028), and stroke with prostate cancer (β = − 0.299, p = 0.017), with no evidence of a positive correlation. Results from the reverse MR causal analysis revealed a positive correlation between prostate cancer and angina pectoris. An observational study linked CVDs risk to cancer risk. MR analysis has shown that the expected incidence ofCVDs can reduce the probability of developing certain forms of cancer. Further investigation is required to examine the clinical correlations and underlying processes between these two illnesses.  \nKeywords Cardiovascular disease, Cancer, Observational study, Mendelian randomization  \nCancer stands as a major contributor to mortality, placing a considerable burden on affected individuals, their families, and society as a whole1,2. The most commonly diagnosed cancers globally are lung, breast, colorectal, prostate, and stomach, while the leading causes of cancer-related mortality are lung, breast, colorectal, liver, and stomach cancers. These specific cancers typically contribute to a substantial disease burden3. The cause of cancer is complex and involves multiple factors. It is also linked to various chronic disorders, including cardiovascular diseases (CVD) and diabetes4,5.  \nThe correlation between cancer and cardiovascular illnesses has received significant attention in recent years. CVD and an increased risk of developing non-small cell lung cancer, specifically adenocarcinoma and squamous cell carcinoma, were conclusively linked in a study of 455,804 adults from the UK Biobank cohort6. The risk of CVD mortality is heightened in individuals with localized cancers, which are classified as highcompeting cancers, according to a cohort study utilizing data from the Surveillance, Epidemiology, and End Results (SEER) database encompassing 1,672,561 patients with non-metastatic cancer from 1975 to 20187. The results from these previous cohort studies indicate that CVD and cancer are not only associated with eachother but may also influence the development of one another. These conditions share similar pathophysiological pathways, including inflammation, neurohormonal activation, and oxidative stress, in addition to a multitude of overlapping risk factors, including obesity, diabetes, hyperlipidemia, and lifestyle choices8–11. Moreover, specific cancer therapies can result in cardiotoxicity, thus heightening the likelihood of cardiovascular disease in individuals who have survived cancer12. The underlying mechanisms ofthis association are intricate. The existing evidence regarding the association between CVDs and cancer has certain limitations, including a lack of large-  \n1 Dongfang Hospital, Beijing University of","cbCaidwIIuhevRzm","https://ap.wps.com/l/cbCaidwIIuhevRzm","pdf",1932788,12,"English","# Methods\n## Overall study design","[{\"question\":\"What datasets and statistical approaches are used to study the CVD–cancer relationship?\",\"answer\":\"The observational component relies on NHANES data from 2005–2018 and uses weighted multivariable logistic regression with many confounding factors. The causal component uses Mendelian randomization, primarily the inverse variance weighted approach.\"},{\"question\":\"What did observational analysis show about the CVD–cancer association?\",\"answer\":\"A positive cross-sectional correlation was reported between CVD and cancer in the specified model results (Model 3), including an odds ratio with a statistically significant p value.\"},{\"question\":\"How did Mendelian randomization change the interpretation of causality between CVD and cancer?\",\"answer\":\"MR indicated a negative causal relationship for certain CVD subtypes with specific cancers, and it found a reverse direction where prostate cancer showed a positive correlation with angina pectoris. The overall implication is that genetically informed risk estimates can differ from observational associations.\"}]","Association of cardiovascular disease on cancer - observational and mendelian randomization analyses | PDF",1789994490]