[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"detail-sidebar-cat-0-en-105":3,"doc-seo-372605-105":59,"doc-detail-372605-en":131},{"code":4,"msg":5,"data":6},0,"success",[7,13,18,23,28,33,38,43,48,51,55],{"id":8,"doc_module":4,"doc_module_name":9,"category_name":10,"show_sort_weight":11,"slug":12},1,"Document","Story & Novel",90,"story-novel",{"id":14,"doc_module":4,"doc_module_name":9,"category_name":15,"show_sort_weight":16,"slug":17},2,"Literature",80,"literature",{"id":19,"doc_module":4,"doc_module_name":9,"category_name":20,"show_sort_weight":21,"slug":22},4,"Exam",70,"exam",{"id":24,"doc_module":4,"doc_module_name":9,"category_name":25,"show_sort_weight":26,"slug":27},5,"Comic",60,"comic",{"id":29,"doc_module":4,"doc_module_name":9,"category_name":30,"show_sort_weight":31,"slug":32},6,"Technology",50,"technology",{"id":34,"doc_module":4,"doc_module_name":9,"category_name":35,"show_sort_weight":36,"slug":37},7,"Healthcare",40,"healthcare",{"id":39,"doc_module":4,"doc_module_name":9,"category_name":40,"show_sort_weight":41,"slug":42},8,"Research & Report",30,"research-report",{"id":44,"doc_module":4,"doc_module_name":9,"category_name":45,"show_sort_weight":46,"slug":47},9,"Religion & Spirituality",20,"religion-spirituality",{"id":46,"doc_module":4,"doc_module_name":9,"category_name":49,"show_sort_weight":46,"slug":50},"World Cup","world-cup",{"id":52,"doc_module":4,"doc_module_name":9,"category_name":53,"show_sort_weight":52,"slug":54},10,"Lifestyle","lifestyle",{"id":56,"doc_module":4,"doc_module_name":9,"category_name":57,"show_sort_weight":24,"slug":58},19,"General","general",{"code":4,"msg":60,"data":61},"ok",{"site_id":62,"language":63,"slug":64,"title":65,"keywords":66,"description":67,"schema_data":68,"social_meta":124,"head_meta":126,"extra_data":128,"updated_unix":130},105,"en","association-of-abo-and-rhesus-blood-groups-with-oral-cancers-review","Association of ABO and Rhesus Blood Groups - With Oral Cancers - Review","","The ABO and Rhesus blood systems are extensively investigated for links to human diseases, including cancer. Emerging findings indicate that ABO blood group may affect susceptibility to oral potentially malignant disorders (OPMDs) and oral cancers, especially oral squamous cell carcinoma (OSCC). This review synthesizes evidence from epidemiological, molecular, and immunological studies to clarify biological mechanisms that may explain the relationship between ABO/Rh phenotypes and oral malignancies.",{"@graph":69,"@context":123},[70,84,106],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":35,"@type":76,"position":81},"https://docshare.wps.com/document/healthcare/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/association-of-abo-and-rhesus-blood-groups-with-oral-cancers-review/372605/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/association-of-abo-and-rhesus-blood-groups-with-oral-cancers-review/372605.png","ImageObject",300,407,{"name":92,"@type":93},"McQueen","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-10-31","2026-09-23",true,{"@type":102,"interactionType":103,"userInteractionCount":105},"InteractionCounter",{"@type":104},"ViewAction",11,{"@type":107,"mainEntity":108},"FAQPage",[109,115,119],{"name":110,"@type":111,"acceptedAnswer":112},"What is the focus of this review on ABO and Rhesus blood groups?","Question",{"text":113,"@type":114},"It summarizes how ABO and Rhesus blood group phenotypes relate to oral cancers and oral potentially malignant disorders.","Answer",{"name":116,"@type":111,"acceptedAnswer":117},"Which oral cancer type is specifically highlighted in the evidence?",{"text":118,"@type":114},"Oral squamous cell carcinoma (OSCC) is specifically emphasized as a key cancer in the association discussed.",{"name":120,"@type":111,"acceptedAnswer":121},"What types of studies does the review integrate to explain the association?",{"text":122,"@type":114},"It integrates epidemiological, molecular, and immunological studies to propose potential biological mechanisms.","https://schema.org",{"og:url":83,"og:type":125,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":127,"canonical":83},"index,follow",{"doc_id":129,"site_id":62},372605,1790261870,{"code":4,"msg":5,"data":132},{"doc_id":129,"user_id":133,"nickname":92,"user_avatar":134,"doc_module":4,"category_id":34,"category_name":35,"doc_title":65,"doc_description":67,"doc_content":135,"file_id":136,"file_url":137,"file_type":138,"file_size":139,"view_count":105,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":39,"language":140,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":141,"faqs":142,"seo_title":143,"seo_description":67,"update_tm":144,"read_time":46},5909890329169,"https://ap-avatar.wpscdn.com/davatar_9964176cb1d06d4a9deccf72a44ae3dc","Review J Clin Med Res. 2025;17(7):357-364  \nAssociation of ABO and Rhesus Blood Groups  \nWith Oral Cancers  \nKhaldun Jacouba, Ali Abdelfattaha, b, c  \nAbstract  \nThe ABO and Rhesus blood systems have been studied extensively in relation to various diseases, including cancers. Recent evidence suggests that ABO blood group may influence susceptibility to oral potentially malignant disorders (OPMDs) and oral cancers, particularly oral squamous cell carcinoma (OSCC) . The current review explores the association of ABO and Rhesus blood groups with oral cancers, summarizing epidemiological, molecular, and immunological studies to elucidate potential mechanisms underlying this relationship.  \nKeywords: ABO blood group; Oral cancers; Oral potentially malignant disorders; Rhesus blood groups  \nIntroduction  \nOral cancer is a significant global health concern, accounting for a considerable number of cancer-related morbidity and mortality. While early detection improves survival outcomes, addressing risk factors such as tobacco use, alcohol consumption, and viral infections is essential for effective prevention and control. However, genetic and hereditary predispositions, including ABO and Rhesus (Rh) blood groups, have emerged as potential factors influencing susceptibility and prognosis of oral potentially malignant disorders (OPMDs) and oral cancers. This review provides an up-to-date synthesis of the correlation between ABO/Rh blood group phenotypes and oral malignancies, integrating epidemiological, molecular, and immunological studies to elucidate the potential biological mechanisms underlying this association.  \nManuscript submitted May 12, 2025, accepted July 9, 2025 Published online July 31, 2025  \naDepartment of Medical Laboratory Sciences, Faculty of Applied Medical Sciences, The Hashemite University, Zarqa 13133, Jordan  \nbEuropean Cancer Stem Cell Research Institute, Cardiff University, School of Biosciences, Cardiff, UK  \ncCorresponding Author: Ali Abdelfattah, Department of Medical Laboratory Sciences, Faculty of Applied Medical Sciences, The Hashemite University, Zarqa 13133, [Jordan. Email: Alisharif@hu.edu.jo](Jordan. Email: Alisharif@hu.edu.jo)  \ndoi: [https://doi.org/10.14740/jocmr6276](https://doi.org/10.14740/jocmr6276)  \nThe ABO Blood Group System and Its Link to Diseases  \nThe ABO blood group antigens, in addition to their expression on erythrocytes, are also prominently expressed on various human cell types, including sensory neurons, platelets, and vascular endothelial cells [1] . Erythrocyte cell surface antigens play a crucial role in maintaining membrane structural integrity, facilitating cell motility, mediating tissue differentiation, participating in inflammatory responses, transporting molecules across the membranes, and enabling cell adhesion [2-4] . The ABO blood group system was first identified by Karl Landsteinner in 1900 [5] . This system comprises three antigens (A, B, and H) and categorizes individuals into four major groups based on the presence or absence of these antigens on the surface of erythrocytes: A (presence of agglutinogen A), B (presence of agglutinogen B), AB (presence of both A and B agglutinogens), and O (absence of both A and B agglutinogens) [5, 6] . The ABO gene is located on chromosome 9, specifically at locus q34.1 to q34.2, and encodes glycosyltransferase responsible for antigen synthesis [7, 8] . These antigens are oligosaccharides expressed on the extracellular surface of the erythrocyte membrane. The A antigen is characterized by the presence of N-acetylgalactosamine (GalNAc), while the B antigen is defined by galactose (Gal) [7, 8] . These sugars are enzymatically transferred to a precursor structure, the H antigen, under the regulation of the ABO gene. In epithelial tissues, ABH antigens are carbohydrate-based and exhibit highly regulated expression patterns associated with epithelial differentiation and cell maturation [9] . Following the ABO system, the Rh blood group s","cbCaii8FjN4Q8dEf","https://ap.wps.com/l/cbCaii8FjN4Q8dEf","pdf",379114,"English","# Abstract\n# Introduction\n# The ABO Blood Group System and Its Link to Diseases","[{\"question\":\"What is the focus of this review on ABO and Rhesus blood groups?\",\"answer\":\"It summarizes how ABO and Rhesus blood group phenotypes relate to oral cancers and oral potentially malignant disorders.\"},{\"question\":\"Which oral cancer type is specifically highlighted in the evidence?\",\"answer\":\"Oral squamous cell carcinoma (OSCC) is specifically emphasized as a key cancer in the association discussed.\"},{\"question\":\"What types of studies does the review integrate to explain the association?\",\"answer\":\"It integrates epidemiological, molecular, and immunological studies to propose potential biological mechanisms.\"}]","Association of ABO and Rhesus Blood Groups - With Oral Cancers - Review | PDF",1790194928]