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In the NIH-funded ASCEND study, cognitively normal middle-aged adults with a parental history of AD were assessed using the Perceived Stress Scale and related to CSF biomarkers of Aβ and tau, MMP-2, vascular markers, and inflammation markers, alongside blood inflammatory measures and cognition testing. Higher perceived stress correlated with increased central and systemic inflammation and with Aβ1-42, while also associating with lower backwards Digit Span performance.",{"@graph":69,"@context":123},[70,84,106],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":35,"@type":76,"position":81},"https://docshare.wps.com/document/healthcare/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/association-between-perceived-stress-and-alzheimers-biomarkers-in-a-cohort-of-middle-aged-high-risk-adults-poster-presentation/456228/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/association-between-perceived-stress-and-alzheimers-biomarkers-in-a-cohort-of-middle-aged-high-risk-adults-poster-presentation/456228.png","ImageObject",300,407,{"name":92,"@type":93},"4398046744996","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-11-02","2026-09-30",true,{"@type":102,"interactionType":103,"userInteractionCount":105},"InteractionCounter",{"@type":104},"ViewAction",13,{"@type":107,"mainEntity":108},"FAQPage",[109,115,119],{"name":110,"@type":111,"acceptedAnswer":112},"What is the central focus of this poster presentation?","Question",{"text":113,"@type":114},"It examines how perceived stress relates to Alzheimer’s disease biomarkers and cognition in middle-aged adults at high risk with parental history of AD.","Answer",{"name":116,"@type":111,"acceptedAnswer":117},"How were stress and cognition measured?",{"text":118,"@type":114},"Perceived stress was assessed using the 10-question Perceived Stress Scale (PSS), and cognition was measured using the Digit Span task, including backwards Digit Span.",{"name":120,"@type":111,"acceptedAnswer":121},"What associations were found between PSS and biomarkers?",{"text":122,"@type":114},"PSS was positively correlated with IL-7, IL-12, MMP-2, VCAM-1, and Aβ1-42, and negatively correlated with correct answers on backwards Digit Span.","https://schema.org",{"og:url":83,"og:type":125,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":127,"canonical":83},"index,follow",{"doc_id":129,"site_id":62},456228,1790816148,{"code":4,"msg":5,"data":132},{"doc_id":129,"user_id":133,"nickname":92,"user_avatar":66,"doc_module":4,"category_id":34,"category_name":35,"doc_title":65,"doc_description":67,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":105,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":14,"language":139,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":140,"faqs":141,"seo_title":142,"seo_description":67,"update_tm":143,"read_time":24,"preview_page_count":4},4398046744996,"DOI: 10. 1002/alz70856_106513  \nBIOMARKERS  \nPOSTER PRESENTATION  \nBIOMARKERS (NON-NEUROIMAGING)  \nAssociation Between Perceived Stress and Alzheimer’s Biomarkers in a Cohort of Middle-Aged, High-Risk Adults  \nChloe Park1  Whitney Wharton 1  William T. Hu2  Hanfeng Huang3 Patrick Gavin Kehoe4  James Scott Miners5  Danielle D Verble 1   \nHenrik Zetterberg6 Karima Benameur9  \nBruno L. Hammerschlag7 Brittany Butts 1  \nLynn Marie Trotti8  \n1 Emory University, Atlanta, GA, USA  \n2 Rutgers-Robert Wood Johnson Medical School, New Brunswick, NJ, USA  \n3 Georgetown University School of Medicine, Washington, DC, USA  \n4 University of Bristol, Bristol, United Kingdom  \n5 University of Bristol, Bristol, Horfield, United Kingdom  \n6 Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, The Sahlgrenska Academy, University of Gothenburg, Mölndal, Sweden  \n7AthinoulaA. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA, USA  \n8 Emory University School of Medicine, Atlanta, GA, USA  \n9 Emory University, Altanta, GA, USA  \nCorrespondence  \nChloe Park, Emory University, Atlanta, GA, USA.  \n[Email:](Email: chloe.park@emory.edu)[ chloe.park@emory.edu](Email: chloe.park@emory.edu)  \nAbstract  \nBackground: Studies suggest a chronic stress-activated pathway in the development of Alzheimer’s disease (AD) and cognitive decline, underscoring the need to better understand mechanisms of stress and downstream impacts. Inflammation andvascular dysfunction caused by subjective stress may contribute to pathology in AD. Here, we investigated how stress relates to AD biomarkers and cognition in a cohort of B/AA (Black/African Americans) and NHW (non-Hispanic White) participants in the NIH-funded ASCEND study.  \nMethod: Cognitively normal, middle-aged (45-65 years) B/AA and NHW adults with a parental history ofAD were enrolled ina2-year observational study. CSF was collected for measurement of Aβ and tau, MMPs (MMP-2), and markers of vascular function (sPDGFRβ, VCAM-1) and inflammation (IL-7). At the same visit, blood was collected for APOE genotyping and inflammatory markers (IL-12), in addition to the Digit Span for measurement of cognition. The 10-question Perceived Stress Scale (PSS) assessed perceived stress.  \nResult: Participants (N = 50, mean age 58 ± 7 years) were mostly female (66%), welleducated (84% college or higher), 36% earning ≥ $40K, 30% B/AA, and 48% APOE ε4 positive. PSS was positively correlated with IL-7 (r=.392, p = .024), IL-12 (r=.375, p = .021), MMP-2 (r=.333, p = .029), VCAM-1 (r=.352, p = .033), and Aβ1-42 (r=.328, p = .032), and negatively correlated with the number correct on backwards Digit Span (r= -.365, p = .009). Linear models showed sPDGFRβ was positively associated with MMP-2 (r=.409, p = .008) and VCAM-1 (r=.473, p = .005).  \nConclusion: Higher perceived stress was associated with higher central and systemic inflammation in a cohort of cognitively normal, middle-aged individuals at risk for AD.  \nThis is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.  \n© 2025 The Alzheimer’s Association. Alzheimer’s & Dementia published by Wiley Periodicals LLC on behalf of Alzheimer’s Association.  \nAlzheimer’s Dement. 2025;21(Suppl. 2):e106513.  \n[https://doi.org/10.1002/alz70856_106513](https://doi.org/10.1002/alz70856_106513)  \nwi[leyonlinelibrary.com/journal/alz](leyonlinelibrary.com/journal/alz)  \n1of2  \nBIOMARKERS  \nStress was associated with CSF markers of MMP-2, linked with early AD pathology, and VCAM-1, which is involved in vascular dysfunction. SPDGFRβ in CSF was also positively correlated with MMP-2 and VCAM-1, suggesting that these processes may elicit blood brain barrier breakdown. The correlation between stress and Aβ1-42 reflects that participants were cognitively unimpaired, but higher st","cbCain8IFYFLg1nm","https://ap.wps.com/l/cbCain8IFYFLg1nm","pdf",97622,"English","# Abstract\n## Background\n## Method\n## Result\n## Conclusion\n## Notes","[{\"question\":\"What is the central focus of this poster presentation?\",\"answer\":\"It examines how perceived stress relates to Alzheimer’s disease biomarkers and cognition in middle-aged adults at high risk with parental history of AD.\"},{\"question\":\"How were stress and cognition measured?\",\"answer\":\"Perceived stress was assessed using the 10-question Perceived Stress Scale (PSS), and cognition was measured using the Digit Span task, including backwards Digit Span.\"},{\"question\":\"What associations were found between PSS and biomarkers?\",\"answer\":\"PSS was positively correlated with IL-7, IL-12, MMP-2, VCAM-1, and Aβ1-42, and negatively correlated with correct answers on backwards Digit Span.\"}]","Association Between Perceived Stress and Alzheimer’s Biomarkers in a Cohort of Middle-Aged, High-Risk Adults - Poster Presentation | PDF",1790745384]