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Obesity defined as BMI ≥ 25 kg/m2 was assessed for odds of non-AIDS-defining and AIDS-defining cancers.",{"@graph":14,"@context":73},[15,34,56],{"@type":16,"itemListElement":17},"BreadcrumbList",[18,23,27,31],{"item":19,"name":20,"@type":21,"position":22},"https://docshare.wps.com","Home","ListItem",1,{"item":24,"name":25,"@type":21,"position":26},"https://docshare.wps.com/document/","Document",2,{"item":28,"name":29,"@type":21,"position":30},"https://docshare.wps.com/document/research-report/","Research & 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Janga,b, Taehwa Kima,c, Yunsu Choia, Kyoung Hwan Ahna, Jung Ho Kimd, Hye Seonge, Youn Jeong Kimf, Shin-Woo Kimg,  \nJun Yong Choid, Hyo Youl Kimh, Joon Young Songe, Hee Jung Choii, Sang Il. Kimj, Jang Wook Sohne, BumSik Chink, Bo-Youl Choia  \nand Boyoung Parka  \nIntroduction: This study aimed to investigate the association between obesity and cancer risk as well as site-speciﬁc cancer risks in adults with HIV using a nationwide  \nhealth screening database in Korea.  \nMethods: Of the 16,671 adults with a new diagnosis of HIV from 2004 to 2020, 456 incident cancer cases and 1814 individually matched controls by sex, year of birth, year of HIV diagnosis, and follow-up duration (1:4 ratio) were included in this nested case– control study. The association between obesity (BMI 􀀁25kg/m2) and cancer risks was estimated and presented as odds ratios (ORs) and 95% conﬁdence intervals (95% CIs) .  \nResults: Of the 456 cancer incident cases, there were 146 AIDS-deﬁning cancer cases and 310 non-AIDS-deﬁning cancer cases. Compared with nonobese adults with HIV, obese adults with HIV were at higher risk of non-AIDS-deﬁning cancer (OR ¼ 1.478, 95% CI ¼ 1.118–1.955) . Otherwise, the overall risk of AIDS-deﬁning cancer (OR ¼ 0.816, 95% CI ¼ 0.520–1.279) and each type of AIDS-deﬁning cancer (Kaposi sarcoma and non-Hodgkin’s lymphoma) were not high in obese adults with HIV. Of the speciﬁc types of non-AIDS-deﬁning cancers, obesity was associated with an increased risk of colorectal cancer (OR ¼ 3.090, 95% CI ¼ 1.110–8. 604) and liver, bile duct, and  \npancreatic cancers (OR ¼ 2.532, 95% CI ¼ 1.141–5.617) .  \nConclusion: Obesity, which is one of the important health concerns in HIV management, was associated with an increased risk of non-AIDS-deﬁning cancer but not AIDS  \ndeﬁning cancer.  \nCopyright © 2024 The Author(s) . Published by Wolters Kluwer Health, Inc.  \nAIDS 2024, 38 : 1386–1394  \nKeywords: AIDS, AIDS-deﬁning cancer, HIV,  \nnon-AIDS-deﬁning cancer, obesity  \n1386  \na Department of Preventive Medicine, Hanyang University College of Medicine, b Department of Agricultural Economics and Rural Development, Seoul National University, c Department of Psychology, Sungkyunkwan University, d Department of Internal Medicine and AIDS Research Institute, Yonsei University College of Medicine, e Division of Infectious Diseases, Department of Internal Medicine, Korea University College of Medicine, Seoul, fDivision of Infectious Disease, Department of Internal Medicine, Incheon St. Mary’s Hospital, College of Medicine, The Catholic University of Korea, Incheon, g Department of Internal Medicine, School of Medicine, Kyungpook National University, Daegu, h Division of Infectious Diseases, Department of Internal Medicine, Yonsei University Wonju College of Medicine, Wonju, i Division of Infectious Diseases, Department of Internal Medicine, Ewha Womans University College of Medicine, j Division of Infectious Disease, Department of Internal Medicine, Seoul St. Mary’s Hospital, College of Medicine, The Catholic University of Korea, and k Division of Infectious Diseases, Department of Internal Medicine, National Medical Center, Seoul, Korea.  \nCorrespondence to Boyoung Park, MD, PhD, Department of Preventive Medicine, Hanyang University College of Medicine, 222 Wangsimni-ro, Seongdong-gu, Seoul 04763, Republic of Korea.  \nTel: +82 2 2220 0682; fax: +82 31 2220 0699; e-mail: [hayejine@hanmail.net](hayejine@hanmail.net)  \n[Received: 10 December 2023](Received: 10 December 2023); [revised: 21 February 2024](revised: 21 February 2024); [accepted: 29 February 2024](accepted: 29 February 2024) .  \nDOI:10.1097/QAD.0000000000003904  \nISSN 0269-9370 Copyright Q 2024 The Author(s). Published by Wolters Kluwer Health, Inc. This is an open access article distributed under the terms of the Creative Commons Attribution-Non Commercial-No Derivatives License 4.0 (CCBY-NC-ND), where it is per","cbCaidodG52FClyo","https://ap.wps.com/l/cbCaidodG52FClyo","pdf",494820,"English","# Introduction\n# Methods\n# Results\n# Conclusion","[{\"question\":\"What is the main objective of the study?\",\"answer\":\"To assess the association between obesity and cancer risk, including site-specific cancer risks, in adults with HIV in Korea.\"},{\"question\":\"How were participants selected and matched in the analysis?\",\"answer\":\"From 16,671 adults with newly diagnosed HIV (2004–2020), 456 incident cancer cases were included and matched 1:4 with 1,814 controls by sex, year of birth, year of HIV diagnosis, and follow-up duration.\"},{\"question\":\"What did the results show about obesity and cancer types?\",\"answer\":\"Obese adults had a higher risk of non-AIDS-defining cancer, with increased risks for colorectal cancer and liver, bile duct, and pancreatic cancers, while overall AIDS-defining cancer risk and specific AIDS-defining cancers were not elevated.\"}]","Association between obesity and cancer risk in adults with HIV in Korea | PDF",1789997209,23]