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A nationally representative sample of 19,460 males (weighted N=50,842,517) aged ≥50 was analyzed by user category: cannabis-only, classic psychedelic-only, co-users, and non-users. Physician-diagnosed prostate cancer served as the outcome. Multivariable logistic regression estimated adjusted odds ratios after controlling socio-demographic, behavioral, and clinical covariates, with further age stratification.",{"@graph":69,"@context":122},[70,84,105],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":35,"@type":76,"position":81},"https://docshare.wps.com/document/healthcare/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/association-between-lifetime-couse-of-classic-psychedelics-and-cannabis-and-prostate-cancer-diagnosis-among-us-adults-50-years-and-older/369021/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/association-between-lifetime-couse-of-classic-psychedelics-and-cannabis-and-prostate-cancer-diagnosis-among-us-adults-50-years-and-older/369021.png","ImageObject",300,407,{"name":92,"@type":93},"LangkahRina","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-10-29","2026-09-23",true,{"@type":102,"interactionType":103,"userInteractionCount":34},"InteractionCounter",{"@type":104},"ViewAction",{"@type":106,"mainEntity":107},"FAQPage",[108,114,118],{"name":109,"@type":110,"acceptedAnswer":111},"What data source and population were used in the study?","Question",{"text":112,"@type":113},"The analysis used 2015–2019 National Survey on Drug Use and Health (NSDUH) data and included a nationally representative sample of 19,460 males aged 50 years and older.","Answer",{"name":115,"@type":110,"acceptedAnswer":116},"How was prostate cancer measured as the study outcome?",{"text":117,"@type":113},"Prostate cancer was defined as self-report of physician-diagnosed prostate cancer.",{"name":119,"@type":110,"acceptedAnswer":120},"What did the study find about classic psychedelic use and prostate cancer odds?",{"text":121,"@type":113},"Exclusive classic psychedelic use was associated with higher odds of prostate cancer compared with non-users, including a higher odds estimate among participants aged 65 and older.","https://schema.org",{"og:url":83,"og:type":124,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":126,"canonical":83},"index,follow",{"doc_id":128,"site_id":62},369021,1790789207,{"code":4,"msg":5,"data":131},{"doc_id":128,"user_id":132,"nickname":92,"user_avatar":133,"doc_module":4,"category_id":34,"category_name":35,"doc_title":65,"doc_description":67,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":34,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":139,"language":140,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":141,"faqs":142,"seo_title":143,"seo_description":67,"update_tm":144,"read_time":41},962090893776,"https://ap-avatar.wpscdn.com/davatar_155a257f0dc6eb9ab79c44ca47cae57d","[www. nature.com/scientificreports](www. nature.com/scientificreports)  \nOPEN  \nAssociation between lifetime couse of classic psychedelics and cannabis and prostate cancer diagnosis among US adults 50 years and older  \nAmrit Baral1,2,3,4􀀍, Yue Pan1, WayWay M. Hlaing1, Albert Garcia-Romeu5,6, Paulo S. Pinheiro1,3 & Denise C. Vidot1,3,4  \nProstate cancer is the second [leading cause of cancer-related deaths among U.S. men. While cannabis](leading cause of cancer-related deaths among U.S. men. While cannabis)[ ](leading cause of cancer-related deaths among U.S. men. While cannabis)and classic psychedelics gain attention for symptom management in oncology, their associations with prostate cancer remain unexplored. This study evaluates associations between lifetime classic psychedelic and cannabis use with prostate cancer diagnoses among older U.S. adults using 2015– 2019 National Survey on Drug Use and Health (NSDUH) data. A nationally representative sample of 19,460 males (weighted N = 50,842,517) aged ≥ 50 years was included in the analysis. Participants were categorized as: cannabis-only users, classic psychedelic-only users, co-users, and non-users. The primary outcome was self-report of physician-diagnosed prostate cancer. Multivariable logistic regression models estimated the adjusted odds ratios (AORs) for lifetime use and prostate cancer, adjusting for socio-demographic, behavioral, and clinical covariates, and analyses further stratified by age. Among participants, 3.9% reported prostate cancer. Exclusive classic psychedelic use was associated with increased odds of prostate cancer (AOR: 2.62, 95% CI: 1.31–5.22, p \u003C 0.01) versus non-users. Among those ≥ 65, classic psychedelic-only use was also associated with higher odds (AOR: 3.60, 95% CI: 1.71–7.55, p \u003C 0.01) of prostate cancer than non-users. Classic psychedelic-only users had higher odds of prostate cancer versus co-users (AOR: 4.58, 95% CI: 1.89–11.1, p \u003C 0.01) .  \nThis study identified a novel association between classic psychedelic use and prostate cancer in older adults. Future research should explore reasons for use, potential biological mechanisms, and consider longitudinal studies to clarify causality.  \nKeywords Classic psychedelic, Cannabis, Co-use, Prostate cancer, Older adults, NSDUH  \nProstate cancer is the most commonly diagnosed cancer among men in the United States (U.S.), excluding skin cancer, and is the second leading cause of cancer-related deaths [in U.S. men](in U.S. men1)[1](in U.S. men1),2. It is the most frequently diagnosed cancer in men in 112 countries, accounting for 15% of all cancers3. The incidence and mortality of prostate cancer increase with age, with an average age at diagnosis being 65 years4. By 2040, it is estimated that there will be 2,293,818 new cases globally4. This rising burden of prostate cancer is largely attributed to population aging and economic growth5. In 2021, prostate cancer incidence increased markedly with age, with 6% of cases diagnosed in men aged 45–54 years, 52% in those aged 55–69 years, and 42% in men aged 70 years and older6. Prostate cancer has an excellent prognosis, with an overall five-year relative survival rate of 97.9% in the U.S . Survival is highest for localized and regional diseases (100%) but drops to 37.9% for distant stage disease7.  \n1Division of Epidemiology, Department of Public Health Sciences, University of Miami Miller School of Medicine, Miami, FL, USA. 2Department of Mental Health, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD, USA. 3Sylvester Comprehensive Cancer Center, University of Miami Miller School of Medicine, Miami, FL, USA. 4Global Cannabis and Psychedelics Research Collaboratory, School of Nursing and Health Studies, University of Miami, Coral Gables, FL, USA. 5Center for Psychedelic and Consciousness Research, Johns Hopkins University, Baltimore, MD, USA. 6Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medi","cbCaif2XBQxuOrHN","https://ap.wps.com/l/cbCaif2XBQxuOrHN","pdf",2248211,12,"English","# Background\n## Prostate cancer burden and prognosis\n## Rationale for studying cannabis and classic psychedelics\n# Study design and methods\n## Data source and sample\n## User categories and outcome definition\n## Statistical analysis\n# Results\n## Association for classic psychedelic-only users\n## Age-stratified findings\n# Discussion and future directions","[{\"question\":\"What data source and population were used in the study?\",\"answer\":\"The analysis used 2015–2019 National Survey on Drug Use and Health (NSDUH) data and included a nationally representative sample of 19,460 males aged 50 years and older.\"},{\"question\":\"How was prostate cancer measured as the study outcome?\",\"answer\":\"Prostate cancer was defined as self-report of physician-diagnosed prostate cancer.\"},{\"question\":\"What did the study find about classic psychedelic use and prostate cancer odds?\",\"answer\":\"Exclusive classic psychedelic use was associated with higher odds of prostate cancer compared with non-users, including a higher odds estimate among participants aged 65 and older.\"}]","Association between lifetime couse of classic psychedelics and cannabis and prostate cancer diagnosis among US adults 50 years and older | PDF",1790180209]