[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"detail-sidebar-cat-0-en-105":3,"doc-seo-448024-105":59,"doc-detail-448024-en":130},{"code":4,"msg":5,"data":6},0,"success",[7,13,18,23,28,33,38,43,48,51,55],{"id":8,"doc_module":4,"doc_module_name":9,"category_name":10,"show_sort_weight":11,"slug":12},1,"Document","Story & Novel",90,"story-novel",{"id":14,"doc_module":4,"doc_module_name":9,"category_name":15,"show_sort_weight":16,"slug":17},2,"Literature",80,"literature",{"id":19,"doc_module":4,"doc_module_name":9,"category_name":20,"show_sort_weight":21,"slug":22},4,"Exam",70,"exam",{"id":24,"doc_module":4,"doc_module_name":9,"category_name":25,"show_sort_weight":26,"slug":27},5,"Comic",60,"comic",{"id":29,"doc_module":4,"doc_module_name":9,"category_name":30,"show_sort_weight":31,"slug":32},6,"Technology",50,"technology",{"id":34,"doc_module":4,"doc_module_name":9,"category_name":35,"show_sort_weight":36,"slug":37},7,"Healthcare",40,"healthcare",{"id":39,"doc_module":4,"doc_module_name":9,"category_name":40,"show_sort_weight":41,"slug":42},8,"Research & Report",30,"research-report",{"id":44,"doc_module":4,"doc_module_name":9,"category_name":45,"show_sort_weight":46,"slug":47},9,"Religion & Spirituality",20,"religion-spirituality",{"id":46,"doc_module":4,"doc_module_name":9,"category_name":49,"show_sort_weight":46,"slug":50},"World Cup","world-cup",{"id":52,"doc_module":4,"doc_module_name":9,"category_name":53,"show_sort_weight":52,"slug":54},10,"Lifestyle","lifestyle",{"id":56,"doc_module":4,"doc_module_name":9,"category_name":57,"show_sort_weight":24,"slug":58},19,"General","general",{"code":4,"msg":60,"data":61},"ok",{"site_id":62,"language":63,"slug":64,"title":65,"keywords":66,"description":67,"schema_data":68,"social_meta":123,"head_meta":125,"extra_data":127,"updated_unix":129},105,"en","association-between-hydration-status-and-mortality-in-elderly-obese-critically-ill-patients-with-acute-kidney-injury-a-retrospective-cohort-study-article-focus-study","Association between hydration status and mortality in elderly obese critically ill patients with acute kidney injury: A retrospective cohort study - Article focus - study","","Fluid management in elderly obese critically ill patients with acute kidney injury is difficult because standard weight-based formulas can precipitate fluid overload. This retrospective cohort study evaluated how hydration status relates to 90-day all-cause mortality in patients admitted to a tertiary ICU from January 2020 to December 2022. Fluid overload was defined as body weight-adjusted fluid balance >10% and AKI followed KDIGO criteria. Kaplan–Meier and multivariate Cox analyses assessed survival and mortality predictors, including fluid overload and SOFA score.",{"@graph":69,"@context":122},[70,84,105],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":40,"@type":76,"position":81},"https://docshare.wps.com/document/research-report/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/association-between-hydration-status-and-mortality-in-elderly-obese-critically-ill-patients-with-acute-kidney-injury-a-retrospective-cohort-study-article-focus-study/448024/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/association-between-hydration-status-and-mortality-in-elderly-obese-critically-ill-patients-with-acute-kidney-injury-a-retrospective-cohort-study-article-focus-study/448024.png","ImageObject",300,407,{"name":92,"@type":93},"Ivy","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-10-04","2026-09-29",true,{"@type":102,"interactionType":103,"userInteractionCount":81},"InteractionCounter",{"@type":104},"ViewAction",{"@type":106,"mainEntity":107},"FAQPage",[108,114,118],{"name":109,"@type":110,"acceptedAnswer":111},"What was the study's main objective?","Question",{"text":112,"@type":113},"To evaluate the association between hydration status and 90-day all-cause mortality in elderly obese critically ill patients with acute kidney injury.","Answer",{"name":115,"@type":110,"acceptedAnswer":116},"How did the study define fluid overload?",{"text":117,"@type":113},"Fluid overload was defined as a body weight-adjusted fluid balance greater than 10%.",{"name":119,"@type":110,"acceptedAnswer":120},"What statistical methods were used to assess mortality risk?",{"text":121,"@type":113},"Kaplan–Meier survival curves and multivariate Cox regression were used to analyze survival differences and independent predictors of mortality.","https://schema.org",{"og:url":83,"og:type":124,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":126,"canonical":83},"index,follow",{"doc_id":128,"site_id":62},448024,1790934245,{"code":4,"msg":5,"data":131},{"doc_id":128,"user_id":132,"nickname":92,"user_avatar":133,"doc_module":4,"category_id":39,"category_name":40,"doc_title":65,"doc_description":67,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":81,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":139,"language":140,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":141,"faqs":142,"seo_title":143,"seo_description":67,"update_tm":144,"read_time":41},549758252649,"https://ap-avatar.wpscdn.com/avatar/8000253669c5317157?_k=1778319167496531819","Association between hydration status and mortality in elderly obese critically ill patients with acute kidney injury: A retrospective cohort study  \nJiesheng Yang 1 and Junhua Yang 1   \nScience Progress 2026, Vol. 109(1) 1–12 © The Author(s) 2026 Article reuse guidelines:  \n[sagepub.com/journals-permissions](sagepub.com/journals-permissions)[ ](sagepub.com/journals-permissions)[DOI: 10.1177/00368504251404080](DOI: 10.1177/00368504251404080)[ ](DOI: 10.1177/00368504251404080)[journals.sagepub.com/home/sci](journals.sagepub.com/home/sci)  \nAbstract  \nObjectives: Fluid management in critically ill obese patients is challenging due to the risk of fluid overload when using standard weight-based formulas. This study aims to evaluate the association between hydration status and mortality in elderly obese critically ill patients with acute kidney injury (AKI).  \nMethods: This retrospective cohort study included elderly obese critically ill patients with AKI admitted to a tertiary care ICU between January 2020 and December 2022. AKI was diagnosed according to the Kidney Disease: Improving Global Outcomes (KDIGO) criteria. Fluid overload was defined as body weight-adjusted fluid balance >10%. The primary outcome was 90-day all-cause mortality. Statistical analyses included Kaplan–Meier survival curves and multivariate Cox regression.  \nResults: A total of 539 elderly obese critically ill patients with AKI were included, of whom 244 (45.3%) developed fluid overload. During the 90-day follow-up, 209 patients (38.8%) died. Patients with fluid overload had significantly higher 90-day mortality compared to those without fluid overload (50.4% vs. 29.2%, P \u003C0.01). Kaplan–Meier analysis showed a higher mortality risk for fluid-overloaded patients (P \u003C0.01). Multivariate Cox regression indicated that fluid overload (HR = 2.04, 95% CI: 1.24–3.36, P \u003C0.01) and SOFA score (HR = 1.13, 95% CI: 1.04–1.22, P \u003C0.01) were independent predictors of increased mortality.  \n1 Department of Nephrology, Pu’er People’s Hospital, Pu’er, China  \nCorresponding author:  \nJunhua Yang, Department of Nephrology, Pu’er People’s Hospital, No.44 Zhenxing Avenue, Pu’er 666500, China.  \nEmail: [yangjunhuape@163.com](yangjunhuape@163.com)  \nCreative Commons Non Commercial CC BY-NC: This article is distributed under the terms  \nof the Creative Commons Attribution-NonCommercial 4.0 License ([https://](https://)[ ](https://)[creativecommons.org/l](creativecommons.org/l)icenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access page ([https://us.sagepub.com/en-us/nam/open-access-at-sage](https://us.sagepub.com/en-us/nam/open-access-at-sage)).  \nConclusions: Fluid overload is significantly associated with increased 90-day mortality in elderly obese critically ill patients with AKI.  \nKeywords  \nAcute kidney injury, elderly, fluid overload, obesity, mortality  \nIntroduction  \nAcute kidney injury (AKI) is a common and serious condition in critically ill patients, characterized by a sudden decline in kidney function that can lead to significant morbidity and mortality.1 AKI affects approximately 13 .3 million people globally each year, with an estimated mortality rate ranging from 20% to 50% in critically ill patients.2,3  \nThe management of AKI is intrinsically associated with fluid status. On one hand, hypovolemia is a major cause of AKI, making prompt and adequate rehydration a cornerstone of treatment to restore renal perfusion.4 On the other hand, the kidneys’ impaired ability to excrete excess fluid in AKI creates a high risk for fluid overload.5 This paradoxical situation makes precise fluid management critically important yet challenging.6 This challenge is particularly magnified in obese patients. Conventional fluid calculation formulas, which are often based on total body weight, are poorly suited for this population.7 Adipose tissue has a lower m","cbCainJwVrvvYtL4","https://ap.wps.com/l/cbCainJwVrvvYtL4","pdf",450861,12,"English","# Abstract\n## Objectives\n## Methods\n## Results\n## Conclusions\n# Introduction\n# Materials and methods\n## Patients","[{\"question\":\"What was the study's main objective?\",\"answer\":\"To evaluate the association between hydration status and 90-day all-cause mortality in elderly obese critically ill patients with acute kidney injury.\"},{\"question\":\"How did the study define fluid overload?\",\"answer\":\"Fluid overload was defined as a body weight-adjusted fluid balance greater than 10%.\"},{\"question\":\"What statistical methods were used to assess mortality risk?\",\"answer\":\"Kaplan–Meier survival curves and multivariate Cox regression were used to analyze survival differences and independent predictors of mortality.\"}]","Association between hydration status and mortality in elderly obese critically ill patients with acute kidney injury: A retrospective cohort study - Article focus - study | PDF",1790724780]