[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"detail-sidebar-cat-0-en-105":3,"doc-seo-454924-105":59,"doc-detail-454924-en":135},{"code":4,"msg":5,"data":6},0,"success",[7,13,18,23,28,33,38,43,48,51,55],{"id":8,"doc_module":4,"doc_module_name":9,"category_name":10,"show_sort_weight":11,"slug":12},1,"Document","Story & Novel",90,"story-novel",{"id":14,"doc_module":4,"doc_module_name":9,"category_name":15,"show_sort_weight":16,"slug":17},2,"Literature",80,"literature",{"id":19,"doc_module":4,"doc_module_name":9,"category_name":20,"show_sort_weight":21,"slug":22},4,"Exam",70,"exam",{"id":24,"doc_module":4,"doc_module_name":9,"category_name":25,"show_sort_weight":26,"slug":27},5,"Comic",60,"comic",{"id":29,"doc_module":4,"doc_module_name":9,"category_name":30,"show_sort_weight":31,"slug":32},6,"Technology",50,"technology",{"id":34,"doc_module":4,"doc_module_name":9,"category_name":35,"show_sort_weight":36,"slug":37},7,"Healthcare",40,"healthcare",{"id":39,"doc_module":4,"doc_module_name":9,"category_name":40,"show_sort_weight":41,"slug":42},8,"Research & Report",30,"research-report",{"id":44,"doc_module":4,"doc_module_name":9,"category_name":45,"show_sort_weight":46,"slug":47},9,"Religion & Spirituality",20,"religion-spirituality",{"id":46,"doc_module":4,"doc_module_name":9,"category_name":49,"show_sort_weight":46,"slug":50},"World Cup","world-cup",{"id":52,"doc_module":4,"doc_module_name":9,"category_name":53,"show_sort_weight":52,"slug":54},10,"Lifestyle","lifestyle",{"id":56,"doc_module":4,"doc_module_name":9,"category_name":57,"show_sort_weight":24,"slug":58},19,"General","general",{"code":4,"msg":60,"data":61},"ok",{"site_id":62,"language":63,"slug":64,"title":65,"keywords":66,"description":67,"schema_data":68,"social_meta":128,"head_meta":130,"extra_data":132,"updated_unix":134},105,"en","association-between-flavonoid-intake-and-arterial-stiffness-persian-cohort-study","Association between flavonoid intake and arterial stiffness - Persian cohort study","","Study evaluates whether dietary flavonoid intake is linked to arterial stiffness as a predictor of cardiovascular disease risk. Using the PERSIAN cohort study data from Mashhad, 3423 adults aged 35–70 were assessed via food frequency questionnaire and Phenol Explorer. Total flavonoids and subclasses were related to blood pressure and stiffness indices, including pulse wave velocity (PWV) and central augmentation index (AIx), with logistic regression and multivariable confounder adjustment. Total flavonoids showed no significant inverse associations with high-risk PWV or AIx.",{"@graph":69,"@context":127},[70,84,106],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":35,"@type":76,"position":81},"https://docshare.wps.com/document/healthcare/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/association-between-flavonoid-intake-and-arterial-stiffness-persian-cohort-study/454924/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/association-between-flavonoid-intake-and-arterial-stiffness-persian-cohort-study/454924.png","ImageObject",300,407,{"name":92,"@type":93},"Dipper","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-10-31","2026-09-30",true,{"@type":102,"interactionType":103,"userInteractionCount":105},"InteractionCounter",{"@type":104},"ViewAction",14,{"@type":107,"mainEntity":108},"FAQPage",[109,115,119,123],{"name":110,"@type":111,"acceptedAnswer":112},"What was the objective of the study?","Question",{"text":113,"@type":114},"To investigate the association between flavonoid intake and arterial stiffness as a predictor of cardiovascular disease risk.","Answer",{"name":116,"@type":111,"acceptedAnswer":117},"How were flavonoid intakes and arterial stiffness assessed?",{"text":118,"@type":114},"Flavonoid intake was estimated using a food frequency questionnaire and Phenol Explorer, and arterial stiffness was evaluated using PWV and AIx.",{"name":120,"@type":111,"acceptedAnswer":121},"What did the results show about total flavonoid intake?",{"text":122,"@type":114},"Total flavonoid intake had no significant association with high-risk levels of PWV or AIx compared between the highest and lowest quintiles.",{"name":124,"@type":111,"acceptedAnswer":125},"Did flavonoid subclasses show any significant association with blood pressure or stiffness indices?",{"text":126,"@type":114},"No significant associations were detected between each flavonoid subclass and high-risk levels of blood pressure or arterial stiffness indices including PWV and AIx.","https://schema.org",{"og:url":83,"og:type":129,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":131,"canonical":83},"index,follow",{"doc_id":133,"site_id":62},454924,1790816149,{"code":4,"msg":5,"data":136},{"doc_id":133,"user_id":137,"nickname":92,"user_avatar":138,"doc_module":4,"category_id":34,"category_name":35,"doc_title":65,"doc_description":67,"doc_content":139,"file_id":140,"file_url":141,"file_type":142,"file_size":143,"view_count":105,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":144,"language":145,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":146,"faqs":147,"seo_title":148,"seo_description":67,"update_tm":149,"read_time":150,"preview_page_count":4},1374404997633,"https://ap-avatar.wpscdn.com/davatar_a8503ba1806abce46bf441b54a3ca4cd","Short-Communication  \nAssociation between flavonoid intake and arterial stiffness: PERSIAN  \ncohort study  \nSara Ghodrat 1, Mostafa Shahraki Jazinaki 1, Reza Rezvani 1, Majid Khadem-Rezaiyan2, Seyyed Mostafa Arabi3, Saeid Eslami4, Mohammad Hassan Abolhassani5, Seyed Mohammad  \nTabatabaee Jabali6, Abdolreza Norouzy1, 5,*  \n1Department of Nutrition, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran 2Department of Community Medicine, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran 3Clinical nutrition and biochemistry department, Faculty of Medicine, Neyashbur University of Medical Sciences, Neyshabur, Iran  \n4Department of Medical Informatics, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran 5Department of Clinical Nutrition, Faculty of Medicine, Iran University of Medical Sciences, Tehran, Iran 6Department of Sports Medicine, School of Medicine, Iran University of Medical Sciences, Tehran, Iran  \n\n| Article history:\u003Cbr>Received: Apr 21, 2024 Received in revised form:\u003Cbr>Jun 09, 2024\u003Cbr>Accepted: Jun 21, 2024 AJP, Vol. 15, No. 6, Nov-Dec 2025, 1571-1583. [https://dx.doi.org/10.22038/](https://dx.doi.org/10.22038/)[ ](https://dx.doi.org/10.22038/)[ajp.2025.25958](ajp.2025.25958)\u003Cbr>* Corresponding Author:\u003Cbr>Tel: +985138828573\u003Cbr>Fax: +985138002359 [Norouzy@gmail.com](Norouzy@gmail.com)\u003Cbr>Keywords:\u003Cbr>Flavonoids Polyphenols Arterial stiffness Pulse wave velocity\u003Cbr>Cardiovascular diseases | Abstract\u003Cbr>Objective: Given the growing prevalence of cardiovascular diseases (CVDs), preventing them is considered one of the most critical global health goals. Evidence suggests that high flavonoid intake may reduce the risk of CVDs. Therefore, this study investigates the association between flavonoid intake and arterial stiffness as a predictor of CVDs.\u003Cbr>Materials and Methods: The PERSIAN cohort study in Mashhad data was used in this cross-sectional study. From data registered in the cohort center, 3423 men and women aged 35 to 70 years were recruited for this study. Total flavonoid intake and intakes of each flavonoid subclass were obtained through a food frequency questionnaire using the Phenol Explorer. Then, their association with blood pressure and arterial stiffness indices, including pulse wave velocity (PWV) and central augmentation index (AIx) , was assessed using univariate logistic regression, and confounding factors were adjusted by performing the multivariable analysis. Results: The findings showed that total flavonoid intake had a nonsignificant inverse relationship with high-risk levels of PWV and AIx (OR (95% CI) for the highest quintile compared to the lowest quintile were 0.83 (0.65-1.06) and 0.95 (0.74-1.21), respectively) . Also, no significant association was detected between intake of each flavonoid subclass and high-risk levels of blood pressure or arterial stiffness indices including PWV and AIx.\u003Cbr>Conclusion: This study revealed that total flavonoid and each flavonoid subclass had no significant association with high-risk arterial stiffness or blood pressure levels. More studies on flavonoids' impact on arterial stiffness are needed for a definite conclusion. |\n| --- | --- |\n| Please cite this paper as:\u003Cbr>Ghodrat S, Ghorayshi F, Shahraki Jazinaki M, Akbari H, Rezvani R, Khadem Rezaiyan M, Arabi S.M, Eslami Hasanabadi S, Abolhasani M.H, Tabatabei Jabali S.M, Norouzy A. Association between flavonoid intake and arterial stiffness: Persian cohort study. Avicenna J Phytomed, 2025; 15(6): 1571-1583. |  |\n\nIntroduction  \nFlavonoids are a group of polyphenols that exist in many herbs, fruits, and vegetables (Tanwar and Modgil 2012) . Flavonoids have a common basic chemical structure (Escobar-Cévoli et al. 2017) . The structural components of the flavonoids include a basic flavonoid skeleton and a variation of multiple hydroxyl and methoxyl group substituents (Babu and Liu 2009) . All of the main flavonoid subclasses are comprised of three six","cbCaitZPbZ3Mj1y4","https://ap.wps.com/l/cbCaitZPbZ3Mj1y4","pdf",743457,13,"English","# Article history\n# Abstract\n## Objective\n## Materials and Methods\n## Results\n## Conclusion\n# Introduction","[{\"question\":\"What was the objective of the study?\",\"answer\":\"To investigate the association between flavonoid intake and arterial stiffness as a predictor of cardiovascular disease risk.\"},{\"question\":\"How were flavonoid intakes and arterial stiffness assessed?\",\"answer\":\"Flavonoid intake was estimated using a food frequency questionnaire and Phenol Explorer, and arterial stiffness was evaluated using PWV and AIx.\"},{\"question\":\"What did the results show about total flavonoid intake?\",\"answer\":\"Total flavonoid intake had no significant association with high-risk levels of PWV or AIx compared between the highest and lowest quintiles.\"},{\"question\":\"Did flavonoid subclasses show any significant association with blood pressure or stiffness indices?\",\"answer\":\"No significant associations were detected between each flavonoid subclass and high-risk levels of blood pressure or arterial stiffness indices including PWV and AIx.\"}]","Association between flavonoid intake and arterial stiffness - Persian cohort study | PDF",1790741714,33]